90 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27977181	8	An Orally Active Bradykinin B	Nanyang Technological University
1433218	3	Guanidinophenyl-substituted enol lactones as selective, mechanism-based inhibitors of trypsin-like serine proteases.	University Of Illinois
19715320	87	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.	University Of Florida
15837303	52	Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors.	Berlex Biosciences
12904065	30	Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide.	Lg Life Sciences
10956211	14	GRID/CPCA: a new computational tool to design selective ligands.	Boehringer Ingelheim Pharma
8759623	31	Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.	R. W. Johnson Pharmaceutical Research Institute
7966150	60	Design and synthesis of potent and highly selective thrombin inhibitors.	F. Hoffmann-La Roche
8478905	53	Inhibition studies of some serine and thiol proteinases by new leupeptin analogues.	University Of Arkansas
8496923	9	New mechanism-based inactivators of trypsin-like proteinases. Selective inactivation of urokinase by functionalized cyclopeptides incorporating a sulfoniomethyl-substituted m-aminobenzoic acid residue.	Cnrs-Cercoa
2231595	96	Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses.	Abbott Laboratories
15081015	91	Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.	The Bristol-Myers Squibb Pharmaceutical Research Institute
12781189	6	D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety.	Basf
11909707	69	Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1.	Life Science R & D, Lgci
11459667	13	Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors.	Medical University Of South Carolina
	34	Peptidyl -keto thiazole as potent thrombin inhibitors	TBA
	22	Design and synthesis of conformationally constrained arginal thrombin inhibitors	TBA
	48	DERIVATIVES OF 4-AMINO-PYRIDINE AS SELECTIVE THROMBIN INHIBITORS	TBA
	19	Rational design of selective thrombin inhibitors	TBA
	37	Synthesis and biological activity of P2–P4 azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives: a novel class of serine protease inhibitors	TBA
	4	Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor	TBA
	24	Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif	TBA
	2	Kinetic characterization of a peptide inhibitor of trypsin isolated from a synthetic peptide combinatorial library	TBA
	9	Diphenylborinic acid is a strong inhibitor of serine proteases	TBA
	13	Characterization of LY806303 as a potent and selective inhibitor of thrombin	TBA
12951087	23	Selective 3-amino-2-pyridinone acetamide thrombin inhibitors incorporating weakly basic partially saturated heterobicyclic P1-arginine mimetics.	University Of Ljubljana
12372529	21	Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.	Bristol-Myers Squibb Pharmaceutical Research Institute
12372525	2	A mechanism-based probe for gp120-Hydrolyzing antibodies.	University Of Texas-Houston Medical School
11965377	66	Design and synthesis of aminophenol-based factor Xa inhibitors.	Berlex Biosciences
11881991	21	PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.	Protherics Molecular Design
11425539	23	Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones.	Shionogi
11133089	28	Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1.	Lg Chemical
11078187	36	Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.	Shionogi
10853669	102	Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors.	Berlex Biosciences
10782664	42	Isoxazolines and isoxazoles as factor Xa inhibitors.	Dupont Pharmaceuticals
10639283	135	Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors.	Berlex Biosciences
10636250	20	Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.	3-Dimensional Pharmaceuticals
10636229	27	Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.	3-Dimensional Pharmaceuticals
10560742	85	3-Amidinophenylalanine-based inhibitors of urokinase.	UniversitäT Jena
10508439	4	Conformations of trypsin-bound amidine inhibitors of blood coagulant factor Xa by double REDOR NMR and MD simulations.	Washington University
10498193	22	Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption.	Biotech Research Institute
10346927	114	Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.	Berlex Biosciences
10230630	36	Thrombin inhibitors based on a propargylglycine template.	Biotech Research Institute
10212122	35	Secondary structure peptide mimetics: design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors.	Molecumetics
9934479	17	Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety.	Nv Organon Scientific Development Group
9925737	57	N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.	Nippon Steel
9876114	111	Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.	Institut FüR Biochemie
9873581	21	Benzylamine-based selective and orally bioavailable inhibitors of thrombin.	Biotech Research Institute
9873520	27	Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors.	Berlex Biosciences
9873414	13	Potent and efficacious thienylamidine-incorporated thrombin inhibitors.	Biotech Research Institute
9733491	21	Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.	Novartis Pharma
9733480	93	Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.	Berlex Biosciences
9733479	18	(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.	Berlex Biosciences
9544206	94	2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease.	Warner-Lambert
9406602	7	Assessment of solvation effects on calculated binding affinity differences: trypsin inhibition by flavonoids as a model system for congeneric series.	Universidad De Alcalá
9371237	69	Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.	Merck Research Laboratories
7739010	118	Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.	Thrombosis Research Institute
7473571	90	Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions.	Eli Lilly
6219223	94	Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.	TBA
2391691	55	Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters.	Merck Sharp And Dohme Research Laboratories
1447734	29	Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases.	University Of Illinois
10869410	62	S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.	Centre De Recherches De Croissy
9802391	31	The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4.	Uppsala University
9195867	15	Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.	University Of California Berkeley
20383151	2	Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.	Dana-Farber Cancer Institute
19648931	16	Design, synthesis and selection of DNA-encoded small-molecule libraries.	Praecis Pharmaceuticals
19305397	22	Molecular docking and ligand specificity in fragment-based inhibitor discovery.	University Of California San Francisco
	28	A Thermodynamic Study of the Reactions of Cyclodextrins with Primary and Secondary Aliphatic Alcohols, with D- and L-Phenylalanine, and with L-Phenylalanine Amide	Nist
19699645	12	Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.	Northern Kentucky University
17184135	28	HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.	Rutgers University
14761195	114	Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.	University Of Athens
10531324	22	Thermodynamic analyses reveal role of water release in epitope recognition by a monoclonal antibody against the human guanylyl cyclase C receptor.	Indian Institute Of Science