135 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
26820555	87	Synthesis and evaluation of colletoic acid core derivatives.	St. Jude Children'S Research Hospital
26306982	4	Novel 11ß-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold.	Universitat De Barcelona
26187704	63	Discovery of 11ß-hydroxysteroid dehydrogenase type 1 inhibitor.	Incheon National University
25590374	23	Hupehenols A-E, selective 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors from Viburnum hupehense.	Chinese Academy of Sciences
25800116	62	Synthesis and optimization of picolinamide derivatives as a novel class of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.	Seoul National University
25529735	27	Synthesis and biological evaluation of picolinamides as potent inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).	Seoul National University
25050169	52	Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).	Bristol-Myers Squibb
24960438	24	Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17ß-hydroxysteroid dehydrogenase 2 inhibitors.	University of Innsbruck
25098388	7	Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus.	Chinese Academy of Sciences
25453795	6	Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus.	TBA
25266782	41	Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors for the treatment of metabolic disorders.	Bristol-Myers Squibb
24815509	51	Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.	Hoffmann-La Roche
24294985	42	Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).	Astrazeneca
24422550	107	Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice.	Astrazeneca
24507919	45	3-Amino-N-adamantyl-3-methylbutanamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitor.	Yonsei University
24360604	60	Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).	Bristol-Myers Squibb
24074876	17	Synthesis of sterically encumbered 11ß-aminoprogesterone derivatives and evaluation as 11ß-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists.	University of Alberta
23981897	6	Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.	Leopold-Franzens-Universit£T
23845218	86	1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes.	Sanofi Deutschland
23795939	5	11ß-HSD1 inhibitors from Walsura cochinchinensis.	Chinese Academy of Sciences
23800686	45	Mono-carbonyl curcumin analogues as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.	Wenzhou Medical College
23747808	51	Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.	Chinese Academy of Sciences
23659858	17	Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension.	Merck
23478147	42	Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.	Sanofi R & D
23489629	19	N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11ß-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.	Pfizer
23414800	47	Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.	Toray Industries
23353742	29	Design, synthesis and SAR of piperidyl-oxadiazoles as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.	Chinese Academy of Sciences
23145773	45	Structural optimization of 2,5-thiophene amides as highly potent and selective 17ß-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.	Saarland University
24900572	54	Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.	Pfizer
18314331	70	Docking-based 3D-QSAR study for 11beta-HSD1 inhibitors.	Korea Research Institute of Chemical Technology
23153367	92	Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.	Astrazeneca
23088558	36	Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).	Astrazeneca
23040895	37	Adamantyl carboxamides and acetamides as potent human 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.	University of Bath
23013933	59	Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors.	Astrazeneca
24900382	41	Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.	TBA
22691057	32	Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).	Astrazeneca
22901389	28	Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I.	Merck Serono
22542009	102	Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11ß-HSD1 inhibitors.	Amgen
22360639	12	Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases.	Chinese Academy of Sciences
24900439	34	Synthesis and biological evaluation of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.	TBA
22440625	44	Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.	Chinese Academy of Sciences
24900270	22	Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.	TBA
21138273	11	Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17ß-hydroxysteroid dehydrogenase type 1.	University of Ljubljana
19564108	48	4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.	Chinese Academy of Sciences
19574056	25	Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.	Chinese Academy of Sciences
19185488	56	Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.	Amgen
18553955	43	Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.	Amgen
18533708	25	Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.	University of Innsbruck
18440812	113	Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Merck Research Laboratories
18434143	96	Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.	Merck
18242087	18	Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.	Shanghai Institute of Materia Medica
17490884	39	beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.	Wyeth Research
12190302	9	Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.	Biovitrum
22148241	3	Cyclopeptide Alkaloids from Ziziphus apetala.	Kunming Institute of Botany
21983444	78	Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).	Bristol-Myers Squibb Research & Development
21983439	65	Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).	Bristol-Myers Squibb
21873057	13	Potent and novel 11ß-HSD1 inhibitors identified from shape and docking based virtual screening.	Shanghai Pharmaceutical Holding
21786805	130	Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1.	Vitae Pharmaceuticals
21689935	55	Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).	Bristol-Myers Squibb
21334894	218	Substituted phenyl triazoles as selective inhibitors of 11 β-Hydroxysteroid Dehydrogenase Type 1.	Merck
21439819	49	Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.	Sanofi-Aventis R&D
21421311	135	Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.	Merck Research Laboratories
21376605	26	Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.	University of Technology
21093259	38	Synthesis and 11ß hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group.	Korea University
21093258	66	Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11ß-HSD1 inhibitors.	Amgen
20971000	76	The synthesis and SAR of novel diarylsulfone 11ß-HSD1 inhibitors.	Amgen
20864344	110	Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1.	Vitae Pharmaceuticals
20851614	22	Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.	University of Natural Resources and Applied Life Sciences
20510621	44	A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemical series.	Astrazeneca
20465278	27	Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).	Amgen
20452767	65	Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.	University of Edinburgh
20363126	50	The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.	Pfizer
20149650	65	Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.	Merck Research Laboratories
20045318	18	Discovery of cyclicsulfonamide derivatives as 11beta-hydroxysteroid dehydrogenase 1 inhibitors.	Korea University
20100662	6	11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.	University of Innsbruck
20064717	64	Spirocyclic ureas: orally bioavailable 11beta-HSD1 inhibitors identified by computer-aided drug design.	Vitae Pharmaceuticals
19625185	44	The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.	Schering-Plough Research Institute
19673466	101	Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.	Wyeth Research
19395260	29	Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Merck Serono
19181519	71	Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).	TBA
19053753	67	Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.	Amgen
18789704	4	Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.	Amgen
18653260	24	Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors.	Institute of Materia Medica
18578516	83	Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.	Wyeth Research
18440811	207	4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Merck Research Laboratories
17919905	56	The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.	Amgen
17600707	48	Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.	Biovitrum
17442567	27	Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.	Biovitrum
17350260	56	Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.	University of Edinburgh
17201418	105	Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.	Abbott Laboratories
17070044	102	Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.	Abbott Laboratories
17000111	127	Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.	Abbott Laboratories
16996734	93	Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.	Abbott Laboratories
16931002	73	Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.	Abbott Laboratories
16899366	85	Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.	Abbott Laboratories
16890427	81	Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.	Abbott Laboratories
16759088	38	The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.	University of Innsbruck
16185866	53	Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.	Merck
15911270	19	Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Wyeth Research
31759849	24	Optimization of cyclic sulfamide derivatives as 11?-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.	Korea Research Institute of Chemical Technology
26936592	8	Limonoids and Triterpenoids as 11?-HSD1 Inhibitors from Walsura robusta.	Chinese Academy of Sciences
30613321	31	Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11?-Hydroxysteroid Dehydrogenase Type 1 (11?-HSD-1).	Bristol-Myers Squibb
31294974	62	Mechanistic Insight on the Mode of Action of Colletoic Acid.	The University of Tennessee Health Science Center
26596711	3	Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11?-HSD1 inhibitors.	Universitat De Barcelona
29207342	7	Accelerated skin wound healing by selective 11?-Hydroxylase (CYP11B1) inhibitors.	Saarland University
30245006	5	Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11?-hydroxysteroid dehydrogenase 1.	Dsm Nutritional Products
28818766	23	Design, synthesis and in vivo study of novel pyrrolidine-based 11?-HSD1 inhibitors for age-related cognitive dysfunction.	Universitat De Barcelona
28458137	25	Synthesis of selective 11?-HSD1 inhibitors based on dammarane scaffold.	Chinese Academy of Sciences
28528082	140	Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11? hydroxysteroid dehydrogenase type 1 inhibitor.	Vitae Pharmaceuticals
28537398	114	Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11?-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.	Bristol-Myers Squibb
22145694	64	Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.	Agri Ibrahim Cecen University
20233015	6	Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp. str. Lukesová 27/97.	Brno University of Technology
28460360	13	Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors.	China Pharmaceutical University
27982494	6	Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides.	University of Glasgow
21538764	6	Identification and characterization of new inhibitors of fungal homoserine kinase.	Mcmaster University
21337480	17	Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans.	The University of Edinburgh
8097160	35	Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.	University of Toronto
20187655	12	Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.	Academia Sinica
19807124	8	Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.	University of Pittsburgh
19438227	71	Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.	Pfizer