48 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28302510	7	Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.	University of Iowa
28208018	26	Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.	Mcgill University
26713103	7	Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase.	University of Iowa
25815158	6	Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.	University of Illinois At Urbana-Champaign
25935643	5	N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation.	University of Iowa
25630225	5	Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.	Mcgill University
24811300	20	Biased and unbiased strategies to identify biologically active small molecules.	Institut De Chimie Des Substances Naturelles
25184810	4	Structural evidence of N6-isopentenyladenosine as a new ligand of farnesyl pyrophosphate synthase.	Universit£
24911527	30	Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.	Mcgill University
24726306	11	Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.	University of Iowa
23998921	19	Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.	Mcgill University
23477945	3	Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate.	Mcgill University
23610597	64	Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.	Prenylx Research Institute
12825934	55	A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.	University of Illinois At Urbana-Champaign
22884353	15	Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.	Mcgill University
21780776	40	Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.	Wroclaw University of Technology
22390415	28	Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.	Mcgill University
20394422	6	Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.	University of Southern California
18434151	2	Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies.	University of Southern California
18308574	15	Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.	University of Iowa
18327899	106	Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.	University of Oxford
18295483	50	Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.	Novartis Institutes For Biomedical Research
20801032	3	Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.	Mcgill University
20303767	5	Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.	University of California Santa Cruz
18937434	7	Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.	Universita Di Ferrara
18789701	2	Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation.	University of Illinois At Urbana-Champaign
17975902	8	Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.	University of Southern California
17963374	11	Activity of sulfonium bisphosphonates on tumor cell lines.	University of Illinois At Urbana-Champaign
16143525	8	Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase.	Universidad De Buenos Aires
14613320	186	3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.	University of Illinois At Urbana-Champaign
12951099	28	Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.	Universidad De Buenos Aires
12014956	34	Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.	University of Illinois At Urbana-Champaign
30730737	10	Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.	Chinese Academy of Sciences
31725297	280	Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells.	Tsinghua University
30016091	31	Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.	Mcgill University
31257875	5	Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure-Activity Relationship.	Korea University
31577901	15	Chirality-Driven Mode of Binding of ?-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).	Mcgill University
31699606	43	Novel benzimidazole phosphonates as potential inhibitors of protein prenylation.	University of Iowa
31474482	5	?-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors.	University of Iowa
30216851	4	Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis.	University of Bari "A. Moro
29248353	17	?-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.	University of Iowa