The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28302510 |
7 |
Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
University of Iowa |
28208018 |
26 |
Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. |
Mcgill University |
26713103 |
7 |
Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase. |
University of Iowa |
25815158 |
6 |
Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. |
University of Illinois At Urbana-Champaign |
25935643 |
5 |
N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. |
University of Iowa |
25630225 |
5 |
Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. |
Mcgill University |
24811300 |
20 |
Biased and unbiased strategies to identify biologically active small molecules. |
Institut De Chimie Des Substances Naturelles |
25184810 |
4 |
Structural evidence of N6-isopentenyladenosine as a new ligand of farnesyl pyrophosphate synthase. |
Universit£ |
24911527 |
30 |
Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. |
Mcgill University |
24726306 |
11 |
Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
University of Iowa |
23998921 |
19 |
Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition. |
Mcgill University |
23477945 |
3 |
Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate. |
Mcgill University |
23610597 |
64 |
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. |
Prenylx Research Institute |
12825934 |
55 |
A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. |
University of Illinois At Urbana-Champaign |
22884353 |
15 |
Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls. |
Mcgill University |
21780776 |
40 |
Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry. |
Wroclaw University of Technology |
22390415 |
28 |
Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. |
Mcgill University |
20394422 |
6 |
Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. |
University of Southern California |
18434151 |
2 |
Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies. |
University of Southern California |
18308574 |
15 |
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. |
University of Iowa |
18327899 |
106 |
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. |
University of Oxford |
18295483 |
50 |
Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. |
Novartis Institutes For Biomedical Research |
20801032 |
3 |
Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase. |
Mcgill University |
20303767 |
5 |
Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. |
University of California Santa Cruz |
18937434 |
7 |
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism. |
Universita Di Ferrara |
18789701 |
2 |
Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation. |
University of Illinois At Urbana-Champaign |
17975902 |
8 |
Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. |
University of Southern California |
17963374 |
11 |
Activity of sulfonium bisphosphonates on tumor cell lines. |
University of Illinois At Urbana-Champaign |
16143525 |
8 |
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase. |
Universidad De Buenos Aires |
14613320 |
186 |
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. |
University of Illinois At Urbana-Champaign |
12951099 |
28 |
Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. |
Universidad De Buenos Aires |
12014956 |
34 |
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. |
University of Illinois At Urbana-Champaign |