82 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
26638042	5	Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.	China Pharmaceutical University
25462262	98	Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.	Goethe-University Frankfurt
1848292	116	Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.	Ici Pharmaceuticals Group
	4	Cyclic aryl hydroxamic acids: synthesis and inhibition of 5-lipoxygenase	TBA
22380511	73	Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.	Peking University
9207936	198	Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.	Abbott Laboratories
8831759	16	1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.	Smithkline Beecham Pharmaceuticals
7932529	37	Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.	Eisai
8478906	25	Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.	Warner-Lambert
1433181	39	Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.	Warner-Lambert
1635053	47	5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.	Wyeth-Ayerst Research
2113951	134	1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.	Pfizer
2104936	98	2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.	E.I. Du Pont De Nemours
3133478	16	4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities.	Centre De Recherches Roussel-Uclaf
3599023	29	Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.	TBA
3820229	51	Hydroxamic acid inhibitors of 5-lipoxygenase.	TBA
3806609	30	Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.	TBA
3681891	27	Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.	Beecham Pharmaceuticals Research Division
	35	Antiinflammatory -benzeneethanamines. III	TBA
	22	Topical antiinflammatory dehydroabietylamine derivatives. IV	TBA
	39	O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitors	TBA
	19	Catechol based inhibitors of 15-lipoxygenase	TBA
	42	Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitor	TBA
	8	Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists	TBA
	76	2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis	TBA
	14	A novel series of highly potent 5-lipoxygenase inhibitors; 2-aryldienylbenzoxazoles	TBA
	13	Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic properties	TBA
	12	4-[5-(2,3-dihydroxyphenyl)pentyloxy]-2-hydroxy-3-propylbenzoic acid (Ro 24-0553): an orally active 5-lipoxygenase inhibitor with antiinflammatory activity	TBA
	11	Cyclooxygenase and 5-lipoxygenase inhibitory activity of 2,6 di-t-butylphenols linked by a sulfur atom to 1,3,4-thiadiazoles and 1,3,4-oxadiazoles	TBA
	24	Vinylogous hydroxamic acids: 5-lipoxygenase inhibitors	TBA
	11	Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acid	TBA
	17	Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors	TBA
	16	Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenase	TBA
	21	1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor	TBA
	19	Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenase	TBA
	14	Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenase	TBA
10514305	4	Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation.	Peking Union Medical College And Chinese Academy Of Medical Sciences
17336065	12	Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.	Chinese Academy Of Sciences
15081022	20	5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.	Ucb Pharma
11277534	3	N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.	Université
10230624	110	N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.	The R. W. Johnson Pharmaceutical Research Institute
9599246	28	(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.	University Of Virginia
9544212	37	New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.	Procter & Gamble Pharmaceuticals
9484493	11	Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.	Oxis International
9057869	25	Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.	Abbott Laboratories
8978834	33	Bicyclic N-hydroxyurea inhibitors of 5-lipoxygenase: pharmacodynamic, pharmacokinetic, and in vitro metabolic studies characterizing N-hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea.	Smithkline Beecham Pharmaceuticals
8831760	108	5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.	Abbott Laboratories
8809171	13	(E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.	Smithkline Beecham Pharmaceuticals
8568814	23	Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.	Hoechst-Roussel Pharmaceuticals
8515419	29	1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.	Warner-Lambert
8410991	88	Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.	Merck Frosst Centre For Therapeutic Research
8295221	28	Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.	Warner-Lambert
8254620	62	3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.	Tokushima Bunri University
8151626	4	Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.	Dupont Pharmaceuticals
7932593	24	Synthesis and 5-lipoxygenase inhibitory activities of some novel 2-substituted 5-benzofuran hydroxamic acids.	R. W. Johnson Pharmaceutical Research Institute
7739006	2	Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds.	Wyeth Research (U.K.)
3806620	16	Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.	TBA
3783588	51	Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase.	TBA
3669019	11	In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.	Abbott Laboratories
3336029	8	Orally active hydroxamic acid inhibitors of leukotriene biosynthesis.	Abbott Laboratories
3172130	35	Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis.	Abbott Laboratories
3090264	28	Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.	TBA
2878078	43	Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors.	TBA
2542553	31	Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.	Merck Frosst Canada
2502629	90	Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.	Rorer Central Research
2498516	4	N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.	Wyeth-Ayerst Research
2319562	12	Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.	Molecular Therapeutics
2308149	221	Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.	Abbott Laboratories
2213827	73	Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.	Centre De Recherches De Vitry
2115586	29	Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.	Warner-Lambert
2104935	10	N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.	Wyeth-Ayerst Research
2066989	89	4-hydroxythiazole inhibitors of 5-lipoxygenase.	Abbott Laboratories
2016727	30	Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase.	Institute For Bio-Medical Research
1992126	54	Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.	Takeda Chemical Industries
1903450	34	5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones.	Sterling Research Group
1847426	56	Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.	Warner-Lambert
1648621	55	(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.	Ici Pharmaceuticals Group
1507204	18	Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.	Dupont Pharmaceuticals
1433212	59	Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.	Dupont Pharmaceuticals
1313879	21	Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.	Merck Frosst Centre For Therapeutic Research