The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 8230117 |
4 |
The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one. |
Smithkline Beecham Pharmaceuticals |
| 1479586 |
8 |
New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones. |
Kyowa Hakko Kogyo |
| 1656043 |
4 |
New 5H-pyridazino[4,5-b]indole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics. |
Universidad De Navarra |
| 2153209 |
6 |
Synthesis and cardiotonic activity of novel biimidazoles. |
Merrell Dow Research Institute |
| 2738882 |
9 |
Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites. |
Eli Lilly |
| 2846840 |
20 |
Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856). |
Syntex Research |
| 3039132 |
26 |
Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents. |
TBA |
| 3965705 |
10 |
2-(beta-Arylethylamino)- and 4-(beta-arylethylamino)quinazolines as phosphodiesterase inhibitors. |
TBA |
| 14980691 |
15 |
Orally active PDE4 inhibitors with therapeutic potential. |
Minase Research Institute |
| 14684291 |
14 |
New orally active PDE4 inhibitors with therapeutic potential. |
Minase Research Institute |
| 14684329 |
27 |
Highly potent PDE4 inhibitors with therapeutic potential. |
Minase Research Institute |
| 12668000 |
29 |
3D-QSAR studies on thieno[3,2-d]pyrimidines as phosphodiesterase IV inhibitors. |
National Institute of Pharmaceutical Education and Research (NIPER) |
| 12852946 |
69 |
Comparative molecular field analysis (CoMFA) of phthalazine derivatives as phosphodiesterase IV inhibitors. |
National Institute of Pharmaceutical Education and Research |
| 12824031 |
26 |
Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors. |
Tanabe Seiyaku |
| 11814830 |
26 |
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma. |
Celltech R&D |
| 12039576 |
17 |
Synthesis and profile of SCH351591, a novel PDE4 inhibitor. |
Schering-Plough |
| 12039575 |
18 |
8-Methoxyquinolines as PDE4 inhibitors. |
Schering-Plough |
| 12039574 |
16 |
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma. |
Celltech R&D |
| 11738561 |
34 |
Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor. |
Zambon Group |
| 11140727 |
31 |
Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives. |
Zambon Group |
| 11128646 |
69 |
Synthesis and biological evaluation of 2,5-dihydropyrazol. |
RhôNe-Poulenc Rorer |
| 11012037 |
25 |
The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I. |
Zambon Group |
| 10999488 |
34 |
7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma. |
Celltech-Chiroscience |
| 10636238 |
71 |
Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors. |
Institut De Recherche Jouveinal-Parke Davis |
| 9871607 |
32 |
Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds. |
RhôNe-Poulenc Rorer |
| 9871693 |
46 |
Quaternary substituted PDE IV inhibitors II: the synthesis and in vitro evaluation of a novel series of gamma-lactams. |
Rh£Ne-Poulenc Rorer Central Research |
| 9873675 |
44 |
Orally active indole N-oxide PDE4 inhibitors. |
Rh£Ne-Poulenc Rorer Central Research |
| 9873649 |
25 |
PDE4 inhibitors: new xanthine analogues. |
Chiroscience |
| 9871649 |
26 |
Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles. |
Rh£Ne-Poulenc Rorer Central Research |
| 9873600 |
14 |
Thalidomide analogs and PDE4 inhibition. |
Celgene |
| 9873613 |
15 |
2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors. |
Rh£Ne-Poulenc Rorer |
| 9873593 |
15 |
Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma. |
Chiroscience |
| 9873449 |
49 |
The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I. |
Rh£Ne-Poulenc Rorer Central Research |
| 26681511 |
33 |
Preparation and optimization of pyrazolo[1,5-a]pyrimidines as new potent PDE4 inhibitors. |
Sanofi Research Center |
| 26526739 |
35 |
Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. |
Southern Medical University |
| 26288683 |
43 |
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. |
Bristol-Myers Squibb R & D |
| 26005524 |
147 |
Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes. |
Merck Research Laboratories |
| 25736998 |
37 |
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors. |
Merck Serono |
| 15887951 |
29 |
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. |
Monash University (Parkville Campus) |
| 11405657 |
123 |
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives. |
Tanabe Seiyaku |
| 10090791 |
77 |
Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives. |
Tanabe Seiyaku |
| 8388468 |
37 |
Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
Smithkline Beecham Pharmaceuticals |
| 12824030 |
67 |
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors. |
Tanabe Seiyaku |
| 11755362 |
24 |
Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor. |
Novartis Pharma |
| | 5 |
The Gif system as a tool in medicinal chemistry: The oxidation of Sch 57726 under GoAggIII conditions |
TBA |
| 15149695 |
24 |
New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. |
Pfizer |
| 14521415 |
44 |
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. |
Glaxosmithkline |
| 11958981 |
25 |
Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors. |
Bayer |
| 32209292 |
6 |
Ultrasound assisted rapid synthesis of mefenamic acid based indole derivatives under ligand free Cu-catalysis: Their pharmacological evaluation. |
Andhra University |
| 32171616 |
32 |
Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease. |
Changzhou University |
| 10937713 |
186 |
Solid-phase synthesis of an arylsulfone hydroxamate library. |
Rhone-Poulenc Rorer |
| 31099559 |
36 |
Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. |
Shanghai Institute of Materia Medica |
| 31021628 |
50 |
Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. |
Chinese Academy of Sciences |
| 10197972 |
133 |
1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor. |
Tanabe Seiyaku |
| 30554955 |
34 |
Design, synthesis of novel purin-6-one derivatives as phosphodiesterase 2 (PDE2) inhibitors: The neuroprotective and anxiolytic-like effects. |
Changzhou University |
| 9873594 |
44 |
Aryl sulfonamides as selective PDE4 inhibitors. |
Chiroscience |
| 31235264 |
13 |
Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. |
Mitsubishi Tanabe Pharma |
| 30986068 |
112 |
Structure Overhaul Affords a Potent Purine PI3K? Inhibitor with Improved Tolerability. |
TBA |
| 32071685 |
40 |
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGF?R1 Inhibitor as an Immuno-oncology Agent. |
Bristol-Myers Squibb Research & Development |
| 8496906 |
127 |
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. |
Hokuriku University |
| 25062128 |
16 |
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). |
Amgen |
| 24794103 |
1 |
Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors. |
Dainippon Sumitomo Pharma |
| 24400806 |
101 |
Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases. |
Chiesi Farmaceutici |
| 23582272 |
25 |
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. |
Pfizer |
| 21955454 |
53 |
1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4. |
Celgene |
| 20413313 |
14 |
Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity. |
Universit£ |
| 15916433 |
10 |
Design of small-sized libraries by combinatorial assembly of linkers and functional groups to a given scaffold: application to the structure-based optimization of a phosphodiesterase 4 inhibitor. |
Umr Cnrs 7081 |
| 12723963 |
41 |
Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents. |
Vrije Universiteit |
| 12036361 |
28 |
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones. |
Vrije Universiteit |
| 12036360 |
58 |
Novel selective PDE4 inhibitors. 3. In vivo antiinflammatory activity of a new series of N-substituted cis-tetra- and cis-hexahydrophthalazinones. |
Vrije Universiteit |
| 12014973 |
3 |
Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers. |
Wyeth Research |
| 11472206 |
72 |
Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones. |
Vrije Universiteit |
| 11472205 |
37 |
Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues. |
Vrije Universiteit |
| 10737755 |
8 |
Novel and selective calcitonin-inducing agents. |
Wyeth-Ayerst Research |
| 11123995 |
113 |
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors. |
Pfizer |
| 9526558 |
38 |
1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma. |
Smithkline Beecham Pharmaceuticals |
| 9822544 |
15 |
Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth. |
University of Kaiserslautern |
| 9784096 |
38 |
Novel cyclic compounds as potent phosphodiesterase 4 inhibitors. |
Sw 8 Rh£Ne-Poulenc Rorer Central Research |
| 9767640 |
122 |
Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors. |
RhôNe-Poulenc Rorer |
| 9632360 |
26 |
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase. |
Pfizer |
| 9379444 |
54 |
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. |
Hokuriku University |
| 9154964 |
25 |
Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. |
Dipartimento Di Scienze Farmaceutiche, Firenze, Italy. |
| 8568798 |
29 |
Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret. |
Pfizer |
| 2544722 |
94 |
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. |
Centre De Neurochimie Du Cnrs |
| 1331453 |
106 |
Effects of alkyl substitutions of xanthine skeleton on bronchodilation. |
Hokuriku University |
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