The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27939345 |
22 |
Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). |
University of Bergen |
| 27576294 |
2 |
Synthesis and evaluation of 2,5 and 2,6 pyridine-based CXCR4 inhibitors. |
Georgia State University |
| 27434274 |
56 |
Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists. |
Universit£ |
| 27571038 |
18 |
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists. |
Second University of Naples |
| 26509831 |
29 |
Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends. |
Shandong University |
| 26974376 |
2 |
Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities. |
Shandong University |
| 26453409 |
2 |
Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands. |
Tokyo Medical and Dental University |
| 26348881 |
54 |
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening. |
National Health Research Institutes |
| 25935642 |
17 |
Discovery of novel N-aryl piperazine CXCR4 antagonists. |
Emory Institute For Drug Development |
| 26191361 |
6 |
Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase. |
Emory University |
| 25082513 |
30 |
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). |
Uit The Arctic University of Norway |
| 26042340 |
77 |
Development of novel CXC chemokine receptor 7 (CXCR7) ligands: selectivity switch from CXCR4 antagonists with a cyclic pentapeptide scaffold. |
Kyoto University |
| 24983484 |
11 |
Toward fluorescent probes for G-protein-coupled receptors (GPCRs). |
Shandong University |
| 24936240 |
39 |
Discovery of tetrahydroisoquinoline-based CXCR4 antagonists. |
Emory University |
| 23434419 |
13 |
Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection. |
Montana State University |
| 11128640 |
22 |
Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. |
Kyoto University |
| 21381769 |
56 |
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. |
Universite£ |
| 24900366 |
1 |
Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo. |
TBA |
| 23043442 |
30 |
Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4). |
University of Troms£ |
| 22931505 |
69 |
Chemokine receptor antagonists. |
National Heart and Lung Institute |
| 22909088 |
6 |
Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells. |
Universitat Ramon Llull |
| 24900333 |
9 |
Potent CXCR4 antagonists containing amidine type Peptide bond isosteres. |
TBA |
| 22352868 |
8 |
Structure-activity relationship study of a CXC chemokine receptor type 4 antagonist, FC131, using a series of alkene dipeptide isosteres. |
Kyoto University |
| 21841963 |
13 |
Agonists for the Chemokine Receptor CXCR4. |
TBA |
| 16821774 |
86 |
Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists. |
Ono Pharmaceutical |
| 10508445 |
10 |
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4. |
Anormed |
| 11459656 |
27 |
Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. |
Kyoto University |
| 22365757 |
2 |
Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: new insight into CXCR4-FC131 interactions. |
Pharmadesign |
| 21905730 |
20 |
Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4. |
Technische Universit£T M£Nchen |
| 21658961 |
72 |
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist. |
Ono Pharmaceutical |
| 21105715 |
4 |
Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. |
Emory University |
| 21295470 |
27 |
Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. |
Genzyme |
| 19451305 |
3 |
The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100. |
National Institute of Infectious Diseases |
| 21109432 |
22 |
Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication. |
Genzyme |
| 20728351 |
4 |
CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. |
Tokyo Medical and Dental University |
| 19949058 |
15 |
Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist. |
Glaxosmithkline |
| 20443225 |
3 |
Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity. |
Glaxosmithkline |
| 20297846 |
33 |
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. |
Genzyme |
| 20207537 |
3 |
Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents. |
Glaxosmithkline |
| 19674898 |
31 |
Spiropiperidine CCR5 antagonists. |
Roche Palo Alto |
| 20004096 |
49 |
Identification of a new class of small molecule C5a receptor antagonists. |
Wyeth Research |
| 19188071 |
2 |
64Cu-AMD3100--a novel imaging agent for targeting chemokine receptor CXCR4. |
National Institute of Biomedical Imaging and Bioengineering |
| 19053768 |
64 |
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. |
Novartis Institutes For Biomedical Research |
| 19014885 |
32 |
Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist. |
Roche Palo Alto |
| 18539453 |
9 |
Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach. |
Kyoto University |
| 17715128 |
6 |
Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. |
Université |
| 17599916 |
6 |
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. |
University of Copenhagen |
| 17958344 |
2 |
Discovery of small molecule CXCR4 antagonists. |
Emory University |
| 17228861 |
34 |
Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. |
Kyoto University |
| 15857134 |
32 |
Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds. |
Kyoto University |
| 15658852 |
8 |
Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. |
Kyoto University |
| 11958995 |
9 |
Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety. |
Kyoto University |
| 11720852 |
51 |
Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection. |
Merck Research Laboratories |
| 11720851 |
52 |
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection. |
Merck Research Laboratories |
| 32551020 |
15 |
Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel ?-Arrestin Antagonist Activity. |
Pfizer |
| 31882297 |
129 |
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma. |
Sanford Burnham Prebys Medical Discovery Institute |
| 27658790 |
24 |
Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4. |
Upstate Medical University |
| 30978562 |
19 |
High affinity CXCR4 inhibitors generated by linking low affinity peptides. |
University of California San Diego |
| 30655949 |
14 |
Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor. |
Emory University |
| 30476826 |
48 |
Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists. |
Griffin Discoveries |
| 30772128 |
7 |
Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands. |
Tokyo Medical and Dental University (Tmdu) |
| 31521459 |
95 |
The discovery and optimization of a series of 2-aminobenzoxazole derivatives as ChemR23 inhibitors. |
Kyowa Kirin |
| 23409871 |
48 |
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists. |
Glaxosmithkline |
| 23157587 |
54 |
HIV-1 X4 activities of polycationic "viologen" based dendrimers by interaction with the chemokine receptor CXCR4: study of structure-activity relationship. |
University of Osnabr£Ck |
| 29500940 |
25 |
The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential. |
Central South University |
| 29494843 |
29 |
Design, synthesis, and structure-activity-relationship of a novel series of CXCR4 antagonists. |
Soochow University |
| 30052039 |
172 |
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties. |
Emory University |
| 29777988 |
2 |
Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators. |
University of Ljubljana |
| 29795757 |
100 |
Discovery of |
Emory University |
| 29456793 |
72 |
Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains. |
Emory University |
| 29348805 |
56 |
Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists. |
Emory University |
| 28826086 |
20 |
An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics. |
University of Calabria |
| 29350534 |
211 |
Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties. |
Emory University |
| 29627981 |
45 |
Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis. |
Pfizer |
| 29608300 |
118 |
Structure-Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3). |
Kyoto University |
| 29406702 |
128 |
Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. |
Gsk Pharmaceuticals R & D |
| 29125295 |
21 |
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist. |
University of Campania |
| 29314840 |
32 |
Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond. |
National Health Research Institutes |
| 29522685 |
6 |
Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells. |
Universit£ |
Search and Browse
