The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 6313919 |
6 |
C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues. |
TBA |
| 27485602 |
183 |
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors. |
Jagiellonian University Medical College |
| 6133953 |
2 |
alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants. |
TBA |
| 20188574 |
141 |
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. |
University of Bonn |
| 19569717 |
251 |
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. |
Institute |
| 12646033 |
124 |
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists. |
Universit£ |
| 9667957 |
5 |
Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein. |
Hokkaido University |
| 7658429 |
31 |
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431). |
Abbott Laboratories |
| 8246243 |
9 |
Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
Kyowa Hakko Kogyo |
| 8355252 |
54 |
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
Kyowa Hakko Kogyo |
| 1548682 |
126 |
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. |
Kyowa Hakko Kogyo |
| 1738138 |
62 |
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
Niddk |
| 1433217 |
31 |
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists. |
National Institute of Diabetes |
| 1732541 |
60 |
Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects. |
Hokkaido University |
| 1501234 |
111 |
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
Kyowa Hakko Kogyo |
| 1495019 |
57 |
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. |
Hokkaido University |
| 1619615 |
71 |
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
Universit£ |
| 1613750 |
46 |
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects. |
Yamasa Shoyu |
| 1895305 |
75 |
N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. |
University of South Florida |
| 1875349 |
94 |
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines. |
Ciba-Geigy |
| 2002461 |
37 |
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. |
Center For Bio-Pharmaceutical Sciences |
| 2002448 |
112 |
N6-substituted adenosine receptor agonists: potential antihypertensive agents. |
Warner-Lambert |
| 1766003 |
18 |
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. |
University of South Florida |
| 2374150 |
193 |
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. |
Pfizer |
| 2362269 |
30 |
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands. |
Ciba-Geigy |
| 2258897 |
23 |
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors. |
Merrell Dow Research Institute |
| 2213824 |
20 |
Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists. |
Pfizer |
| 2754711 |
102 |
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. |
Niddk |
| 2709373 |
63 |
Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors. |
Niddk |
| 2909748 |
18 |
N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. |
Warner-Lambert |
| 3385722 |
42 |
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. |
Warner-Lambert |
| 3373486 |
44 |
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
Universit£ |
| 3336027 |
32 |
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
Warner-Lambert |
| 2441057 |
22 |
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors. |
TBA |
| 3572985 |
28 |
N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors. |
TBA |
| 2888894 |
32 |
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
Parke-Davis Pharmaceutical Research Division |
| 3018244 |
91 |
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors. |
TBA |
| 3005574 |
34 |
Ribose-modified adenosine analogues as adenosine receptor agonists. |
TBA |
| 2995663 |
26 |
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists. |
TBA |
| 6279840 |
53 |
Adenosine receptors: targets for future drugs. |
TBA |
| 9873707 |
18 |
Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. |
Glaxowellcome Medicines Research Center |
| | 22 |
High selectivity of novel isoguanosine analogues for the adenosine A1 receptor |
TBA |
| | 13 |
Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist |
TBA |
| | 44 |
5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists |
TBA |
| | 52 |
The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties |
TBA |
| | 8 |
An explanation of the substituent effect of 1,3,8-trisubstituted xanthines on adenosine A1/A2 affinity. |
TBA |
| 12014951 |
139 |
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. |
National Institute of Diabetes & Digestive & Kidney Diseases |
| 30576906 |
92 |
Novel non-xanthine antagonist of the A |
Bayer Pharmaceuticals |
| 10479303 |
36 |
Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists. |
Warner-Lambert |
| 9873377 |
54 |
Isoindolinone enantiomers having affinity for the dopamine D4 receptor. |
Parke-Davis Pharmaceutical Research |
| 30835463 |
202 |
A |
Rheinische Friedrich-Wilhelms-Universitat Bonn |
| 9191952 |
63 |
Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. |
Warner-Lambert |
| 8496902 |
139 |
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. |
National Institute of Diabetes |
| 8230124 |
92 |
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. |
Pharmazeutische Chemie |
| 10072675 |
7 |
Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)- pyridazinebutanoic acid (FK 838): a novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity. |
Fujisawa Pharmaceutical |
| 3361572 |
38 |
Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists. |
Ciba-Geigy |
| 3361571 |
30 |
[1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists. |
Warner-Lambert |
| 3172141 |
35 |
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. |
Merrell Dow Research Institute |
| 3016270 |
40 |
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents. |
TBA |
| 29681156 |
71 |
Fluorescent-Labeled Selective Adenosine A |
University of Bonn |
| 2795597 |
43 |
Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists. |
University of South Florida |
| 2724296 |
113 |
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. |
National Institutes of Health |
| 2213835 |
66 |
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists. |
National Institute of Diabetes |
| 2213834 |
56 |
Imidazodiazepinediones: a new class of adenosine receptor antagonists. |
National Institute of Diabetes |
| 2016719 |
68 |
1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity. |
Nova Pharmaceutical |
| 1992150 |
60 |
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
Kyowa Hakko Kogyo |
| 1895306 |
13 |
Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogues of 1-methylisoguanosine. |
Griffith University |
| 1694546 |
64 |
Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors. |
Vanderbilt University |
| 1613758 |
95 |
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. |
Kyowa Hakko Kogyo |
| 1507211 |
28 |
Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors. |
Marion Merrell Dow Research Institute |
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