Found 29 hits for monomerid = 50015214 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Riboflavin-binding protein
(Gallus gallus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| Article PubMed
| 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Calvin College
Curated by ChEMBL
| Assay Description Competitive inhibition of chicken riboflavin binding protein by surface plasmon resonance assay |
ACS Med Chem Lett 2: 363-367 (2011)
Article DOI: 10.1021/ml100296z BindingDB Entry DOI: 10.7270/Q2SX6DP8 |
More data for this Ligand-Target Pair | |
Trypanothione reductase
(Trypanosoma cruzi) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
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| 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
| Assay Description Inhibition of Trypanosoma cruzi trypanothione reductase |
Bioorg Med Chem Lett 19: 3031-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.060 BindingDB Entry DOI: 10.7270/Q29G5MVS |
More data for this Ligand-Target Pair | |
Trypanothione reductase
(Trypanosoma cruzi) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
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| 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg University
Curated by ChEMBL
| Assay Description The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plots |
J Med Chem 42: 5448-54 (2000)
BindingDB Entry DOI: 10.7270/Q2FJ2G0Q |
More data for this Ligand-Target Pair | |
Trypanothione reductase
(Trypanosoma cruzi) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
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| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound against trypanothione reductase was determined |
Bioorg Med Chem Lett 11: 2655-7 (2001)
BindingDB Entry DOI: 10.7270/Q2154G90 |
More data for this Ligand-Target Pair | |
Glutathione reductase (GR)
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cape Town
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound against human Glutathione reductase was determined |
Bioorg Med Chem Lett 11: 2655-7 (2001)
BindingDB Entry DOI: 10.7270/Q2154G90 |
More data for this Ligand-Target Pair | |
Calcium channel
(RAT) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| Article PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University
Curated by ChEMBL
| Assay Description Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes |
J Appl Toxicol 32: 858-66 (2012)
Article DOI: 10.1002/jat.2784 BindingDB Entry DOI: 10.7270/Q2D79D5C |
More data for this Ligand-Target Pair | |
Phospholipase A2, acidic
(Naja naja) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.16E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Val£ncia
Curated by ChEMBL
| Assay Description Inhibition of snake venom phospholipase A2 assessed as oxygen consumption for 3 mins |
J Nat Prod 59: 977-9 (1997)
Article DOI: 10.1021/np9604339 BindingDB Entry DOI: 10.7270/Q2SX6D8W |
More data for this Ligand-Target Pair | |
Aldehyde oxidase
(Oryctolagus cuniculus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | KEGG
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| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of rabbit aldehyde oxidase |
J Med Chem 53: 8441-60 (2010)
Article DOI: 10.1021/jm100888d BindingDB Entry DOI: 10.7270/Q2057G6G |
More data for this Ligand-Target Pair | |
Aldehyde oxidase
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human aldehyde oxidase |
J Med Chem 53: 8441-60 (2010)
Article DOI: 10.1021/jm100888d BindingDB Entry DOI: 10.7270/Q2057G6G |
More data for this Ligand-Target Pair | |
Butyrylcholinesterase (BuChE)
(Equus caballus (Horse)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| Article PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Genova
Curated by ChEMBL
| Assay Description Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assay |
Eur J Med Chem 46: 2170-84 (2011)
Article DOI: 10.1016/j.ejmech.2011.02.071 BindingDB Entry DOI: 10.7270/Q2BK1CPG |
More data for this Ligand-Target Pair | |
Riboflavin-binding protein
(Gallus gallus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| n/a | n/a | n/a | 264 | n/a | n/a | n/a | 7.4 | n/a |
Calvin College
Curated by ChEMBL
| Assay Description Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calori... |
ACS Med Chem Lett 2: 363-367 (2011)
Article DOI: 10.1021/ml100296z BindingDB Entry DOI: 10.7270/Q2SX6DP8 |
More data for this Ligand-Target Pair | |
Phospholipase A2, major isoenzyme
(Sus scrofa (pig)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested for its inhibitory activity against Phospholipase A2 (PLA2) |
Bioorg Med Chem Lett 3: 2087-2092 (1993)
Article DOI: 10.1016/S0960-894X(01)81022-2 BindingDB Entry DOI: 10.7270/Q2G73F6K |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase
(Rattus norvegicus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
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| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested for its inhibitory activity against 5-lipoxygenase |
Bioorg Med Chem Lett 3: 2087-2092 (1993)
Article DOI: 10.1016/S0960-894X(01)81022-2 BindingDB Entry DOI: 10.7270/Q2G73F6K |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase
(Rattus norvegicus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
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| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat basophilic leukemia cell 5-lipoxygenase |
Bioorg Med Chem Lett 3: 711-716 (1993)
Article DOI: 10.1016/S0960-894X(01)81260-9 BindingDB Entry DOI: 10.7270/Q2SJ1M3F |
More data for this Ligand-Target Pair | |
Phospholipase A2 group 1B
(Rattus norvegicus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | Reactome pathway KEGG
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against polymorphonuclear cell phospholipase-A2 in rat |
Bioorg Med Chem Lett 3: 711-716 (1993)
Article DOI: 10.1016/S0960-894X(01)81260-9 BindingDB Entry DOI: 10.7270/Q2SJ1M3F |
More data for this Ligand-Target Pair | |
Phospholipase A2 group IIA
(Rattus norvegicus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 3.20E+8 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of rat secretory Phospholipase A2 (group II). |
J Med Chem 39: 5183-91 (1997)
Article DOI: 10.1021/jm960437a BindingDB Entry DOI: 10.7270/Q2K64JQH |
More data for this Ligand-Target Pair | |
Phospholipase A2, membrane associated
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 7.60E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of human recombinant secretory Phospholipase A2 (group II). |
J Med Chem 39: 5183-91 (1997)
Article DOI: 10.1021/jm960437a BindingDB Entry DOI: 10.7270/Q2K64JQH |
More data for this Ligand-Target Pair | |
Prion protein
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
Institut f£r Molekularbiologie und Biophysik
Curated by ChEMBL
| Assay Description Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells |
J Med Chem 46: 3563-4 (2003)
Article DOI: 10.1021/jm034093h BindingDB Entry DOI: 10.7270/Q2J103WT |
More data for this Ligand-Target Pair | |
Cyclooxygenase
(Bos taurus) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| Article
| n/a | n/a | 3.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested for its inhibitory activity against PGS (prostaglandin synthetase). |
Bioorg Med Chem Lett 3: 2087-2092 (1993)
Article DOI: 10.1016/S0960-894X(01)81022-2 BindingDB Entry DOI: 10.7270/Q2G73F6K |
More data for this Ligand-Target Pair | |
Sodium channel protein type I I alpha subunit
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea... |
J Med Chem 28: 381-8 (1985)
BindingDB Entry DOI: 10.7270/Q2Z321T8 |
More data for this Ligand-Target Pair | |
P-glycoprotein 1
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a |
Strasbourg 1 University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cells |
Anticancer Drugs 7: 568-78 (1997)
Article DOI: 10.1097/00001813-199607000-00012 BindingDB Entry DOI: 10.7270/Q23F4QXB |
More data for this Ligand-Target Pair | |
Phospholipase A2, acidic
(Naja naja) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.15E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Val£ncia
Curated by ChEMBL
| Assay Description Inhibition of Naja Naja PLA2 |
J Nat Prod 60: 1158-60 (1998)
Article DOI: 10.1021/np970221r BindingDB Entry DOI: 10.7270/Q2QV3ND4 |
More data for this Ligand-Target Pair | |
Histidine-rich protein
(Plasmodium falciparum) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.92E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of Tween 20-induced beta-hematin formation by colorimetric assay |
Antimicrob Agents Chemother 51: 350-3 (2006)
Article DOI: 10.1128/AAC.00985-06 BindingDB Entry DOI: 10.7270/Q2C82BJV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article
| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of ovine seminal vesicle prostaglandin synthetase |
Bioorg Med Chem Lett 3: 711-716 (1993)
Article DOI: 10.1016/S0960-894X(01)81260-9 BindingDB Entry DOI: 10.7270/Q2SJ1M3F |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.01E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human placental Monoamine oxidase A (competitive inhibition was observed) |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this Ligand-Target Pair | |
DNA-directed RNA polymerase subunit beta'
(Escherichia coli K-12) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA-primed RNA polymerase activity using [8-14C]ATP by scintillation counting |
J Med Chem 19: 994-8 (1976)
BindingDB Entry DOI: 10.7270/Q2668FQC |
More data for this Ligand-Target Pair | |
Replicase polyprotein 1ab
(2019-nCoV) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Pasteur Korea
| Assay Description Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ... |
Antimicrob Agents Chemother 64: (2020)
Article DOI: 10.1128/AAC.00819-20 BindingDB Entry DOI: 10.7270/Q22N54QR |
More data for this Ligand-Target Pair | |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
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| PCBioAssay
| n/a | n/a | 1.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by PubChem BioAssay
| |
PubChem Bioassay (2016)
BindingDB Entry DOI: 10.7270/Q2CZ35ZF |
More data for this Ligand-Target Pair | |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50015214
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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| n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by PubChem BioAssay
| |
PubChem Bioassay (2016)
BindingDB Entry DOI: 10.7270/Q2CZ35ZF |
More data for this Ligand-Target Pair | |