Found 100 hits with Last Name = 'kabcenell' and Initial = 'a' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302462
![PNG](/data/jpeg/tenK5030/BindingDB_50302462.png) (CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F Show InChI InChI=1S/C17H13BrF6N2O3/c18-12-3-1-10(13(7-12)29-17(22,23)24)8-26-15(27)11-2-4-14(25-9-11)28-6-5-16(19,20)21/h1-4,7,9H,5-6,8H2,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330100
![PNG](/data/jpeg/tenK5033/BindingDB_50330100.png) (CHEMBL1271550 | N-(4-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)cc1)-c1cccnc1 Show InChI InChI=1S/C22H15F3N4O/c23-22(24,25)20-13-19(16-7-4-12-26-14-16)28-29(20)18-10-8-17(9-11-18)27-21(30)15-5-2-1-3-6-15/h1-14H,(H,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302475
![PNG](/data/jpeg/tenK5030/BindingDB_50302475.png) (CHEMBL567491 | N-(3,3-diphenylpropyl)-1-(2-ethoxye...)Show SMILES CCOCCn1cc(ccc1=O)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H28N2O3/c1-2-30-18-17-27-19-22(13-14-24(27)28)25(29)26-16-15-23(20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-14,19,23H,2,15-18H2,1H3,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302475
![PNG](/data/jpeg/tenK5030/BindingDB_50302475.png) (CHEMBL567491 | N-(3,3-diphenylpropyl)-1-(2-ethoxye...)Show SMILES CCOCCn1cc(ccc1=O)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H28N2O3/c1-2-30-18-17-27-19-22(13-14-24(27)28)25(29)26-16-15-23(20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-14,19,23H,2,15-18H2,1H3,(H,26,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302461
![PNG](/data/jpeg/tenK5030/BindingDB_50302461.png) (CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302464
![PNG](/data/jpeg/tenK5030/BindingDB_50302464.png) (CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)7-8-27-14-6-5-12(10-24-14)15(26)25-9-11-3-1-2-4-13(11)28-17(21,22)23/h1-6,10H,7-9H2,(H,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330103
![PNG](/data/jpeg/tenK5033/BindingDB_50330103.png) (CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)nc1)-c1cccnc1 Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)18-11-17(15-7-4-10-25-12-15)28-29(18)16-8-9-19(26-13-16)27-20(30)14-5-2-1-3-6-14/h1-13H,(H,26,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330103
![PNG](/data/jpeg/tenK5033/BindingDB_50330103.png) (CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)nc1)-c1cccnc1 Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)18-11-17(15-7-4-10-25-12-15)28-29(18)16-8-9-19(26-13-16)27-20(30)14-5-2-1-3-6-14/h1-13H,(H,26,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302473
![PNG](/data/jpeg/tenK5030/BindingDB_50302473.png) (CHEMBL565628 | N-(3,3-diphenylpropyl)-6-(2,2,2-tri...)Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C23H21F3N2O2/c24-23(25,26)16-30-21-12-11-19(15-28-21)22(29)27-14-13-20(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-12,15,20H,13-14,16H2,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302464
![PNG](/data/jpeg/tenK5030/BindingDB_50302464.png) (CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)7-8-27-14-6-5-12(10-24-14)15(26)25-9-11-3-1-2-4-13(11)28-17(21,22)23/h1-6,10H,7-9H2,(H,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302476
![PNG](/data/jpeg/tenK5030/BindingDB_50302476.png) (CHEMBL567283 | N-(2,4-dichlorobenzyl)-1-(2-ethoxye...)Show InChI InChI=1S/C17H18Cl2N2O3/c1-2-24-8-7-21-11-13(4-6-16(21)22)17(23)20-10-12-3-5-14(18)9-15(12)19/h3-6,9,11H,2,7-8,10H2,1H3,(H,20,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330100
![PNG](/data/jpeg/tenK5033/BindingDB_50330100.png) (CHEMBL1271550 | N-(4-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)cc1)-c1cccnc1 Show InChI InChI=1S/C22H15F3N4O/c23-22(24,25)20-13-19(16-7-4-12-26-14-16)28-29(20)18-10-8-17(9-11-18)27-21(30)15-5-2-1-3-6-15/h1-14H,(H,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302474
![PNG](/data/jpeg/tenK5030/BindingDB_50302474.png) (CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)Show InChI InChI=1S/C15H11Cl2F3N2O2/c16-11-3-1-9(12(17)5-11)6-22-14(23)10-2-4-13(21-7-10)24-8-15(18,19)20/h1-5,7H,6,8H2,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302471
![PNG](/data/jpeg/tenK5030/BindingDB_50302471.png) (CHEMBL565841 | N-(4-chlorobenzyl)-6-(3,3,3-trifluo...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-4-1-11(2-5-13)9-22-15(23)12-3-6-14(21-10-12)24-8-7-16(18,19)20/h1-6,10H,7-9H2,(H,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302462
![PNG](/data/jpeg/tenK5030/BindingDB_50302462.png) (CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F Show InChI InChI=1S/C17H13BrF6N2O3/c18-12-3-1-10(13(7-12)29-17(22,23)24)8-26-15(27)11-2-4-14(25-9-11)28-6-5-16(19,20)21/h1-4,7,9H,5-6,8H2,(H,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50297413
![PNG](/data/jpeg/tenK5029/BindingDB_50297413.png) (CHEMBL560537 | N-(3,3-diphenyl-propyl)-nicotinamid...)Show InChI InChI=1S/C21H20N2O/c24-21(19-12-7-14-22-16-19)23-15-13-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-12,14,16,20H,13,15H2,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302474
![PNG](/data/jpeg/tenK5030/BindingDB_50302474.png) (CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)Show InChI InChI=1S/C15H11Cl2F3N2O2/c16-11-3-1-9(12(17)5-11)6-22-14(23)10-2-4-13(21-7-10)24-8-15(18,19)20/h1-5,7H,6,8H2,(H,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330099
![PNG](/data/jpeg/tenK5033/BindingDB_50330099.png) (CHEMBL1271498 | N-(4-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccncc2)cc1)-c1cccnc1 Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)19-12-18(15-2-1-9-26-13-15)28-29(19)17-5-3-16(4-6-17)27-20(30)14-7-10-25-11-8-14/h1-13H,(H,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302473
![PNG](/data/jpeg/tenK5030/BindingDB_50302473.png) (CHEMBL565628 | N-(3,3-diphenylpropyl)-6-(2,2,2-tri...)Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C23H21F3N2O2/c24-23(25,26)16-30-21-12-11-19(15-28-21)22(29)27-14-13-20(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-12,15,20H,13-14,16H2,(H,27,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302463
![PNG](/data/jpeg/tenK5030/BindingDB_50302463.png) (CHEMBL567314 | N-(2-chloro-4-cyanobenzyl)-6-(3,3,3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)C#N Show InChI InChI=1S/C17H13ClF3N3O2/c18-14-7-11(8-22)1-2-12(14)9-24-16(25)13-3-4-15(23-10-13)26-6-5-17(19,20)21/h1-4,7,10H,5-6,9H2,(H,24,25) | PDB MMDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302481
![PNG](/data/jpeg/tenK5030/BindingDB_50302481.png) (CHEMBL567503 | N-(3,3-diphenylpropyl)-6-oxo-1,6-di...)Show InChI InChI=1S/C21H20N2O2/c24-20-12-11-18(15-23-20)21(25)22-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H,22,25)(H,23,24) | PDB
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| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302479
![PNG](/data/jpeg/tenK5030/BindingDB_50302479.png) (6-amino-N-(3,3-diphenylpropyl)nicotinamide | CHEMB...)Show InChI InChI=1S/C21H21N3O/c22-20-12-11-18(15-24-20)21(25)23-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H2,22,24)(H,23,25) | PDB MMDB
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| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330105
![PNG](/data/jpeg/tenK5033/BindingDB_50330105.png) (CHEMBL1271659 | N-(6-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)nn1)-c1cccnc1 Show InChI InChI=1S/C20H13F3N6O/c21-20(22,23)16-11-15(14-7-4-10-24-12-14)28-29(16)18-9-8-17(26-27-18)25-19(30)13-5-2-1-3-6-13/h1-12H,(H,25,26,30) | PDB
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Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302477
![PNG](/data/jpeg/tenK5030/BindingDB_50302477.png) (CHEMBL566038 | N-(3,3-diphenylpropyl)-6-(2-(pyrrol...)Show SMILES O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(CCN2CCCC2)nc1 Show InChI InChI=1S/C27H31N3O/c31-27(24-13-14-25(29-21-24)16-20-30-18-7-8-19-30)28-17-15-26(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-6,9-14,21,26H,7-8,15-20H2,(H,28,31) | PDB MMDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302479
![PNG](/data/jpeg/tenK5030/BindingDB_50302479.png) (6-amino-N-(3,3-diphenylpropyl)nicotinamide | CHEMB...)Show InChI InChI=1S/C21H21N3O/c22-20-12-11-18(15-24-20)21(25)23-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H2,22,24)(H,23,25) | PDB
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| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330104
![PNG](/data/jpeg/tenK5033/BindingDB_50330104.png) (CHEMBL1271658 | N-(6-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)cn1)-c1cccnc1 Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)18-11-17(15-7-4-10-25-12-15)28-29(18)19-9-8-16(13-26-19)27-20(30)14-5-2-1-3-6-14/h1-13H,(H,27,30) | PDB
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Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302481
![PNG](/data/jpeg/tenK5030/BindingDB_50302481.png) (CHEMBL567503 | N-(3,3-diphenylpropyl)-6-oxo-1,6-di...)Show InChI InChI=1S/C21H20N2O2/c24-20-12-11-18(15-23-20)21(25)22-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-12,15,19H,13-14H2,(H,22,25)(H,23,24) | PDB MMDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302468
![PNG](/data/jpeg/tenK5030/BindingDB_50302468.png) (CHEMBL585949 | N-(4-chloro-2-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1cc(Cl)ccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)14-8-13(18)4-2-11(14)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB MMDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302462
![PNG](/data/jpeg/tenK5030/BindingDB_50302462.png) (CHEMBL566648 | N-(4-bromo-2-(trifluoromethoxy)benz...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F Show InChI InChI=1S/C17H13BrF6N2O3/c18-12-3-1-10(13(7-12)29-17(22,23)24)8-26-15(27)11-2-4-14(25-9-11)28-6-5-16(19,20)21/h1-4,7,9H,5-6,8H2,(H,26,27) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302461
![PNG](/data/jpeg/tenK5030/BindingDB_50302461.png) (CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302463
![PNG](/data/jpeg/tenK5030/BindingDB_50302463.png) (CHEMBL567314 | N-(2-chloro-4-cyanobenzyl)-6-(3,3,3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)C#N Show InChI InChI=1S/C17H13ClF3N3O2/c18-14-7-11(8-22)1-2-12(14)9-24-16(25)13-3-4-15(23-10-13)26-6-5-17(19,20)21/h1-4,7,10H,5-6,9H2,(H,24,25) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302465
![PNG](/data/jpeg/tenK5030/BindingDB_50302465.png) (CHEMBL566048 | N-(2-chloro-4-(N-methylsulfamoyl)be...)Show SMILES CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H17ClF3N3O4S/c1-22-29(26,27)13-4-2-11(14(18)8-13)9-24-16(25)12-3-5-15(23-10-12)28-7-6-17(19,20)21/h2-5,8,10,22H,6-7,9H2,1H3,(H,24,25) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302463
![PNG](/data/jpeg/tenK5030/BindingDB_50302463.png) (CHEMBL567314 | N-(2-chloro-4-cyanobenzyl)-6-(3,3,3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)C#N Show InChI InChI=1S/C17H13ClF3N3O2/c18-14-7-11(8-22)1-2-12(14)9-24-16(25)13-3-4-15(23-10-13)26-6-5-17(19,20)21/h1-4,7,10H,5-6,9H2,(H,24,25) | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302469
![PNG](/data/jpeg/tenK5030/BindingDB_50302469.png) (CHEMBL568544 | N-(2-chloro-4-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)13-4-2-11(14(18)8-13)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302476
![PNG](/data/jpeg/tenK5030/BindingDB_50302476.png) (CHEMBL567283 | N-(2,4-dichlorobenzyl)-1-(2-ethoxye...)Show InChI InChI=1S/C17H18Cl2N2O3/c1-2-24-8-7-21-11-13(4-6-16(21)22)17(23)20-10-12-3-5-14(18)9-15(12)19/h3-6,9,11H,2,7-8,10H2,1H3,(H,20,23) | PDB
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| Article PubMed
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302469
![PNG](/data/jpeg/tenK5030/BindingDB_50302469.png) (CHEMBL568544 | N-(2-chloro-4-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)13-4-2-11(14(18)8-13)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB MMDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302477
![PNG](/data/jpeg/tenK5030/BindingDB_50302477.png) (CHEMBL566038 | N-(3,3-diphenylpropyl)-6-(2-(pyrrol...)Show SMILES O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(CCN2CCCC2)nc1 Show InChI InChI=1S/C27H31N3O/c31-27(24-13-14-25(29-21-24)16-20-30-18-7-8-19-30)28-17-15-26(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-6,9-14,21,26H,7-8,15-20H2,(H,28,31) | PDB
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Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302474
![PNG](/data/jpeg/tenK5030/BindingDB_50302474.png) (CHEMBL572205 | N-(2,4-dichlorobenzyl)-6-(2,2,2-tri...)Show InChI InChI=1S/C15H11Cl2F3N2O2/c16-11-3-1-9(12(17)5-11)6-22-14(23)10-2-4-13(21-7-10)24-8-15(18,19)20/h1-5,7H,6,8H2,(H,22,23) | PDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302465
![PNG](/data/jpeg/tenK5030/BindingDB_50302465.png) (CHEMBL566048 | N-(2-chloro-4-(N-methylsulfamoyl)be...)Show SMILES CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H17ClF3N3O4S/c1-22-29(26,27)13-4-2-11(14(18)8-13)9-24-16(25)12-3-5-15(23-10-12)28-7-6-17(19,20)21/h2-5,8,10,22H,6-7,9H2,1H3,(H,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302464
![PNG](/data/jpeg/tenK5030/BindingDB_50302464.png) (CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)7-8-27-14-6-5-12(10-24-14)15(26)25-9-11-3-1-2-4-13(11)28-17(21,22)23/h1-6,10H,7-9H2,(H,25,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302460
![PNG](/data/jpeg/tenK5030/BindingDB_50302460.png) (CHEMBL567294 | N-(2-chloro-4-(1H-tetrazol-1-yl)ben...)Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccc(cc1Cl)-n1cnnn1 Show InChI InChI=1S/C17H14ClF3N6O2/c18-14-7-13(27-10-24-25-26-27)3-1-11(14)8-23-16(28)12-2-4-15(22-9-12)29-6-5-17(19,20)21/h1-4,7,9-10H,5-6,8H2,(H,23,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302472
![PNG](/data/jpeg/tenK5030/BindingDB_50302472.png) (CHEMBL572206 | N-(2-chlorobenzyl)-6-(3,3,3-trifluo...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-4-2-1-3-11(13)9-22-15(23)12-5-6-14(21-10-12)24-8-7-16(18,19)20/h1-6,10H,7-9H2,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human soluble EH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330107
![PNG](/data/jpeg/tenK5033/BindingDB_50330107.png) (CHEMBL1271712 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1cnc(NC(=O)c2ccccc2)nc1)-c1cccnc1 Show InChI InChI=1S/C20H13F3N6O/c21-20(22,23)17-9-16(14-7-4-8-24-10-14)28-29(17)15-11-25-19(26-12-15)27-18(30)13-5-2-1-3-6-13/h1-12H,(H,25,26,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302472
![PNG](/data/jpeg/tenK5030/BindingDB_50302472.png) (CHEMBL572206 | N-(2-chlorobenzyl)-6-(3,3,3-trifluo...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-4-2-1-3-11(13)9-22-15(23)12-5-6-14(21-10-12)24-8-7-16(18,19)20/h1-6,10H,7-9H2,(H,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330098
![PNG](/data/jpeg/tenK5033/BindingDB_50330098.png) (CHEMBL1271497 | N-(4-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2cccnc2)cc1)-c1cccnc1 Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)19-11-18(14-3-1-9-25-12-14)28-29(19)17-7-5-16(6-8-17)27-20(30)15-4-2-10-26-13-15/h1-13H,(H,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302461
![PNG](/data/jpeg/tenK5030/BindingDB_50302461.png) (CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50302467
![PNG](/data/jpeg/tenK5030/BindingDB_50302467.png) (CHEMBL566658 | N-(4-(methylsulfonyl)benzyl)-6-(3,3...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1 Show InChI InChI=1S/C17H17F3N2O4S/c1-27(24,25)14-5-2-12(3-6-14)10-22-16(23)13-4-7-15(21-11-13)26-9-8-17(18,19)20/h2-7,11H,8-10H2,1H3,(H,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of rat sEH |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50302469
![PNG](/data/jpeg/tenK5030/BindingDB_50302469.png) (CHEMBL568544 | N-(2-chloro-4-(methylsulfonyl)benzy...)Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1 Show InChI InChI=1S/C17H16ClF3N2O4S/c1-28(25,26)13-4-2-11(14(18)8-13)9-23-16(24)12-3-5-15(22-10-12)27-7-6-17(19,20)21/h2-5,8,10H,6-7,9H2,1H3,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of soluble EH in human HepG2 cells by cellular assay |
Bioorg Med Chem Lett 19: 5864-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.074 BindingDB Entry DOI: 10.7270/Q27944SC |
More data for this Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50330106
![PNG](/data/jpeg/tenK5033/BindingDB_50330106.png) (CHEMBL1271711 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1cnc(NC(=O)c2ccccc2)cn1)-c1cccnc1 Show InChI InChI=1S/C20H13F3N6O/c21-20(22,23)16-9-15(14-7-4-8-24-10-14)28-29(16)18-12-25-17(11-26-18)27-19(30)13-5-2-1-3-6-13/h1-12H,(H,25,27,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50330103
![PNG](/data/jpeg/tenK5033/BindingDB_50330103.png) (CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)nc1)-c1cccnc1 Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)18-11-17(15-7-4-10-25-12-15)28-29(18)16-8-9-19(26-13-16)27-20(30)14-5-2-1-3-6-14/h1-13H,(H,26,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >30 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
Bioorg Med Chem Lett 20: 6379-83 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.095 BindingDB Entry DOI: 10.7270/Q2V69JT7 |
More data for this Ligand-Target Pair | |