Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24198 (3-aminopropylphosphinic derivative, (R)-8 | [(2R)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.30 | -47.3 | n/a | n/a | 14 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24195 (3-aminopropylphosphinic derivative, (R)-7 | AZD335...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 5.10 | -46.9 | n/a | n/a | 8.64 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24193 ((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 10 | -45.2 | n/a | n/a | 15 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50271255 (1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24196 ((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 14 | -44.4 | n/a | n/a | 23 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24184 ((3-aminopropyl)phosphinic acid | 3-aminopropylphos...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 15 | -44.2 | n/a | n/a | 19 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50497435 (CHEMBL3343699) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50497438 (CHEMBL3343704) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50334197 (7-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 30.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | Bioorg Med Chem 19: 321-9 (2011) Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50497439 (CHEMBL3343700) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50164835 (CHEMBL3800398) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation counting | Eur J Med Chem 115: 406-15 (2016) Article DOI: 10.1016/j.ejmech.2016.03.026 BindingDB Entry DOI: 10.7270/Q2GH9KVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50497436 (CHEMBL3343703) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 33 | -42.3 | n/a | n/a | 41 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50497435 (CHEMBL3343699) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50334195 (4-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 45.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | Bioorg Med Chem 19: 321-9 (2011) Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24191 ((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 48 | -41.4 | n/a | n/a | 81 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 50 | -41.3 | n/a | n/a | 130 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50271255 (1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50497440 (CHEMBL3343698) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50497439 (CHEMBL3343700) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24194 (3-aminopropylphosphinic derivative, (S)-7 | [(2S)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 70 | -40.4 | n/a | n/a | 250 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2B adrenergic receptor (Homo sapiens (Human)) | BDBM50497435 (CHEMBL3343699) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50164841 (CHEMBL3798191) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation counting | Eur J Med Chem 115: 406-15 (2016) Article DOI: 10.1016/j.ejmech.2016.03.026 BindingDB Entry DOI: 10.7270/Q2GH9KVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2B adrenergic receptor (Homo sapiens (Human)) | BDBM50271255 (1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 94 | -39.7 | n/a | n/a | 220 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50334196 (3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 133 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | Bioorg Med Chem 19: 321-9 (2011) Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50334194 (3-[(Imidazolidin-2-yl)imino]indazole hydrochloride...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 134 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | Bioorg Med Chem 19: 321-9 (2011) Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2B adrenergic receptor (Homo sapiens (Human)) | BDBM50497439 (CHEMBL3343700) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50334206 (3-[(Imidazolidin-2-yl)imino]-4-methoxyindazole hyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 167 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | Bioorg Med Chem 19: 321-9 (2011) Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 | 3-amin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 180 | -38.1 | n/a | n/a | 150 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50497433 (CHEMBL3343702) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 187 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24192 ((3-amino-2-oxopropyl)(methyl)phosphinic acid | (3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 200 | -37.9 | n/a | n/a | 270 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24182 (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 220 | -37.6 | n/a | n/a | 750 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nischarin (RAT) | BDBM50334204 (3-[(Imidazolidin-2-yl)imino]-6-methylindazole hydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 325 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | Bioorg Med Chem 19: 321-9 (2011) Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50334203 (6-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | Bioorg Med Chem 19: 321-9 (2011) Article DOI: 10.1016/j.bmc.2010.11.020 BindingDB Entry DOI: 10.7270/Q2FQ9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50497434 (CHEMBL3343697) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 416 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50164834 (CHEMBL3798638) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 468 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation counting | Eur J Med Chem 115: 406-15 (2016) Article DOI: 10.1016/j.ejmech.2016.03.026 BindingDB Entry DOI: 10.7270/Q2GH9KVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50497436 (CHEMBL3343703) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 476 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24197 (3-aminopropylphosphinic derivative, (S)-8 | [(2S)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 480 | -35.7 | n/a | n/a | 1.70E+3 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50497438 (CHEMBL3343704) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 518 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50497433 (CHEMBL3343702) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 535 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50497435 (CHEMBL3343699) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50271255 (1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50164837 (CHEMBL3800446) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 789 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation counting | Eur J Med Chem 115: 406-15 (2016) Article DOI: 10.1016/j.ejmech.2016.03.026 BindingDB Entry DOI: 10.7270/Q2GH9KVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 | 3-amin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 840 | -34.3 | n/a | n/a | 600 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50497435 (CHEMBL3343699) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 918 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nischarin (RAT) | BDBM50164842 (CHEMBL3798387) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation counting | Eur J Med Chem 115: 406-15 (2016) Article DOI: 10.1016/j.ejmech.2016.03.026 BindingDB Entry DOI: 10.7270/Q2GH9KVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50497439 (CHEMBL3343700) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50497439 (CHEMBL3343700) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation counting | Eur J Med Chem 87: 386-97 (2014) Article DOI: 10.1016/j.ejmech.2014.09.083 BindingDB Entry DOI: 10.7270/Q2MW2M45 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.10E+3 | -32.1 | n/a | n/a | 1.10E+3 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 261 total ) | Next | Last >> |