Found 330 hits with Last Name = 'sheehan' and Initial = 'd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6302
![PNG](/data/jpeg/tenK0/BindingDB_6302.png) (8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H30N6O2/c1-16-21-15-27-25(28-18-7-9-19(10-8-18)30-13-11-26-12-14-30)29-23(21)31(20-5-3-4-6-20)24(33)22(16)17(2)32/h7-10,15,20,26H,3-6,11-14H2,1-2H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6326
![PNG](/data/jpeg/tenK0/BindingDB_6326.png) (6-Acetyl-8-cyclopentyl-5-methyl-2-(5-morpholin-4-y...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCOCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C24H28N6O3/c1-15-19-14-26-24(27-20-8-7-18(13-25-20)29-9-11-33-12-10-29)28-22(19)30(17-5-3-4-6-17)23(32)21(15)16(2)31/h7-8,13-14,17H,3-6,9-12H2,1-2H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6321
![PNG](/data/jpeg/tenK0/BindingDB_6321.png) (6-Acetyl-8-cyclopentyl-5-methyl-2-[5-(4-methyl-pip...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C25H31N7O2/c1-16-20-15-27-25(28-21-9-8-19(14-26-21)31-12-10-30(3)11-13-31)29-23(20)32(18-6-4-5-7-18)24(34)22(16)17(2)33/h8-9,14-15,18H,4-7,10-13H2,1-3H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6324
![PNG](/data/jpeg/tenK0/BindingDB_6324.png) (6-Acetyl-8-cyclopentyl-5-methyl-2-(3,4,5,6-tetrahy...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCCCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H30N6O2/c1-16-20-15-27-25(28-21-11-10-19(14-26-21)30-12-6-3-7-13-30)29-23(20)31(18-8-4-5-9-18)24(33)22(16)17(2)32/h10-11,14-15,18H,3-9,12-13H2,1-2H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6301
![PNG](/data/jpeg/tenK0/BindingDB_6301.png) (6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)Show SMILES Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc12 Show InChI InChI=1S/C23H27BrN6O/c1-15-19-14-26-23(27-16-6-8-17(9-7-16)29-12-10-25-11-13-29)28-21(19)30(22(31)20(15)24)18-4-2-3-5-18/h6-9,14,18,25H,2-5,10-13H2,1H3,(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6303
![PNG](/data/jpeg/tenK0/BindingDB_6303.png) (Pyrido-[2,3-d]-pyrimidin-7-one 37 | ethyl 8-cyclop...)Show SMILES CCOC(=O)c1c(C)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C26H32N6O3/c1-3-35-25(34)22-17(2)21-16-28-26(30-23(21)32(24(22)33)20-6-4-5-7-20)29-18-8-10-19(11-9-18)31-14-12-27-13-15-31/h8-11,16,20,27H,3-7,12-15H2,1-2H3,(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6309
![PNG](/data/jpeg/tenK0/BindingDB_6309.png) (6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM6253
![PNG](/data/jpeg/tenK0/BindingDB_6253.png) (8-Cyclopentyl-2-phenylamino-8H-pyrido[2,3-d]pyrimi...)Show InChI InChI=1S/C18H18N4O/c23-16-11-10-13-12-19-18(20-14-6-2-1-3-7-14)21-17(13)22(16)15-8-4-5-9-15/h1-3,6-7,10-12,15H,4-5,8-9H2,(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6323
![PNG](/data/jpeg/tenK0/BindingDB_6323.png) (6-Acetyl-8-cyclopentyl-2-(5-[1,4]diazepan-1-yl-pyr...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H31N7O2/c1-16-20-15-28-25(29-21-9-8-19(14-27-21)31-12-5-10-26-11-13-31)30-23(20)32(18-6-3-4-7-18)24(34)22(16)17(2)33/h8-9,14-15,18,26H,3-7,10-13H2,1-2H3,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6293
![PNG](/data/jpeg/tenK0/BindingDB_6293.png) (8-Cyclopentyl-6-methoxymethyl-2-(5-piperazin-1-ylp...)Show SMILES COCc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C23H29N7O2/c1-32-15-17-12-16-13-26-23(28-21(16)30(22(17)31)18-4-2-3-5-18)27-20-7-6-19(14-25-20)29-10-8-24-9-11-29/h6-7,12-14,18,24H,2-5,8-11,15H2,1H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6292
![PNG](/data/jpeg/tenK0/BindingDB_6292.png) (8-Cyclopentyl-6-hydroxymethyl-2-(5-piperazin-1-ylp...)Show SMILES OCc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C22H27N7O2/c30-14-16-11-15-12-25-22(27-20(15)29(21(16)31)17-3-1-2-4-17)26-19-6-5-18(13-24-19)28-9-7-23-8-10-28/h5-6,11-13,17,23,30H,1-4,7-10,14H2,(H,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6286
![PNG](/data/jpeg/tenK0/BindingDB_6286.png) (8-Cyclohexyl-2-(5-piperazin-1-yl-pyridin-2-ylamino...)Show SMILES O=c1ccc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCCC1 Show InChI InChI=1S/C22H27N7O/c30-20-9-6-16-14-25-22(27-21(16)29(20)17-4-2-1-3-5-17)26-19-8-7-18(15-24-19)28-12-10-23-11-13-28/h6-9,14-15,17,23H,1-5,10-13H2,(H,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6322
![PNG](/data/jpeg/tenK0/BindingDB_6322.png) (2-{[5-(3-aminopyrrolidin-1-yl)pyridin-2-yl]amino}-...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCC(N)C3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C24H29N7O2/c1-14-19-12-27-24(28-20-8-7-18(11-26-20)30-10-9-16(25)13-30)29-22(19)31(17-5-3-4-6-17)23(33)21(14)15(2)32/h7-8,11-12,16-17H,3-6,9-10,13,25H2,1-2H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50360603
![PNG](/data/jpeg/tenK5036/BindingDB_50360603.png) (CHEMBL1933536)Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N1C[C@]2(CCN(C2)C2CCNC2)c2ccccc12 |r| Show InChI InChI=1S/C24H25ClN4O/c25-17-5-6-20-16(11-17)12-21(27-20)23(30)29-15-24(19-3-1-2-4-22(19)29)8-10-28(14-24)18-7-9-26-13-18/h1-6,11-12,18,26-27H,7-10,13-15H2/t18?,24-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 using dextromethorphan as substrate |
Bioorg Med Chem Lett 22: 190-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.036 BindingDB Entry DOI: 10.7270/Q2CF9QJS |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6285
![PNG](/data/jpeg/tenK0/BindingDB_6285.png) (8-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamin...)Show SMILES O=c1ccc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 Show InChI InChI=1S/C21H25N7O/c29-19-8-5-15-13-24-21(26-20(15)28(19)16-3-1-2-4-16)25-18-7-6-17(14-23-18)27-11-9-22-10-12-27/h5-8,13-14,16,22H,1-4,9-12H2,(H,23,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6287
![PNG](/data/jpeg/tenK0/BindingDB_6287.png) (6-Bromo-8-cyclopentyl-2-(5-piperazin-1-yl-pyridin-...)Show SMILES Brc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C21H24BrN7O/c22-17-11-14-12-25-21(27-19(14)29(20(17)30)15-3-1-2-4-15)26-18-6-5-16(13-24-18)28-9-7-23-8-10-28/h5-6,11-13,15,23H,1-4,7-10H2,(H,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6294
![PNG](/data/jpeg/tenK0/BindingDB_6294.png) (8-Cyclopentyl-6-ethoxymethyl-2-(5-piperazin-1-yl-p...)Show SMILES CCOCc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C24H31N7O2/c1-2-33-16-18-13-17-14-27-24(29-22(17)31(23(18)32)19-5-3-4-6-19)28-21-8-7-20(15-26-21)30-11-9-25-10-12-30/h7-8,13-15,19,25H,2-6,9-12,16H2,1H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6289
![PNG](/data/jpeg/tenK0/BindingDB_6289.png) (6-Amino-8-cyclopentyl-2-(5-piperazin-1-yl-pyridin-...)Show SMILES Nc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C21H26N8O/c22-17-11-14-12-25-21(27-19(14)29(20(17)30)15-3-1-2-4-15)26-18-6-5-16(13-24-18)28-9-7-23-8-10-28/h5-6,11-13,15,23H,1-4,7-10,22H2,(H,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6325
![PNG](/data/jpeg/tenK0/BindingDB_6325.png) (6-Acetyl-8-cyclopentyl-2-(4-hydroxy-3,4,5,6-tetrah...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCC(O)CC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H30N6O3/c1-15-20-14-27-25(28-21-8-7-18(13-26-21)30-11-9-19(33)10-12-30)29-23(20)31(17-5-3-4-6-17)24(34)22(15)16(2)32/h7-8,13-14,17,19,33H,3-6,9-12H2,1-2H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6319
![PNG](/data/jpeg/tenK0/BindingDB_6319.png) (6-Acetyl-8-cyclopentyl-2-[5-(3,3-dimethyl-piperazi...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNC(C)(C)C3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C26H33N7O2/c1-16-20-14-28-25(30-21-10-9-19(13-27-21)32-12-11-29-26(3,4)15-32)31-23(20)33(18-7-5-6-8-18)24(35)22(16)17(2)34/h9-10,13-14,18,29H,5-8,11-12,15H2,1-4H3,(H,27,28,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6291
![PNG](/data/jpeg/tenK0/BindingDB_6291.png) (8-Cyclopentyl-6-ethyl-2-(5-piperazin-1-yl-pyridin-...)Show SMILES CCc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C23H29N7O/c1-2-16-13-17-14-26-23(28-21(17)30(22(16)31)18-5-3-4-6-18)27-20-8-7-19(15-25-20)29-11-9-24-10-12-29/h7-8,13-15,18,24H,2-6,9-12H2,1H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6290
![PNG](/data/jpeg/tenK0/BindingDB_6290.png) (8-Cyclopentyl-6-methyl-2-(5-piperazin-1-yl-pyridin...)Show SMILES Cc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C22H27N7O/c1-15-12-16-13-25-22(27-20(16)29(21(15)30)17-4-2-3-5-17)26-19-7-6-18(14-24-19)28-10-8-23-9-11-28/h6-7,12-14,17,23H,2-5,8-11H2,1H3,(H,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6327
![PNG](/data/jpeg/tenK0/BindingDB_6327.png) (6-Acetyl-8-cyclopentyl-2-[5-(2,6-dimethyl-morpholi...)Show SMILES CC1CN(CC(C)O1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C26H32N6O3/c1-15-13-31(14-16(2)35-15)20-9-10-22(27-11-20)29-26-28-12-21-17(3)23(18(4)33)25(34)32(24(21)30-26)19-7-5-6-8-19/h9-12,15-16,19H,5-8,13-14H2,1-4H3,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6295
![PNG](/data/jpeg/tenK0/BindingDB_6295.png) (8-Cyclopentyl-6-(2-methoxy-ethoxymethyl)-2-(5-pipe...)Show SMILES COCCOCc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H33N7O3/c1-34-12-13-35-17-19-14-18-15-28-25(30-23(18)32(24(19)33)20-4-2-3-5-20)29-22-7-6-21(16-27-22)31-10-8-26-9-11-31/h6-7,14-16,20,26H,2-5,8-13,17H2,1H3,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425842
![PNG](/data/jpeg/tenK5042/BindingDB_50425842.png) (CHEMBL2312292)Show SMILES COc1cc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)ccc1O Show InChI InChI=1S/C26H36N6O4/c1-36-22-16-18(9-10-21(22)33)11-13-28-26-29-17-20(24(31-26)30-19-6-2-3-7-19)25(35)27-12-5-15-32-14-4-8-23(32)34/h9-10,16-17,19,33H,2-8,11-15H2,1H3,(H,27,35)(H2,28,29,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6297
![PNG](/data/jpeg/tenK0/BindingDB_6297.png) (8-Cyclopentyl-6-(2-ethoxy-ethoxy)-2-(5-piperazin-1...)Show SMILES CCOCCOc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H33N7O3/c1-2-34-13-14-35-21-15-18-16-28-25(30-23(18)32(24(21)33)19-5-3-4-6-19)29-22-8-7-20(17-27-22)31-11-9-26-10-12-31/h7-8,15-17,19,26H,2-6,9-14H2,1H3,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6320
![PNG](/data/jpeg/tenK0/BindingDB_6320.png) (6-Acetyl-8-cyclopentyl-2-[5-(3,5-dimethyl-piperazi...)Show SMILES CC1CN(CC(C)N1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C26H33N7O2/c1-15-13-32(14-16(2)29-15)20-9-10-22(27-11-20)30-26-28-12-21-17(3)23(18(4)34)25(35)33(24(21)31-26)19-7-5-6-8-19/h9-12,15-16,19,29H,5-8,13-14H2,1-4H3,(H,27,28,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425844
![PNG](/data/jpeg/tenK5042/BindingDB_50425844.png) (CHEMBL2312318)Show SMILES COc1cccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)c1 Show InChI InChI=1S/C26H36N6O3/c1-35-21-10-4-7-19(17-21)12-14-28-26-29-18-22(24(31-26)30-20-8-2-3-9-20)25(34)27-13-6-16-32-15-5-11-23(32)33/h4,7,10,17-18,20H,2-3,5-6,8-9,11-16H2,1H3,(H,27,34)(H2,28,29,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6310
![PNG](/data/jpeg/tenK0/BindingDB_6310.png) (8-Cyclopentyl-5-methyl-7-oxo-2-(5-piperazin-1-yl-p...)Show SMILES CCOC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H31N7O3/c1-3-35-24(34)21-16(2)19-15-28-25(30-22(19)32(23(21)33)17-6-4-5-7-17)29-20-9-8-18(14-27-20)31-12-10-26-11-13-31/h8-9,14-15,17,26H,3-7,10-13H2,1-2H3,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6318
![PNG](/data/jpeg/tenK0/BindingDB_6318.png) (2-({5-[bis(2-methoxyethyl)amino]pyridin-2-yl}amino...)Show SMILES COCCN(CCOC)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C26H34N6O4/c1-17-21-16-28-26(29-22-10-9-20(15-27-22)31(11-13-35-3)12-14-36-4)30-24(21)32(19-7-5-6-8-19)25(34)23(17)18(2)33/h9-10,15-16,19H,5-8,11-14H2,1-4H3,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6288
![PNG](/data/jpeg/tenK0/BindingDB_6288.png) (8-Cyclopentyl-6-fluoro-2-(5-piperazin-1-yl-pyridin...)Show SMILES Fc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C21H24FN7O/c22-17-11-14-12-25-21(27-19(14)29(20(17)30)15-3-1-2-4-15)26-18-6-5-16(13-24-18)28-9-7-23-8-10-28/h5-6,11-13,15,23H,1-4,7-10H2,(H,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50425832
![PNG](/data/jpeg/tenK5042/BindingDB_50425832.png) (CHEMBL2312290)Show SMILES COc1ccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)cc1OC Show InChI InChI=1S/C27H38N6O4/c1-36-22-11-10-19(17-23(22)37-2)12-14-29-27-30-18-21(25(32-27)31-20-7-3-4-8-20)26(35)28-13-6-16-33-15-5-9-24(33)34/h10-11,17-18,20H,3-9,12-16H2,1-2H3,(H,28,35)(H2,29,30,31,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Axl (unknown origin) |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6312
![PNG](/data/jpeg/tenK0/BindingDB_6312.png) (6-Bromo-8-cyclopentyl-2-[5-(3,5-dimethyl-piperazin...)Show SMILES CC1CN(CC(C)N1)c1ccc(Nc2ncc3c(C)c(Br)c(=O)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C24H30BrN7O/c1-14-12-31(13-15(2)28-14)18-8-9-20(26-10-18)29-24-27-11-19-16(3)21(25)23(33)32(22(19)30-24)17-6-4-5-7-17/h8-11,14-15,17,28H,4-7,12-13H2,1-3H3,(H,26,27,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425843
![PNG](/data/jpeg/tenK5042/BindingDB_50425843.png) (CHEMBL2312291)Show SMILES Oc1ccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)cc1 Show InChI InChI=1S/C25H34N6O3/c32-20-10-8-18(9-11-20)12-14-27-25-28-17-21(23(30-25)29-19-5-1-2-6-19)24(34)26-13-4-16-31-15-3-7-22(31)33/h8-11,17,19,32H,1-7,12-16H2,(H,26,34)(H2,27,28,29,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425829
![PNG](/data/jpeg/tenK5042/BindingDB_50425829.png) (CHEMBL2312304)Show SMILES Clc1ccc(Cl)c(CNc2ncc(C(=O)NCCCN3CCOC3=O)c(NC3CCCC3)n2)c1 Show InChI InChI=1S/C23H28Cl2N6O3/c24-16-6-7-19(25)15(12-16)13-27-22-28-14-18(20(30-22)29-17-4-1-2-5-17)21(32)26-8-3-9-31-10-11-34-23(31)33/h6-7,12,14,17H,1-5,8-11,13H2,(H,26,32)(H2,27,28,29,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6316
![PNG](/data/jpeg/tenK0/BindingDB_6316.png) (6-Bromo-8-cyclopentyl-2-(4-hydroxy-3,4,5,6-tetrahy...)Show SMILES Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(cn3)N3CCC(O)CC3)ncc12 Show InChI InChI=1S/C23H27BrN6O2/c1-14-18-13-26-23(28-21(18)30(22(32)20(14)24)15-4-2-3-5-15)27-19-7-6-16(12-25-19)29-10-8-17(31)9-11-29/h6-7,12-13,15,17,31H,2-5,8-11H2,1H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425849
![PNG](/data/jpeg/tenK5042/BindingDB_50425849.png) (CHEMBL2312313)Show SMILES Fc1ccccc1CCNc1ncc(C(=O)NCCCN2CCCC2=O)c(NC2CCCC2)n1 Show InChI InChI=1S/C25H33FN6O2/c26-21-10-4-1-7-18(21)12-14-28-25-29-17-20(23(31-25)30-19-8-2-3-9-19)24(34)27-13-6-16-32-15-5-11-22(32)33/h1,4,7,10,17,19H,2-3,5-6,8-9,11-16H2,(H,27,34)(H2,28,29,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6299
![PNG](/data/jpeg/tenK0/BindingDB_6299.png) (6-Acetyl-8-cyclopentyl-2-(5-piperazin-1-yl-pyridin...)Show SMILES CC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C23H27N7O2/c1-15(31)19-12-16-13-26-23(28-21(16)30(22(19)32)17-4-2-3-5-17)27-20-7-6-18(14-25-20)29-10-8-24-9-11-29/h6-7,12-14,17,24H,2-5,8-11H2,1H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6296
![PNG](/data/jpeg/tenK0/BindingDB_6296.png) (8-Cyclopentyl-6-(2-ethoxy-ethyl)-2-(5-piperazin-1-...)Show SMILES CCOCCc1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H33N7O2/c1-2-34-14-9-18-15-19-16-28-25(30-23(19)32(24(18)33)20-5-3-4-6-20)29-22-8-7-21(17-27-22)31-12-10-26-11-13-31/h7-8,15-17,20,26H,2-6,9-14H2,1H3,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 124 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50425832
![PNG](/data/jpeg/tenK5042/BindingDB_50425832.png) (CHEMBL2312290)Show SMILES COc1ccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)cc1OC Show InChI InChI=1S/C27H38N6O4/c1-36-22-11-10-19(17-23(22)37-2)12-14-29-27-30-18-21(25(32-27)31-20-7-3-4-8-20)26(35)28-13-6-16-33-15-5-9-24(33)34/h10-11,17-18,20H,3-9,12-16H2,1-2H3,(H,28,35)(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Mer (unknown origin) |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6313
![PNG](/data/jpeg/tenK0/BindingDB_6313.png) (6-Bromo-8-cyclopentyl-5-methyl-2-[5-(4-methyl-pipe...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(C)c(Br)c(=O)n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C23H28BrN7O/c1-15-18-14-26-23(28-21(18)31(22(32)20(15)24)16-5-3-4-6-16)27-19-8-7-17(13-25-19)30-11-9-29(2)10-12-30/h7-8,13-14,16H,3-6,9-12H2,1-2H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6283
![PNG](/data/jpeg/tenK0/BindingDB_6283.png) (8-Cyclopentyl-2-(pyridin-2-ylamino)-8H-pyrido[2,3-...)Show InChI InChI=1S/C17H17N5O/c23-15-9-8-12-11-19-17(20-14-7-3-4-10-18-14)21-16(12)22(15)13-5-1-2-6-13/h3-4,7-11,13H,1-2,5-6H2,(H,18,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6307
![PNG](/data/jpeg/tenK0/BindingDB_6307.png) (6-Bromo-8-cyclopentyl-5-methyl-2-(5-piperizin-1-yl...)Show SMILES Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(cn3)N3CCNCC3)ncc12 Show InChI InChI=1S/C22H26BrN7O/c1-14-17-13-26-22(27-18-7-6-16(12-25-18)29-10-8-24-9-11-29)28-20(17)30(21(31)19(14)23)15-4-2-3-5-15/h6-7,12-13,15,24H,2-5,8-11H2,1H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425847
![PNG](/data/jpeg/tenK5042/BindingDB_50425847.png) (CHEMBL2312315)Show SMILES Clc1cccc(Cl)c1CCNc1ncc(C(=O)NCCCN2CCCC2=O)c(NC2CCCC2)n1 Show InChI InChI=1S/C25H32Cl2N6O2/c26-20-8-3-9-21(27)18(20)11-13-29-25-30-16-19(23(32-25)31-17-6-1-2-7-17)24(35)28-12-5-15-33-14-4-10-22(33)34/h3,8-9,16-17H,1-2,4-7,10-15H2,(H,28,35)(H2,29,30,31,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425848
![PNG](/data/jpeg/tenK5042/BindingDB_50425848.png) (CHEMBL2312314)Show SMILES Clc1ccccc1CCNc1ncc(C(=O)NCCCN2CCCC2=O)c(NC2CCCC2)n1 Show InChI InChI=1S/C25H33ClN6O2/c26-21-10-4-1-7-18(21)12-14-28-25-29-17-20(23(31-25)30-19-8-2-3-9-19)24(34)27-13-6-16-32-15-5-11-22(32)33/h1,4,7,10,17,19H,2-3,5-6,8-9,11-16H2,(H,27,34)(H2,28,29,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase
(Mus musculus) | BDBM50360610
![PNG](/data/jpeg/tenK5036/BindingDB_50360610.png) (CHEMBL1933552)Show SMILES C[C@@H]1CCC(CN1)N1CC[C@@]2(C1)CN(C(=O)c1cc3ccc(F)cc3[nH]1)c1ccccc21 |r| Show InChI InChI=1S/C26H29FN4O/c1-17-6-9-20(14-28-17)30-11-10-26(15-30)16-31(24-5-3-2-4-21(24)26)25(32)23-12-18-7-8-19(27)13-22(18)29-23/h2-5,7-8,12-13,17,20,28-29H,6,9-11,14-16H2,1H3/t17-,20?,26-/m1/s1 | PDB MMDB
KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA |
Bioorg Med Chem Lett 22: 190-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.036 BindingDB Entry DOI: 10.7270/Q2CF9QJS |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425845
![PNG](/data/jpeg/tenK5042/BindingDB_50425845.png) (CHEMBL2312317)Show SMILES COc1ccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)cc1 Show InChI InChI=1S/C26H36N6O3/c1-35-21-11-9-19(10-12-21)13-15-28-26-29-18-22(24(31-26)30-20-6-2-3-7-20)25(34)27-14-5-17-32-16-4-8-23(32)33/h9-12,18,20H,2-8,13-17H2,1H3,(H,27,34)(H2,28,29,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
(Homo sapiens (Human)) | BDBM6253
![PNG](/data/jpeg/tenK0/BindingDB_6253.png) (8-Cyclopentyl-2-phenylamino-8H-pyrido[2,3-d]pyrimi...)Show InChI InChI=1S/C18H18N4O/c23-16-11-10-13-12-19-18(20-14-6-2-1-3-7-14)21-17(13)22(16)15-8-4-5-9-15/h1-3,6-7,10-12,15H,4-5,8-9H2,(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM50425833
![PNG](/data/jpeg/tenK5042/BindingDB_50425833.png) (CHEMBL2312302)Show SMILES CCOc1ccccc1CNc1ncc(C(=O)NCCCN2CCCC2=O)c(NC2CCCC2)n1 Show InChI InChI=1S/C26H36N6O3/c1-2-35-22-12-6-3-9-19(22)17-28-26-29-18-21(24(31-26)30-20-10-4-5-11-20)25(34)27-14-8-16-32-15-7-13-23(32)33/h3,6,9,12,18,20H,2,4-5,7-8,10-11,13-17H2,1H3,(H,27,34)(H2,28,29,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 215 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA |
Bioorg Med Chem Lett 23: 1046-50 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.013 BindingDB Entry DOI: 10.7270/Q26D5V9W |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM6302
![PNG](/data/jpeg/tenK0/BindingDB_6302.png) (8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc2n(C2CCCC2)c1=O Show InChI InChI=1S/C25H30N6O2/c1-16-21-15-27-25(28-18-7-9-19(10-8-18)30-13-11-26-12-14-30)29-23(21)31(20-5-3-4-6-20)24(33)22(16)17(2)32/h7-10,15,20,26H,3-6,11-14H2,1-2H3,(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in... |
J Med Chem 48: 2388-406 (2005)
Article DOI: 10.1021/jm049354h BindingDB Entry DOI: 10.7270/Q21J97Z9 |
More data for this Ligand-Target Pair | |