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Compile Data Set for Download or QSAR

Found 553 hits with Last Name = 'stratikos' and Initial = 'e'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50236826
PNG
(CHEMBL4065841)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C35H40N3O4P/c36-33(22-21-26-13-5-1-6-14-26)43(41,42)25-30(35(40)38-32(34(37)39)23-27-15-7-2-8-16-27)24-31(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30-33H,21-25,36H2,(H2,37,39)(H,38,40)(H,41,42)/t30-,32+,33-/m1/s1
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18n/an/an/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of recombinant human IRAP expressed in GnT1 deficient HEK293S cells using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 m...


J Med Chem 60: 2963-2972 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01890
BindingDB Entry DOI: 10.7270/Q29G5Q35
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50236826
PNG
(CHEMBL4065841)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C35H40N3O4P/c36-33(22-21-26-13-5-1-6-14-26)43(41,42)25-30(35(40)38-32(34(37)39)23-27-15-7-2-8-16-27)24-31(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30-33H,21-25,36H2,(H2,37,39)(H,38,40)(H,41,42)/t30-,32+,33-/m1/s1
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200n/an/an/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ERAP2 using L-arginyl-7-amido-4-methyl coumarin as substrate by fluorimetric assay


J Med Chem 60: 2963-2972 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01890
BindingDB Entry DOI: 10.7270/Q29G5Q35
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529326
PNG
(CHEMBL4557197)
Show SMILES Oc1cccn(CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)c1=O |r|
Show InChI InChI=1S/C25H23N3O5/c29-22-11-6-12-28(24(22)31)15-23(30)27-21(25(32)33-16-17-7-2-1-3-8-17)13-18-14-26-20-10-5-4-9-19(18)20/h1-12,14,21,26,29H,13,15-16H2,(H,27,30)/t21-/m0/s1
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700n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529330
PNG
(CHEMBL4527760)
Show SMILES CCCC[C@H](N)C(=O)NNc1ccc(cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H35N5O4/c1-2-3-12-26(32)30(38)36-35-24-16-14-22(15-17-24)29(37)34-28(31(39)40-20-21-9-5-4-6-10-21)18-23-19-33-27-13-8-7-11-25(23)27/h4-11,13-17,19,26,28,33,35H,2-3,12,18,20,32H2,1H3,(H,34,37)(H,36,38)/t26-,28-/m0/s1
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1.20E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529330
PNG
(CHEMBL4527760)
Show SMILES CCCC[C@H](N)C(=O)NNc1ccc(cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H35N5O4/c1-2-3-12-26(32)30(38)36-35-24-16-14-22(15-17-24)29(37)34-28(31(39)40-20-21-9-5-4-6-10-21)18-23-19-33-27-13-8-7-11-25(23)27/h4-11,13-17,19,26,28,33,35H,2-3,12,18,20,32H2,1H3,(H,34,37)(H,36,38)/t26-,28-/m0/s1
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1.30E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529329
PNG
(CHEMBL4560993)
Show SMILES CCCC[C@H](N)C(=O)Nc1cccc(c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H34N4O4/c1-2-3-15-26(32)30(37)34-24-13-9-12-22(17-24)29(36)35-28(31(38)39-20-21-10-5-4-6-11-21)18-23-19-33-27-16-8-7-14-25(23)27/h4-14,16-17,19,26,28,33H,2-3,15,18,20,32H2,1H3,(H,34,37)(H,35,36)/t26-,28-/m0/s1
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3.20E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50236826
PNG
(CHEMBL4065841)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C35H40N3O4P/c36-33(22-21-26-13-5-1-6-14-26)43(41,42)25-30(35(40)38-32(34(37)39)23-27-15-7-2-8-16-27)24-31(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30-33H,21-25,36H2,(H2,37,39)(H,38,40)(H,41,42)/t30-,32+,33-/m1/s1
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3.50E+3n/an/an/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]citalopram to (SERT) serotonin transporter in rat striatum


J Med Chem 60: 2963-2972 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01890
BindingDB Entry DOI: 10.7270/Q29G5Q35
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529320
PNG
(CHEMBL4540943)
Show SMILES CCCC[C@H](N)C(=O)NNc1cccc(c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H35N5O4/c1-2-3-15-26(32)30(38)36-35-24-13-9-12-22(17-24)29(37)34-28(31(39)40-20-21-10-5-4-6-11-21)18-23-19-33-27-16-8-7-14-25(23)27/h4-14,16-17,19,26,28,33,35H,2-3,15,18,20,32H2,1H3,(H,34,37)(H,36,38)/t26-,28-/m0/s1
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3.80E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50519953
PNG
(CHEMBL2140832)
Show SMILES COc1ccc(cc1S(=O)(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H21F3N2O5S/c1-30-17-8-5-13(19(26)27)11-18(17)31(28,29)24-15-12-14(20(21,22)23)6-7-16(15)25-9-3-2-4-10-25/h5-8,11-12,24H,2-4,9-10H2,1H3,(H,26,27)
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3.80E+3n/an/an/an/an/an/an/an/a



Kansas University Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using varying le...


J Med Chem 63: 103-121 (2020)


Article DOI: 10.1021/acs.jmedchem.9b00293
BindingDB Entry DOI: 10.7270/Q2DN48D3
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529320
PNG
(CHEMBL4540943)
Show SMILES CCCC[C@H](N)C(=O)NNc1cccc(c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H35N5O4/c1-2-3-15-26(32)30(38)36-35-24-13-9-12-22(17-24)29(37)34-28(31(39)40-20-21-10-5-4-6-11-21)18-23-19-33-27-16-8-7-14-25(23)27/h4-14,16-17,19,26,28,33,35H,2-3,15,18,20,32H2,1H3,(H,34,37)(H,36,38)/t26-,28-/m0/s1
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4.30E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529322
PNG
(CHEMBL4466281)
Show SMILES CCCC[C@H](N)C(=O)Nc1cc(ccn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C30H33N5O4/c1-2-3-12-24(31)29(37)35-27-17-21(14-15-32-27)28(36)34-26(30(38)39-19-20-9-5-4-6-10-20)16-22-18-33-25-13-8-7-11-23(22)25/h4-11,13-15,17-18,24,26,33H,2-3,12,16,19,31H2,1H3,(H,34,36)(H,32,35,37)/t24-,26-/m0/s1
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4.60E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50529323
PNG
(CHEMBL4452852)
Show SMILES N[C@@H](CCc1ccccc1)C(=O)NNc1ccc(cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C35H35N5O4/c36-30(20-15-24-9-3-1-4-10-24)34(42)40-39-28-18-16-26(17-19-28)33(41)38-32(35(43)44-23-25-11-5-2-6-12-25)21-27-22-37-31-14-8-7-13-29(27)31/h1-14,16-19,22,30,32,37,39H,15,20-21,23,36H2,(H,38,41)(H,40,42)/t30-,32-/m0/s1
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4.70E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529321
PNG
(CHEMBL4575946)
Show SMILES CCCC[C@H](N)C(=O)Nc1ccc(cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H34N4O4/c1-2-3-12-26(32)30(37)34-24-16-14-22(15-17-24)29(36)35-28(31(38)39-20-21-9-5-4-6-10-21)18-23-19-33-27-13-8-7-11-25(23)27/h4-11,13-17,19,26,28,33H,2-3,12,18,20,32H2,1H3,(H,34,37)(H,35,36)/t26-,28-/m0/s1
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4.80E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529325
PNG
(CHEMBL4436776)
Show SMILES CC(C)[C@H](NC(=O)Cn1cccc(O)c1=O)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C19H22N2O5/c1-13(2)17(19(25)26-12-14-7-4-3-5-8-14)20-16(23)11-21-10-6-9-15(22)18(21)24/h3-10,13,17,22H,11-12H2,1-2H3,(H,20,23)/t17-/m0/s1
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4.90E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529326
PNG
(CHEMBL4557197)
Show SMILES Oc1cccn(CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)c1=O |r|
Show InChI InChI=1S/C25H23N3O5/c29-22-11-6-12-28(24(22)31)15-23(30)27-21(25(32)33-16-17-7-2-1-3-8-17)13-18-14-26-20-10-5-4-9-19(18)20/h1-12,14,21,26,29H,13,15-16H2,(H,27,30)/t21-/m0/s1
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5.70E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529328
PNG
(CHEMBL4475441)
Show SMILES COc1cccn(CC(=O)NCCc2ccc(cc2)-c2ccccc2)c1=S
Show InChI InChI=1S/C22H22N2O2S/c1-26-20-8-5-15-24(22(20)27)16-21(25)23-14-13-17-9-11-19(12-10-17)18-6-3-2-4-7-18/h2-12,15H,13-14,16H2,1H3,(H,23,25)
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8.70E+3n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50529330
PNG
(CHEMBL4527760)
Show SMILES CCCC[C@H](N)C(=O)NNc1ccc(cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H35N5O4/c1-2-3-12-26(32)30(38)36-35-24-16-14-22(15-17-24)29(37)34-28(31(39)40-20-21-9-5-4-6-10-21)18-23-19-33-27-13-8-7-11-25(23)27/h4-11,13-17,19,26,28,33,35H,2-3,12,18,20,32H2,1H3,(H,34,37)(H,36,38)/t26-,28-/m0/s1
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1.09E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50519944
PNG
(CHEMBL4456470)
Show SMILES CC(=O)N1CCN(CC1)C(=O)C1(CCCCC1)NC(=N)Nc1ccc(C)cc1
Show InChI InChI=1S/C21H31N5O2/c1-16-6-8-18(9-7-16)23-20(22)24-21(10-4-3-5-11-21)19(28)26-14-12-25(13-15-26)17(2)27/h6-9H,3-5,10-15H2,1-2H3,(H3,22,23,24)
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1.28E+4n/an/an/an/an/an/an/an/a



Kansas University Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using varying le...


J Med Chem 63: 103-121 (2020)


Article DOI: 10.1021/acs.jmedchem.9b00293
BindingDB Entry DOI: 10.7270/Q2DN48D3
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529324
PNG
(CHEMBL4445197)
Show SMILES Oc1cccn(CC(=O)NCCc2ccc(cc2)-c2ccccc2)c1=O
Show InChI InChI=1S/C21H20N2O3/c24-19-7-4-14-23(21(19)26)15-20(25)22-13-12-16-8-10-18(11-9-16)17-5-2-1-3-6-17/h1-11,14,24H,12-13,15H2,(H,22,25)
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1.30E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529328
PNG
(CHEMBL4475441)
Show SMILES COc1cccn(CC(=O)NCCc2ccc(cc2)-c2ccccc2)c1=S
Show InChI InChI=1S/C22H22N2O2S/c1-26-20-8-5-15-24(22(20)27)16-21(25)23-14-13-17-9-11-19(12-10-17)18-6-3-2-4-7-18/h2-12,15H,13-14,16H2,1H3,(H,23,25)
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1.74E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50529324
PNG
(CHEMBL4445197)
Show SMILES Oc1cccn(CC(=O)NCCc2ccc(cc2)-c2ccccc2)c1=O
Show InChI InChI=1S/C21H20N2O3/c24-19-7-4-14-23(21(19)26)15-20(25)22-13-12-16-8-10-18(11-9-16)17-5-2-1-3-6-17/h1-11,14,24H,12-13,15H2,(H,22,25)
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1.75E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50529325
PNG
(CHEMBL4436776)
Show SMILES CC(C)[C@H](NC(=O)Cn1cccc(O)c1=O)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C19H22N2O5/c1-13(2)17(19(25)26-12-14-7-4-3-5-8-14)20-16(23)11-21-10-6-9-15(22)18(21)24/h3-10,13,17,22H,11-12H2,1-2H3,(H,20,23)/t17-/m0/s1
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1.76E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant IRAP expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by M...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529327
PNG
(CHEMBL4455738)
Show SMILES Oc1cccn(CC(=O)NCCc2c[nH]c3ccccc23)c1=O
Show InChI InChI=1S/C17H17N3O3/c21-15-6-3-9-20(17(15)23)11-16(22)18-8-7-12-10-19-14-5-2-1-4-13(12)14/h1-6,9-10,19,21H,7-8,11H2,(H,18,22)
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1.77E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50529326
PNG
(CHEMBL4557197)
Show SMILES Oc1cccn(CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2ccccc2)c1=O |r|
Show InChI InChI=1S/C25H23N3O5/c29-22-11-6-12-28(24(22)31)15-23(30)27-21(25(32)33-16-17-7-2-1-3-8-17)13-18-14-26-20-10-5-4-9-19(18)20/h1-12,14,21,26,29H,13,15-16H2,(H,27,30)/t21-/m0/s1
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1.85E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529331
PNG
(CHEMBL4535014)
Show SMILES OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cccc(O)c1=O |r|
Show InChI InChI=1S/C18H17N3O5/c22-15-6-3-7-21(17(15)24)10-16(23)20-14(18(25)26)8-11-9-19-13-5-2-1-4-12(11)13/h1-7,9,14,19,22H,8,10H2,(H,20,23)(H,25,26)/t14-/m0/s1
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2.14E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50529328
PNG
(CHEMBL4475441)
Show SMILES COc1cccn(CC(=O)NCCc2ccc(cc2)-c2ccccc2)c1=S
Show InChI InChI=1S/C22H22N2O2S/c1-26-20-8-5-15-24(22(20)27)16-21(25)23-14-13-17-9-11-19(12-10-17)18-6-3-2-4-7-18/h2-12,15H,13-14,16H2,1H3,(H,23,25)
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2.34E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50529324
PNG
(CHEMBL4445197)
Show SMILES Oc1cccn(CC(=O)NCCc2ccc(cc2)-c2ccccc2)c1=O
Show InChI InChI=1S/C21H20N2O3/c24-19-7-4-14-23(21(19)26)15-20(25)22-13-12-16-8-10-18(11-9-16)17-5-2-1-3-6-17/h1-11,14,24H,12-13,15H2,(H,22,25)
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2.74E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP2 expressed in baculovirus infected sf9 cells using R-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50529325
PNG
(CHEMBL4436776)
Show SMILES CC(C)[C@H](NC(=O)Cn1cccc(O)c1=O)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C19H22N2O5/c1-13(2)17(19(25)26-12-14-7-4-3-5-8-14)20-16(23)11-21-10-6-9-15(22)18(21)24/h3-10,13,17,22H,11-12H2,1-2H3,(H,20,23)/t17-/m0/s1
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4.40E+4n/an/an/an/an/an/an/an/a



National Centre for Scientific Research "Demokritos"

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant ERAP1 expressed in baculovirus infected sf9 cells using L-AMC as substrate incubated for 5 to 10 mins by ...


Bioorg Med Chem 27: (2019)


Article DOI: 10.1016/j.bmc.2019.115177
BindingDB Entry DOI: 10.7270/Q2FN19NT
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))
BDBM50519948
PNG
(CHEMBL1700161)
Show SMILES Fc1ccc(F)c(c1)S(=O)(=O)NC(=N)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C17H16F2N4O2S/c18-12-5-6-14(19)16(9-12)26(24,25)23-17(20)21-8-7-11-10-22-15-4-2-1-3-13(11)15/h1-6,9-10,22H,7-8H2,(H3,20,21,23)
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5.17E+4n/an/an/an/an/an/an/an/a



Kansas University Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using varying le...


J Med Chem 63: 103-121 (2020)


Article DOI: 10.1021/acs.jmedchem.9b00293
BindingDB Entry DOI: 10.7270/Q2DN48D3
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245396
PNG
(CHEMBL4101200)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](CC#C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C24H30N3O4P/c1-2-9-20(17-32(30,31)22(25)15-14-18-10-5-3-6-11-18)24(29)27-21(23(26)28)16-19-12-7-4-8-13-19/h1,3-8,10-13,20-22H,9,14-17,25H2,(H2,26,28)(H,27,29)(H,30,31)/t20-,21+,22-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245391
PNG
(CHEMBL4095882)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](Cc1cc(no1)-c1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C31H35N4O6P/c32-29(16-11-21-7-3-1-4-8-21)42(39,40)20-24(18-26-19-27(35-41-26)23-12-14-25(36)15-13-23)31(38)34-28(30(33)37)17-22-9-5-2-6-10-22/h1-10,12-15,19,24,28-29,36H,11,16-18,20,32H2,(H2,33,37)(H,34,38)(H,39,40)/t24-,28+,29-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50331042
PNG
(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Show SMILES N[C@H]1CCSSC[C@H](NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)NCc1ccccc1CC(O)=O |r|
Show InChI InChI=1S/C26H32N4O6S2/c27-21-9-10-37-38-15-22(26(36)28-14-18-4-2-1-3-17(18)12-24(33)34)30-23(32)13-19(29-25(21)35)11-16-5-7-20(31)8-6-16/h1-8,19,21-22,31H,9-15,27H2,(H,28,36)(H,29,35)(H,30,32)(H,33,34)/t19-,21-,22-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of human IRAP soluble domain expressed in HEK293S GnTI(-) cells using Leu-AMC as substrate incubated for 2 hrs by fluorescence based assay


ACS Med Chem Lett 11: 1429-1434 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00172
BindingDB Entry DOI: 10.7270/Q2WM1J0W
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50601034
PNG
(CHEMBL5191661)
Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)COc1ccc(O)cc1 |r|
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n/an/a 6.5n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00904
BindingDB Entry DOI: 10.7270/Q2222ZVG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245390
PNG
(CHEMBL4077855)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](Cc1cc(no1)-c1ccccc1O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C31H35N4O6P/c32-29(16-15-21-9-3-1-4-10-21)42(39,40)20-23(18-24-19-26(35-41-24)25-13-7-8-14-28(25)36)31(38)34-27(30(33)37)17-22-11-5-2-6-12-22/h1-14,19,23,27,29,36H,15-18,20,32H2,(H2,33,37)(H,34,38)(H,39,40)/t23-,27+,29-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245400
PNG
(CHEMBL4099107)
Show SMILES COc1ccc(cc1)-c1cc(C[C@H](CP(O)(=O)[C@@H](N)CCc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)on1 |r|
Show InChI InChI=1S/C32H37N4O6P/c1-41-26-15-13-24(14-16-26)28-20-27(42-36-28)19-25(21-43(39,40)30(33)17-12-22-8-4-2-5-9-22)32(38)35-29(31(34)37)18-23-10-6-3-7-11-23/h2-11,13-16,20,25,29-30H,12,17-19,21,33H2,1H3,(H2,34,37)(H,35,38)(H,39,40)/t25-,29+,30-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r|
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n/an/a 11n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ERAP2 expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-arginyl-7-amido-4-methyl coumarin as s...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245382
PNG
(CHEMBL4080145)
Show SMILES COc1ccccc1-c1cc(C[C@H](CP(O)(=O)[C@@H](N)CCc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)on1 |r|
Show InChI InChI=1S/C32H37N4O6P/c1-41-29-15-9-8-14-26(29)27-20-25(42-36-27)19-24(21-43(39,40)30(33)17-16-22-10-4-2-5-11-22)32(38)35-28(31(34)37)18-23-12-6-3-7-13-23/h2-15,20,24,28,30H,16-19,21,33H2,1H3,(H2,34,37)(H,35,38)(H,39,40)/t24-,28+,30-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50601033
PNG
(CHEMBL5209483)
Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CCOc1ccc(O)cc1 |r|
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n/an/a 13n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00904
BindingDB Entry DOI: 10.7270/Q2222ZVG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245388
PNG
(CHEMBL4081073)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](Cc1cc(no1)-c1ccccc1Cl)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C31H34ClN4O5P/c32-26-14-8-7-13-25(26)27-19-24(41-36-27)18-23(20-42(39,40)29(33)16-15-21-9-3-1-4-10-21)31(38)35-28(30(34)37)17-22-11-5-2-6-12-22/h1-14,19,23,28-29H,15-18,20,33H2,(H2,34,37)(H,35,38)(H,39,40)/t23-,28+,29-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245349
PNG
(CHEMBL4089555)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O |r|
Show InChI InChI=1S/C21H34N3O4P/c1-15(2)13-17(21(26)24-12-6-9-18(24)20(23)25)14-29(27,28)19(22)11-10-16-7-4-3-5-8-16/h3-5,7-8,15,17-19H,6,9-14,22H2,1-2H3,(H2,23,25)(H,27,28)/t17-,18+,19-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50331042
PNG
(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Show SMILES N[C@H]1CCSSC[C@H](NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)NCc1ccccc1CC(O)=O |r|
Show InChI InChI=1S/C26H32N4O6S2/c27-21-9-10-37-38-15-22(26(36)28-14-18-4-2-1-3-17(18)12-24(33)34)30-23(32)13-19(29-25(21)35)11-16-5-7-20(31)8-6-16/h1-8,19,21-22,31H,9-15,27H2,(H,28,36)(H,29,35)(H,30,32)(H,33,34)/t19-,21-,22-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



National Center for Scientific Research Demokritos

Curated by ChEMBL


Assay Description
Inhibition of human IRAP soluble domain expressed in HEK293S GnTI(-) cells using Arg-AMC as substrate incubated for 2 hrs by fluorescence based assay


ACS Med Chem Lett 11: 1429-1434 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00172
BindingDB Entry DOI: 10.7270/Q2WM1J0W
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245428
PNG
(CHEMBL4069576)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(O)(=O)[C@@H](N)CCc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C32H42N3O4P/c1-23(2)20-29(31(34)36)35-32(37)27(22-40(38,39)30(33)19-18-24-12-6-3-7-13-24)21-28(25-14-8-4-9-15-25)26-16-10-5-11-17-26/h3-17,23,27-30H,18-22,33H2,1-2H3,(H2,34,36)(H,35,37)(H,38,39)/t27-,29+,30-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245399
PNG
(CHEMBL4069425)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](Cc1cc(no1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C31H35N4O5P/c32-29(17-16-22-10-4-1-5-11-22)41(38,39)21-25(19-26-20-27(35-40-26)24-14-8-3-9-15-24)31(37)34-28(30(33)36)18-23-12-6-2-7-13-23/h1-15,20,25,28-29H,16-19,21,32H2,(H2,33,36)(H,34,37)(H,38,39)/t25-,28+,29-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Interleukin-1 receptor antagonist protein


(Homo sapiens)
BDBM50601042
PNG
(CHEMBL5195885)
Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)COc1cc(F)c(F)c(F)c1 |r|
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n/an/a 19n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00904
BindingDB Entry DOI: 10.7270/Q2222ZVG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245383
PNG
(CHEMBL4104383)
Show SMILES COc1cccc(c1)-c1cc(C[C@H](CP(O)(=O)[C@@H](N)CCc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)on1 |r|
Show InChI InChI=1S/C32H37N4O6P/c1-41-26-14-8-13-24(18-26)28-20-27(42-36-28)19-25(21-43(39,40)30(33)16-15-22-9-4-2-5-10-22)32(38)35-29(31(34)37)17-23-11-6-3-7-12-23/h2-14,18,20,25,29-30H,15-17,19,21,33H2,1H3,(H2,34,37)(H,35,38)(H,39,40)/t25-,29+,30-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245446
PNG
(CHEMBL4094131)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](Cc1cc(cc(c1)-c1ccccc1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C40H42N3O4P/c41-38(22-21-29-13-5-1-6-14-29)48(46,47)28-36(40(45)43-37(39(42)44)26-30-15-7-2-8-16-30)25-31-23-34(32-17-9-3-10-18-32)27-35(24-31)33-19-11-4-12-20-33/h1-20,23-24,27,36-38H,21-22,25-26,28,41H2,(H2,42,44)(H,43,45)(H,46,47)/t36-,37+,38-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245354
PNG
(CHEMBL4097268)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Show InChI InChI=1S/C25H36N3O5P/c1-17(2)14-20(16-34(32,33)23(26)13-10-18-6-4-3-5-7-18)25(31)28-22(24(27)30)15-19-8-11-21(29)12-9-19/h3-9,11-12,17,20,22-23,29H,10,13-16,26H2,1-2H3,(H2,27,30)(H,28,31)(H,32,33)/t20-,22+,23-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50076744
PNG
(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r|
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n/an/a 30n/an/an/an/an/an/a



National Center for Scientific Research"Demokritos"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as su...


J Med Chem 58: 1524-43 (2015)


Article DOI: 10.1021/jm501867s
BindingDB Entry DOI: 10.7270/Q2Z321B0
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50245347
PNG
(CHEMBL4081682)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O |r|
Show InChI InChI=1S/C22H38N3O4P/c1-15(2)12-18(22(27)25-19(21(24)26)13-16(3)4)14-30(28,29)20(23)11-10-17-8-6-5-7-9-17/h5-9,15-16,18-20H,10-14,23H2,1-4H3,(H2,24,26)(H,25,27)(H,28,29)/t18-,19+,20-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM50236826
PNG
(CHEMBL4065841)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Show InChI InChI=1S/C35H40N3O4P/c36-33(22-21-26-13-5-1-6-14-26)43(41,42)25-30(35(40)38-32(34(37)39)23-27-15-7-2-8-16-27)24-31(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30-33H,21-25,36H2,(H2,37,39)(H,38,40)(H,41,42)/t30-,32+,33-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



National and Kapodistrian University of Athens

Curated by ChEMBL


Assay Description
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay


J Med Chem 59: 9107-9123 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01031
BindingDB Entry DOI: 10.7270/Q2PK0JJG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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