Compile Data Set for Download or QSAR

Found 231 hits with Last Name = 'kendall' and Initial = 'l'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5413 (1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C23H24N4OS/c1-2-9-26(10-3-1)11-12-28-21-6-4-18(5-7-21)20-14-24-23-22(15-25-27(23)16-20)19-8-13-29-17-19/h4-8,13-17H,1-3,9-12H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5358 (N-(6-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...) Show SMILES COc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C15H13N3OS/c1-19-14-9-5-8-13(17-14)18-15-16-10-12(20-15)11-6-3-2-4-7-11/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5409 (4-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...) Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C22H22N4O2S/c1-3-20(28-11-8-25-6-9-27-10-7-25)4-2-17(1)19-13-23-22-21(14-24-26(22)15-19)18-5-12-29-16-18/h1-5,12-16H,6-11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5281 (5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...) Show SMILES C(N1CCCC1)c1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5351 (N-(4-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C15H13N3S/c1-11-7-8-16-14(9-11)18-15-17-10-13(19-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5435 (1-[3-(4-methylpiperazin-1-yl)propyl]-4-[3-(thiophe...) Show SMILES CN1CCN(CCCn2ccc(cc2=O)-c2cnc3c(cnn3c2)-c2ccsc2)CC1 Show InChI InChI=1S/C23H26N6OS/c1-26-8-10-27(11-9-26)5-2-6-28-7-3-18(13-22(28)30)20-14-24-23-21(15-25-29(23)16-20)19-4-12-31-17-19/h3-4,7,12-17H,2,5-6,8-11H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5328 (2-quinolinone deriv. 3 | 3-(1H-indol-2-yl)-1,2-dih...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2ccccc2[nH]1 Show InChI InChI=1S/C17H12N2O/c20-17-13(9-11-5-1-4-8-15(11)19-17)16-10-12-6-2-3-7-14(12)18-16/h1-10,18H,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5410 (4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...) Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1 Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50326206 (CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)cc1 Show InChI InChI=1S/C29H24N6O2/c1-30-29-32-19-17-26(35-29)24-11-7-18-31-28(24)37-22-15-13-21(14-16-22)34-27(36)23-10-5-6-12-25(23)33-20-8-3-2-4-9-20/h2-19,33H,1H3,(H,34,36)(H,30,32,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5353 (N-(6-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-14(17-11)18-15-16-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5412 (dimethyl(3-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyr...) Show SMILES CN(C)CCCOc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C21H22N4OS/c1-24(2)9-3-10-26-19-6-4-16(5-7-19)18-12-22-21-20(13-23-25(21)14-18)17-8-11-27-15-17/h4-8,11-15H,3,9-10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5357 (N-(4-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...) Show SMILES COc1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C15H13N3OS/c1-19-12-7-8-16-14(9-12)18-15-17-10-13(20-15)11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5416 (4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...) Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5434 (1-[3-(4-methylpiperazin-1-yl)propyl]-4-{3-phenylpy...) Show SMILES CN1CCN(CCCn2ccc(cc2=O)-c2cnc3c(cnn3c2)-c2ccccc2)CC1 Show InChI InChI=1S/C25H28N6O/c1-28-12-14-29(15-13-28)9-5-10-30-11-8-21(16-24(30)32)22-17-26-25-23(18-27-31(25)19-22)20-6-3-2-4-7-20/h2-4,6-8,11,16-19H,5,9-10,12-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5350 (N-(3-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1cccnc1Nc1ncc(s1)-c1ccccc1 Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-16-14(11)18-15-17-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5375 (1-phenyl-5-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1H...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H27N3O/c1-3-7-23(8-4-1)29-20-27-25-19-22(11-14-26(25)29)21-9-12-24(13-10-21)30-18-17-28-15-5-2-6-16-28/h1,3-4,7-14,19-20H,2,5-6,15-18H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5355 (N-(6-bromopyridin-2-yl)-5-phenyl-1,3-thiazol-2-ami...) Show SMILES Brc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C14H10BrN3S/c15-12-7-4-8-13(17-12)18-14-16-9-11(19-14)10-5-2-1-3-6-10/h1-9H,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5411 (4-(2-{3-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...) Show SMILES C(CN1CCOCC1)Oc1cccc(c1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C22H22N4O2S/c1-2-17(12-20(3-1)28-10-7-25-5-8-27-9-6-25)19-13-23-22-21(14-24-26(22)15-19)18-4-11-29-16-18/h1-4,11-16H,5-10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5433 (4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}-1-[3-(pi...) Show SMILES O=c1cc(ccn1CCCN1CCCCC1)-c1cnc2c(cnn2c1)-c1ccccc1 Show InChI InChI=1S/C25H27N5O/c31-24-16-21(10-15-29(24)14-7-13-28-11-5-2-6-12-28)22-17-26-25-23(18-27-30(25)19-22)20-8-3-1-4-9-20/h1,3-4,8-10,15-19H,2,5-7,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5323 (1-[3-(4-methylpiperazin-1-yl)propyl]-3-[5-(thiophe...) Show SMILES CN1CCN(CCCn2cc(-c3cncc(c3)-c3ccsc3)c3ccccc23)CC1 Show InChI InChI=1S/C25H28N4S/c1-27-10-12-28(13-11-27)8-4-9-29-18-24(23-5-2-3-6-25(23)29)22-15-21(16-26-17-22)20-7-14-30-19-20/h2-3,5-7,14-19H,4,8-13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50326204 (CHEMBL1243137 | N-(3-Methyl-4-(3-(2-(methylamino)p...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)cc1C Show InChI InChI=1S/C30H26N6O2/c1-20-19-22(35-28(37)23-11-6-7-13-25(23)34-21-9-4-3-5-10-21)14-15-27(20)38-29-24(12-8-17-32-29)26-16-18-33-30(31-2)36-26/h3-19,34H,1-2H3,(H,35,37)(H,31,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5432 (6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...) Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C17H13N3OS/c1-21-15-4-2-12(3-5-15)14-8-18-17-16(9-19-20(17)10-14)13-6-7-22-11-13/h2-11H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5414 (benzyl(2-methoxyethyl)(2-{4-[3-(thiophen-3-yl)pyra...) Show SMILES COCCN(CCOc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1)Cc1ccccc1 Show InChI InChI=1S/C28H28N4O2S/c1-33-14-12-31(19-22-5-3-2-4-6-22)13-15-34-26-9-7-23(8-10-26)25-17-29-28-27(18-30-32(28)20-25)24-11-16-35-21-24/h2-11,16-18,20-21H,12-15,19H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5352 (N-(5-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C15H13N3S/c1-11-7-8-14(16-9-11)18-15-17-10-13(19-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5415 (3-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccnc1 Show InChI InChI=1S/C24H25N5O/c1-2-11-28(12-3-1)13-14-30-22-8-6-19(7-9-22)21-16-26-24-23(17-27-29(24)18-21)20-5-4-10-25-15-20/h4-10,15-18H,1-3,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50326207 (CHEMBL1243294 | N-(4-(3-(2-(Methylamino)pyrimidin-...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H23N7O/c1-31-30-33-19-17-26(35-30)25-12-7-18-32-29(25)38-22-15-13-21(14-16-22)34-28-24-11-6-5-10-23(24)27(36-37-28)20-8-3-2-4-9-20/h2-19H,1H3,(H,34,37)(H,31,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5366 (1-phenyl-5-{6-[2-(piperidin-1-yl)ethoxy]pyridin-3-...) Show SMILES C(CN1CCCCC1)Oc1ccc(cn1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c1-3-7-22(8-4-1)29-19-27-23-17-20(9-11-24(23)29)21-10-12-25(26-18-21)30-16-15-28-13-5-2-6-14-28/h1,3-4,7-12,17-19H,2,5-6,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5431 (4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl]...) Show SMILES c1cc(cs1)-c1cnn2cc(cnc12)-c1ccncc1 Show InChI InChI=1S/C15H10N4S/c1-4-16-5-2-11(1)13-7-17-15-14(8-18-19(15)9-13)12-3-6-20-10-12/h1-10H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5368 (4-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...) Show SMILES O=c1cc(ccn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-19-22(12-17-29(26)16-7-15-28-13-5-2-6-14-28)21-10-11-25-24(18-21)27-20-30(25)23-8-3-1-4-9-23/h1,3-4,8-12,17-20H,2,5-7,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5437 (4-[3-(cyclopent-1-en-1-yl)pyrazolo[1,5-a]pyrimidin...) Show SMILES C1CC=C(C1)c1cnn2cc(cnc12)-c1ccncc1 |c:2| Show InChI InChI=1S/C16H14N4/c1-2-4-13(3-1)15-10-19-20-11-14(9-18-16(15)20)12-5-7-17-8-6-12/h3,5-11H,1-2,4H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5354 (N-(5-chloropyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Clc1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C14H10ClN3S/c15-11-6-7-13(16-8-11)18-14-17-9-12(19-14)10-4-2-1-3-5-10/h1-9H,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5362 (2-(pyridin-2-ylamino)-1,3-thiazole-5-carbonitrile ...) Show SMILES N#Cc1cnc(Nc2ccccn2)s1 Show InChI InChI=1S/C9H6N4S/c10-5-7-6-12-9(14-7)13-8-3-1-2-4-11-8/h1-4,6H,(H,11,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5420 (4-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...) Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C18H14N4O/c1-23-16-4-2-13(3-5-16)15-10-20-18-17(11-21-22(18)12-15)14-6-8-19-9-7-14/h2-12H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5369 (5-(1-phenyl-1H-1,3-benzodiazol-5-yl)-1-[3-(piperid...) Show SMILES O=c1ccc(cn1CCCN1CCCCC1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-13-11-22(19-29(26)17-7-16-28-14-5-2-6-15-28)21-10-12-25-24(18-21)27-20-30(25)23-8-3-1-4-9-23/h1,3-4,8-13,18-20H,2,5-7,14-17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5376 (1-[2-(4-{3-phenyl-3H-imidazo[4,5-b]pyridin-6-yl}ph...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c1-3-7-22(8-4-1)29-19-27-24-17-21(18-26-25(24)29)20-9-11-23(12-10-20)30-16-15-28-13-5-2-6-14-28/h1,3-4,7-12,17-19H,2,5-6,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5322 (1-[3-(piperidin-1-yl)propyl]-3-[5-(thiophen-3-yl)p...) Show SMILES C(CN1CCCCC1)Cn1cc(-c2cncc(c2)-c2ccsc2)c2ccccc12 Show InChI InChI=1S/C25H27N3S/c1-4-10-27(11-5-1)12-6-13-28-18-24(23-7-2-3-8-25(23)28)22-15-21(16-26-17-22)20-9-14-29-19-20/h2-3,7-9,14-19H,1,4-6,10-13H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5438 (4-[3-(cyclohex-1-en-1-yl)pyrazolo[1,5-a]pyrimidin-...) Show SMILES C1CCC(=CC1)c1cnn2cc(cnc12)-c1ccncc1 |c:3| Show InChI InChI=1S/C17H16N4/c1-2-4-14(5-3-1)16-11-20-21-12-15(10-19-17(16)21)13-6-8-18-9-7-13/h4,6-12H,1-3,5H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5421 (3-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...) Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccnc1 Show InChI InChI=1S/C18H14N4O/c1-23-16-6-4-13(5-7-16)15-10-20-18-17(11-21-22(18)12-15)14-3-2-8-19-9-14/h2-12H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5327 (2-quinolinone deriv. 2 | 3-(1H-1,3-benzodiazol-2-y...) Show SMILES O=c1[nH]c2ccccc2cc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C16H11N3O/c20-16-11(9-10-5-1-2-6-12(10)19-16)15-17-13-7-3-4-8-14(13)18-15/h1-9H,(H,17,18)(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5403 (2,4-Disubstituted Pyrimidine 5e | N-(3,5-dimethylp...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2cccc(F)c2)c1 Show InChI InChI=1S/C21H18FN5/c1-14-10-15(2)12-18(11-14)25-21-24-7-6-19(26-21)27-9-8-23-20(27)16-4-3-5-17(22)13-16/h3-13H,1-2H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5356 (N-(3-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...) Show SMILES COc1cccnc1Nc1ncc(s1)-c1ccccc1 Show InChI InChI=1S/C15H13N3OS/c1-19-12-8-5-9-16-14(12)18-15-17-10-13(20-15)11-6-3-2-4-7-11/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5325 (3-(5-Thien-3-ylpyridin-3-yl)-1Hindole 3h | dimethy...) Show SMILES CC(CN(C)C)Cn1cc(-c2cncc(c2)-c2ccsc2)c2ccccc12 Show InChI InChI=1S/C23H25N3S/c1-17(13-25(2)3)14-26-15-22(21-6-4-5-7-23(21)26)20-10-19(11-24-12-20)18-8-9-27-16-18/h4-12,15-17H,13-14H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5367 (N-[2-(morpholin-4-yl)ethyl]-5-(1-phenyl-1H-1,3-ben...) Show SMILES C(CN1CCOCC1)Nc1ccc(cn1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C24H25N5O/c1-2-4-21(5-3-1)29-18-27-22-16-19(6-8-23(22)29)20-7-9-24(26-17-20)25-10-11-28-12-14-30-15-13-28/h1-9,16-18H,10-15H2,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50326202 (CHEMBL1243042 | N-(3-Methyl-4-(3-(2-(methylamino)p...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Oc2ccccc2)cc1C Show InChI InChI=1S/C30H25N5O3/c1-20-19-21(34-28(36)24-11-6-7-13-27(24)37-22-9-4-3-5-10-22)14-15-26(20)38-29-23(12-8-17-32-29)25-16-18-33-30(31-2)35-25/h3-19H,1-2H3,(H,34,36)(H,31,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5321 (3-(5-Thien-3-ylpyridin-3-yl)-1Hindole 3d | 4-(2-{3...) Show SMILES C(Cn1cc(-c2cncc(c2)-c2ccsc2)c2ccccc12)N1CCOCC1 Show InChI InChI=1S/C23H23N3OS/c1-2-4-23-21(3-1)22(16-26(23)7-6-25-8-10-27-11-9-25)20-13-19(14-24-15-20)18-5-12-28-17-18/h1-5,12-17H,6-11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5405 (2,4-Disubstituted Pyrimidine 5g | 4-(2-chloro-1H-i...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2Cl)c1 Show InChI InChI=1S/C15H14ClN5/c1-10-7-11(2)9-12(8-10)19-15-18-4-3-13(20-15)21-6-5-17-14(21)16/h3-9H,1-2H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5419 (4-[6-(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl...) Show SMILES Cc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C18H14N4/c1-13-2-4-14(5-3-13)16-10-20-18-17(11-21-22(18)12-16)15-6-8-19-9-7-15/h2-12H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5426 (4-[3-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl...) Show SMILES Fc1ccc(cc1)-c1cnn2cc(cnc12)-c1ccncc1 Show InChI InChI=1S/C17H11FN4/c18-15-3-1-13(2-4-15)16-10-21-22-11-14(9-20-17(16)22)12-5-7-19-8-6-12/h1-11H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5324 (3-(5-Thien-3-ylpyridin-3-yl)-1Hindole 3g | dimethy...) Show SMILES CN(C)CCCn1cc(-c2cncc(c2)-c2ccsc2)c2ccccc12 Show InChI InChI=1S/C22H23N3S/c1-24(2)9-5-10-25-15-21(20-6-3-4-7-22(20)25)19-12-18(13-23-14-19)17-8-11-26-16-17/h3-4,6-8,11-16H,5,9-10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair

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