Compile Data Set for Download or QSAR

Found 169 hits with Last Name = 'backer' and Initial = 'rt'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186863 (CHEMBL379497 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES CCN(CC)CC(CC1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C36H52ClN5O2/c1-3-40(4-2)26-31(22-27-10-6-5-7-11-27)41-18-20-42(21-19-41)36(44)34(23-28-14-16-30(37)17-15-28)39-35(43)24-33-32-13-9-8-12-29(32)25-38-33/h8-9,12-17,27,31,33-34,38H,3-7,10-11,18-26H2,1-2H3,(H,39,43)/t31?,33?,34-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177564 (CHEMBL380540 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)C1Cc2ccccc2C(C)(C)N1)c1ccccc1F Show InChI InChI=1S/C37H47ClFN5O2/c1-5-42(6-2)25-34(29-12-8-10-14-31(29)39)43-19-21-44(22-20-43)36(46)33(23-26-15-17-28(38)18-16-26)40-35(45)32-24-27-11-7-9-13-30(27)37(3,4)41-32/h7-18,32-34,41H,5-6,19-25H2,1-4H3,(H,40,45)/t32?,33-,34?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177560 (CHEMBL206042 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1Cl Show InChI InChI=1S/C36H45Cl2N5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177560 (CHEMBL206042 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1Cl Show InChI InChI=1S/C36H45Cl2N5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186868 (CHEMBL213340 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CN1CCC(CC2CCCCC2)(CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C36H50ClN5O2/c1-40-17-15-36(16-18-40,25-28-7-3-2-4-8-28)42-21-19-41(20-22-42)35(44)33(23-27-11-13-30(37)14-12-27)39-34(43)24-32-31-10-6-5-9-29(31)26-38-32/h5-6,9-14,28,32-33,38H,2-4,7-8,15-26H2,1H3,(H,39,43)/t32?,33-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177563 (CHEMBL380855 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1F Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177557 (CHEMBL380365 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCCc2ccccc12)c1ccccc1F Show InChI InChI=1S/C36H45ClFN5O2/c1-3-41(4-2)25-34(30-11-7-8-12-31(30)38)42-19-21-43(22-20-42)36(45)33(23-26-13-15-28(37)16-14-26)40-35(44)24-32-29-10-6-5-9-27(29)17-18-39-32/h5-16,32-34,39H,3-4,17-25H2,1-2H3,(H,40,44)/t32?,33-,34?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186874 (CHEMBL376999 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)CC1(CCN(C)CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C33H46ClN5O2/c1-24(2)22-33(12-14-37(3)15-13-33)39-18-16-38(17-19-39)32(41)30(20-25-8-10-27(34)11-9-25)36-31(40)21-29-28-7-5-4-6-26(28)23-35-29/h4-11,24,29-30,35H,12-23H2,1-3H3,(H,36,40)/t29?,30-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186862 (CHEMBL211260 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)CC1(CCN(CC1)C(C)C)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C35H50ClN5O2/c1-25(2)23-35(13-15-39(16-14-35)26(3)4)41-19-17-40(18-20-41)34(43)32(21-27-9-11-29(36)12-10-27)38-33(42)22-31-30-8-6-5-7-28(30)24-37-31/h5-12,25-26,31-32,37H,13-24H2,1-4H3,(H,38,42)/t31?,32-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139027 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) Show SMILES CCN(CC)Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C34H42ClN5O2/c1-3-38(4-2)24-28-11-7-8-12-32(28)39-17-19-40(20-18-39)34(42)31(21-25-13-15-29(35)16-14-25)37-33(41)30-22-26-9-5-6-10-27(26)23-36-30/h5-16,30-31,36H,3-4,17-24H2,1-2H3,(H,37,41)/t30-,31-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174056 (CHEMBL381015 | Diethyl-[(S)-2-(2-fluoro-phenyl)-2-...) Show SMILES CCN(CC)C[C@@H](N1CCN(C)CC1)c1ccccc1F Show InChI InChI=1S/C17H28FN3/c1-4-20(5-2)14-17(15-8-6-7-9-16(15)18)21-12-10-19(3)11-13-21/h6-9,17H,4-5,10-14H2,1-3H3/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186865 (CHEMBL211202 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(1-...) Show SMILES CCN1CCC(CC(C)C)(CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C34H48ClN5O2/c1-4-38-15-13-34(14-16-38,23-25(2)3)40-19-17-39(18-20-40)33(42)31(21-26-9-11-28(35)12-10-26)37-32(41)22-30-29-8-6-5-7-27(29)24-36-30/h5-12,25,30-31,36H,4,13-24H2,1-3H3,(H,37,41)/t30?,31-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177565 (CHEMBL380858 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1N(C)Cc2ccccc12)c1ccccc1F Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-34(30-12-8-9-13-31(30)38)42-18-20-43(21-19-42)36(45)32(22-26-14-16-28(37)17-15-26)39-35(44)23-33-29-11-7-6-10-27(29)24-40(33)3/h6-17,32-34H,4-5,18-25H2,1-3H3,(H,39,44)/t32-,33?,34?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174055 (CHEMBL198379 | Diethyl-[2-(2-fluoro-phenyl)-2-(4-m...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccccc1F Show InChI InChI=1S/C17H28FN3/c1-4-20(5-2)14-17(15-8-6-7-9-16(15)18)21-12-10-19(3)11-13-21/h6-9,17H,4-5,10-14H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139046 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2CN2CCCC2)cc1 Show InChI InChI=1S/C34H40ClN5O2/c35-29-13-11-25(12-14-29)21-31(37-33(41)30-22-26-7-1-2-8-27(26)23-36-30)34(42)40-19-17-39(18-20-40)32-10-4-3-9-28(32)24-38-15-5-6-16-38/h1-4,7-14,30-31,36H,5-6,15-24H2,(H,37,41)/t30-,31-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139032 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2CN2CCCCC2)cc1 Show InChI InChI=1S/C35H42ClN5O2/c36-30-14-12-26(13-15-30)22-32(38-34(42)31-23-27-8-2-3-9-28(27)24-37-31)35(43)41-20-18-40(19-21-41)33-11-5-4-10-29(33)25-39-16-6-1-7-17-39/h2-5,8-15,31-32,37H,1,6-7,16-25H2,(H,38,42)/t31-,32-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186869 (CHEMBL375388 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)CC1(CCN(CC1)S(C)(=O)=O)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C33H46ClN5O4S/c1-24(2)22-33(12-14-39(15-13-33)44(3,42)43)38-18-16-37(17-19-38)32(41)30(20-25-8-10-27(34)11-9-25)36-31(40)21-29-28-7-5-4-6-26(28)23-35-29/h4-11,24,29-30,35H,12-23H2,1-3H3,(H,36,40)/t29?,30-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186861 (CHEMBL213940 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)CC1(CCOCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C32H43ClN4O3/c1-23(2)21-32(11-17-40-18-12-32)37-15-13-36(14-16-37)31(39)29(19-24-7-9-26(33)10-8-24)35-30(38)20-28-27-6-4-3-5-25(27)22-34-28/h3-10,23,28-29,34H,11-22H2,1-2H3,(H,35,38)/t28?,29-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139027 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) Show SMILES CCN(CC)Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C34H42ClN5O2/c1-3-38(4-2)24-28-11-7-8-12-32(28)39-17-19-40(20-18-39)34(42)31(21-25-13-15-29(35)16-14-25)37-33(41)30-22-26-9-5-6-10-27(26)23-36-30/h5-16,30-31,36H,3-4,17-24H2,1-2H3,(H,37,41)/t30-,31-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139043 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES CCCN(CCC)Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C36H46ClN5O2/c1-3-17-40(18-4-2)26-30-11-7-8-12-34(30)41-19-21-42(22-20-41)36(44)33(23-27-13-15-31(37)16-14-27)39-35(43)32-24-28-9-5-6-10-29(28)25-38-32/h5-16,32-33,38H,3-4,17-26H2,1-2H3,(H,39,43)/t32-,33-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human melanocortin 4 receptor using [125I]NDP-alpha-MSH as a radioligand in HEK293 cells				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186864 (CHEMBL373735 | N-[(R)-2-[4-(1-acetyl-4-isobutyl-pi...) Show SMILES CC(C)CC1(CCN(CC1)C(C)=O)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C34H46ClN5O3/c1-24(2)22-34(12-14-38(15-13-34)25(3)41)40-18-16-39(17-19-40)33(43)31(20-26-8-10-28(35)11-9-26)37-32(42)21-30-29-7-5-4-6-27(29)23-36-30/h4-11,24,30-31,36H,12-23H2,1-3H3,(H,37,42)/t30?,31-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174062 (CHEMBL371896 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(Cc1ccccc1)N1CCN(C)CC1 Show InChI InChI=1S/C18H31N3/c1-4-20(5-2)16-18(15-17-9-7-6-8-10-17)21-13-11-19(3)12-14-21/h6-10,18H,4-5,11-16H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174050 (CHEMBL365184 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C18H28F3N3/c1-4-23(5-2)14-17(24-12-10-22(3)11-13-24)15-8-6-7-9-16(15)18(19,20)21/h6-9,17H,4-5,10-14H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177561 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamin...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)c1ccccc1F Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31-,32-,33?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186871 (CHEMBL211032 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)C1(CCN(C)CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C32H44ClN5O2/c1-23(2)32(12-14-36(3)15-13-32)38-18-16-37(17-19-38)31(40)29(20-24-8-10-26(33)11-9-24)35-30(39)21-28-27-7-5-4-6-25(27)22-34-28/h4-11,23,28-29,34H,12-22H2,1-3H3,(H,35,39)/t28?,29-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186867 (CHEMBL378415 | N-[(R)-2-[4-(4-benzyl-1-methyl-pipe...) Show SMILES CN1CCC(Cc2ccccc2)(CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C36H44ClN5O2/c1-40-17-15-36(16-18-40,25-28-7-3-2-4-8-28)42-21-19-41(20-22-42)35(44)33(23-27-11-13-30(37)14-12-27)39-34(43)24-32-31-10-6-5-9-29(31)26-38-32/h2-14,32-33,38H,15-26H2,1H3,(H,39,43)/t32?,33-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186875 (CHEMBL375389 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(1-...) Show SMILES CC(C)CC1(CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C33H45ClN4O2/c1-24(2)22-33(14-6-3-7-15-33)38-18-16-37(17-19-38)32(40)30(20-25-10-12-27(34)13-11-25)36-31(39)21-29-28-9-5-4-8-26(28)23-35-29/h4-5,8-13,24,29-30,35H,3,6-7,14-23H2,1-2H3,(H,36,39)/t29?,30-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	47	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174045 (CHEMBL373042 | Diethyl-[(R)-2-(4-methyl-piperazin-...) Show SMILES CCN(CC)C[C@H](N1CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C17H29N3/c1-4-19(5-2)15-17(16-9-7-6-8-10-16)20-13-11-18(3)12-14-20/h6-10,17H,4-5,11-15H2,1-3H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139028 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) Show SMILES CN(C)Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C32H38ClN5O2/c1-36(2)22-26-9-5-6-10-30(26)37-15-17-38(18-16-37)32(40)29(19-23-11-13-27(33)14-12-23)35-31(39)28-20-24-7-3-4-8-25(24)21-34-28/h3-14,28-29,34H,15-22H2,1-2H3,(H,35,39)/t28-,29-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186859 (CHEMBL211475 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)CC1(CCSCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C32H43ClN4O2S/c1-23(2)21-32(11-17-40-18-12-32)37-15-13-36(14-16-37)31(39)29(19-24-7-9-26(33)10-8-24)35-30(38)20-28-27-6-4-3-5-25(27)22-34-28/h3-10,23,28-29,34H,11-22H2,1-2H3,(H,35,38)/t28?,29-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174060 (CHEMBL198320 | [2-(2-Chloro-phenyl)-2-(4-methyl-pi...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccccc1Cl Show InChI InChI=1S/C17H28ClN3/c1-4-20(5-2)14-17(15-8-6-7-9-16(15)18)21-12-10-19(3)11-13-21/h6-9,17H,4-5,10-14H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186860 (CHEMBL210922 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CCCCCCC1(CCN(C)CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C35H50ClN5O2/c1-3-4-5-8-15-35(16-18-39(2)19-17-35)41-22-20-40(21-23-41)34(43)32(24-27-11-13-29(36)14-12-27)38-33(42)25-31-30-10-7-6-9-28(30)26-37-31/h6-7,9-14,31-32,37H,3-5,8,15-26H2,1-2H3,(H,38,42)/t31?,32-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174053 (CHEMBL198378 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccccc1C Show InChI InChI=1S/C18H31N3/c1-5-20(6-2)15-18(17-10-8-7-9-16(17)3)21-13-11-19(4)12-14-21/h7-10,18H,5-6,11-15H2,1-4H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177558 (CHEMBL438432 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1(C)NCc2ccccc12)c1ccccc1F Show InChI InChI=1S/C36H45ClFN5O2/c1-4-41(5-2)25-33(29-11-7-9-13-31(29)38)42-18-20-43(21-19-42)35(45)32(22-26-14-16-28(37)17-15-26)40-34(44)23-36(3)30-12-8-6-10-27(30)24-39-36/h6-17,32-33,39H,4-5,18-25H2,1-3H3,(H,40,44)/t32-,33?,36?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	74	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186866 (CHEMBL211792 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)CC1(CCS(=O)(=O)CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C32H43ClN4O4S/c1-23(2)21-32(11-17-42(40,41)18-12-32)37-15-13-36(14-16-37)31(39)29(19-24-7-9-26(33)10-8-24)35-30(38)20-28-27-6-4-3-5-25(27)22-34-28/h3-10,23,28-29,34H,11-22H2,1-2H3,(H,35,38)/t28?,29-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174065 (CHEMBL448473 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C17H29N3/c1-4-19(5-2)15-17(16-9-7-6-8-10-16)20-13-11-18(3)12-14-20/h6-10,17H,4-5,11-15H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177562 (CHEMBL206840 | N-((R)-3-(4-chlorophenyl)-1-(4-(2-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)c1cc2ccccc2cn1)c1ccccc1F Show InChI InChI=1S/C35H39ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,22-23,32-33H,3-4,17-21,24H2,1-2H3,(H,39,43)/t32-,33?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	96	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174061 (CHEMBL197288 | [2-(2,4-Difluoro-phenyl)-2-(4-methy...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccc(F)cc1F Show InChI InChI=1S/C17H27F2N3/c1-4-21(5-2)13-17(22-10-8-20(3)9-11-22)15-7-6-14(18)12-16(15)19/h6-7,12,17H,4-5,8-11,13H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186873 (CHEMBL209417 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-...) Show SMILES CC(C)CC1(CCN(CC1)C(=O)C(C)C)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 Show InChI InChI=1S/C36H50ClN5O3/c1-25(2)23-36(13-15-40(16-14-36)34(44)26(3)4)42-19-17-41(18-20-42)35(45)32(21-27-9-11-29(37)12-10-27)39-33(43)22-31-30-8-6-5-7-28(30)24-38-31/h5-12,25-26,31-32,38H,13-24H2,1-4H3,(H,39,43)/t31?,32-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	101	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3843-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.016 BindingDB Entry DOI: 10.7270/Q2SQ900D
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174048 (CHEMBL197820 | N-Ethyl-N-[2-(2-fluoro-phenyl)-2-(4...) Show SMILES CCN(CC(N1CCN(C)CC1)c1ccccc1F)C(C)=O Show InChI InChI=1S/C17H26FN3O/c1-4-20(14(2)22)13-17(15-7-5-6-8-16(15)18)21-11-9-19(3)10-12-21/h5-8,17H,4,9-13H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	106	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177559 (CHEMBL379352 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1Cl Show InChI InChI=1S/C35H43Cl2N5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177559 (CHEMBL379352 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1Cl Show InChI InChI=1S/C35H43Cl2N5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-27(36)16-14-25)39-34(43)22-31-28-10-6-5-9-26(28)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31?,32-,33?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from cloned human MC4R expressed in HEK293 cells				Bioorg Med Chem Lett 16: 2341-6 (2006) Article DOI: 10.1016/j.bmcl.2005.10.103 BindingDB Entry DOI: 10.7270/Q2NS0TF6
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174057 (CHEMBL194464 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(CCCc1ccccc1)N1CCN(C)CC1 Show InChI InChI=1S/C20H35N3/c1-4-22(5-2)18-20(23-16-14-21(3)15-17-23)13-9-12-19-10-7-6-8-11-19/h6-8,10-11,20H,4-5,9,12-18H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139023 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2Cn2ccnc2)cc1 Show InChI InChI=1S/C33H35ClN6O2/c34-28-11-9-24(10-12-28)19-30(37-32(41)29-20-25-5-1-2-6-26(25)21-36-29)33(42)40-17-15-39(16-18-40)31-8-4-3-7-27(31)22-38-14-13-35-23-38/h1-14,23,29-30,36H,15-22H2,(H,37,41)/t29-,30-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174054 (CHEMBL199192 | Diethyl-[(R)-2-(2-fluoro-phenyl)-2-...) Show SMILES CCN(CC)C[C@H](N1CCN(C)CC1)c1ccccc1F Show InChI InChI=1S/C17H28FN3/c1-4-20(5-2)14-17(15-8-6-7-9-16(15)18)21-12-10-19(3)11-13-21/h6-9,17H,4-5,10-14H2,1-3H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	111	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174051 (CHEMBL198319 | N,N-Diethyl-2-(2-fluoro-phenyl)-2-(...) Show SMILES CCN(CC)C(=O)C(N1CCN(C)CC1)c1ccccc1F Show InChI InChI=1S/C17H26FN3O/c1-4-20(5-2)17(22)16(14-8-6-7-9-15(14)18)21-12-10-19(3)11-13-21/h6-9,16H,4-5,10-13H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	125	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174047 (CHEMBL195998 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(CCc1ccccc1)N1CCN(C)CC1 Show InChI InChI=1S/C19H33N3/c1-4-21(5-2)17-19(22-15-13-20(3)14-16-22)12-11-18-9-7-6-8-10-18/h6-10,19H,4-5,11-17H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139029 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Cc1nccn1Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C34H37ClN6O2/c1-24-36-14-15-41(24)23-28-8-4-5-9-32(28)39-16-18-40(19-17-39)34(43)31(20-25-10-12-29(35)13-11-25)38-33(42)30-21-26-6-2-3-7-27(26)22-37-30/h2-15,30-31,37H,16-23H2,1H3,(H,38,42)/t30-,31-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174059 (CHEMBL194761 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C18H28F3N3/c1-4-23(5-2)14-17(24-11-9-22(3)10-12-24)15-7-6-8-16(13-15)18(19,20)21/h6-8,13,17H,4-5,9-12,14H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174052 (CHEMBL199071 | [2-(2,6-Difluoro-phenyl)-2-(4-methy...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1c(F)cccc1F Show InChI InChI=1S/C17H27F2N3/c1-4-21(5-2)13-16(22-11-9-20(3)10-12-22)17-14(18)7-6-8-15(17)19/h6-8,16H,4-5,9-13H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair

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