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Compile Data Set for Download or QSAR

Found 242 hits with Last Name = 'bailey' and Initial = 'ma'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 0.470n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]-sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 0.470n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 0.610n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036649
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-4-[5-fl...)
Show SMILES Fc1ccc2c(CCCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:9:10:15.16.17:13.12,THB:25:15:10:13.12,18:16:10:13.12|
Show InChI InChI=1S/C24H23F2N3O/c25-14-5-8-19-18(11-14)24-21(27-19)13-16-6-9-22(24)29(16)10-2-1-3-20-17-7-4-15(26)12-23(17)30-28-20/h4-5,7-8,11-12,16,22,27H,1-3,6,9-10,13H2
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 0.710n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]-sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036649
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-4-[5-fl...)
Show SMILES Fc1ccc2c(CCCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:9:10:15.16.17:13.12,THB:25:15:10:13.12,18:16:10:13.12|
Show InChI InChI=1S/C24H23F2N3O/c25-14-5-8-19-18(11-14)24-21(27-19)13-16-6-9-22(24)29(16)10-2-1-3-20-17-7-4-15(26)12-23(17)30-28-20/h4-5,7-8,11-12,16,22,27H,1-3,6,9-10,13H2
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 0.710n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]-sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036648
PNG
((7R,10S)-4-[5-fluoro-9,15-diazatetracyclo[10.2.1.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:11:12:17.18.19:15.14,THB:27:17:12:15.14,20:18:12:15.14|
Show InChI InChI=1S/C23H22F2N2O/c24-15-5-3-14(4-6-15)22(28)2-1-11-27-17-8-10-21(27)23-18-12-16(25)7-9-19(18)26-20(23)13-17/h3-7,9,12,17,21,26H,1-2,8,10-11,13H2
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 0.800n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 0.820n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50046475
PNG
(4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadec...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:11:12:17.18.19:15.14,THB:20:18:12:15.14,26:17:12:15.14|
Show InChI InChI=1S/C23H23FN2O/c24-16-9-7-15(8-10-16)22(27)6-3-13-26-17-11-12-21(26)23-18-4-1-2-5-19(18)25-20(23)14-17/h1-2,4-5,7-10,17,21,25H,3,6,11-14H2
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 0.820n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047457
PNG
(4-[9,16-diazatetracyclo[10.3.1.02,10.03,8]hexadeca...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCCC1c1c(C2)[nH]c2ccccc12 |TLB:11:12:18.19.20:16.14.15,THB:21:19:12:16.14.15,27:18:12:16.14.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-12-10-16(11-13-17)23(28)9-4-14-27-18-5-3-8-22(27)24-19-6-1-2-7-20(19)26-21(24)15-18/h1-2,6-7,10-13,18,22,26H,3-5,8-9,14-15H2
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 0.850n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50047436
PNG
(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-8-aza-bicyclo[...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1CC(=O)C2 |THB:19:18:12:14.15|
Show InChI InChI=1S/C17H20FNO2/c18-13-5-3-12(4-6-13)17(21)2-1-9-19-14-7-8-15(19)11-16(20)10-14/h3-6,14-15H,1-2,7-11H2
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 1.30n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 1.70n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]-sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50036648
PNG
((7R,10S)-4-[5-fluoro-9,15-diazatetracyclo[10.2.1.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:11:12:17.18.19:15.14,THB:27:17:12:15.14,20:18:12:15.14|
Show InChI InChI=1S/C23H22F2N2O/c24-15-5-3-14(4-6-15)22(28)2-1-11-27-17-8-10-21(27)23-18-12-16(25)7-9-19(18)26-20(23)13-17/h3-7,9,12,17,21,26H,1-2,8,10-11,13H2
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 1.80n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036650
PNG
((7R,10S)-5-[5-fluoro-9,15-diazatetracyclo[10.2.1.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:12:13:18.19.20:16.15,THB:28:18:13:16.15,21:19:13:16.15|
Show InChI InChI=1S/C24H24F2N2O/c25-16-6-4-15(5-7-16)23(29)3-1-2-12-28-18-9-11-22(28)24-19-13-17(26)8-10-20(19)27-21(24)14-18/h4-8,10,13,18,22,27H,1-3,9,11-12,14H2
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 1.87n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036648
PNG
((7R,10S)-4-[5-fluoro-9,15-diazatetracyclo[10.2.1.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:11:12:17.18.19:15.14,THB:27:17:12:15.14,20:18:12:15.14|
Show InChI InChI=1S/C23H22F2N2O/c24-15-5-3-14(4-6-15)22(28)2-1-11-27-17-8-10-21(27)23-18-12-16(25)7-9-19(18)26-20(23)13-17/h3-7,9,12,17,21,26H,1-2,8,10-11,13H2
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 1.96n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036648
PNG
((7R,10S)-4-[5-fluoro-9,15-diazatetracyclo[10.2.1.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:11:12:17.18.19:15.14,THB:27:17:12:15.14,20:18:12:15.14|
Show InChI InChI=1S/C23H22F2N2O/c24-15-5-3-14(4-6-15)22(28)2-1-11-27-17-8-10-21(27)23-18-12-16(25)7-9-19(18)26-20(23)13-17/h3-7,9,12,17,21,26H,1-2,8,10-11,13H2
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 2n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 2.13n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036649
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-4-[5-fl...)
Show SMILES Fc1ccc2c(CCCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:9:10:15.16.17:13.12,THB:25:15:10:13.12,18:16:10:13.12|
Show InChI InChI=1S/C24H23F2N3O/c25-14-5-8-19-18(11-14)24-21(27-19)13-16-6-9-22(24)29(16)10-2-1-3-20-17-7-4-15(26)12-23(17)30-28-20/h4-5,7-8,11-12,16,22,27H,1-3,6,9-10,13H2
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 2.70n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50047442
PNG
(5-[5-fluoro-9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc2[nH]c3CC4CCC(N4CCCCC(=O)c4ccccc4)c3c2c1 |TLB:13:12:25.6.7:10.9,26:25:12:10.9,5:6:12:10.9|
Show InChI InChI=1S/C24H25FN2O/c25-17-9-11-20-19(14-17)24-21(26-20)15-18-10-12-22(24)27(18)13-5-4-8-23(28)16-6-2-1-3-7-16/h1-3,6-7,9,11,14,18,22,26H,4-5,8,10,12-13,15H2
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 2.80n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047445
PNG
(1-(4-fluorophenyl)-4-[9-methyl-9,15-diazatetracycl...)
Show SMILES Cn1c2CC3CCC(N3CCCC(=O)c3ccc(F)cc3)c2c2ccccc12 |TLB:9:8:21.2.3:6.5,1:2:8:6.5,22:21:8:6.5|
Show InChI InChI=1S/C24H25FN2O/c1-26-20-6-3-2-5-19(20)24-21-13-12-18(15-22(24)26)27(21)14-4-7-23(28)16-8-10-17(25)11-9-16/h2-3,5-6,8-11,18,21H,4,7,12-15H2,1H3
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 2.80n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 2.80n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047446
PNG
(4-{5-fluoro-9,16-diazatetracyclo[10.3.1.0^{2,10}.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:11:12:18.19.20:16.14.15,THB:28:18:12:16.14.15,21:19:12:16.14.15|
Show InChI InChI=1S/C24H24F2N2O/c25-16-8-6-15(7-9-16)23(29)5-2-12-28-18-3-1-4-22(28)24-19-13-17(26)10-11-20(19)27-21(24)14-18/h6-11,13,18,22,27H,1-5,12,14H2
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 2.80n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 2.80n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 2.81n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047442
PNG
(5-[5-fluoro-9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc2[nH]c3CC4CCC(N4CCCCC(=O)c4ccccc4)c3c2c1 |TLB:13:12:25.6.7:10.9,26:25:12:10.9,5:6:12:10.9|
Show InChI InChI=1S/C24H25FN2O/c25-17-9-11-20-19(14-17)24-21(26-20)15-18-10-12-22(24)27(18)13-5-4-8-23(28)16-6-2-1-3-7-16/h1-3,6-7,9,11,14,18,22,26H,4-5,8,10,12-13,15H2
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 3n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 3.70n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036651
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-3-[5-fl...)
Show SMILES Fc1ccc2c(CCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:8:9:14.15.16:12.11,THB:24:14:9:12.11,17:15:9:12.11|
Show InChI InChI=1S/C23H21F2N3O/c24-13-4-7-18-17(10-13)23-20(26-18)12-15-5-8-21(23)28(15)9-1-2-19-16-6-3-14(25)11-22(16)29-27-19/h3-4,6-7,10-11,15,21,26H,1-2,5,8-9,12H2
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 4.25n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 4.40n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 4.40n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036647
PNG
((7R,10S)-5-[9,15-diazatetracyclo[10.2.1.02,10.03,8...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:12:13:18.19.20:16.15,THB:21:19:13:16.15,27:18:13:16.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-10-8-16(9-11-17)23(28)7-3-4-14-27-18-12-13-22(27)24-19-5-1-2-6-20(19)26-21(24)15-18/h1-2,5-6,8-11,18,22,26H,3-4,7,12-15H2
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 4.43n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50046488
PNG
(8-Fluoro-2-(3-pyridin-4-yl-propyl)-2,3,4,5-tetrahy...)
Show SMILES Fc1ccc2[nH]c3CCN(CCCc4ccncc4)Cc3c2c1
Show InChI InChI=1S/C19H20FN3/c20-15-3-4-18-16(12-15)17-13-23(11-7-19(17)22-18)10-1-2-14-5-8-21-9-6-14/h3-6,8-9,12,22H,1-2,7,10-11,13H2
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 6n/an/an/an/an/an/an/an/a



Scios-Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against D2 receptor in rat corpus striatum using [3H]-sulpiride as the radioligand

J Med Chem 36: 343-52 (1993)


BindingDB Entry DOI: 10.7270/Q21J98TX
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036649
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-4-[5-fl...)
Show SMILES Fc1ccc2c(CCCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:9:10:15.16.17:13.12,THB:25:15:10:13.12,18:16:10:13.12|
Show InChI InChI=1S/C24H23F2N3O/c25-14-5-8-19-18(11-14)24-21(27-19)13-16-6-9-22(24)29(16)10-2-1-3-20-17-7-4-15(26)12-23(17)30-28-20/h4-5,7-8,11-12,16,22,27H,1-3,6,9-10,13H2
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 6.10n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036649
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-4-[5-fl...)
Show SMILES Fc1ccc2c(CCCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:9:10:15.16.17:13.12,THB:25:15:10:13.12,18:16:10:13.12|
Show InChI InChI=1S/C24H23F2N3O/c25-14-5-8-19-18(11-14)24-21(27-19)13-16-6-9-22(24)29(16)10-2-1-3-20-17-7-4-15(26)12-23(17)30-28-20/h4-5,7-8,11-12,16,22,27H,1-3,6,9-10,13H2
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 6.11n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047440
PNG
(4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadec...)
Show SMILES O=C(CCCN1C2CCC1c1c(C2)[nH]c2ccccc12)c1ccccc1 |TLB:4:5:10.11.12:8.7,THB:13:11:5:8.7,19:10:5:8.7|
Show InChI InChI=1S/C23H24N2O/c26-22(16-7-2-1-3-8-16)11-6-14-25-17-12-13-21(25)23-18-9-4-5-10-19(18)24-20(23)15-17/h1-5,7-10,17,21,24H,6,11-15H2
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 6.60n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50036649
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-4-[5-fl...)
Show SMILES Fc1ccc2c(CCCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:9:10:15.16.17:13.12,THB:25:15:10:13.12,18:16:10:13.12|
Show InChI InChI=1S/C24H23F2N3O/c25-14-5-8-19-18(11-14)24-21(27-19)13-16-6-9-22(24)29(16)10-2-1-3-20-17-7-4-15(26)12-23(17)30-28-20/h4-5,7-8,11-12,16,22,27H,1-3,6,9-10,13H2
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 8n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036651
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-3-[5-fl...)
Show SMILES Fc1ccc2c(CCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:8:9:14.15.16:12.11,THB:24:14:9:12.11,17:15:9:12.11|
Show InChI InChI=1S/C23H21F2N3O/c24-13-4-7-18-17(10-13)23-20(26-18)12-15-5-8-21(23)28(15)9-1-2-19-16-6-3-14(25)11-22(16)29-27-19/h3-4,6-7,10-11,15,21,26H,1-2,5,8-9,12H2
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 8.5n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50036651
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-3-[5-fl...)
Show SMILES Fc1ccc2c(CCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:8:9:14.15.16:12.11,THB:24:14:9:12.11,17:15:9:12.11|
Show InChI InChI=1S/C23H21F2N3O/c24-13-4-7-18-17(10-13)23-20(26-18)12-15-5-8-21(23)28(15)9-1-2-19-16-6-3-14(25)11-22(16)29-27-19/h3-4,6-7,10-11,15,21,26H,1-2,5,8-9,12H2
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 8.5n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50036651
PNG
((7R,10S)-1-(6-fluorobenzo[d]isoxazol-3-yl)-3-[5-fl...)
Show SMILES Fc1ccc2c(CCCN3C4CCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:8:9:14.15.16:12.11,THB:24:14:9:12.11,17:15:9:12.11|
Show InChI InChI=1S/C23H21F2N3O/c24-13-4-7-18-17(10-13)23-20(26-18)12-15-5-8-21(23)28(15)9-1-2-19-16-6-3-14(25)11-22(16)29-27-19/h3-4,6-7,10-11,15,21,26H,1-2,5,8-9,12H2
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 8.54n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047437
PNG
(1-(6-fluorobenzo[d]isoxazol-3-yl)-3-[5-fluoro-9,16...)
Show SMILES Fc1ccc2c(CCCN3C4CCCC3c3c(C4)[nH]c4ccc(F)cc34)noc2c1 |TLB:8:9:15.16.17:13.11.12,THB:25:15:9:13.11.12,18:16:9:13.11.12|
Show InChI InChI=1S/C24H23F2N3O/c25-14-7-9-19-18(11-14)24-21(27-19)13-16-3-1-5-22(24)29(16)10-2-4-20-17-8-6-15(26)12-23(17)30-28-20/h6-9,11-12,16,22,27H,1-5,10,13H2
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 13n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50036650
PNG
((7R,10S)-5-[5-fluoro-9,15-diazatetracyclo[10.2.1.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:12:13:18.19.20:16.15,THB:28:18:13:16.15,21:19:13:16.15|
Show InChI InChI=1S/C24H24F2N2O/c25-16-6-4-15(5-7-16)23(29)3-1-2-12-28-18-9-11-22(28)24-19-13-17(26)8-10-20(19)27-21(24)14-18/h4-8,10,13,18,22,27H,1-3,9,11-12,14H2
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 16n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047449
PNG
(5-[9,16-diazatetracyclo[10.3.1.02,10.03,8]hexadeca...)
Show SMILES O=C(CCCCN1C2CCCC1c1c(C2)[nH]c2ccccc12)c1ccccc1 |TLB:5:6:12.13.14:10.8.9,THB:15:13:6:10.8.9,21:12:6:10.8.9|
Show InChI InChI=1S/C25H28N2O/c28-24(18-9-2-1-3-10-18)15-6-7-16-27-19-11-8-14-23(27)25-20-12-4-5-13-21(20)26-22(25)17-19/h1-5,9-10,12-13,19,23,26H,6-8,11,14-17H2
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 21n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50046479
PNG
(1-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadec...)
Show SMILES Fc1ccc(CCCCN2C3CCC2c2c(C3)[nH]c3ccccc23)cc1 |TLB:8:9:14.15.16:12.11,THB:17:15:9:12.11,23:14:9:12.11|
Show InChI InChI=1S/C23H25FN2/c24-17-10-8-16(9-11-17)5-3-4-14-26-18-12-13-22(26)23-19-6-1-2-7-20(19)25-21(23)15-18/h1-2,6-11,18,22,25H,3-5,12-15H2
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 22n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047450
PNG
(1-[9,16-diazatetracyclo[10.3.1.02,10.03,8]hexadeca...)
Show SMILES Fc1ccc(CCCCN2C3CCCC2c2c(C3)[nH]c3ccccc23)cc1 |TLB:8:9:15.16.17:13.11.12,THB:18:16:9:13.11.12,24:15:9:13.11.12|
Show InChI InChI=1S/C24H27FN2/c25-18-13-11-17(12-14-18)6-3-4-15-27-19-7-5-10-23(27)24-20-8-1-2-9-21(20)26-22(24)16-19/h1-2,8-9,11-14,19,23,26H,3-7,10,15-16H2
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 25n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 27n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]-sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50047452
PNG
(4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadec...)
Show SMILES O=C(CCCN1C2CCC1c1c(C2)[nH]c2ccccc12)c1cccs1 |TLB:4:5:10.11.12:8.7,THB:13:11:5:8.7,19:10:5:8.7|
Show InChI InChI=1S/C21H22N2OS/c24-19(20-8-4-12-25-20)7-3-11-23-14-9-10-18(23)21-15-5-1-2-6-16(15)22-17(21)13-14/h1-2,4-6,8,12,14,18,22H,3,7,9-11,13H2
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 27n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 27n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036650
PNG
((7R,10S)-5-[5-fluoro-9,15-diazatetracyclo[10.2.1.0...)
Show SMILES Fc1ccc(cc1)C(=O)CCCCN1C2CCC1c1c(C2)[nH]c2ccc(F)cc12 |TLB:12:13:18.19.20:16.15,THB:28:18:13:16.15,21:19:13:16.15|
Show InChI InChI=1S/C24H24F2N2O/c25-16-6-4-15(5-7-16)23(29)3-1-2-12-28-18-9-11-22(28)24-19-13-17(26)8-10-20(19)27-21(24)14-18/h4-8,10,13,18,22,27H,1-3,9,11-12,14H2
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 34n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50047457
PNG
(4-[9,16-diazatetracyclo[10.3.1.02,10.03,8]hexadeca...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1C2CCCC1c1c(C2)[nH]c2ccccc12 |TLB:11:12:18.19.20:16.14.15,THB:21:19:12:16.14.15,27:18:12:16.14.15|
Show InChI InChI=1S/C24H25FN2O/c25-17-12-10-16(11-13-17)23(28)9-4-14-27-18-5-3-8-22(27)24-19-6-1-2-7-20(19)26-21(24)15-18/h1-2,6-7,10-13,18,22,26H,3-5,8-9,14-15H2
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 38n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50047449
PNG
(5-[9,16-diazatetracyclo[10.3.1.02,10.03,8]hexadeca...)
Show SMILES O=C(CCCCN1C2CCCC1c1c(C2)[nH]c2ccccc12)c1ccccc1 |TLB:5:6:12.13.14:10.8.9,THB:15:13:6:10.8.9,21:12:6:10.8.9|
Show InChI InChI=1S/C25H28N2O/c28-24(18-9-2-1-3-10-18)15-6-7-16-27-19-11-8-14-23(27)25-20-12-4-5-13-21(20)26-22(25)17-19/h1-5,9-10,12-13,19,23,26H,6-8,11,14-17H2
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 44n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]-sulpiride

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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 47n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]-sulpiride displacement.

J Med Chem 36: 3073-6 (1993)


BindingDB Entry DOI: 10.7270/Q2RF5T2N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A/2B/2C


(Mus musculus (Mouse))		BDBM50046482
PNG
(1-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadec...)
Show SMILES C(CCc1ccccc1)CN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:9:10:15.16.17:13.12,THB:18:16:10:13.12,24:15:10:13.12|
Show InChI InChI=1S/C23H26N2/c1-2-8-17(9-3-1)10-6-7-15-25-18-13-14-22(25)23-19-11-4-5-12-20(19)24-21(23)16-18/h1-5,8-9,11-12,18,22,24H,6-7,10,13-16H2
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 57n/an/an/an/an/an/an/an/a



Scios Nova Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2 receptor from rat cortical synaptosomal membrane using radioligand [3H]ketanserin.

J Med Chem 36: 1488-95 (1993)


BindingDB Entry DOI: 10.7270/Q2KD1X0K
More data for this
Ligand-Target Pair
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