Found 19 hits with Last Name = 'craig' and Initial = 'sp' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128869
(2,2-Dichloro-N-chrysen-6-yl-acetamide | CHEMBL8805...)Show InChI InChI=1S/C20H13Cl2NO/c21-19(22)20(24)23-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11,19H,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128871
(CHEMBL313154 | Chrysen-6-ylamine)Show InChI InChI=1S/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128867
(3,5-diphenyl-4'-methyl-2-nitrobiphenyl | CHEMBL875...)Show SMILES Cc1ccc(cc1)-c1cc(cc(-c2ccccc2)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C25H19NO2/c1-18-12-14-21(15-13-18)24-17-22(19-8-4-2-5-9-19)16-23(25(24)26(27)28)20-10-6-3-7-11-20/h2-17H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128866
(2-(2,4,7-Trinitro-fluoren-9-ylidene)-malononitrile...)Show SMILES [#8-]-[#7+](=O)-c1ccc-2c(c1)\[#6](=[#6](/C#N)C#N)-c1cc(cc(c-21)-[#7+](-[#8-])=O)-[#7+](-[#8-])=O Show InChI InChI=1S/C16H5N5O6/c17-6-8(7-18)15-12-3-9(19(22)23)1-2-11(12)16-13(15)4-10(20(24)25)5-14(16)21(26)27/h1-5H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128872
(6-Fluoro-chrysene | CHEMBL83242)Show InChI InChI=1S/C18H11F/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128866
(2-(2,4,7-Trinitro-fluoren-9-ylidene)-malononitrile...)Show SMILES [#8-]-[#7+](=O)-c1ccc-2c(c1)\[#6](=[#6](/C#N)C#N)-c1cc(cc(c-21)-[#7+](-[#8-])=O)-[#7+](-[#8-])=O Show InChI InChI=1S/C16H5N5O6/c17-6-8(7-18)15-12-3-9(19(22)23)1-2-11(12)16-13(15)4-10(20(24)25)5-14(16)21(26)27/h1-5H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128865
(6-Nitro-chrysene | CHEMBL82858)Show InChI InChI=1S/C18H11NO2/c20-19(21)18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128870
(CHEMBL85685 | chrysene)Show InChI InChI=1S/C18H12/c1-3-7-15-13(5-1)9-11-18-16-8-4-2-6-14(16)10-12-17(15)18/h1-12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 8.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128867
(3,5-diphenyl-4'-methyl-2-nitrobiphenyl | CHEMBL875...)Show SMILES Cc1ccc(cc1)-c1cc(cc(-c2ccccc2)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C25H19NO2/c1-18-12-14-21(15-13-18)24-17-22(19-8-4-2-5-9-19)16-23(25(24)26(27)28)20-10-6-3-7-11-20/h2-17H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128868
(5-(2,4-Dichloro-phenoxy)-3-(2-fluoro-phenyl)-[1,2,...)Show SMILES Fc1ccccc1-c1nnc2c3ccccc3nc(Oc3ccc(Cl)cc3Cl)n12 Show InChI InChI=1S/C21H11Cl2FN4O/c22-12-9-10-18(15(23)11-12)29-21-25-17-8-4-2-6-14(17)20-27-26-19(28(20)21)13-5-1-3-7-16(13)24/h1-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128867
(3,5-diphenyl-4'-methyl-2-nitrobiphenyl | CHEMBL875...)Show SMILES Cc1ccc(cc1)-c1cc(cc(-c2ccccc2)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C25H19NO2/c1-18-12-14-21(15-13-18)24-17-22(19-8-4-2-5-9-19)16-23(25(24)26(27)28)20-10-6-3-7-11-20/h2-17H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with bacterial Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128869
(2,2-Dichloro-N-chrysen-6-yl-acetamide | CHEMBL8805...)Show InChI InChI=1S/C20H13Cl2NO/c21-19(22)20(24)23-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11,19H,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Trypanosoma brucei brucei) | BDBM50150875
(hydrogen 2-(1,2-dihydropyridin-3-yl)-1-hydroxy-1-(...)Show SMILES OC(CC1=CCC=NC1)(P(O)([O-])=O)P(O)([O-])=O |c:6,t:3| Show InChI InChI=1S/C7H13NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h2-3,9H,1,4-5H2,(H2,10,11,12)(H2,13,14,15)/p-2 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 2.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT) |
Bioorg Med Chem Lett 14: 4501-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.042 BindingDB Entry DOI: 10.7270/Q2DJ5GDX |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128869
(2,2-Dichloro-N-chrysen-6-yl-acetamide | CHEMBL8805...)Show InChI InChI=1S/C20H13Cl2NO/c21-19(22)20(24)23-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11,19H,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with bacterial Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128868
(5-(2,4-Dichloro-phenoxy)-3-(2-fluoro-phenyl)-[1,2,...)Show SMILES Fc1ccccc1-c1nnc2c3ccccc3nc(Oc3ccc(Cl)cc3Cl)n12 Show InChI InChI=1S/C21H11Cl2FN4O/c22-12-9-10-18(15(23)11-12)29-21-25-17-8-4-2-6-14(17)20-27-26-19(28(20)21)13-5-1-3-7-16(13)24/h1-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 2.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50128868
(5-(2,4-Dichloro-phenoxy)-3-(2-fluoro-phenyl)-[1,2,...)Show SMILES Fc1ccccc1-c1nnc2c3ccccc3nc(Oc3ccc(Cl)cc3Cl)n12 Show InChI InChI=1S/C21H11Cl2FN4O/c22-12-9-10-18(15(23)11-12)29-21-25-17-8-4-2-6-14(17)20-27-26-19(28(20)21)13-5-1-3-7-16(13)24/h1-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 4.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description Kinetic inhibition constant of compound with bacterial Hypoxanthine Phosphoribosyltransferase (HPRT) |
J Med Chem 46: 2548-50 (2003)
Article DOI: 10.1021/jm030061i BindingDB Entry DOI: 10.7270/Q2CF9PGG |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Trypanosoma brucei brucei) | BDBM12581
((3-amino-1-hydroxy-1-phosphonopropyl)phosphonic ac...)Show InChI InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11) | PDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 5.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT) |
Bioorg Med Chem Lett 14: 4501-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.042 BindingDB Entry DOI: 10.7270/Q2DJ5GDX |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Trypanosoma brucei brucei) | BDBM50150877
(hydrogen 3-(dimethylammonio)-1-hydroxy-1-(hydroxyp...)Show InChI InChI=1S/C5H15NO7P2/c1-6(2)4-3-5(7,14(8,9)10)15(11,12)13/h7H,3-4H2,1-2H3,(H2,8,9,10)(H2,11,12,13)/p-1 | PDB
KEGG
UniProtKB/SwissProt
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PC cid PC sid UniChem
Similars
| Article PubMed
| 1.26E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT) |
Bioorg Med Chem Lett 14: 4501-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.042 BindingDB Entry DOI: 10.7270/Q2DJ5GDX |
More data for this Ligand-Target Pair | |
Hypoxanthine-guanine phosphoribosyltransferase
(Trypanosoma brucei brucei) | BDBM25313
((4-amino-1-hydroxy-1-phosphonobutyl)phosphonic aci...)Show InChI InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12) | PDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 1.89E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Buenos Aires
Curated by ChEMBL
| Assay Description Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT) |
Bioorg Med Chem Lett 14: 4501-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.042 BindingDB Entry DOI: 10.7270/Q2DJ5GDX |
More data for this Ligand-Target Pair | |