Compile Data Set for Download or QSAR

Found 14 hits with Last Name = 'franchet' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332633 (CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...) Show SMILES Cc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O3/c1-11-6-8-12(9-7-11)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)23-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332634 (CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...) Show SMILES COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O4/c1-23-12-8-6-11(7-9-12)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)24-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332632 (CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...) Show SMILES Clc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C17H13ClN2O3/c18-10-5-7-11(8-6-10)19-16(21)17-9-13(17)15(20-22)12-3-1-2-4-14(12)23-17/h1-8,13,15H,9H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332631 (CHEMBL1630804 | N-(4-Fluorophenyl)-7-oxo-7,7a-dihy...) Show SMILES Fc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C17H13FN2O3/c18-10-5-7-11(8-6-10)19-16(21)17-9-13(17)15(20-22)12-3-1-2-4-14(12)23-17/h1-8,13,15H,9H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332632 (CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...) Show SMILES Clc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C17H13ClN2O3/c18-10-5-7-11(8-6-10)19-16(21)17-9-13(17)15(20-22)12-3-1-2-4-14(12)23-17/h1-8,13,15H,9H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332634 (CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...) Show SMILES COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O4/c1-23-12-8-6-11(7-9-12)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)24-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332633 (CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...) Show SMILES Cc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O3/c1-11-6-8-12(9-7-11)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)23-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Stromal cell-derived factor 1 (Homo sapiens (Human))	BDBM86004 (Chalcone 2 | Chalcone, 3) Show SMILES Oc1ccc(\C=C\C(=O)c2ccccc2)cc1 Show InChI InChI=1S/C15H12O2/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-11,16H/b11-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	20
Université Louis Pasteur					Assay Description Binding of chalcone 4 and chlcone 1 to CSCL12 was examined by monitoring changes in the emission intensity of intrinsic Trp fluorescence of the chemo...				J Biol Chem 283: 23189-99 (2008) Article DOI: 10.1074/jbc.M803947200 BindingDB Entry DOI: 10.7270/Q23X858J
					More data for this Ligand-Target Pair
Stromal cell-derived factor 1 (Homo sapiens (Human))	BDBM50042978 ((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccccc2O)cc1 Show InChI InChI=1S/C15H12O3/c16-12-8-5-11(6-9-12)7-10-15(18)13-3-1-2-4-14(13)17/h1-10,16-17H/b10-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	20
Université Louis Pasteur					Assay Description Binding of chalcone 4 and chlcone 1 to CSCL12 was examined by monitoring changes in the emission intensity of intrinsic Trp fluorescence of the chemo...				J Biol Chem 283: 23189-99 (2008) Article DOI: 10.1074/jbc.M803947200 BindingDB Entry DOI: 10.7270/Q23X858J
					More data for this Ligand-Target Pair
Stromal cell-derived factor 1 (Homo sapiens (Human))	BDBM50042947 (1-(4-Chloro-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)...) Show SMILES COc1cc(\C=C\C(=O)c2ccc(Cl)cc2)ccc1O Show InChI InChI=1S/C16H13ClO3/c1-20-16-10-11(3-9-15(16)19)2-8-14(18)12-4-6-13(17)7-5-12/h2-10,19H,1H3/b8-2+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a	n/a	20
Université Louis Pasteur					Assay Description Binding of chalcone 4 and chlcone 1 to CSCL12 was examined by monitoring changes in the emission intensity of intrinsic Trp fluorescence of the chemo...				J Biol Chem 283: 23189-99 (2008) Article DOI: 10.1074/jbc.M803947200 BindingDB Entry DOI: 10.7270/Q23X858J
					More data for this Ligand-Target Pair
Stromal cell-derived factor 1 (Homo sapiens (Human))	BDBM29143 (CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...) Show SMILES O=C(\C=C\c1ccccc1)c1ccccc1 Show InChI InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	20
Université Louis Pasteur					Assay Description Binding of chalcone 4 and chlcone 1 to CSCL12 was examined by monitoring changes in the emission intensity of intrinsic Trp fluorescence of the chemo...				J Biol Chem 283: 23189-99 (2008) Article DOI: 10.1074/jbc.M803947200 BindingDB Entry DOI: 10.7270/Q23X858J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50332632 (CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...) Show SMILES Clc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C17H13ClN2O3/c18-10-5-7-11(8-6-10)19-16(21)17-9-13(17)15(20-22)12-3-1-2-4-14(12)23-17/h1-8,13,15H,9H2,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50332633 (CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...) Show SMILES Cc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O3/c1-11-6-8-12(9-7-11)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)23-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50332634 (CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...) Show SMILES COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O4/c1-23-12-8-6-11(7-9-12)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)24-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair