Found 643 hits with Last Name = 'ireland' and Initial = 'l' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50060964
((R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-...)Show SMILES CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(c1)S(N)(=O)=O Show InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 | PDB
Reactome pathway
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PC sid
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| DrugBank
Article
PubMed
| 0.0290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 300: 478-86 (2002)
Article DOI: 10.1124/jpet.300.2.478
BindingDB Entry DOI: 10.7270/Q2HX1B77 |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50060964
((R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-...)Show SMILES CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(c1)S(N)(=O)=O Show InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 | Reactome pathway
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| DrugBank
Article
PubMed
| 0.0560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 300: 478-86 (2002)
Article DOI: 10.1124/jpet.300.2.478
BindingDB Entry DOI: 10.7270/Q2HX1B77 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220468
(CHEMBL61120)Show InChI InChI=1S/C20H29N3O3/c21-9-8-19(24)23-13-11-22(12-14-23)10-1-15-26-18-6-4-17(5-7-18)20(25)16-2-3-16/h4-7,16H,1-3,8-15,21H2 | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50060964
((R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-...)Show SMILES CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(c1)S(N)(=O)=O Show InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 | UniProtKB/SwissProt
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| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 300: 478-86 (2002)
Article DOI: 10.1124/jpet.300.2.478
BindingDB Entry DOI: 10.7270/Q2HX1B77 |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50033111
(1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetra...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 Show InChI InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22) | Reactome pathway
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| DrugBank
Article
PubMed
| 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 300: 478-86 (2002)
Article DOI: 10.1124/jpet.300.2.478
BindingDB Entry DOI: 10.7270/Q2HX1B77 |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM85848
(CAS_172307 | Fiduxosin | NSC_172307)Show SMILES COc1cccc2OCC3CN(CCCCn4c(=O)[nH]c5c6nc(cnc6sc5c4=O)-c4ccccc4)CC3c12 Show InChI InChI=1S/C30H29N5O4S/c1-38-22-10-7-11-23-24(22)20-16-34(15-19(20)17-39-23)12-5-6-13-35-29(36)27-25(33-30(35)37)26-28(40-27)31-14-21(32-26)18-8-3-2-4-9-18/h2-4,7-11,14,19-20H,5-6,12-13,15-17H2,1H3,(H,33,37) | Reactome pathway
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| Article
PubMed
| 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 300: 478-86 (2002)
Article DOI: 10.1124/jpet.300.2.478
BindingDB Entry DOI: 10.7270/Q2HX1B77 |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50033111
(1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetra...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 Show InChI InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22) | UniProtKB/SwissProt
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| 1.15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 300: 478-86 (2002)
Article DOI: 10.1124/jpet.300.2.478
BindingDB Entry DOI: 10.7270/Q2HX1B77 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220419
(CHEMBL63125)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)[C@@H](C)NC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C27H43N3O5/c1-6-7-8-10-24(31)22-11-13-23(14-12-22)34-20-9-15-29-16-18-30(19-17-29)25(32)21(2)28-26(33)35-27(3,4)5/h11-14,21H,6-10,15-20H2,1-5H3,(H,28,33)/t21-/m1/s1 | PDB
Reactome pathway
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| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220473
(CHEMBL305144)Show SMILES O=C(C1CC1)c1ccc(OCCCN2CCN(CC2)C(=O)[C@H]2CCN2)cc1 Show InChI InChI=1S/C21H29N3O3/c25-20(16-2-3-16)17-4-6-18(7-5-17)27-15-1-10-23-11-13-24(14-12-23)21(26)19-8-9-22-19/h4-7,16,19,22H,1-3,8-15H2/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50139308
((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)Show SMILES C[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C20H29N3O3/c1-15(21)20(25)23-12-10-22(11-13-23)9-2-14-26-18-7-5-17(6-8-18)19(24)16-3-4-16/h5-8,15-16H,2-4,9-14,21H2,1H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119707
(4-[3-(4-Hexanoyl-phenoxy)-propyl]-piperazine-1-car...)Show InChI InChI=1S/C22H34N2O4/c1-3-5-6-8-21(25)19-9-11-20(12-10-19)28-18-7-13-23-14-16-24(17-15-23)22(26)27-4-2/h9-12H,3-8,13-18H2,1-2H3 | PDB
Reactome pathway
KEGG
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| CHEMBL
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| PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119704
(CHEMBL104809 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Fc1cccc(c1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27FN2O4S/c24-19-3-1-4-22(15-19)31(28,29)25-20-11-13-26(16-20)12-2-14-30-21-9-7-18(8-10-21)23(27)17-5-6-17/h1,3-4,7-10,15,17,20,25H,2,5-6,11-14,16H2/t20-/m0/s1 | PDB
Reactome pathway
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PC sid
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| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50033111
(1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetra...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 Show InChI InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22) | PDB
Reactome pathway
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| DrugBank
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PubMed
| 1.82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 300: 478-86 (2002)
Article DOI: 10.1124/jpet.300.2.478
BindingDB Entry DOI: 10.7270/Q2HX1B77 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220430
(CHEMBL302829)Show SMILES CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C21H31N3O3/c1-2-19(22)21(26)24-13-11-23(12-14-24)10-3-15-27-18-8-6-17(7-9-18)20(25)16-4-5-16/h6-9,16,19H,2-5,10-15,22H2,1H3/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220467
(CHEMBL62421)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)[C@@H](C)N)cc1 Show InChI InChI=1S/C22H35N3O3/c1-3-4-5-7-21(26)19-8-10-20(11-9-19)28-17-6-12-24-13-15-25(16-14-24)22(27)18(2)23/h8-11,18H,3-7,12-17,23H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220430
(CHEMBL302829)Show SMILES CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C21H31N3O3/c1-2-19(22)21(26)24-13-11-23(12-14-24)10-3-15-27-18-8-6-17(7-9-18)20(25)16-4-5-16/h6-9,16,19H,2-5,10-15,22H2,1H3/t19-/m1/s1 | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
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Similars
| PubMed
| 1.95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119707
(4-[3-(4-Hexanoyl-phenoxy)-propyl]-piperazine-1-car...)Show InChI InChI=1S/C22H34N2O4/c1-3-5-6-8-21(25)19-9-11-20(12-10-19)28-18-7-13-23-14-16-24(17-15-23)22(26)27-4-2/h9-12H,3-8,13-18H2,1-2H3 | PDB
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity of the compound towards rats Histamine type 3 (H3) receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220417
(CHEMBL64406)Show SMILES C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C25H37N3O5/c1-18(26-24(31)33-25(2,3)4)23(30)28-15-13-27(14-16-28)12-5-17-32-21-10-8-20(9-11-21)22(29)19-6-7-19/h8-11,18-19H,5-7,12-17H2,1-4H3,(H,26,31)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220338
(CHEMBL302886)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)C2CC2)cc1 Show InChI InChI=1S/C23H34N2O3/c1-2-3-4-6-22(26)19-9-11-21(12-10-19)28-18-5-13-24-14-16-25(17-15-24)23(27)20-7-8-20/h9-12,20H,2-8,13-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220422
(CHEMBL60401)Show InChI InChI=1S/C20H29N3O3/c1-21-15-19(24)23-12-10-22(11-13-23)9-2-14-26-18-7-5-17(6-8-18)20(25)16-3-4-16/h5-8,16,21H,2-4,9-15H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220449
(CHEMBL60837)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)[C@@H](CO)NC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C27H43N3O6/c1-5-6-7-9-24(32)21-10-12-22(13-11-21)35-19-8-14-29-15-17-30(18-16-29)25(33)23(20-31)28-26(34)36-27(2,3)4/h10-13,23,31H,5-9,14-20H2,1-4H3,(H,28,34)/t23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220428
(CHEMBL418666)Show SMILES CC[C@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C21H31N3O3/c1-2-19(22)21(26)24-13-11-23(12-14-24)10-3-15-27-18-8-6-17(7-9-18)20(25)16-4-5-16/h6-9,16,19H,2-5,10-15,22H2,1H3/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
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PC sid
UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119721
(CHEMBL103027 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Cc1cccc(c1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C24H30N2O4S/c1-18-4-2-5-23(16-18)31(28,29)25-21-12-14-26(17-21)13-3-15-30-22-10-8-20(9-11-22)24(27)19-6-7-19/h2,4-5,8-11,16,19,21,25H,3,6-7,12-15,17H2,1H3/t21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119710
(CHEMBL104618 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Fc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27FN2O4S/c24-21-4-1-2-5-22(21)31(28,29)25-19-12-14-26(16-19)13-3-15-30-20-10-8-18(9-11-20)23(27)17-6-7-17/h1-2,4-5,8-11,17,19,25H,3,6-7,12-16H2/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119735
(3-Cyano-N-{(S)-1-[3-(4-cyclopropanecarbonyl-phenox...)Show SMILES O=C(C1CC1)c1ccc(OCCCN2CC[C@@H](C2)NS(=O)(=O)c2cccc(c2)C#N)cc1 Show InChI InChI=1S/C24H27N3O4S/c25-16-18-3-1-4-23(15-18)32(29,30)26-21-11-13-27(17-21)12-2-14-31-22-9-7-20(8-10-22)24(28)19-5-6-19/h1,3-4,7-10,15,19,21,26H,2,5-6,11-14,17H2/t21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
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Similars
| PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119722
(CHEMBL107162 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C24H30N2O5S/c1-30-21-9-11-23(12-10-21)32(28,29)25-20-13-15-26(17-20)14-2-16-31-22-7-5-19(6-8-22)24(27)18-3-4-18/h5-12,18,20,25H,2-4,13-17H2,1H3/t20-/m0/s1 | PDB
Reactome pathway
KEGG
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| CHEMBL
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PC sid
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| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220339
(CHEMBL64408)Show InChI InChI=1S/C21H32N2O4/c1-3-4-5-7-20(24)18-8-10-19(11-9-18)27-17-6-12-22-13-15-23(16-14-22)21(25)26-2/h8-11H,3-7,12-17H2,1-2H3 | PDB
Reactome pathway
KEGG
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| CHEMBL
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| PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119705
(CHEMBL101691 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES O=C(C1CC1)c1ccc(OCCCN2CC[C@@H](C2)NS(=O)(=O)c2ccccc2)cc1 Show InChI InChI=1S/C23H28N2O4S/c26-23(18-7-8-18)19-9-11-21(12-10-19)29-16-4-14-25-15-13-20(17-25)24-30(27,28)22-5-2-1-3-6-22/h1-3,5-6,9-12,18,20,24H,4,7-8,13-17H2/t20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119712
(3-Chloro-N-{(S)-1-[3-(4-cyclopropanecarbonyl-pheno...)Show SMILES Clc1cccc(c1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27ClN2O4S/c24-19-3-1-4-22(15-19)31(28,29)25-20-11-13-26(16-20)12-2-14-30-21-9-7-18(8-10-21)23(27)17-5-6-17/h1,3-4,7-10,15,17,20,25H,2,5-6,11-14,16H2/t20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220401
(CHEMBL294502)Show InChI InChI=1S/C22H34N2O3/c1-3-5-6-8-21(25)19-9-11-20(12-10-19)27-18-7-13-23-14-16-24(17-15-23)22(26)4-2/h9-12H,3-8,13-18H2,1-2H3 | PDB
Reactome pathway
KEGG
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| CHEMBL
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| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220101
(CHEMBL64100)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)C2CCC2)cc1 Show InChI InChI=1S/C24H36N2O3/c1-2-3-4-9-23(27)20-10-12-22(13-11-20)29-19-6-14-25-15-17-26(18-16-25)24(28)21-7-5-8-21/h10-13,21H,2-9,14-19H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119701
(CHEMBL104808 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Fc1ccc(cc1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27FN2O4S/c24-19-6-10-22(11-7-19)31(28,29)25-20-12-14-26(16-20)13-1-15-30-21-8-4-18(5-9-21)23(27)17-2-3-17/h4-11,17,20,25H,1-3,12-16H2/t20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220109
(CHEMBL304714)Show InChI InChI=1S/C20H30N2O4/c1-3-6-19(23)17-7-9-18(10-8-17)26-16-5-11-21-12-14-22(15-13-21)20(24)25-4-2/h7-10H,3-6,11-16H2,1-2H3 | PDB
Reactome pathway
KEGG
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| CHEMBL
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Similars
| PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220143
(CHEMBL449040)Show SMILES CCCCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)OCC)cc1 Show InChI InChI=1S/C24H38N2O4/c1-3-5-6-7-8-10-23(27)21-11-13-22(14-12-21)30-20-9-15-25-16-18-26(19-17-25)24(28)29-4-2/h11-14H,3-10,15-20H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119711
(2-Chloro-N-{(S)-1-[3-(4-cyclopropanecarbonyl-pheno...)Show SMILES Clc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27ClN2O4S/c24-21-4-1-2-5-22(21)31(28,29)25-19-12-14-26(16-19)13-3-15-30-20-10-8-18(9-11-20)23(27)17-6-7-17/h1-2,4-5,8-11,17,19,25H,3,6-7,12-16H2/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119728
(4-Chloro-N-{(S)-1-[3-(4-cyclopropanecarbonyl-pheno...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27ClN2O4S/c24-19-6-10-22(11-7-19)31(28,29)25-20-12-14-26(16-20)13-1-15-30-21-8-4-18(5-9-21)23(27)17-2-3-17/h4-11,17,20,25H,1-3,12-16H2/t20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Alpha-2B adrenergic receptor
(NEONATAL RAT) | BDBM50471340
(CHEMBL317912)Show InChI InChI=1S/C13H14N2O/c16-13-6-2-3-9-10(4-1-5-11(9)13)12-7-14-8-15-12/h2-3,6-8,10,16H,1,4-5H2,(H,14,15) | PDB
Reactome pathway
KEGG
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| PC cid
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| Article
PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay |
J Med Chem 47: 3220-35 (2004)
Article DOI: 10.1021/jm030551a
BindingDB Entry DOI: 10.7270/Q2HD7ZD1 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220434
(CHEMBL291821)Show SMILES CCC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C22H33N3O3/c1-2-4-20(23)22(27)25-14-12-24(13-15-25)11-3-16-28-19-9-7-18(8-10-19)21(26)17-5-6-17/h7-10,17,20H,2-6,11-16,23H2,1H3/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50404001
(CHEMBL2112451)Show SMILES O=C(C1CC1)c1ccc(OCCCN2CC[C@@H](C2)NS(=O)(=O)c2ccc(cc2)C#N)cc1 |r| Show InChI InChI=1S/C24H27N3O4S/c25-16-18-2-10-23(11-3-18)32(29,30)26-21-12-14-27(17-21)13-1-15-31-22-8-6-20(7-9-22)24(28)19-4-5-19/h2-3,6-11,19,21,26H,1,4-5,12-15,17H2/t21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220457
(CHEMBL60143)Show SMILES CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C31H41N3O5/c1-31(2,3)39-30(37)32-27(22-23-8-5-4-6-9-23)29(36)34-19-17-33(18-20-34)16-7-21-38-26-14-12-25(13-15-26)28(35)24-10-11-24/h4-6,8-9,12-15,24,27H,7,10-11,16-22H2,1-3H3,(H,32,37)/t27-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220400
(CHEMBL64884)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)c2cccn2C)cc1 Show InChI InChI=1S/C25H35N3O3/c1-3-4-5-9-24(29)21-10-12-22(13-11-21)31-20-7-15-27-16-18-28(19-17-27)25(30)23-8-6-14-26(23)2/h6,8,10-14H,3-5,7,9,15-20H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119720
(CHEMBL107293 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C24H30N2O4S/c1-18-3-11-23(12-4-18)31(28,29)25-21-13-15-26(17-21)14-2-16-30-22-9-7-20(8-10-22)24(27)19-5-6-19/h3-4,7-12,19,21,25H,2,5-6,13-17H2,1H3/t21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220459
(CHEMBL62596)Show SMILES O=C(C1CC1)c1ccc(OCCCN2CCN(CC2)[C@@H]2CC(=O)N2)cc1 Show InChI InChI=1S/C20H27N3O3/c24-19-14-18(21-19)23-11-9-22(10-12-23)8-1-13-26-17-6-4-16(5-7-17)20(25)15-2-3-15/h4-7,15,18H,1-3,8-14H2,(H,21,24)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220008
(CHEMBL59715)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)c2c[nH]cn2)cc1 Show InChI InChI=1S/C23H32N4O3/c1-2-3-4-6-22(28)19-7-9-20(10-8-19)30-16-5-11-26-12-14-27(15-13-26)23(29)21-17-24-18-25-21/h7-10,17-18H,2-6,11-16H2,1H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220396
(CHEMBL62527)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)C(C)C)cc1 Show InChI InChI=1S/C23H36N2O3/c1-4-5-6-8-22(26)20-9-11-21(12-10-20)28-18-7-13-24-14-16-25(17-15-24)23(27)19(2)3/h9-12,19H,4-8,13-18H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220437
(CHEMBL61792)Show SMILES N[C@H](Cc1c[nH]cn1)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C23H31N5O3/c24-21(14-19-15-25-16-26-19)23(30)28-11-9-27(10-12-28)8-1-13-31-20-6-4-18(5-7-20)22(29)17-2-3-17/h4-7,15-17,21H,1-3,8-14,24H2,(H,25,26)/t21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119702
(CHEMBL102925 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C25H32N2O4S/c1-2-19-4-12-24(13-5-19)32(29,30)26-22-14-16-27(18-22)15-3-17-31-23-10-8-21(9-11-23)25(28)20-6-7-20/h4-5,8-13,20,22,26H,2-3,6-7,14-18H2,1H3/t22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220439
(CHEMBL64059)Show SMILES N[C@H](CCc1ccccc1)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C27H35N3O3/c28-25(14-7-21-5-2-1-3-6-21)27(32)30-18-16-29(17-19-30)15-4-20-33-24-12-10-23(11-13-24)26(31)22-8-9-22/h1-3,5-6,10-13,22,25H,4,7-9,14-20,28H2/t25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220403
(CHEMBL62948)Show InChI InChI=1S/C20H28N2O4/c1-2-25-20(24)22-13-11-21(12-14-22)10-3-15-26-18-8-6-17(7-9-18)19(23)16-4-5-16/h6-9,16H,2-5,10-15H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220433
(CHEMBL60435)Show SMILES O=C(C[C@H]1CCCN1)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C23H33N3O3/c27-22(17-20-3-1-10-24-20)26-14-12-25(13-15-26)11-2-16-29-21-8-6-19(7-9-21)23(28)18-4-5-18/h6-9,18,20,24H,1-5,10-17H2/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this
Ligand-Target Pair | |
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