Compile Data Set for Download or QSAR

Found 76 hits with Last Name = 'lin' and Initial = 'kk'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) Show SMILES Cc1cccc(n1)C#Cc1ccccc1 Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGlu5 receptor in rat brain				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216746 (3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(F)cc(c1)C#N Show InChI InChI=1S/C17H11FN2/c1-11-2-3-13-4-5-14(9-17(13)20-11)15-6-12(10-19)7-16(18)8-15/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGlu5 receptor in rat brain				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50210964 (3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(c1)C#N Show InChI InChI=1S/C17H12N2/c1-12-5-6-14-7-8-16(10-17(14)19-12)15-4-2-3-13(9-15)11-18/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGlu5 receptor in rat brain				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Glycogen [starch] synthase, muscle (Homo sapiens (Human))	BDBM50527393 (CHEMBL4446895) Show SMILES Oc1ccc(cc1)-c1c(n[nH]c1C(F)(F)F)-c1ccc(O)c(O)c1O Show InChI InChI=1S/C16H11F3N2O4/c17-16(18,19)15-11(7-1-3-8(22)4-2-7)12(20-21-15)9-5-6-10(23)14(25)13(9)24/h1-6,22-25H,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Competitive inhibition of C-terminal 6His-tagged human GYS1 using UDPG as substrate in presence of G-6-P by 14C-glucose incorporation based Michaelis...				J Med Chem 63: 3538-3551 (2020) Article DOI: 10.1021/acs.jmedchem.9b01851 BindingDB Entry DOI: 10.7270/Q2MS3X64
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) Show SMILES Cc1cccc(n1)C#Cc1ccccc1 Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50391056 (CHEMBL2088421) Show SMILES COc1ccc(NC(=O)N(CCCCC2CCCCC2)CCc2ccc(SC(C)(C)C(O)=O)cc2)cc1 Show InChI InChI=1S/C30H42N2O4S/c1-30(2,28(33)34)37-27-18-12-24(13-19-27)20-22-32(21-8-7-11-23-9-5-4-6-10-23)29(35)31-25-14-16-26(36-3)17-15-25/h12-19,23H,4-11,20-22H2,1-3H3,(H,31,35)(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay				Bioorg Med Chem Lett 22: 6233-6 (2012) Article DOI: 10.1016/j.bmcl.2012.08.010 BindingDB Entry DOI: 10.7270/Q25M66SF
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay				Bioorg Med Chem Lett 22: 6233-6 (2012) Article DOI: 10.1016/j.bmcl.2012.08.010 BindingDB Entry DOI: 10.7270/Q25M66SF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50391057 (CHEMBL2088422) Show SMILES COc1cccc(NC(=O)N(CCCCC2CCCCC2)CCc2ccc(SC(C)(C)C(O)=O)cc2)c1 Show InChI InChI=1S/C30H42N2O4S/c1-30(2,28(33)34)37-27-17-15-24(16-18-27)19-21-32(20-8-7-12-23-10-5-4-6-11-23)29(35)31-25-13-9-14-26(22-25)36-3/h9,13-18,22-23H,4-8,10-12,19-21H2,1-3H3,(H,31,35)(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay				Bioorg Med Chem Lett 22: 6233-6 (2012) Article DOI: 10.1016/j.bmcl.2012.08.010 BindingDB Entry DOI: 10.7270/Q25M66SF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216746 (3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(F)cc(c1)C#N Show InChI InChI=1S/C17H11FN2/c1-11-2-3-13-4-5-14(9-17(13)20-11)15-6-12(10-19)7-16(18)8-15/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216762 (3-chloro-5-(2-methylquinolin-7-yl)benzonitrile | C...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(Cl)cc(c1)C#N Show InChI InChI=1S/C17H11ClN2/c1-11-2-3-13-4-5-14(9-17(13)20-11)15-6-12(10-19)7-16(18)8-15/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216758 (3-methyl-5-(2-methylquinolin-7-yl)benzonitrile | C...) Show SMILES Cc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C18H14N2/c1-12-7-14(11-19)9-17(8-12)16-6-5-15-4-3-13(2)20-18(15)10-16/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50099489 (2-(4-{2-[1-(4-Cyclohexyl-butyl)-3-(2-methoxy-pheny...) Show SMILES COc1ccccc1NC(=O)N(CCCCC1CCCCC1)CCc1ccc(SC(C)(C)C(O)=O)cc1 Show InChI InChI=1S/C30H42N2O4S/c1-30(2,28(33)34)37-25-18-16-24(17-19-25)20-22-32(21-10-9-13-23-11-5-4-6-12-23)29(35)31-26-14-7-8-15-27(26)36-3/h7-8,14-19,23H,4-6,9-13,20-22H2,1-3H3,(H,31,35)(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay				Bioorg Med Chem Lett 22: 6233-6 (2012) Article DOI: 10.1016/j.bmcl.2012.08.010 BindingDB Entry DOI: 10.7270/Q25M66SF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216750 (5-(2-methylquinolin-7-yl)isophthalonitrile | CHEMB...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(cc(c1)C#N)C#N Show InChI InChI=1S/C18H11N3/c1-12-2-3-15-4-5-16(9-18(15)21-12)17-7-13(10-19)6-14(8-17)11-20/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216749 (3-(methoxymethyl)-5-(2-methylquinolin-7-yl)benzoni...) Show SMILES COCc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C19H16N2O/c1-13-3-4-16-5-6-17(10-19(16)21-13)18-8-14(11-20)7-15(9-18)12-22-2/h3-10H,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216761 (3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile | ...) Show SMILES COc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C18H14N2O/c1-12-3-4-14-5-6-15(10-18(14)20-12)16-7-13(11-19)8-17(9-16)21-2/h3-10H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50210964 (3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(c1)C#N Show InChI InChI=1S/C17H12N2/c1-12-5-6-14-7-8-16(10-17(14)19-12)15-4-2-3-13(9-15)11-18/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216741 (3-bromo-5-(2-methylquinolin-7-yl)benzonitrile | CH...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(Br)cc(c1)C#N Show InChI InChI=1S/C17H11BrN2/c1-11-2-3-13-4-5-14(9-17(13)20-11)15-6-12(10-19)7-16(18)8-15/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216770 (3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile | C...) Show SMILES CCOc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C19H16N2O/c1-3-22-18-9-14(12-20)8-17(10-18)16-7-6-15-5-4-13(2)21-19(15)11-16/h4-11H,3H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216745 (5-(2-methylquinolin-7-yl)nicotinonitrile | CHEMBL2...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cncc(c1)C#N Show InChI InChI=1S/C16H11N3/c1-11-2-3-13-4-5-14(7-16(13)19-11)15-6-12(8-17)9-18-10-15/h2-7,9-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216752 (3-(ethylthio)-5-(2-methylquinolin-7-yl)benzonitril...) Show SMILES CCSc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C19H16N2S/c1-3-22-18-9-14(12-20)8-17(10-18)16-7-6-15-5-4-13(2)21-19(15)11-16/h4-11H,3H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216766 (3-(2-methylquinolin-7-yl)-5-(trifluoromethoxy)benz...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(OC(F)(F)F)cc(c1)C#N Show InChI InChI=1S/C18H11F3N2O/c1-11-2-3-13-4-5-14(9-17(13)23-11)15-6-12(10-22)7-16(8-15)24-18(19,20)21/h2-9H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216768 (3-(2-methoxyethoxy)-5-(2-methylquinolin-7-yl)benzo...) Show SMILES COCCOc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C20H18N2O2/c1-14-3-4-16-5-6-17(12-20(16)22-14)18-9-15(13-21)10-19(11-18)24-8-7-23-2/h3-6,9-12H,7-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216767 (3-isopropoxy-5-(2-methylquinolin-7-yl)benzonitrile...) Show SMILES CC(C)Oc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C20H18N2O/c1-13(2)23-19-9-15(12-21)8-18(10-19)17-7-6-16-5-4-14(3)22-20(16)11-17/h4-11,13H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216737 (3-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile | ...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cc(O)cc(c1)C#N Show InChI InChI=1S/C17H12N2O/c1-11-2-3-13-4-5-14(9-17(13)19-11)15-6-12(10-18)7-16(20)8-15/h2-9,20H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216769 (2-(3-(2-methylquinolin-7-yl)phenyl)acetonitrile | ...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(CC#N)c1 Show InChI InChI=1S/C18H14N2/c1-13-5-6-15-7-8-17(12-18(15)20-13)16-4-2-3-14(11-16)9-10-19/h2-8,11-12H,9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
NADPH oxidase 4 (Homo sapiens (Human))	BDBM50455025 (CHEMBL4208156) Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(C1=O)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C17H15F3N2O4S/c1-26-14-6-8-15(9-7-14)27(24,25)22-11-10-21(16(22)23)13-4-2-12(3-5-13)17(18,19)20/h2-9H,10-11H2,1H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of Nox4 in HASMCs assessed as reduction in TGFbeta-induced increase in smooth muscle alpha actin level pretreated for 30 mins followed by ...				Bioorg Med Chem 26: 989-998 (2018) Article DOI: 10.1016/j.bmc.2017.12.023 BindingDB Entry DOI: 10.7270/Q2VD722W
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216747 (2-methyl-7-(pyridin-3-yl)quinoline | CHEMBL231763) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccnc1 Show InChI InChI=1S/C15H12N2/c1-11-4-5-12-6-7-13(9-15(12)17-11)14-3-2-8-16-10-14/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216748 (7-(3-methoxyphenyl)-2-methylquinoline | CHEMBL3948...) Show SMILES COc1cccc(c1)-c1ccc2ccc(C)nc2c1 Show InChI InChI=1S/C17H15NO/c1-12-6-7-13-8-9-15(11-17(13)18-12)14-4-3-5-16(10-14)19-2/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216764 (3-(ethylsulfonyl)-5-(2-methylquinolin-7-yl)benzoni...) Show SMILES CCS(=O)(=O)c1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C19H16N2O2S/c1-3-24(22,23)18-9-14(12-20)8-17(10-18)16-7-6-15-5-4-13(2)21-19(15)11-16/h4-11H,3H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216759 (7-(3-fluorophenyl)-2-methylquinoline | CHEMBL23176...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(F)c1 Show InChI InChI=1S/C16H12FN/c1-11-5-6-12-7-8-14(10-16(12)18-11)13-3-2-4-15(17)9-13/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Glycogen [starch] synthase, muscle (Homo sapiens (Human))	BDBM50527393 (CHEMBL4446895) Show SMILES Oc1ccc(cc1)-c1c(n[nH]c1C(F)(F)F)-c1ccc(O)c(O)c1O Show InChI InChI=1S/C16H11F3N2O4/c17-16(18,19)15-11(7-1-3-8(22)4-2-7)12(20-21-15)9-5-6-10(23)14(25)13(9)24/h1-6,22-25H,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of C-terminal 6His-tagged wild type human GYS1 using UDPG as substrate in presence of 1 mM G-6-P by 14C-glucose incorporation assay				J Med Chem 63: 3538-3551 (2020) Article DOI: 10.1021/acs.jmedchem.9b01851 BindingDB Entry DOI: 10.7270/Q2MS3X64
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216755 (2-methyl-7-m-tolylquinoline | CHEMBL231765) Show SMILES Cc1cccc(c1)-c1ccc2ccc(C)nc2c1 Show InChI InChI=1S/C17H15N/c1-12-4-3-5-15(10-12)16-9-8-14-7-6-13(2)18-17(14)11-16/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
NADPH oxidase 4 (Homo sapiens (Human))	BDBM50455023 (CHEMBL4204145) Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCCN(C1=O)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C17H14F4N2O3S/c18-13-4-8-15(9-5-13)27(25,26)23-11-1-10-22(16(23)24)14-6-2-12(3-7-14)17(19,20)21/h2-9H,1,10-11H2	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of Nox4 in HASMCs assessed as reduction in TGFbeta-induced increase in smooth muscle alpha actin level pretreated for 30 mins followed by ...				Bioorg Med Chem 26: 989-998 (2018) Article DOI: 10.1016/j.bmc.2017.12.023 BindingDB Entry DOI: 10.7270/Q2VD722W
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216754 (7-(2-methoxyphenyl)-2-methylquinoline | CHEMBL2319...) Show SMILES COc1ccccc1-c1ccc2ccc(C)nc2c1 Show InChI InChI=1S/C17H15NO/c1-12-7-8-13-9-10-14(11-16(13)18-12)15-5-3-4-6-17(15)19-2/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216740 (1-(3-(2-methylquinolin-7-yl)phenyl)ethanone | CHEM...) Show SMILES CC(=O)c1cccc(c1)-c1ccc2ccc(C)nc2c1 Show InChI InChI=1S/C18H15NO/c1-12-6-7-14-8-9-17(11-18(14)19-12)16-5-3-4-15(10-16)13(2)20/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216757 (7-(3-(methoxymethyl)phenyl)-2-methylquinoline | CH...) Show SMILES COCc1cccc(c1)-c1ccc2ccc(C)nc2c1 Show InChI InChI=1S/C18H17NO/c1-13-6-7-15-8-9-17(11-18(15)19-13)16-5-3-4-14(10-16)12-20-2/h3-11H,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Glycogen [starch] synthase, muscle (Homo sapiens (Human))	BDBM50527392 (CHEMBL4540791) Show SMILES Oc1ccc(-c2n[nH]c(c2-c2ccc(cc2)[N+]([O-])=O)C(F)(F)F)c(O)c1O Show InChI InChI=1S/C16H10F3N3O5/c17-16(18,19)15-11(7-1-3-8(4-2-7)22(26)27)12(20-21-15)9-5-6-10(23)14(25)13(9)24/h1-6,23-25H,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of C-terminal 6His-tagged wild type human GYS1 using UDPG as substrate in presence of 1 mM G-6-P by 14C-glucose incorporation assay				J Med Chem 63: 3538-3551 (2020) Article DOI: 10.1021/acs.jmedchem.9b01851 BindingDB Entry DOI: 10.7270/Q2MS3X64
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216753 ((3-(2-methylquinolin-7-yl)phenyl)methanol | CHEMBL...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(CO)c1 Show InChI InChI=1S/C17H15NO/c1-12-5-6-14-7-8-16(10-17(14)18-12)15-4-2-3-13(9-15)11-19/h2-10,19H,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216765 (2-methyl-7-phenylquinoline | CHEMBL244418) Show SMILES Cc1ccc2ccc(cc2n1)-c1ccccc1 Show InChI InChI=1S/C16H13N/c1-12-7-8-14-9-10-15(11-16(14)17-12)13-5-3-2-4-6-13/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216756 (2-(2-methylquinolin-7-yl)benzonitrile | CHEMBL4345...) Show SMILES Cc1ccc2ccc(cc2n1)-c1ccccc1C#N Show InChI InChI=1S/C17H12N2/c1-12-6-7-13-8-9-14(10-17(13)19-12)16-5-3-2-4-15(16)11-18/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Glycogen [starch] synthase, muscle (Homo sapiens (Human))	BDBM50527395 (CHEMBL4475137) Show SMILES Oc1ccc(cc1)-c1c[nH]nc1-c1ccc(O)c(O)c1O Show InChI InChI=1S/C15H12N2O4/c18-9-3-1-8(2-4-9)11-7-16-17-13(11)10-5-6-12(19)15(21)14(10)20/h1-7,18-21H,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of C-terminal 6His-tagged wild type human GYS1 using UDPG as substrate in presence of 1 mM G-6-P by 14C-glucose incorporation assay				J Med Chem 63: 3538-3551 (2020) Article DOI: 10.1021/acs.jmedchem.9b01851 BindingDB Entry DOI: 10.7270/Q2MS3X64
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216751 (2-methyl-7-(3-(trifluoromethyl)phenyl)quinoline | ...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C17H12F3N/c1-11-5-6-12-7-8-14(10-16(12)21-11)13-3-2-4-15(9-13)17(18,19)20/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216742 (4-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2321...) Show SMILES Cc1ccc2ccc(cc2n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C17H12N2/c1-12-2-5-15-8-9-16(10-17(15)19-12)14-6-3-13(11-18)4-7-14/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216760 (3-(2-methylquinolin-7-yl)benzamide | CHEMBL231989) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(c1)C(N)=O Show InChI InChI=1S/C17H14N2O/c1-11-5-6-12-7-8-14(10-16(12)19-11)13-3-2-4-15(9-13)17(18)20/h2-10H,1H3,(H2,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216739 (2-methyl-7-(3-(trifluoromethoxy)phenyl)quinoline |...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C17H12F3NO/c1-11-5-6-12-7-8-14(10-16(12)21-11)13-3-2-4-15(9-13)22-17(18,19)20/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Glycogen [starch] synthase, muscle (Homo sapiens (Human))	BDBM50527401 (CHEMBL4542006) Show SMILES Oc1ccc(-c2n[nH]c(c2-c2ccc(cc2)C#N)C(F)(F)F)c(O)c1O Show InChI InChI=1S/C17H10F3N3O3/c18-17(19,20)16-12(9-3-1-8(7-21)2-4-9)13(22-23-16)10-5-6-11(24)15(26)14(10)25/h1-6,24-26H,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of C-terminal 6His-tagged wild type human GYS1 using UDPG as substrate in presence of 1 mM G-6-P by 14C-glucose incorporation assay				J Med Chem 63: 3538-3551 (2020) Article DOI: 10.1021/acs.jmedchem.9b01851 BindingDB Entry DOI: 10.7270/Q2MS3X64
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216744 (3-isobutoxy-5-(2-methylquinolin-7-yl)benzonitrile ...) Show SMILES CC(C)COc1cc(cc(c1)-c1ccc2ccc(C)nc2c1)C#N Show InChI InChI=1S/C21H20N2O/c1-14(2)13-24-20-9-16(12-22)8-19(10-20)18-7-6-17-5-4-15(3)23-21(17)11-18/h4-11,14H,13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Glycogen [starch] synthase, muscle (Homo sapiens (Human))	BDBM50527391 (CHEMBL4557551) Show SMILES Oc1ccc(-c2n[nH]c(c2-c2ccc(Cl)c(Cl)c2)C(F)(F)F)c(O)c1O Show InChI InChI=1S/C16H9Cl2F3N2O3/c17-8-3-1-6(5-9(8)18)11-12(22-23-15(11)16(19,20)21)7-2-4-10(24)14(26)13(7)25/h1-5,24-26H,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of C-terminal 6His-tagged wild type human GYS1 using UDPG as substrate in presence of 1 mM G-6-P by 14C-glucose incorporation assay				J Med Chem 63: 3538-3551 (2020) Article DOI: 10.1021/acs.jmedchem.9b01851 BindingDB Entry DOI: 10.7270/Q2MS3X64
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50216743 (7-(3-chlorophenyl)-2-methylquinoline | CHEMBL23198...) Show SMILES Cc1ccc2ccc(cc2n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C16H12ClN/c1-11-5-6-12-7-8-14(10-16(12)18-11)13-3-2-4-15(17)9-13/h2-10H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay				Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC
					More data for this Ligand-Target Pair
Glycogen [starch] synthase, muscle (Homo sapiens (Human))	BDBM50527397 (CHEMBL4566254) Show SMILES Oc1ccc(-c2n[nH]c(c2-c2ccc(F)cc2)C(F)(F)F)c(O)c1O Show InChI InChI=1S/C16H10F4N2O3/c17-8-3-1-7(2-4-8)11-12(21-22-15(11)16(18,19)20)9-5-6-10(23)14(25)13(9)24/h1-6,23-25H,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of C-terminal 6His-tagged wild type human GYS1 using UDPG as substrate in presence of 1 mM G-6-P by 14C-glucose incorporation assay				J Med Chem 63: 3538-3551 (2020) Article DOI: 10.1021/acs.jmedchem.9b01851 BindingDB Entry DOI: 10.7270/Q2MS3X64
					More data for this Ligand-Target Pair

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