Compile Data Set for Download or QSAR

Found 140 hits with Last Name = 'mcfall' and Initial = 'rc'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5284 (4-{[4-(Methylsulfonyl)piperazin-1-yl]methyl}-N-(5-...) Show SMILES CS(=O)(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C20H23N5O2S2/c1-29(26,27)25-11-9-24(10-12-25)15-16-7-8-21-19(13-16)23-20-22-14-18(28-20)17-5-3-2-4-6-17/h2-8,13-14H,9-12,15H2,1H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5358 (N-(6-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...) Show SMILES COc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C15H13N3OS/c1-19-14-9-5-8-13(17-14)18-15-16-10-12(20-15)11-6-3-2-4-7-11/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5282 ((5-Phenylthiazol-2-yl)(4-pyrrolidin-1-ylmethylpyri...) Show SMILES C(N1CCCC1)c1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-12-15(8-9-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5413 (1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C23H24N4OS/c1-2-9-26(10-3-1)11-12-28-21-6-4-18(5-7-21)20-14-24-23-22(15-25-27(23)16-20)19-8-13-29-17-19/h4-8,13-17H,1-3,9-12H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5409 (4-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...) Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C22H22N4O2S/c1-3-20(28-11-8-25-6-9-27-10-7-25)4-2-17(1)19-13-23-22-21(14-24-26(22)15-19)18-5-12-29-16-18/h1-5,12-16H,6-11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5332 (3-{5-[2-(piperidin-1-yl)ethoxy]-1H-indol-2-yl}-1,2...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2cc(OCCN3CCCCC3)ccc2[nH]1 Show InChI InChI=1S/C24H25N3O2/c28-24-20(15-17-6-2-3-7-21(17)26-24)23-16-18-14-19(8-9-22(18)25-23)29-13-12-27-10-4-1-5-11-27/h2-3,6-9,14-16,25H,1,4-5,10-13H2,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5330 (3-{5-[2-(4-acetylpiperazin-1-yl)ethoxy]-1H-indol-2...) Show SMILES CC(=O)N1CCN(CCOc2ccc3[nH]c(cc3c2)-c2cc3ccccc3[nH]c2=O)CC1 Show InChI InChI=1S/C25H26N4O3/c1-17(30)29-10-8-28(9-11-29)12-13-32-20-6-7-23-19(14-20)16-24(26-23)21-15-18-4-2-3-5-22(18)27-25(21)31/h2-7,14-16,26H,8-13H2,1H3,(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5384 (2,4-Disubstituted Pyrimidine 2h | N-(3,5-dimethoxy...) Show SMILES COc1cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)cc(OC)c1 Show InChI InChI=1S/C21H19N5O2/c1-27-17-12-16(13-18(14-17)28-2)24-21-23-9-8-19(25-21)26-11-10-22-20(26)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5389 (2,4-Disubstituted Pyrimidine 3a | N-[3-methyl-5-(t...) Show SMILES Cc1cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C21H16F3N5/c1-14-11-16(21(22,23)24)13-17(12-14)27-20-26-8-7-18(28-20)29-10-9-25-19(29)15-5-3-2-4-6-15/h2-13H,1H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5335 (3-{5-[(3-aminopyrrolidin-1-yl)carbonyl]-1H-indol-2...) Show SMILES NC1CCN(C1)C(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H20N4O2/c23-16-7-8-26(12-16)22(28)14-5-6-19-15(9-14)11-20(24-19)17-10-13-3-1-2-4-18(13)25-21(17)27/h1-6,9-11,16,24H,7-8,12,23H2,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5334 (3-[5-(piperazin-1-ylcarbonyl)-1H-indol-2-yl]-1,2-d...) Show SMILES O=C(N1CCNCC1)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H20N4O2/c27-21-17(12-14-3-1-2-4-18(14)25-21)20-13-16-11-15(5-6-19(16)24-20)22(28)26-9-7-23-8-10-26/h1-6,11-13,23-24H,7-10H2,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5333 (3-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-indol-2...) Show SMILES CN1CCN(CC1)C(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C23H22N4O2/c1-26-8-10-27(11-9-26)23(29)16-6-7-20-17(12-16)14-21(24-20)18-13-15-4-2-3-5-19(15)25-22(18)28/h2-7,12-14,24H,8-11H2,1H3,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5380 (2,4-Disubstituted Pyrimidine 2d | N-(3,5-dimethylp...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C21H19N5/c1-15-12-16(2)14-18(13-15)24-21-23-9-8-19(25-21)26-11-10-22-20(26)17-6-4-3-5-7-17/h3-14H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5281 (5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...) Show SMILES C(N1CCCC1)c1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5336 (2-(2-oxo-1,2-dihydroquinolin-3-yl)-N-(pyrrolidin-3...) Show SMILES O=C(NC1CCNC1)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H20N4O2/c27-21(24-16-7-8-23-12-16)14-5-6-19-15(9-14)11-20(25-19)17-10-13-3-1-2-4-18(13)26-22(17)28/h1-6,9-11,16,23,25H,7-8,12H2,(H,24,27)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5281 (5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...) Show SMILES C(N1CCCC1)c1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5351 (N-(4-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C15H13N3S/c1-11-7-8-16-14(9-11)18-15-17-10-13(19-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5435 (1-[3-(4-methylpiperazin-1-yl)propyl]-4-[3-(thiophe...) Show SMILES CN1CCN(CCCn2ccc(cc2=O)-c2cnc3c(cnn3c2)-c2ccsc2)CC1 Show InChI InChI=1S/C23H26N6OS/c1-26-8-10-27(11-9-26)5-2-6-28-7-3-18(13-22(28)30)20-14-24-23-21(15-25-29(23)16-20)19-4-12-31-17-19/h3-4,7,12-17H,2,5-6,8-11H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5329 (3-(5-{2-[(2-methoxyethyl)(methyl)amino]ethoxy}-1H-...) Show SMILES COCCN(C)CCOc1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C23H25N3O3/c1-26(9-11-28-2)10-12-29-18-7-8-21-17(13-18)15-22(24-21)19-14-16-5-3-4-6-20(16)25-23(19)27/h3-8,13-15,24H,9-12H2,1-2H3,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5292 (2-({4-[(4-methanesulfonylpiperidin-1-yl)methyl]pyr...) Show SMILES CS(=O)(=O)C1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N5O2S2/c1-25(22,23)14-3-6-21(7-4-14)11-12-2-5-18-15(8-12)20-16-19-10-13(9-17)24-16/h2,5,8,10,14H,3-4,6-7,11H2,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5280 (5-phenyl-N-(pyridin-2-yl)-1,3-thiazol-2-amine | N-...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1ccccn1 Show InChI InChI=1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5280 (5-phenyl-N-(pyridin-2-yl)-1,3-thiazol-2-amine | N-...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1ccccn1 Show InChI InChI=1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5283 (1-[4-({2-[(5-phenyl-1,3-thiazol-2-yl)amino]pyridin...) Show SMILES CC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C21H23N5OS/c1-16(27)26-11-9-25(10-12-26)15-17-7-8-22-20(13-17)24-21-23-14-19(28-21)18-5-3-2-4-6-18/h2-8,13-14H,9-12,15H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5331 (1-(3-{[2-(2-oxo-1,2-dihydroquinolin-3-yl)-1H-indol...) Show SMILES OC(=O)C1CCN(CCCOc2ccc3[nH]c(cc3c2)-c2cc3ccccc3[nH]c2=O)CC1 Show InChI InChI=1S/C26H27N3O4/c30-25-21(15-18-4-1-2-5-22(18)28-25)24-16-19-14-20(6-7-23(19)27-24)33-13-3-10-29-11-8-17(9-12-29)26(31)32/h1-2,4-7,14-17,27H,3,8-13H2,(H,28,30)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5328 (2-quinolinone deriv. 3 | 3-(1H-indol-2-yl)-1,2-dih...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2ccccc2[nH]1 Show InChI InChI=1S/C17H12N2O/c20-17-13(9-11-5-1-4-8-15(11)19-17)16-10-12-6-2-3-7-14(12)18-16/h1-10,18H,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5287 (2-(4-Morpholin-4-ylmethylpyridin-2-ylamino)thiazol...) Show SMILES N#Cc1cnc(Nc2cc(CN3CCOCC3)ccn2)s1 Show InChI InChI=1S/C14H15N5OS/c15-8-12-9-17-14(21-12)18-13-7-11(1-2-16-13)10-19-3-5-20-6-4-19/h1-2,7,9H,3-6,10H2,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5288 (4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...) Show SMILES NC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C15H17N7OS/c16-8-12-9-19-15(24-12)20-13-7-11(1-2-18-13)10-21-3-5-22(6-4-21)14(17)23/h1-2,7,9H,3-6,10H2,(H2,17,23)(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5391 ((3-methyl-5-{[4-(2-phenyl-1H-imidazol-1-yl)pyrimid...) Show SMILES Cc1cc(CO)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C21H19N5O/c1-15-11-16(14-27)13-18(12-15)24-21-23-8-7-19(25-21)26-10-9-22-20(26)17-5-3-2-4-6-17/h2-13,27H,14H2,1H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5291 (2-[(4-{[4-(2-hydroxyacetyl)piperazin-1-yl]methyl}p...) Show SMILES OCC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H18N6O2S/c17-8-13-9-19-16(25-13)20-14-7-12(1-2-18-14)10-21-3-5-22(6-4-21)15(24)11-23/h1-2,7,9,23H,3-6,10-11H2,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5410 (4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...) Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1 Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5337 (3-{5-[(4-methylpiperazine-1-)sulfonyl]-1H-indol-2-...) Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O Show InChI InChI=1S/C22H22N4O3S/c1-25-8-10-26(11-9-25)30(28,29)17-6-7-20-16(12-17)14-21(23-20)18-13-15-4-2-3-5-19(15)24-22(18)27/h2-7,12-14,23H,8-11H2,1H3,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5289 (4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...) Show SMILES CN(C)C(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C17H21N7OS/c1-22(2)17(25)24-7-5-23(6-8-24)12-13-3-4-19-15(9-13)21-16-20-11-14(10-18)26-16/h3-4,9,11H,5-8,12H2,1-2H3,(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5387 (2,4-Disubstituted Pyrimidine 2k | 4-(2-phenyl-1H-i...) Show SMILES FC(F)(F)c1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C20H14F3N5/c21-20(22,23)15-7-4-8-16(13-15)26-19-25-10-9-17(27-19)28-12-11-24-18(28)14-5-2-1-3-6-14/h1-13H,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5353 (N-(6-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-14(17-11)18-15-16-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5412 (dimethyl(3-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyr...) Show SMILES CN(C)CCCOc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C21H22N4OS/c1-24(2)9-3-10-26-19-6-4-16(5-7-19)18-12-22-21-20(13-23-25(21)14-18)17-8-11-27-15-17/h4-8,11-15H,3,9-10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5357 (N-(4-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...) Show SMILES COc1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C15H13N3OS/c1-19-12-7-8-16-14(9-12)18-15-17-10-13(20-15)11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5416 (4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...) Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5338 (3-[5-(piperazine-1-sulfonyl)-1H-indol-2-yl]-1,2-di...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2cc(ccc2[nH]1)S(=O)(=O)N1CCNCC1 Show InChI InChI=1S/C21H20N4O3S/c26-21-17(12-14-3-1-2-4-18(14)24-21)20-13-15-11-16(5-6-19(15)23-20)29(27,28)25-9-7-22-8-10-25/h1-6,11-13,22-23H,7-10H2,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5293 (4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]-3-methylpy...) Show SMILES CNC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2C)CC1 Show InChI InChI=1S/C17H21N7OS/c1-12-13(11-23-5-7-24(8-6-23)17(25)19-2)3-4-20-15(12)22-16-21-10-14(9-18)26-16/h3-4,10H,5-8,11H2,1-2H3,(H,19,25)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5290 (4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-4-y...) Show SMILES CNC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N7OS/c1-18-16(24)23-6-4-22(5-7-23)11-12-2-3-19-14(8-12)21-15-20-10-13(9-17)25-15/h2-3,8,10H,4-7,11H2,1H3,(H,18,24)(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5350 (N-(3-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1cccnc1Nc1ncc(s1)-c1ccccc1 Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-16-14(11)18-15-17-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5285 (2-({4-[(4-acetylpiperazin-1-yl)methyl]pyridin-2-yl...) Show SMILES CC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H18N6OS/c1-12(23)22-6-4-21(5-7-22)11-13-2-3-18-15(8-13)20-16-19-10-14(9-17)24-16/h2-3,8,10H,4-7,11H2,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5434 (1-[3-(4-methylpiperazin-1-yl)propyl]-4-{3-phenylpy...) Show SMILES CN1CCN(CCCn2ccc(cc2=O)-c2cnc3c(cnn3c2)-c2ccccc2)CC1 Show InChI InChI=1S/C25H28N6O/c1-28-12-14-29(15-13-28)9-5-10-30-11-8-21(16-24(30)32)22-17-26-25-23(18-27-31(25)19-22)20-6-3-2-4-7-20/h2-4,6-8,11,16-19H,5,9-10,12-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5433 (4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}-1-[3-(pi...) Show SMILES O=c1cc(ccn1CCCN1CCCCC1)-c1cnc2c(cnn2c1)-c1ccccc1 Show InChI InChI=1S/C25H27N5O/c31-24-16-21(10-15-29(24)14-7-13-28-11-5-2-6-12-28)22-17-26-25-23(18-27-30(25)19-22)20-8-3-1-4-9-20/h1,3-4,8-10,15-19H,2,5-7,11-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5375 (1-phenyl-5-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1H...) Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1ccc2n(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H27N3O/c1-3-7-23(8-4-1)29-20-27-25-19-22(11-14-26(25)29)21-9-12-24(13-10-21)30-18-17-28-15-5-2-6-16-28/h1,3-4,7-14,19-20H,2,5-6,15-18H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2485-8 (2003) Article DOI: 10.1016/s0960-894x(03)00485-2 BindingDB Entry DOI: 10.7270/Q21R6NQ2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5340 (2-(2-oxo-1,2-dihydroquinolin-3-yl)-N-(pyrrolidin-3...) Show SMILES O=c1[nH]c2ccccc2cc1-c1cc2cc(ccc2[nH]1)S(=O)(=O)NC1CCNC1 Show InChI InChI=1S/C21H20N4O3S/c26-21-17(10-13-3-1-2-4-18(13)24-21)20-11-14-9-16(5-6-19(14)23-20)29(27,28)25-15-7-8-22-12-15/h1-6,9-11,15,22-23,25H,7-8,12H2,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 351-5 (2004) Article DOI: 10.1016/j.bmcl.2003.11.007 BindingDB Entry DOI: 10.7270/Q298856Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5355 (N-(6-bromopyridin-2-yl)-5-phenyl-1,3-thiazol-2-ami...) Show SMILES Brc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C14H10BrN3S/c15-12-7-4-8-13(17-12)18-14-16-9-11(19-14)10-5-2-1-3-6-10/h1-9H,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5411 (4-(2-{3-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...) Show SMILES C(CN1CCOCC1)Oc1cccc(c1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C22H22N4O2S/c1-2-17(12-20(3-1)28-10-7-25-5-8-27-9-6-25)19-13-23-22-21(14-24-26(22)15-19)18-4-11-29-16-18/h1-4,11-16H,5-10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 3537-41 (2002) Article DOI: 10.1016/s0960-894x(02)00827-2 BindingDB Entry DOI: 10.7270/Q2S75DHR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5286 (2-(4-Piperazin-1-ylmethylpyridin-2-ylamino)thiazol...) Show SMILES N#Cc1cnc(Nc2cc(CN3CCNCC3)ccn2)s1 Show InChI InChI=1S/C14H16N6S/c15-8-12-9-18-14(21-12)19-13-7-11(1-2-17-13)10-20-5-3-16-4-6-20/h1-2,7,9,16H,3-6,10H2,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5323 (1-[3-(4-methylpiperazin-1-yl)propyl]-3-[5-(thiophe...) Show SMILES CN1CCN(CCCn2cc(-c3cncc(c3)-c3ccsc3)c3ccccc23)CC1 Show InChI InChI=1S/C25H28N4S/c1-27-10-12-28(13-11-27)8-4-9-29-18-24(23-5-2-3-6-25(23)29)22-15-21(16-26-17-22)20-7-14-30-19-20/h2-3,5-7,14-19H,4,8-13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 2973-6 (2003) Article DOI: 10.1016/s0960-894x(03)00627-9 BindingDB Entry DOI: 10.7270/Q2DZ06H6
					More data for this Ligand-Target Pair

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