Compile Data Set for Download or QSAR

Found 59 hits with Last Name = 'mclaren' and Initial = 'fm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50156071 (3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide...) Show SMILES O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)c1cccc(c1)C#N Show InChI InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-MPEP from human mGluR5				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331975 (1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(p...) Show SMILES Fc1ccc(N2CCN(CC2)C(=O)COCc2ccncc2)c(Cl)c1 Show InChI InChI=1S/C18H19ClFN3O2/c19-16-11-15(20)1-2-17(16)22-7-9-23(10-8-22)18(24)13-25-12-14-3-5-21-6-4-14/h1-6,11H,7-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.37E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-MPEP from human mGluR5				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102319 (11-(4-Methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thia...) Show SMILES CN1CCN(CC1)C1=Nc2ccc(O)cc2Sc2ccccc12 |t:8| Show InChI InChI=1S/C18H19N3OS/c1-20-8-10-21(11-9-20)18-14-4-2-3-5-16(14)23-17-12-13(22)6-7-15(17)19-18/h2-7,12,22H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50001884 (2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...) Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102318 (2-{2-[4-(5,5-Dioxo-5H-5lambda*6*-dibenzo[b,f][1,4]...) Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccccc2S(=O)(=O)c2ccccc12 |t:13| Show InChI InChI=1S/C21H25N3O4S/c25-14-16-28-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)29(26,27)20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102320 (11-{4-[2-(2-Hydroxy-ethoxy)-ethyl]-piperazin-1-yl}...) Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccc(O)cc2Sc2ccccc12 |t:13| Show InChI InChI=1S/C21H25N3O3S/c25-12-14-27-13-11-23-7-9-24(10-8-23)21-17-3-1-2-4-19(17)28-20-15-16(26)5-6-18(20)22-21/h1-6,15,25-26H,7-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	166	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102326 (11-[4-(3,4-Dimethoxy-butyl)-piperazin-1-yl]-dibenz...) Show SMILES COCC(CCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12)OC |t:13| Show InChI InChI=1S/C23H29N3O2S/c1-27-17-18(28-2)11-12-25-13-15-26(16-14-25)23-19-7-3-5-9-21(19)29-22-10-6-4-8-20(22)24-23/h3-10,18H,11-17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	293	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50095890 (2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...) Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:13| Show InChI InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102321 (11-[4-(Tetrahydro-furan-2-ylmethyl)-piperazin-1-yl...) Show SMILES C(C1CCCO1)N1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:14| Show InChI InChI=1S/C22H25N3OS/c1-3-9-20-18(7-1)22(23-19-8-2-4-10-21(19)27-20)25-13-11-24(12-14-25)16-17-6-5-15-26-17/h1-4,7-10,17H,5-6,11-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	417	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102323 (2-{2-[4-(7-Fluoro-dibenzo[b,f][1,4]thiazepin-11-yl...) Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccc(F)cc2Sc2ccccc12 |t:13| Show InChI InChI=1S/C21H24FN3O2S/c22-16-5-6-18-20(15-16)28-19-4-2-1-3-17(19)21(23-18)25-9-7-24(8-10-25)11-13-27-14-12-26/h1-6,15,26H,7-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102314 (3-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-...) Show SMILES COC(CO)CN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:13| Show InChI InChI=1S/C21H25N3O2S/c1-26-16(15-25)14-23-10-12-24(13-11-23)21-17-6-2-4-8-19(17)27-20-9-5-3-7-18(20)22-21/h2-9,16,25H,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	755	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102322 (11-[4-(2,3-Dimethoxy-propyl)-piperazin-1-yl]-diben...) Show SMILES COCC(CN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12)OC |t:12| Show InChI InChI=1S/C22H27N3O2S/c1-26-16-17(27-2)15-24-11-13-25(14-12-24)22-18-7-3-5-9-20(18)28-21-10-6-4-8-19(21)23-22/h3-10,17H,11-16H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	795	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102324 (7-Fluoro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...) Show SMILES CN1CCN(CC1)C1=Nc2ccc(F)cc2Sc2ccccc12 |t:8| Show InChI InChI=1S/C18H18FN3S/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-12-13(19)6-7-15(17)20-18/h2-7,12H,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	963	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102327 (2-{2-[4-(3-Chloro-11H-dibenzo[b,e]azepin-6-yl)-pip...) Show SMILES OCCOCCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Cc2ccccc12 |t:13| Show InChI InChI=1S/C22H26ClN3O2/c23-19-6-5-18-15-17-3-1-2-4-20(17)22(24-21(18)16-19)26-9-7-25(8-10-26)11-13-28-14-12-27/h1-6,16,27H,7-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102315 (2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-...) Show SMILES OCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:10| Show InChI InChI=1S/C19H21N3OS/c23-14-13-21-9-11-22(12-10-21)19-15-5-1-3-7-17(15)24-18-8-4-2-6-16(18)20-19/h1-8,23H,9-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102316 (2-{2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-pipera...) Show SMILES OCCOCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:16| Show InChI InChI=1S/C23H29N3O3S/c27-14-16-29-18-17-28-15-13-25-9-11-26(12-10-25)23-19-5-1-3-7-21(19)30-22-8-4-2-6-20(22)24-23/h1-8,27H,9-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102317 (2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-...) Show SMILES COCC(CO)N1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:13| Show InChI InChI=1S/C21H25N3O2S/c1-26-15-16(14-25)23-10-12-24(13-11-23)21-17-6-2-4-8-19(17)27-20-9-5-3-7-18(20)22-21/h2-9,16,25H,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50102325 (6-(4-Methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepin...) Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Cc2ccccc12 |t:8| Show InChI InChI=1S/C19H21N3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9H,10-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals LP Curated by ChEMBL					Assay Description Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.				J Med Chem 44: 372-89 (2001) BindingDB Entry DOI: 10.7270/Q2639P1N
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331980 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazo...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2cscn2)c(Cl)c1 Show InChI InChI=1S/C16H17Cl2N3O2S/c17-12-1-2-15(14(18)7-12)20-3-5-21(6-4-20)16(22)9-23-8-13-10-24-11-19-13/h1-2,7,10-11H,3-6,8-9H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331981 (2-(benzyloxy)-1-(4-(2,4-difluorophenyl)piperazin-1...) Show SMILES Fc1ccc(N2CCN(CC2)C(=O)COCc2ccccc2)c(F)c1 Show InChI InChI=1S/C19H20F2N2O2/c20-16-6-7-18(17(21)12-16)22-8-10-23(11-9-22)19(24)14-25-13-15-4-2-1-3-5-15/h1-7,12H,8-11,13-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331982 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyridi...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2ccccn2)c(Cl)c1 Show InChI InChI=1S/C18H19Cl2N3O2/c19-14-4-5-17(16(20)11-14)22-7-9-23(10-8-22)18(24)13-25-12-15-3-1-2-6-21-15/h1-6,11H,7-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331983 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thioph...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2cccs2)c(Cl)c1 Show InChI InChI=1S/C17H18Cl2N2O2S/c18-13-3-4-16(15(19)10-13)20-5-7-21(8-6-20)17(22)12-23-11-14-2-1-9-24-14/h1-4,9-10H,5-8,11-12H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>310	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331984 (2-(benzyloxy)-1-(4-(4-chlorophenyl)piperazin-1-yl)...) Show SMILES Clc1ccc(cc1)N1CCN(CC1)C(=O)COCc1ccccc1 Show InChI InChI=1S/C19H21ClN2O2/c20-17-6-8-18(9-7-17)21-10-12-22(13-11-21)19(23)15-24-14-16-4-2-1-3-5-16/h1-9H,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331985 (1-(4-(2-chloro-4-fluorophenyl)piperidin-1-yl)-2-(p...) Show SMILES Fc1ccc(C2CCN(CC2)C(=O)COCc2ccncc2)c(Cl)c1 Show InChI InChI=1S/C19H20ClFN2O2/c20-18-11-16(21)1-2-17(18)15-5-9-23(10-6-15)19(24)13-25-12-14-3-7-22-8-4-14/h1-4,7-8,11,15H,5-6,9-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331986 (1-(4-(2,4-dichlorophenyl)piperidin-1-yl)-2-(pyridi...) Show SMILES Clc1ccc(C2CCN(CC2)C(=O)COCc2ccncc2)c(Cl)c1 Show InChI InChI=1S/C19H20Cl2N2O2/c20-16-1-2-17(18(21)11-16)15-5-9-23(10-6-15)19(24)13-25-12-14-3-7-22-8-4-14/h1-4,7-8,11,15H,5-6,9-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331975 (1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(p...) Show SMILES Fc1ccc(N2CCN(CC2)C(=O)COCc2ccncc2)c(Cl)c1 Show InChI InChI=1S/C18H19ClFN3O2/c19-16-11-15(20)1-2-17(16)22-7-9-23(10-8-22)18(24)13-25-12-14-3-5-21-6-4-14/h1-6,11H,7-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331987 (2-(benzyloxy)-1-(4-(4-chloropyridin-2-yl)piperazin...) Show SMILES Clc1ccnc(c1)N1CCN(CC1)C(=O)COCc1ccccc1 Show InChI InChI=1S/C18H20ClN3O2/c19-16-6-7-20-17(12-16)21-8-10-22(11-9-21)18(23)14-24-13-15-4-2-1-3-5-15/h1-7,12H,8-11,13-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	570	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331988 (1-(4-(4-chloro-2-fluorophenyl)piperazin-1-yl)-2-(p...) Show SMILES Fc1cc(Cl)ccc1N1CCN(CC1)C(=O)COCc1ccncc1 Show InChI InChI=1S/C18H19ClFN3O2/c19-15-1-2-17(16(20)11-15)22-7-9-23(10-8-22)18(24)13-25-12-14-3-5-21-6-4-14/h1-6,11H,7-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331989 (1-(4-(4-chlorophenyl)piperidin-1-yl)-2-(pyridin-4-...) Show SMILES Clc1ccc(cc1)C1CCN(CC1)C(=O)COCc1ccncc1 Show InChI InChI=1S/C19H21ClN2O2/c20-18-3-1-16(2-4-18)17-7-11-22(12-8-17)19(23)14-24-13-15-5-9-21-10-6-15/h1-6,9-10,17H,7-8,11-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	680	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331990 (1-(4-(4-chlorophenyl)-4-fluoropiperidin-1-yl)-2-(p...) Show SMILES FC1(CCN(CC1)C(=O)COCc1ccncc1)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClFN2O2/c20-17-3-1-16(2-4-17)19(21)7-11-23(12-8-19)18(24)14-25-13-15-5-9-22-10-6-15/h1-6,9-10H,7-8,11-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331991 (2-(benzyloxy)-1-(4-(2,4-dichlorophenyl)piperazin-1...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2ccccc2)c(Cl)c1 Show InChI InChI=1S/C19H20Cl2N2O2/c20-16-6-7-18(17(21)12-16)22-8-10-23(11-9-22)19(24)14-25-13-15-4-2-1-3-5-15/h1-7,12H,8-11,13-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331992 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyridi...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2cccnc2)c(Cl)c1 Show InChI InChI=1S/C18H19Cl2N3O2/c19-15-3-4-17(16(20)10-15)22-6-8-23(9-7-22)18(24)13-25-12-14-2-1-5-21-11-14/h1-5,10-11H,6-9,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331993 (2-(benzyloxy)-1-(4-(2-chlorophenyl)piperazin-1-yl)...) Show SMILES Clc1ccccc1N1CCN(CC1)C(=O)COCc1ccccc1 Show InChI InChI=1S/C19H21ClN2O2/c20-17-8-4-5-9-18(17)21-10-12-22(13-11-21)19(23)15-24-14-16-6-2-1-3-7-16/h1-9H,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331994 (2-(benzyloxy)-1-(4-(4-fluorophenyl)piperazin-1-yl)...) Show SMILES Fc1ccc(cc1)N1CCN(CC1)C(=O)COCc1ccccc1 Show InChI InChI=1S/C19H21FN2O2/c20-17-6-8-18(9-7-17)21-10-12-22(13-11-21)19(23)15-24-14-16-4-2-1-3-5-16/h1-9H,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331995 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazo...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2cncs2)c(Cl)c1 Show InChI InChI=1S/C16H17Cl2N3O2S/c17-12-1-2-15(14(18)7-12)20-3-5-21(6-4-20)16(22)10-23-9-13-8-19-11-24-13/h1-2,7-8,11H,3-6,9-10H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331996 (1-(4-(4-chlorophenyl)piperazin-1-yl)-2-(pyridin-4-...) Show SMILES Clc1ccc(cc1)N1CCN(CC1)C(=O)COCc1ccncc1 Show InChI InChI=1S/C18H20ClN3O2/c19-16-1-3-17(4-2-16)21-9-11-22(12-10-21)18(23)14-24-13-15-5-7-20-8-6-15/h1-8H,9-14H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331997 (1-(4-(4-chlorophenyl)-4-methylpiperidin-1-yl)-2-(p...) Show SMILES CC1(CCN(CC1)C(=O)COCc1ccncc1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H23ClN2O2/c1-20(17-2-4-18(21)5-3-17)8-12-23(13-9-20)19(24)15-25-14-16-6-10-22-11-7-16/h2-7,10-11H,8-9,12-15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331998 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrimi...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2ccncn2)c(Cl)c1 Show InChI InChI=1S/C17H18Cl2N4O2/c18-13-1-2-16(15(19)9-13)22-5-7-23(8-6-22)17(24)11-25-10-14-3-4-20-12-21-14/h1-4,9,12H,5-8,10-11H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331999 (1-(4-(4-chloropyridin-2-yl)piperazin-1-yl)-2-(pyri...) Show SMILES Clc1ccnc(c1)N1CCN(CC1)C(=O)COCc1ccncc1 Show InChI InChI=1S/C17H19ClN4O2/c18-15-3-6-20-16(11-15)21-7-9-22(10-8-21)17(23)13-24-12-14-1-4-19-5-2-14/h1-6,11H,7-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332000 (1-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-(pyridi...) Show SMILES Fc1ccc(N2CCN(CC2)C(=O)COCc2ccncc2)c(F)c1 Show InChI InChI=1S/C18H19F2N3O2/c19-15-1-2-17(16(20)11-15)22-7-9-23(10-8-22)18(24)13-25-12-14-3-5-21-6-4-14/h1-6,11H,7-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332001 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrazi...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2cnccn2)c(Cl)c1 Show InChI InChI=1S/C17H18Cl2N4O2/c18-13-1-2-16(15(19)9-13)22-5-7-23(8-6-22)17(24)12-25-11-14-10-20-3-4-21-14/h1-4,9-10H,5-8,11-12H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332002 (1-(4-(2,4-dichlorophenyl)-4-fluoropiperidin-1-yl)-...) Show SMILES FC1(CCN(CC1)C(=O)COCc1ccncc1)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H19Cl2FN2O2/c20-15-1-2-16(17(21)11-15)19(22)5-9-24(10-6-19)18(25)13-26-12-14-3-7-23-8-4-14/h1-4,7-8,11H,5-6,9-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332003 (2-(benzyloxy)-1-(4-(3-chlorophenyl)piperazin-1-yl)...) Show SMILES Clc1cccc(c1)N1CCN(CC1)C(=O)COCc1ccccc1 Show InChI InChI=1S/C19H21ClN2O2/c20-17-7-4-8-18(13-17)21-9-11-22(12-10-21)19(23)15-24-14-16-5-2-1-3-6-16/h1-8,13H,9-12,14-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332004 (2-(benzyloxy)-1-(4-phenylpiperazin-1-yl)ethanone |...) Show SMILES O=C(COCc1ccccc1)N1CCN(CC1)c1ccccc1 Show InChI InChI=1S/C19H22N2O2/c22-19(16-23-15-17-7-3-1-4-8-17)21-13-11-20(12-14-21)18-9-5-2-6-10-18/h1-10H,11-16H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332005 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazo...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2nccs2)c(Cl)c1 Show InChI InChI=1S/C16H17Cl2N3O2S/c17-12-1-2-14(13(18)9-12)20-4-6-21(7-5-20)16(22)11-23-10-15-19-3-8-24-15/h1-3,8-9H,4-7,10-11H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332006 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrimi...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2ncccn2)c(Cl)c1 Show InChI InChI=1S/C17H18Cl2N4O2/c18-13-2-3-15(14(19)10-13)22-6-8-23(9-7-22)17(24)12-25-11-16-20-4-1-5-21-16/h1-5,10H,6-9,11-12H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332007 (2-(benzyloxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)et...) Show SMILES O=C(COCc1ccccc1)N1CCN(CC1)c1ccncc1 Show InChI InChI=1S/C18H21N3O2/c22-18(15-23-14-16-4-2-1-3-5-16)21-12-10-20(11-13-21)17-6-8-19-9-7-17/h1-9H,10-15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331967 (1-(4-(4-fluoro-2-chlorophenyl)piperidin-1-yl)-2-(p...) Show SMILES Fc1ccc(C2CCN(CC2)C(=S)COCc2ccncc2)c(Cl)c1 Show InChI InChI=1S/C19H20ClFN2OS/c20-18-11-16(21)1-2-17(18)15-5-9-23(10-6-15)19(25)13-24-12-14-3-7-22-8-4-14/h1-4,7-8,11,15H,5-6,9-10,12-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.06E+4	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331968 (1-(2-(benzyloxy)ethyl)-4-(2,4-dichlorophenyl)piper...) Show SMILES Clc1ccc(N2CCN(CCOCc3ccccc3)CC2)c(Cl)c1 Show InChI InChI=1S/C19H22Cl2N2O/c20-17-6-7-19(18(21)14-17)23-10-8-22(9-11-23)12-13-24-15-16-4-2-1-3-5-16/h1-7,14H,8-13,15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331969 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-4-(pyridi...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)CCCc2ccncc2)c(Cl)c1 Show InChI InChI=1S/C19H21Cl2N3O/c20-16-4-5-18(17(21)14-16)23-10-12-24(13-11-23)19(25)3-1-2-15-6-8-22-9-7-15/h4-9,14H,1-3,10-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair

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