Found 221 hits with Last Name = 'o''neill' and Initial = 'dj' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50005536
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 22.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-WIN-35428 from human DAT expressed in CHO cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50005536
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
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| DrugBank Article PubMed
| 22.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN35428 from human recombinant DAT expressed in CHO cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319577
(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)Show InChI InChI=1S/C16H18FN3O2S/c1-18-11-6-12-19-15-9-4-5-10-16(15)20(23(19,21)22)14-8-3-2-7-13(14)17/h2-5,7-10,18H,6,11-12H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319578
((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319582
(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)Show InChI InChI=1S/C17H20FN3O2S/c1-19-12-6-7-13-20-16-10-4-5-11-17(16)21(24(20,22)23)15-9-3-2-8-14(15)18/h2-5,8-11,19H,6-7,12-13H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319578
((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50023342
(CHEMBL3334567)Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319576
(4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H...)Show InChI InChI=1S/C17H18FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,19H,10-12H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319578
((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319587
(CHEMBL1084042 | {3-[3-(2-Fluoro-phenyl)-2,2-dioxo-...)Show InChI InChI=1S/C17H20FN3O2S/c1-13(11-12-19-2)20-16-9-5-6-10-17(16)21(24(20,22)23)15-8-4-3-7-14(15)18/h3-10,13,19H,11-12H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319575
((2S)-(4-[3-(2,5-Difluorophenyl)-2,2-dioxido-2,1,3-...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2cc(F)ccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H19F2N3O3S/c1-20-11-13(23)8-9-21-15-4-2-3-5-16(15)22(26(21,24)25)17-10-12(18)6-7-14(17)19/h2-7,10,13,20,23H,8-9,11H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319581
((2S)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H19F2N3O3S/c1-20-11-12(23)9-10-21-15-7-2-3-8-16(15)22(26(21,24)25)17-13(18)5-4-6-14(17)19/h2-8,12,20,23H,9-11H2,1H3/t12-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319580
((2S)-4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O |r| Show InChI InChI=1S/C17H21N3O3S/c1-18-13-15(21)11-12-19-16-9-5-6-10-17(16)20(24(19,22)23)14-7-3-2-4-8-14/h2-10,15,18,21H,11-13H2,1H3/t15-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319579
(4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H...)Show InChI InChI=1S/C17H21N3O3S/c1-18-13-15(21)11-12-19-16-9-5-6-10-17(16)20(24(19,22)23)14-7-3-2-4-8-14/h2-10,15,18,21H,11-13H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM28031
(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM28031
(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
(FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50023342
(CHEMBL3334567)Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
(FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319577
(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)Show InChI InChI=1S/C16H18FN3O2S/c1-18-11-6-12-19-15-9-4-5-10-16(15)20(23(19,21)22)14-8-3-2-7-13(14)17/h2-5,7-10,18H,6,11-12H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319575
((2S)-(4-[3-(2,5-Difluorophenyl)-2,2-dioxido-2,1,3-...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2cc(F)ccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H19F2N3O3S/c1-20-11-13(23)8-9-21-15-4-2-3-5-16(15)22(26(21,24)25)17-10-12(18)6-7-14(17)19/h2-7,10,13,20,23H,8-9,11H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319583
((2R)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human NET expressed in MDCK-Net6 cells assessed as inhibition of norepinephrine uptake |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319583
((2R)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319585
((2R)-4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol...)Show SMILES CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O |r| Show InChI InChI=1S/C17H21N3O3S/c1-18-13-15(21)11-12-19-16-9-5-6-10-17(16)20(24(19,22)23)14-7-3-2-4-8-14/h2-10,15,18,21H,11-13H2,1H3/t15-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human NET expressed in MDCK-Net6 cells assessed as inhibition of norepinephrine uptake |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319578
((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human NET expressed in MDCK-Net6 cells assessed as inhibition of norepinephrine uptake |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319581
((2S)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H19F2N3O3S/c1-20-11-12(23)9-10-21-15-7-2-3-8-16(15)22(26(21,24)25)17-13(18)5-4-6-14(17)19/h2-8,12,20,23H,9-11H2,1H3/t12-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319580
((2S)-4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2)S1(=O)=O |r| Show InChI InChI=1S/C17H21N3O3S/c1-18-13-15(21)11-12-19-16-9-5-6-10-17(16)20(24(19,22)23)14-7-3-2-4-8-14/h2-10,15,18,21H,11-13H2,1H3/t15-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319583
((2R)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319582
(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)Show InChI InChI=1S/C17H20FN3O2S/c1-19-12-6-7-13-20-16-10-4-5-11-17(16)21(24(20,22)23)15-9-3-2-8-14(15)18/h2-5,8-11,19H,6-7,12-13H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353928
(CHEMBL1830879)Show SMILES O=S1(=O)N(CC[C@@H]2CNCCO2)c2ccccc2N1c1ccccc1 |r| Show InChI InChI=1S/C18H21N3O3S/c22-25(23)20(12-10-16-14-19-11-13-24-16)17-8-4-5-9-18(17)21(25)15-6-2-1-3-7-15/h1-9,16,19H,10-14H2/t16-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353935
(CHEMBL1830885)Show SMILES Fc1ccccc1N1c2ccccc2N(CC[C@@H]2CNCCO2)S1(=O)=O |r| Show InChI InChI=1S/C18H20FN3O3S/c19-15-5-1-2-6-16(15)22-18-8-4-3-7-17(18)21(26(22,23)24)11-9-14-13-20-10-12-25-14/h1-8,14,20H,9-13H2/t14-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353940
(CHEMBL1828653)Show SMILES Fc1cccc2N(c3ccccc3F)S(=O)(=O)N(CCC3CNCCO3)c12 Show InChI InChI=1S/C18H19F2N3O3S/c19-14-4-1-2-6-16(14)23-17-7-3-5-15(20)18(17)22(27(23,24)25)10-8-13-12-21-9-11-26-13/h1-7,13,21H,8-12H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319602
(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)Show InChI InChI=1S/C17H20FN3O2S/c1-13(19-2)11-12-20-16-9-5-6-10-17(16)21(24(20,22)23)15-8-4-3-7-14(15)18/h3-10,13,19H,11-12H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319576
(4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H...)Show InChI InChI=1S/C17H18FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,19H,10-12H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319586
((2R)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)Show SMILES CNC[C@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H19F2N3O3S/c1-20-11-12(23)9-10-21-15-7-2-3-8-16(15)22(26(21,24)25)17-13(18)5-4-6-14(17)19/h2-8,12,20,23H,9-11H2,1H3/t12-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319578
((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| Show InChI InChI=1S/C17H20FN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM17055
((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)Show SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 |r,t:10| Show InChI InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C beta 2 |
J Med Chem 46: 4021-31 (2003)
Article DOI: 10.1021/jm030115o BindingDB Entry DOI: 10.7270/Q2G44R1D |
More data for this Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM50133057
(17,20,23-trioxa-4,14,26-triazahexacyclo[24.6.1.17,...)Show SMILES O=C1NC(=O)C2=C1c1cn(CCOCCOCCOCCn3cc2c2ccccc32)c2ccccc12 |c:5| Show InChI InChI=1S/C28H27N3O5/c32-27-25-21-17-30(23-7-3-1-5-19(21)23)9-11-34-13-15-36-16-14-35-12-10-31-18-22(26(25)28(33)29-27)20-6-2-4-8-24(20)31/h1-8,17-18H,9-16H2,(H,29,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C beta 2 |
J Med Chem 46: 4021-31 (2003)
Article DOI: 10.1021/jm030115o BindingDB Entry DOI: 10.7270/Q2G44R1D |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353926
(CHEMBL1830877)Show InChI InChI=1S/C18H21N3O3S/c22-25(23)20(12-10-16-14-19-11-13-24-16)17-8-4-5-9-18(17)21(25)15-6-2-1-3-7-15/h1-9,16,19H,10-14H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319587
(CHEMBL1084042 | {3-[3-(2-Fluoro-phenyl)-2,2-dioxo-...)Show InChI InChI=1S/C17H20FN3O2S/c1-13(11-12-19-2)20-16-9-5-6-10-17(16)21(24(20,22)23)15-8-4-3-7-14(15)18/h3-10,13,19H,11-12H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353942
(CHEMBL1830892)Show SMILES Fc1cccc2N(CCC3CNCCO3)S(=O)(=O)N(c12)c1ccccc1F Show InChI InChI=1S/C18H19F2N3O3S/c19-14-4-1-2-6-16(14)23-18-15(20)5-3-7-17(18)22(27(23,24)25)10-8-13-12-21-9-11-26-13/h1-7,13,21H,8-12H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human NET expressed in MDCK-Net6 cells assessed as inhibition of norepinephrine uptake |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353943
(CHEMBL1830890)Show SMILES Fc1ccc2N(c3ccccc3F)S(=O)(=O)N(CCC3CNCCO3)c2c1 Show InChI InChI=1S/C18H19F2N3O3S/c19-13-5-6-17-18(11-13)22(9-7-14-12-21-8-10-26-14)27(24,25)23(17)16-4-2-1-3-15(16)20/h1-6,11,14,21H,7-10,12H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50319590
((2S)-(4-[3-(2-Chlorophenyl)-2,2-dioxido-2,1,3-benz...)Show SMILES CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2Cl)S1(=O)=O |r| Show InChI InChI=1S/C17H20ClN3O3S/c1-19-12-13(22)10-11-20-16-8-4-5-9-17(16)21(25(20,23)24)15-7-3-2-6-14(15)18/h2-9,13,19,22H,10-12H2,1H3/t13-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 4511-21 (2010)
Article DOI: 10.1021/jm100053t BindingDB Entry DOI: 10.7270/Q2PC32JR |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353927
(CHEMBL1830878)Show SMILES O=S1(=O)N(CC[C@H]2CNCCO2)c2ccccc2N1c1ccccc1 |r| Show InChI InChI=1S/C18H21N3O3S/c22-25(23)20(12-10-16-14-19-11-13-24-16)17-8-4-5-9-18(17)21(25)15-6-2-1-3-7-15/h1-9,16,19H,10-14H2/t16-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |