Found 29 hits with Last Name = 'ray' and Initial = 'pc' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299378
(CHEMBL575340 | N4-(2,3-dihydro-1H-inden-2-yl)-2-(p...)Show SMILES C1C(Cc2ccccc12)Nc1cc(Nc2ccncc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C22H25N7/c1-2-4-17-14-19(13-16(17)3-1)26-21-15-20(25-18-5-7-23-8-6-18)27-22(28-21)29-11-9-24-10-12-29/h1-8,15,19,24H,9-14H2,(H2,23,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299360
(CHEMBL575741 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccncc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C21H24N8/c1-2-4-16-14-18(13-15(16)3-1)25-20-26-19(24-17-5-7-22-8-6-17)27-21(28-20)29-11-9-23-10-12-29/h1-8,18,23H,9-14H2,(H2,22,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299366
(4-(2,3-dihydro-1H-inden-2-yloxy)-6-(piperazin-1-yl...)Show SMILES C1C(Cc2ccccc12)Oc1nc(Nc2ccncc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C21H23N7O/c1-2-4-16-14-18(13-15(16)3-1)29-21-26-19(24-17-5-7-22-8-6-17)25-20(27-21)28-11-9-23-10-12-28/h1-8,18,23H,9-14H2,(H,22,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299374
((R)-N2-(2,3-dihydro-1H-inden-2-yl)-6-(3-methylpipe...)Show SMILES C[C@@H]1CN(CCN1)c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1 |r| Show InChI InChI=1S/C22H26N8/c1-15-14-30(11-10-24-15)22-28-20(25-18-6-8-23-9-7-18)27-21(29-22)26-19-12-16-4-2-3-5-17(16)13-19/h2-9,15,19,24H,10-14H2,1H3,(H2,23,25,26,27,28,29)/t15-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299372
(6-(1,4-diazepan-1-yl)-N2-(2,3-dihydro-1H-inden-2-y...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccncc2)nc(n1)N1CCCNCC1 Show InChI InChI=1S/C22H26N8/c1-2-5-17-15-19(14-16(17)4-1)26-21-27-20(25-18-6-9-24-10-7-18)28-22(29-21)30-12-3-8-23-11-13-30/h1-2,4-7,9-10,19,23H,3,8,11-15H2,(H2,24,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299378
(CHEMBL575340 | N4-(2,3-dihydro-1H-inden-2-yl)-2-(p...)Show SMILES C1C(Cc2ccccc12)Nc1cc(Nc2ccncc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C22H25N7/c1-2-4-17-14-19(13-16(17)3-1)26-21-15-20(25-18-5-7-23-8-6-18)27-22(28-21)29-11-9-24-10-12-29/h1-8,15,19,24H,9-14H2,(H2,23,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 in human THP1 cells assessed as inhibition of MCP1-induced cell migration |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299379
(CHEMBL578643 | N4-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1cc(nc(Nc2ccncc2)n1)N1CCNCC1 Show InChI InChI=1S/C22H25N7/c1-2-4-17-14-19(13-16(17)3-1)25-20-15-21(29-11-9-24-10-12-29)28-22(27-20)26-18-5-7-23-8-6-18/h1-8,15,19,24H,9-14H2,(H2,23,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299372
(6-(1,4-diazepan-1-yl)-N2-(2,3-dihydro-1H-inden-2-y...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccncc2)nc(n1)N1CCCNCC1 Show InChI InChI=1S/C22H26N8/c1-2-5-17-15-19(14-16(17)4-1)26-21-27-20(25-18-6-9-24-10-7-18)28-22(29-21)30-12-3-8-23-11-13-30/h1-2,4-7,9-10,19,23H,3,8,11-15H2,(H2,24,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 in human THP1 cells assessed as inhibition of MCP1-induced cell migration |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299364
(6-(piperazin-1-yl)-N2-(pyridin-4-yl)-N4-(1,2,3,4-t...)Show SMILES C1CN(CCN1)c1nc(NC2CCc3ccccc3C2)nc(Nc2ccncc2)n1 Show InChI InChI=1S/C22H26N8/c1-2-4-17-15-19(6-5-16(17)3-1)26-21-27-20(25-18-7-9-23-10-8-18)28-22(29-21)30-13-11-24-12-14-30/h1-4,7-10,19,24H,5-6,11-15H2,(H2,23,25,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299374
((R)-N2-(2,3-dihydro-1H-inden-2-yl)-6-(3-methylpipe...)Show SMILES C[C@@H]1CN(CCN1)c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1 |r| Show InChI InChI=1S/C22H26N8/c1-15-14-30(11-10-24-15)22-28-20(25-18-6-8-23-9-7-18)27-21(29-22)26-19-12-16-4-2-3-5-17(16)13-19/h2-9,15,19,24H,10-14H2,1H3,(H2,23,25,26,27,28,29)/t15-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 in human THP1 cells assessed as inhibition of MCP1-induced cell migration |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299360
(CHEMBL575741 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccncc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C21H24N8/c1-2-4-16-14-18(13-15(16)3-1)25-20-26-19(24-17-5-7-22-8-6-17)27-21(28-20)29-11-9-23-10-12-29/h1-8,18,23H,9-14H2,(H2,22,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 in human THP1 cells assessed as inhibition of MCP1-induced cell migration |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299366
(4-(2,3-dihydro-1H-inden-2-yloxy)-6-(piperazin-1-yl...)Show SMILES C1C(Cc2ccccc12)Oc1nc(Nc2ccncc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C21H23N7O/c1-2-4-16-14-18(13-15(16)3-1)29-21-26-19(24-17-5-7-22-8-6-17)25-20(27-21)28-11-9-23-10-12-28/h1-8,18,23H,9-14H2,(H,22,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 in human THP1 cells assessed as inhibition of MCP1-induced cell migration |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299373
(CHEMBL577177 | N2-(2,3-dihydro-1H-inden-2-yl)-N4-m...)Show SMILES CNCCN(C)c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1 Show InChI InChI=1S/C21H26N8/c1-22-11-12-29(2)21-27-19(24-17-7-9-23-10-8-17)26-20(28-21)25-18-13-15-5-3-4-6-16(15)14-18/h3-10,18,22H,11-14H2,1-2H3,(H2,23,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299377
((S)-N2-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpipe...)Show SMILES C[C@H]1CNCCN1c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1 |r| Show InChI InChI=1S/C22H26N8/c1-15-14-24-10-11-30(15)22-28-20(25-18-6-8-23-9-7-18)27-21(29-22)26-19-12-16-4-2-3-5-17(16)13-19/h2-9,15,19,24H,10-14H2,1H3,(H2,23,25,26,27,28,29)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299376
((R)-N2-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpipe...)Show SMILES C[C@@H]1CNCCN1c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1 |r| Show InChI InChI=1S/C22H26N8/c1-15-14-24-10-11-30(15)22-28-20(25-18-6-8-23-9-7-18)27-21(29-22)26-19-12-16-4-2-3-5-17(16)13-19/h2-9,15,19,24H,10-14H2,1H3,(H2,23,25,26,27,28,29)/t15-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299375
((S)-N2-(2,3-dihydro-1H-inden-2-yl)-6-(3-methylpipe...)Show SMILES C[C@H]1CN(CCN1)c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1 |r| Show InChI InChI=1S/C22H26N8/c1-15-14-30(11-10-24-15)22-28-20(25-18-6-8-23-9-7-18)27-21(29-22)26-19-12-16-4-2-3-5-17(16)13-19/h2-9,15,19,24H,10-14H2,1H3,(H2,23,25,26,27,28,29)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299379
(CHEMBL578643 | N4-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1cc(nc(Nc2ccncc2)n1)N1CCNCC1 Show InChI InChI=1S/C22H25N7/c1-2-4-17-14-19(13-16(17)3-1)25-20-15-21(29-11-9-24-10-12-29)28-22(27-20)26-18-5-7-23-8-6-18/h1-8,15,19,24H,9-14H2,(H2,23,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 in human THP1 cells assessed as inhibition of MCP1-induced cell migration |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299365
(CHEMBL567603 | N2-(2,3-dihydro-1H-inden-1-yl)-6-(p...)Show SMILES C1Cc2ccccc2C1Nc1nc(Nc2ccncc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C21H24N8/c1-2-4-17-15(3-1)5-6-18(17)25-20-26-19(24-16-7-9-22-10-8-16)27-21(28-20)29-13-11-23-12-14-29/h1-4,7-10,18,23H,5-6,11-14H2,(H2,22,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299371
(CHEMBL573152 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(4...)Show SMILES CN1CCN(CC1)c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1 Show InChI InChI=1S/C22H26N8/c1-29-10-12-30(13-11-29)22-27-20(24-18-6-8-23-9-7-18)26-21(28-22)25-19-14-16-4-2-3-5-17(16)15-19/h2-9,19H,10-15H2,1H3,(H2,23,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 305 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299362
(CHEMBL575798 | N2-phenethyl-6-(piperazin-1-yl)-N4-...)Show InChI InChI=1S/C20H24N8/c1-2-4-16(5-3-1)6-11-23-18-25-19(24-17-7-9-21-10-8-17)27-20(26-18)28-14-12-22-13-15-28/h1-5,7-10,22H,6,11-15H2,(H2,21,23,24,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 326 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299363
(CHEMBL575555 | N2-benzyl-6-(piperazin-1-yl)-N4-(py...)Show InChI InChI=1S/C19H22N8/c1-2-4-15(5-3-1)14-22-17-24-18(23-16-6-8-20-9-7-16)26-19(25-17)27-12-10-21-11-13-27/h1-9,21H,10-14H2,(H2,20,22,23,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299361
(CHEMBL575962 | N2-cyclopentyl-6-(piperazin-1-yl)-N...)Show InChI InChI=1S/C17H24N8/c1-2-4-13(3-1)20-15-22-16(21-14-5-7-18-8-6-14)24-17(23-15)25-11-9-19-10-12-25/h5-8,13,19H,1-4,9-12H2,(H2,18,20,21,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299368
(CHEMBL575973 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccccn2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C21H24N8/c1-2-6-16-14-17(13-15(16)5-1)24-19-26-20(25-18-7-3-4-8-23-18)28-21(27-19)29-11-9-22-10-12-29/h1-8,17,22H,9-14H2,(H2,23,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299380
(CHEMBL572911 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccncc2)cc(n1)N1CCNCC1 Show InChI InChI=1S/C22H25N7/c1-2-4-17-14-19(13-16(17)3-1)26-22-27-20(25-18-5-7-23-8-6-18)15-21(28-22)29-11-9-24-10-12-29/h1-8,15,19,24H,9-14H2,(H2,23,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299369
(CHEMBL575974 | N2-(2,3-dihydro-1H-inden-2-yl)-N4-p...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccccc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C22H25N7/c1-2-8-18(9-3-1)24-20-26-21(28-22(27-20)29-12-10-23-11-13-29)25-19-14-16-6-4-5-7-17(16)15-19/h1-9,19,23H,10-15H2,(H2,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299370
(CHEMBL573151 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2ccncc2)nc(n1)N1CCCCC1 Show InChI InChI=1S/C22H25N7/c1-4-12-29(13-5-1)22-27-20(24-18-8-10-23-11-9-18)26-21(28-22)25-19-14-16-6-2-3-7-17(16)15-19/h2-3,6-11,19H,1,4-5,12-15H2,(H2,23,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50299367
(CHEMBL575761 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(p...)Show SMILES C1C(Cc2ccccc12)Nc1nc(Nc2cccnc2)nc(n1)N1CCNCC1 Show InChI InChI=1S/C21H24N8/c1-2-5-16-13-18(12-15(16)4-1)25-20-26-19(24-17-6-3-7-23-14-17)27-21(28-20)29-10-8-22-9-11-29/h1-7,14,18,22H,8-13H2,(H2,24,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of ROCK1 by IMAP assay |
Bioorg Med Chem Lett 19: 6027-31 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50557135
(CHEMBL2098048 | SB-615575 | TCMDC-142445) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01727 BindingDB Entry DOI: 10.7270/Q2X92FZS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50557136
(CHEMBL4759520) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01727 BindingDB Entry DOI: 10.7270/Q2X92FZS |
More data for this Ligand-Target Pair | |