Found 374 hits with Last Name = 'rivier' and Initial = 'c' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085734
(CHEMBL407628 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](Cc3cnc[nH]3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C62H87ClN20O14/c1-5-38(73-33(4)84)53(89)79-43(24-34-12-14-36(63)15-13-34)57(93)80-44(25-35-9-6-19-67-28-35)58(94)81-46-27-50(86)71-30-47(51(64)87)82-60(96)48-11-8-22-83(48)61(97)41-18-21-69-52(88)45(26-37-29-68-31-72-37)74-49(85)17-16-40(76-59(46)95)55(91)75-39(10-7-20-70-62(65)66)54(90)78-42(23-32(2)3)56(92)77-41/h6,9,12-15,19,28-29,31-32,38-48H,5,7-8,10-11,16-18,20-27,30H2,1-4H3,(H2,64,87)(H,68,72)(H,69,88)(H,71,86)(H,73,84)(H,74,85)(H,75,91)(H,76,95)(H,77,92)(H,78,90)(H,79,89)(H,80,93)(H,81,94)(H,82,96)(H4,65,66,70)/t38-,39-,40-,41?,42+,43-,44-,45+,46-,47?,48-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085777
(CHEMBL386166 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCNC(=O)CNC(=O)C[C@@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3cccnc3)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C66H85ClN18O14/c1-35(2)25-45-58(92)78-44(12-7-22-73-66(69)70)65(99)85-24-8-13-52(85)64(98)84-51(56(68)90)33-74-53(87)31-50-63(97)77-43(57(91)80-47(60(94)79-45)28-38-14-17-40-10-4-5-11-41(40)26-38)20-23-72-55(89)34-75-54(88)30-49(76-36(3)86)62(96)81-46(27-37-15-18-42(67)19-16-37)59(93)82-48(61(95)83-50)29-39-9-6-21-71-32-39/h4-6,9-11,14-19,21,26,32,35,43-52H,7-8,12-13,20,22-25,27-31,33-34H2,1-3H3,(H2,68,90)(H,72,89)(H,74,87)(H,75,88)(H,76,86)(H,77,97)(H,78,92)(H,79,94)(H,80,91)(H,81,96)(H,82,93)(H,83,95)(H,84,98)(H4,69,70,73)/t43-,44+,45-,46+,47-,48-,49-,50-,51-,52-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085807
(CHEMBL425966 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCC(=O)NCC(=O)NCC[C@@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)NC(CNC(=O)C[C@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC(C)=O)C(=O)N2)C(N)=O Show InChI InChI=1S/C67H87FN18O14/c1-36(2)27-47-60(94)80-46-22-25-73-56(90)35-76-54(88)21-20-45(59(93)78-44(58(92)81-47)12-7-24-74-67(70)71)79-64(98)51(32-55(89)75-34-52(57(69)91)85-65(99)53-13-8-26-86(53)66(46)100)84-63(97)50(31-40-9-6-23-72-33-40)83-62(96)49(29-38-15-18-43(68)19-16-38)82-61(95)48(77-37(3)87)30-39-14-17-41-10-4-5-11-42(41)28-39/h4-6,9-11,14-19,23,28,33,36,44-53H,7-8,12-13,20-22,24-27,29-32,34-35H2,1-3H3,(H2,69,91)(H,73,90)(H,75,89)(H,76,88)(H,77,87)(H,78,93)(H,79,98)(H,80,94)(H,81,92)(H,82,95)(H,83,96)(H,84,97)(H,85,99)(H4,70,71,74)/t44-,45-,46+,47-,48+,49-,50+,51-,52?,53-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085756
(CHEMBL439532 | cyclo(1,1'-3)Ac-D-Asp (Gly)-D-Cpa-D...)Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O Show InChI InChI=1S/C68H91ClN16O15/c1-37(2)29-49(61(94)79-48(14-9-27-74-68(71)72)67(100)85-28-10-15-55(85)66(99)76-38(3)58(70)91)80-63(96)52(33-42-16-21-43-11-5-6-12-44(43)30-42)82-62(95)51(32-41-19-24-46(88)25-20-41)83-65(98)54(36-86)84-60(93)47-13-7-8-26-73-59(92)50(31-40-17-22-45(69)23-18-40)81-64(97)53(77-39(4)87)34-56(89)75-35-57(90)78-47/h5-6,11-12,16-25,30,37-38,47-55,86,88H,7-10,13-15,26-29,31-36H2,1-4H3,(H2,70,91)(H,73,92)(H,75,89)(H,76,99)(H,77,87)(H,78,90)(H,79,94)(H,80,96)(H,81,97)(H,82,95)(H,83,98)(H,84,93)(H4,71,72,74)/t38?,47-,48+,49-,50-,51+,52?,53?,54+,55-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293 |
J Med Chem 43: 797-806 (2000)
BindingDB Entry DOI: 10.7270/Q2DF6QD5 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085791
(CHEMBL265240 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCNC(=O)CCNC(=O)C[C@@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C70H89ClN18O14/c1-37(2)28-49-62(96)82-48(14-8-24-77-70(73)74)69(103)89-27-9-15-56(89)68(102)88-55(60(72)94)36-79-59(93)34-54-67(101)81-47(61(95)84-51(64(98)83-49)31-40-16-19-41-10-4-5-11-42(41)29-40)22-25-75-57(91)23-26-76-58(92)33-53(80-38(3)90)66(100)85-50(30-39-17-20-44(71)21-18-39)63(97)86-52(65(99)87-54)32-43-35-78-46-13-7-6-12-45(43)46/h4-7,10-13,16-21,29,35,37,47-56,78H,8-9,14-15,22-28,30-34,36H2,1-3H3,(H2,72,94)(H,75,91)(H,76,92)(H,79,93)(H,80,90)(H,81,101)(H,82,96)(H,83,98)(H,84,95)(H,85,100)(H,86,97)(H,87,99)(H,88,102)(H4,73,74,77)/t47-,48+,49-,50+,51-,52-,53-,54-,55-,56-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153477
(CHEMBL3775524)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(C)(C)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C177H298N50O49/c1-31-34-48-104(203-154(259)114(59-66-132(236)237)210-158(263)121(77-90(10)11)219-167(272)136(94(18)19)222-155(260)115(60-67-133(238)239)209-149(254)109(54-45-73-193-174(187)188)206-157(262)119(75-88(6)7)214-159(264)120(76-89(8)9)215-161(266)124(80-103-85-189-86-194-103)217-160(265)123(79-102-46-37-36-38-47-102)220-168(273)138(100(25)228)223-164(269)122(78-91(12)13)216-163(268)126(82-135(242)243)199-101(26)229)144(249)195-96(21)140(245)200-107(52-43-71-191-172(183)184)145(250)196-97(22)141(246)202-113(58-65-131(234)235)153(258)211-116(56-63-128(180)231)165(270)226-176(29,83-92(14)15)170(275)198-98(23)142(247)201-111(55-62-127(179)230)152(257)208-112-57-64-130(233)190-70-42-40-51-110(221-169(274)175(27,28)225-143(248)99(24)197-146(112)251)151(256)218-125(81-129(181)232)162(267)207-108(53-44-72-192-173(185)186)148(253)204-106(50-39-41-69-178)150(255)213-118(74-87(4)5)156(261)205-105(49-35-32-2)147(252)212-117(61-68-134(240)241)166(271)227-177(30,84-93(16)17)171(276)224-137(139(182)244)95(20)33-3/h36-38,46-47,85-100,104-126,136-138,228H,31-35,39-45,48-84,178H2,1-30H3,(H2,179,230)(H2,180,231)(H2,181,232)(H2,182,244)(H,189,194)(H,190,233)(H,195,249)(H,196,250)(H,197,251)(H,198,275)(H,199,229)(H,200,245)(H,201,247)(H,202,246)(H,203,259)(H,204,253)(H,205,261)(H,206,262)(H,207,267)(H,208,257)(H,209,254)(H,210,263)(H,211,258)(H,212,252)(H,213,255)(H,214,264)(H,215,266)(H,216,268)(H,217,265)(H,218,256)(H,219,272)(H,220,273)(H,221,274)(H,222,260)(H,223,269)(H,224,276)(H,225,248)(H,226,270)(H,227,271)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H4,183,184,191)(H4,185,186,192)(H4,187,188,193)/t95?,96?,97-,98-,99-,100+,104?,105?,106-,107-,108?,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123+,124-,125-,126-,136-,137-,138-,176?,177?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085715
(CHEMBL266300 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)CNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C58H83ClN18O14/c1-5-35(68-31(4)78)49(83)73-40(24-32-12-14-34(59)15-13-32)53(87)74-41(25-33-9-6-19-63-27-33)54(88)75-42-26-46(80)66-28-43(48(60)82)76-56(90)44-11-8-22-77(44)57(91)38-18-21-64-47(81)29-67-45(79)17-16-37(70-55(42)89)51(85)69-36(10-7-20-65-58(61)62)50(84)72-39(23-30(2)3)52(86)71-38/h6,9,12-15,19,27,30,35-44H,5,7-8,10-11,16-18,20-26,28-29H2,1-4H3,(H2,60,82)(H,64,81)(H,66,80)(H,67,79)(H,68,78)(H,69,85)(H,70,89)(H,71,86)(H,72,84)(H,73,83)(H,74,87)(H,75,88)(H,76,90)(H4,61,62,65)/t35-,36-,37-,38?,39+,40-,41-,42-,43?,44-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153499
(CHEMBL3774658)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(Cc2cnc[nH]2)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C177H296N52O47/c1-30-33-47-106(206-155(259)115(57-63-133(236)237)214-159(263)122(74-90(10)11)223-169(273)137(94(18)19)225-156(260)116(58-64-134(238)239)213-151(255)112(53-44-70-194-175(187)188)210-158(262)120(72-88(6)7)218-160(264)121(73-89(8)9)219-163(267)126(78-105-84-190-86-196-105)221-161(265)124(76-103-45-36-35-37-46-103)224-170(274)139(101(26)230)226-166(270)123(75-91(12)13)220-165(269)128(80-136(242)243)202-102(27)231)146(250)199-98(23)143(247)203-110(51-42-68-192-173(183)184)147(251)198-96(21)141(245)197-97(22)142(246)205-117(55-61-130(180)233)167(271)228-176(28,81-92(14)15)171(275)201-100(25)145(249)204-113(54-60-129(179)232)154(258)212-114-56-62-132(235)191-67-41-39-50-109(209-162(266)125(77-104-83-189-85-195-104)216-144(248)99(24)200-148(114)252)153(257)222-127(79-131(181)234)164(268)211-111(52-43-69-193-174(185)186)150(254)207-108(49-38-40-66-178)152(256)217-119(71-87(4)5)157(261)208-107(48-34-31-2)149(253)215-118(59-65-135(240)241)168(272)229-177(29,82-93(16)17)172(276)227-138(140(182)244)95(20)32-3/h35-37,45-46,83-101,106-128,137-139,230H,30-34,38-44,47-82,178H2,1-29H3,(H2,179,232)(H2,180,233)(H2,181,234)(H2,182,244)(H,189,195)(H,190,196)(H,191,235)(H,197,245)(H,198,251)(H,199,250)(H,200,252)(H,201,275)(H,202,231)(H,203,247)(H,204,249)(H,205,246)(H,206,259)(H,207,254)(H,208,261)(H,209,266)(H,210,262)(H,211,268)(H,212,258)(H,213,255)(H,214,263)(H,215,253)(H,216,248)(H,217,256)(H,218,264)(H,219,267)(H,220,269)(H,221,265)(H,222,257)(H,223,273)(H,224,274)(H,225,260)(H,226,270)(H,227,276)(H,228,271)(H,229,272)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H4,183,184,192)(H4,185,186,193)(H4,187,188,194)/t95-,96-,97-,98-,99-,100-,101+,106?,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118?,119-,120-,121-,122-,123-,124+,125-,126-,127-,128-,137-,138-,139-,176?,177?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085742
(CHEMBL414350 | cyclo(1,1'-3)Ac-D-Asp (beta-Ala)-D-...)Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O Show InChI InChI=1S/C68H91ClN16O15/c1-37(2)30-49(61(94)79-48(13-8-27-75-68(71)72)67(100)85-29-9-14-55(85)66(99)76-38(3)58(70)91)80-63(96)52(34-42-15-20-43-10-5-6-11-44(43)31-42)82-62(95)51(33-41-18-23-46(88)24-19-41)83-65(98)54(36-86)84-60(93)47-12-7-26-74-59(92)50(32-40-16-21-45(69)22-17-40)81-64(97)53(77-39(4)87)35-57(90)73-28-25-56(89)78-47/h5-6,10-11,15-24,31,37-38,47-55,86,88H,7-9,12-14,25-30,32-36H2,1-4H3,(H2,70,91)(H,73,90)(H,74,92)(H,76,99)(H,77,87)(H,78,89)(H,79,94)(H,80,96)(H,81,97)(H,82,95)(H,83,98)(H,84,93)(H4,71,72,75)/t38?,47-,48+,49-,50-,51+,52?,53?,54+,55-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293 |
J Med Chem 43: 797-806 (2000)
BindingDB Entry DOI: 10.7270/Q2DF6QD5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153480
(CHEMBL3775195)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(C)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C176H296N50O49/c1-30-33-47-104(204-155(259)114(58-65-132(235)236)211-159(263)121(76-89(10)11)220-168(272)136(93(18)19)222-156(260)115(59-66-133(237)238)210-150(254)110(53-44-72-192-174(186)187)207-158(262)119(74-87(6)7)215-160(264)120(75-88(8)9)216-162(266)124(79-103-84-188-85-193-103)218-161(265)123(78-102-45-36-35-37-46-102)221-169(273)138(100(26)227)223-165(269)122(77-90(12)13)217-164(268)126(81-135(241)242)199-101(27)228)145(249)196-97(23)142(246)201-108(51-42-70-190-172(182)183)146(250)197-98(24)143(247)203-113(57-64-131(233)234)154(258)212-116(55-62-128(179)230)166(270)225-175(28,82-91(14)15)170(274)198-99(25)144(248)202-111(54-61-127(178)229)153(257)209-112-56-63-130(232)189-69-41-39-50-106(200-141(245)96(22)194-140(244)95(21)195-147(112)251)151(255)219-125(80-129(180)231)163(267)208-109(52-43-71-191-173(184)185)149(253)205-107(49-38-40-68-177)152(256)214-118(73-86(4)5)157(261)206-105(48-34-31-2)148(252)213-117(60-67-134(239)240)167(271)226-176(29,83-92(16)17)171(275)224-137(139(181)243)94(20)32-3/h35-37,45-46,84-100,104-126,136-138,227H,30-34,38-44,47-83,177H2,1-29H3,(H2,178,229)(H2,179,230)(H2,180,231)(H2,181,243)(H,188,193)(H,189,232)(H,194,244)(H,195,251)(H,196,249)(H,197,250)(H,198,274)(H,199,228)(H,200,245)(H,201,246)(H,202,248)(H,203,247)(H,204,259)(H,205,253)(H,206,261)(H,207,262)(H,208,267)(H,209,257)(H,210,254)(H,211,263)(H,212,258)(H,213,252)(H,214,256)(H,215,264)(H,216,266)(H,217,268)(H,218,265)(H,219,255)(H,220,272)(H,221,273)(H,222,260)(H,223,269)(H,224,275)(H,225,270)(H,226,271)(H,233,234)(H,235,236)(H,237,238)(H,239,240)(H,241,242)(H4,182,183,190)(H4,184,185,191)(H4,186,187,192)/t94?,95-,96-,97?,98-,99-,100+,104?,105?,106-,107-,108-,109?,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123+,124-,125-,126-,136-,137-,138-,175?,176?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085761
(CHEMBL437038 | cyclo(1,1'-3)Ac-D-Asp (Gaba)-D-Cpa-...)Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O Show InChI InChI=1S/C67H89ClN16O15/c1-36(2)28-47(59(92)78-46(12-7-26-73-67(70)71)66(99)84-27-9-13-54(84)65(98)75-37(3)57(69)90)79-61(94)50(32-41-15-20-42-10-5-6-11-43(42)29-41)81-60(93)49(31-40-18-23-45(87)24-19-40)82-64(97)53(35-85)83-63(96)52-34-74-58(91)48(30-39-16-21-44(68)22-17-39)80-62(95)51(76-38(4)86)33-56(89)72-25-8-14-55(88)77-52/h5-6,10-11,15-24,29,36-37,46-54,85,87H,7-9,12-14,25-28,30-35H2,1-4H3,(H2,69,90)(H,72,89)(H,74,91)(H,75,98)(H,76,86)(H,77,88)(H,78,92)(H,79,94)(H,80,95)(H,81,93)(H,82,97)(H,83,96)(H4,70,71,73)/t37?,46-,47+,48+,49-,50?,51?,52+,53-,54+/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293 |
J Med Chem 43: 797-806 (2000)
BindingDB Entry DOI: 10.7270/Q2DF6QD5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153473
(CHEMBL3775796)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C179H298N52O49/c1-29-32-46-106(207-157(263)116(57-64-135(240)241)215-161(267)123(75-91(10)11)225-171(277)139(95(18)19)227-158(264)117(58-65-136(242)243)214-152(258)112(52-43-71-196-177(189)190)211-160(266)121(73-89(6)7)220-162(268)122(74-90(8)9)221-165(271)127(79-105-85-192-87-198-105)223-163(269)125(77-103-44-35-34-36-45-103)226-172(278)141(101(25)232)228-168(274)124(76-92(12)13)222-167(273)129(81-138(246)247)203-102(26)233)147(253)199-97(21)143(249)204-110(50-41-69-194-175(185)186)148(254)200-98(22)144(250)206-115(56-63-134(238)239)156(262)216-118(54-61-131(182)235)169(275)230-178(27,82-93(14)15)173(279)202-100(24)146(252)205-113(53-60-130(181)234)155(261)213-114-55-62-133(237)193-68-40-38-49-109(210-164(270)126(78-104-84-191-86-197-104)218-145(251)99(23)201-149(114)255)154(260)224-128(80-132(183)236)166(272)212-111(51-42-70-195-176(187)188)151(257)208-108(48-37-39-67-180)153(259)219-120(72-88(4)5)159(265)209-107(47-33-30-2)150(256)217-119(59-66-137(244)245)170(276)231-179(28,83-94(16)17)174(280)229-140(142(184)248)96(20)31-3/h34-36,44-45,84-101,106-129,139-141,232H,29-33,37-43,46-83,180H2,1-28H3,(H2,181,234)(H2,182,235)(H2,183,236)(H2,184,248)(H,191,197)(H,192,198)(H,193,237)(H,199,253)(H,200,254)(H,201,255)(H,202,279)(H,203,233)(H,204,249)(H,205,252)(H,206,250)(H,207,263)(H,208,257)(H,209,265)(H,210,270)(H,211,266)(H,212,272)(H,213,261)(H,214,258)(H,215,267)(H,216,262)(H,217,256)(H,218,251)(H,219,259)(H,220,268)(H,221,271)(H,222,273)(H,223,269)(H,224,260)(H,225,277)(H,226,278)(H,227,264)(H,228,274)(H,229,280)(H,230,275)(H,231,276)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H4,185,186,194)(H4,187,188,195)(H4,189,190,196)/t96-,97-,98-,99-,100-,101+,106?,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125+,126-,127-,128-,129-,139-,140-,141-,178?,179?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085718
(CHEMBL410820 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](Cc3ccccc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C65H88ClN17O15/c1-5-41(73-36(4)84)56(89)79-47(30-38-17-19-40(66)20-18-38)60(93)80-48(31-39-14-9-24-69-33-39)61(94)81-49-32-53(86)72-34-50(54(67)87)82-63(96)51-16-11-27-83(51)64(97)44-23-26-70-55(88)46(29-37-12-7-6-8-13-37)74-52(85)22-21-43(76-62(49)95)58(91)75-42(15-10-25-71-65(68)98)57(90)78-45(28-35(2)3)59(92)77-44/h6-9,12-14,17-20,24,33,35,41-51H,5,10-11,15-16,21-23,25-32,34H2,1-4H3,(H2,67,87)(H,70,88)(H,72,86)(H,73,84)(H,74,85)(H,75,91)(H,76,95)(H,77,92)(H,78,90)(H,79,89)(H,80,93)(H,81,94)(H,82,96)(H3,68,71,98)/t41-,42-,43-,44?,45+,46+,47-,48-,49-,50?,51-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085710
(CHEMBL414756 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](CCCNC(N)=N)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C62H92ClN21O14/c1-5-37(74-33(4)85)52(90)80-43(27-34-14-16-36(63)17-15-34)56(94)81-44(28-35-10-6-21-69-30-35)57(95)82-45-29-49(87)73-31-46(50(64)88)83-59(97)47-13-9-25-84(47)60(98)41-20-24-70-51(89)38(11-7-22-71-61(65)66)75-48(86)19-18-40(77-58(45)96)54(92)76-39(12-8-23-72-62(67)68)53(91)79-42(26-32(2)3)55(93)78-41/h6,10,14-17,21,30,32,37-47H,5,7-9,11-13,18-20,22-29,31H2,1-4H3,(H2,64,88)(H,70,89)(H,73,87)(H,74,85)(H,75,86)(H,76,92)(H,77,96)(H,78,93)(H,79,91)(H,80,90)(H,81,94)(H,82,95)(H,83,97)(H4,65,66,71)(H4,67,68,72)/t37-,38+,39-,40-,41?,42+,43-,44-,45-,46?,47-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085719
(CHEMBL438543 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)CN(C)C(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C59H85ClN18O14/c1-6-36(68-32(4)79)50(84)73-41(25-33-13-15-35(60)16-14-33)54(88)74-42(26-34-10-7-20-64-28-34)55(89)75-43-27-46(80)67-29-44(49(61)83)76-57(91)45-12-9-23-78(45)58(92)39-19-22-65-47(81)30-77(5)48(82)18-17-38(70-56(43)90)52(86)69-37(11-8-21-66-59(62)63)51(85)72-40(24-31(2)3)53(87)71-39/h7,10,13-16,20,28,31,36-45H,6,8-9,11-12,17-19,21-27,29-30H2,1-5H3,(H2,61,83)(H,65,81)(H,67,80)(H,68,79)(H,69,86)(H,70,90)(H,71,87)(H,72,85)(H,73,84)(H,74,88)(H,75,89)(H,76,91)(H4,62,63,66)/t36-,37-,38-,39?,40+,41-,42-,43-,44?,45-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153579
(CHEMBL3774395)Show SMILES CCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C175H294N50O49/c1-29-33-37-56-128(231)197-123(84-133(240)241)161(266)214-119(80-91(13)14)162(267)221-136(98(22)226)166(271)218-120(81-99-47-38-36-39-48-99)158(263)215-121(82-100-85-187-86-192-100)159(264)213-117(78-89(9)10)157(262)212-116(77-88(7)8)155(260)204-106(55-46-75-191-172(185)186)147(252)207-112(62-69-131(236)237)153(258)220-134(92(15)16)165(270)217-118(79-90(11)12)156(261)208-111(61-68-130(234)235)152(257)201-101(49-34-30-2)142(247)193-94(18)138(243)198-104(53-44-73-189-170(181)182)143(248)194-95(19)139(244)200-110(60-67-129(232)233)151(256)209-113(58-65-125(178)228)163(268)224-173(23,24)167(272)196-96(20)140(245)199-108(57-64-124(177)227)150(255)206-109-59-66-127(230)188-72-43-41-52-107(219-168(273)174(25,26)223-141(246)97(21)195-144(109)249)149(254)216-122(83-126(179)229)160(265)205-105(54-45-74-190-171(183)184)146(251)202-103(51-40-42-71-176)148(253)211-115(76-87(5)6)154(259)203-102(50-35-31-3)145(250)210-114(63-70-132(238)239)164(269)225-175(27,28)169(274)222-135(137(180)242)93(17)32-4/h36,38-39,47-48,85-98,101-123,134-136,226H,29-35,37,40-46,49-84,176H2,1-28H3,(H2,177,227)(H2,178,228)(H2,179,229)(H2,180,242)(H,187,192)(H,188,230)(H,193,247)(H,194,248)(H,195,249)(H,196,272)(H,197,231)(H,198,243)(H,199,245)(H,200,244)(H,201,257)(H,202,251)(H,203,259)(H,204,260)(H,205,265)(H,206,255)(H,207,252)(H,208,261)(H,209,256)(H,210,250)(H,211,253)(H,212,262)(H,213,264)(H,214,266)(H,215,263)(H,216,254)(H,217,270)(H,218,271)(H,219,273)(H,220,258)(H,221,267)(H,222,274)(H,223,246)(H,224,268)(H,225,269)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H4,181,182,189)(H4,183,184,190)(H4,185,186,191)/t93-,94-,95-,96-,97-,98+,101?,102?,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121-,122-,123-,134-,135-,136-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153499
(CHEMBL3774658)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(Cc2cnc[nH]2)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C177H296N52O47/c1-30-33-47-106(206-155(259)115(57-63-133(236)237)214-159(263)122(74-90(10)11)223-169(273)137(94(18)19)225-156(260)116(58-64-134(238)239)213-151(255)112(53-44-70-194-175(187)188)210-158(262)120(72-88(6)7)218-160(264)121(73-89(8)9)219-163(267)126(78-105-84-190-86-196-105)221-161(265)124(76-103-45-36-35-37-46-103)224-170(274)139(101(26)230)226-166(270)123(75-91(12)13)220-165(269)128(80-136(242)243)202-102(27)231)146(250)199-98(23)143(247)203-110(51-42-68-192-173(183)184)147(251)198-96(21)141(245)197-97(22)142(246)205-117(55-61-130(180)233)167(271)228-176(28,81-92(14)15)171(275)201-100(25)145(249)204-113(54-60-129(179)232)154(258)212-114-56-62-132(235)191-67-41-39-50-109(209-162(266)125(77-104-83-189-85-195-104)216-144(248)99(24)200-148(114)252)153(257)222-127(79-131(181)234)164(268)211-111(52-43-69-193-174(185)186)150(254)207-108(49-38-40-66-178)152(256)217-119(71-87(4)5)157(261)208-107(48-34-31-2)149(253)215-118(59-65-135(240)241)168(272)229-177(29,82-93(16)17)172(276)227-138(140(182)244)95(20)32-3/h35-37,45-46,83-101,106-128,137-139,230H,30-34,38-44,47-82,178H2,1-29H3,(H2,179,232)(H2,180,233)(H2,181,234)(H2,182,244)(H,189,195)(H,190,196)(H,191,235)(H,197,245)(H,198,251)(H,199,250)(H,200,252)(H,201,275)(H,202,231)(H,203,247)(H,204,249)(H,205,246)(H,206,259)(H,207,254)(H,208,261)(H,209,266)(H,210,262)(H,211,268)(H,212,258)(H,213,255)(H,214,263)(H,215,253)(H,216,248)(H,217,256)(H,218,264)(H,219,267)(H,220,269)(H,221,265)(H,222,257)(H,223,273)(H,224,274)(H,225,260)(H,226,270)(H,227,276)(H,228,271)(H,229,272)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H4,183,184,192)(H4,185,186,193)(H4,187,188,194)/t95-,96-,97-,98-,99-,100-,101+,106?,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118?,119-,120-,121-,122-,123-,124+,125-,126-,127-,128-,137-,138-,139-,176?,177?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085799
(CHEMBL439083 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCNC(=O)CNC(=O)C[C@@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C69H87ClN18O14/c1-36(2)26-48-61(95)81-47(14-8-23-75-69(72)73)68(102)88-25-9-15-55(88)67(101)87-54(59(71)93)34-77-56(90)32-53-66(100)80-46(60(94)83-50(63(97)82-48)29-39-16-19-40-10-4-5-11-41(40)27-39)22-24-74-58(92)35-78-57(91)31-52(79-37(3)89)65(99)84-49(28-38-17-20-43(70)21-18-38)62(96)85-51(64(98)86-53)30-42-33-76-45-13-7-6-12-44(42)45/h4-7,10-13,16-21,27,33,36,46-55,76H,8-9,14-15,22-26,28-32,34-35H2,1-3H3,(H2,71,93)(H,74,92)(H,77,90)(H,78,91)(H,79,89)(H,80,100)(H,81,95)(H,82,97)(H,83,94)(H,84,99)(H,85,96)(H,86,98)(H,87,101)(H4,72,73,75)/t46-,47+,48-,49+,50-,51-,52-,53-,54-,55-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153574
(CHEMBL3775778)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C177H296N52O47/c1-30-33-47-106(206-156(260)116(58-64-134(238)239)214-160(264)122(74-90(10)11)223-169(273)137(94(18)19)225-157(261)117(59-65-135(240)241)213-151(255)112(53-44-70-194-175(187)188)210-159(263)120(72-88(6)7)218-161(265)121(73-89(8)9)219-164(268)126(78-105-84-190-86-196-105)221-162(266)124(76-103-45-36-35-37-46-103)224-170(274)139(101(26)230)226-167(271)123(75-91(12)13)220-166(270)128(80-136(242)243)202-102(27)231)146(250)197-96(21)141(245)203-110(51-42-68-192-173(183)184)148(252)198-97(22)142(246)205-115(57-63-133(236)237)155(259)215-118(55-61-130(180)233)168(272)229-176(28,81-92(14)15)171(275)201-99(24)144(248)204-113(54-60-129(179)232)154(258)212-114-56-62-132(235)191-67-41-39-50-109(209-163(267)125(77-104-83-189-85-195-104)216-143(247)98(23)199-149(114)253)153(257)222-127(79-131(181)234)165(269)211-111(52-43-69-193-174(185)186)150(254)207-108(49-38-40-66-178)152(256)217-119(71-87(4)5)158(262)208-107(48-34-31-2)147(251)200-100(25)145(249)228-177(29,82-93(16)17)172(276)227-138(140(182)244)95(20)32-3/h35-37,45-46,83-101,106-128,137-139,230H,30-34,38-44,47-82,178H2,1-29H3,(H2,179,232)(H2,180,233)(H2,181,234)(H2,182,244)(H,189,195)(H,190,196)(H,191,235)(H,197,250)(H,198,252)(H,199,253)(H,200,251)(H,201,275)(H,202,231)(H,203,245)(H,204,248)(H,205,246)(H,206,260)(H,207,254)(H,208,262)(H,209,267)(H,210,263)(H,211,269)(H,212,258)(H,213,255)(H,214,264)(H,215,259)(H,216,247)(H,217,256)(H,218,265)(H,219,268)(H,220,270)(H,221,266)(H,222,257)(H,223,273)(H,224,274)(H,225,261)(H,226,271)(H,227,276)(H,228,249)(H,229,272)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H4,183,184,192)(H4,185,186,193)(H4,187,188,194)/t95-,96-,97-,98-,99-,100-,101+,106?,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124+,125-,126-,127-,128-,137-,138-,139-,176?,177?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153481
(CHEMBL3774868)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc2ccc(NC(N)=O)cc2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C183H302N52O50/c1-29-32-46-109(211-160(267)119(61-68-138(244)245)219-164(271)126(79-93(10)11)229-174(281)142(97(18)19)231-161(268)120(62-69-139(246)247)218-155(262)115(52-43-75-200-180(193)194)215-163(270)124(77-91(6)7)224-165(272)125(78-92(8)9)225-168(275)130(83-108-88-196-89-201-108)227-167(274)129(81-105-44-35-34-36-45-105)230-175(282)144(103(25)236)232-171(278)127(80-94(12)13)226-170(277)132(85-141(250)251)206-104(26)237)150(257)202-99(21)146(253)208-113(50-41-73-198-178(189)190)151(258)203-100(22)147(254)210-118(60-67-137(242)243)159(266)220-121(58-65-134(186)239)172(279)234-182(27,86-95(14)15)176(283)205-102(24)149(256)209-116(57-64-133(185)238)158(265)217-117-59-66-136(241)197-72-40-38-49-112(214-166(273)128(222-148(255)101(23)204-152(117)259)82-106-53-55-107(56-54-106)207-181(195)285)157(264)228-131(84-135(187)240)169(276)216-114(51-42-74-199-179(191)192)154(261)212-111(48-37-39-71-184)156(263)223-123(76-90(4)5)162(269)213-110(47-33-30-2)153(260)221-122(63-70-140(248)249)173(280)235-183(28,87-96(16)17)177(284)233-143(145(188)252)98(20)31-3/h34-36,44-45,53-56,88-103,109-132,142-144,236H,29-33,37-43,46-52,57-87,184H2,1-28H3,(H2,185,238)(H2,186,239)(H2,187,240)(H2,188,252)(H,196,201)(H,197,241)(H,202,257)(H,203,258)(H,204,259)(H,205,283)(H,206,237)(H,208,253)(H,209,256)(H,210,254)(H,211,267)(H,212,261)(H,213,269)(H,214,273)(H,215,270)(H,216,276)(H,217,265)(H,218,262)(H,219,271)(H,220,266)(H,221,260)(H,222,255)(H,223,263)(H,224,272)(H,225,275)(H,226,277)(H,227,274)(H,228,264)(H,229,281)(H,230,282)(H,231,268)(H,232,278)(H,233,284)(H,234,279)(H,235,280)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,189,190,198)(H4,191,192,199)(H4,193,194,200)(H3,195,207,285)/t98-,99-,100-,101-,102-,103+,109?,110?,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128+,129+,130-,131-,132-,142-,143-,144-,182?,183?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085797
(CHEMBL407361 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCNC(=O)[C@@H](C)NC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C71H91ClN18O14/c1-37(2)29-51-64(98)83-50(15-9-26-77-71(74)75)70(104)90-28-10-16-57(90)69(103)89-56(60(73)94)36-79-59(93)34-55-68(102)82-49(63(97)86-53(66(100)84-51)32-41-17-20-42-11-5-6-12-43(42)30-41)25-27-76-61(95)38(3)80-58(92)24-23-48(81-39(4)91)62(96)85-52(31-40-18-21-45(72)22-19-40)65(99)87-54(67(101)88-55)33-44-35-78-47-14-8-7-13-46(44)47/h5-8,11-14,17-22,30,35,37-38,48-57,78H,9-10,15-16,23-29,31-34,36H2,1-4H3,(H2,73,94)(H,76,95)(H,79,93)(H,80,92)(H,81,91)(H,82,102)(H,83,98)(H,84,100)(H,85,96)(H,86,97)(H,87,99)(H,88,101)(H,89,103)(H4,74,75,77)/t38-,48-,49-,50+,51-,52+,53-,54-,55-,56-,57-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085737
(CHEMBL438597 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C65H88Cl2N18O14/c1-5-41(75-35(4)86)56(91)81-47(29-37-14-18-40(67)19-15-37)60(95)82-48(30-38-9-6-23-71-32-38)61(96)83-49-31-53(88)74-33-50(54(68)89)84-63(98)51-11-8-26-85(51)64(99)44-22-25-72-55(90)46(28-36-12-16-39(66)17-13-36)76-52(87)21-20-43(78-62(49)97)58(93)77-42(10-7-24-73-65(69)70)57(92)80-45(27-34(2)3)59(94)79-44/h6,9,12-19,23,32,34,41-51H,5,7-8,10-11,20-22,24-31,33H2,1-4H3,(H2,68,89)(H,72,90)(H,74,88)(H,75,86)(H,76,87)(H,77,93)(H,78,97)(H,79,94)(H,80,92)(H,81,91)(H,82,95)(H,83,96)(H,84,98)(H4,69,70,73)/t41-,42-,43-,44?,45+,46+,47-,48-,49-,50?,51-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085720
(CHEMBL404930 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@H](Cc3ccccc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C65H89ClN18O14/c1-5-41(74-36(4)85)56(90)80-47(30-38-17-19-40(66)20-18-38)60(94)81-48(31-39-14-9-24-70-33-39)61(95)82-49-32-53(87)73-34-50(54(67)88)83-63(97)51-16-11-27-84(51)64(98)44-23-26-71-55(89)46(29-37-12-7-6-8-13-37)75-52(86)22-21-43(77-62(49)96)58(92)76-42(15-10-25-72-65(68)69)57(91)79-45(28-35(2)3)59(93)78-44/h6-9,12-14,17-20,24,33,35,41-51H,5,10-11,15-16,21-23,25-32,34H2,1-4H3,(H2,67,88)(H,71,89)(H,73,87)(H,74,85)(H,75,86)(H,76,92)(H,77,96)(H,78,93)(H,79,91)(H,80,90)(H,81,94)(H,82,95)(H,83,97)(H4,68,69,72)/t41-,42-,43-,44?,45+,46-,47-,48-,49-,50?,51-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085783
(CHEMBL438897 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCNC(=O)CNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C70H89ClN18O14/c1-37(2)28-50-63(97)82-49(14-8-25-76-70(73)74)69(103)89-27-9-15-56(89)68(102)88-55(60(72)94)35-78-58(92)33-54-67(101)81-48(62(96)85-52(65(99)83-50)31-40-16-19-41-10-4-5-11-42(41)29-40)24-26-75-59(93)36-79-57(91)23-22-47(80-38(3)90)61(95)84-51(30-39-17-20-44(71)21-18-39)64(98)86-53(66(100)87-54)32-43-34-77-46-13-7-6-12-45(43)46/h4-7,10-13,16-21,29,34,37,47-56,77H,8-9,14-15,22-28,30-33,35-36H2,1-3H3,(H2,72,94)(H,75,93)(H,78,92)(H,79,91)(H,80,90)(H,81,101)(H,82,97)(H,83,99)(H,84,95)(H,85,96)(H,86,98)(H,87,100)(H,88,102)(H4,73,74,76)/t47-,48-,49+,50-,51+,52-,53-,54-,55-,56-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153497
(CHEMBL3775030)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc1cccs1)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C180H294N52O49S/c1-28-30-45-107(208-157(263)116(55-62-136(241)242)215-160(266)123(74-91(9)10)226-172(278)140(95(17)18)228-158(264)117(56-63-137(243)244)214-152(258)112(50-40-69-197-178(190)191)211-159(265)120(71-88(3)4)220-161(267)122(73-90(7)8)221-165(271)127(78-105-85-193-87-199-105)223-163(269)125(76-103-42-32-31-33-43-103)227-173(279)142(101(24)233)229-169(275)124(75-92(11)12)222-168(274)130(81-139(247)248)204-102(25)234)148(254)200-97(20)144(250)205-110(48-38-67-195-176(186)187)149(255)201-98(21)145(251)207-115(54-61-135(239)240)156(262)216-118(52-59-132(183)236)170(276)231-179(26,82-93(13)14)174(280)203-100(23)147(253)206-113(51-58-131(182)235)155(261)213-114-53-60-134(238)194-66-37-35-47-109(210-164(270)126(77-104-84-192-86-198-104)218-146(252)99(22)202-150(114)256)154(260)225-129(80-133(184)237)167(273)212-111(49-39-68-196-177(188)189)151(257)209-108(46-34-36-65-181)153(259)219-121(72-89(5)6)162(268)224-128(79-106-44-41-70-282-106)166(272)217-119(57-64-138(245)246)171(277)232-180(27,83-94(15)16)175(281)230-141(143(185)249)96(19)29-2/h31-33,41-44,70,84-101,107-130,140-142,233H,28-30,34-40,45-69,71-83,181H2,1-27H3,(H2,182,235)(H2,183,236)(H2,184,237)(H2,185,249)(H,192,198)(H,193,199)(H,194,238)(H,200,254)(H,201,255)(H,202,256)(H,203,280)(H,204,234)(H,205,250)(H,206,253)(H,207,251)(H,208,263)(H,209,257)(H,210,270)(H,211,265)(H,212,273)(H,213,261)(H,214,258)(H,215,266)(H,216,262)(H,217,272)(H,218,252)(H,219,259)(H,220,267)(H,221,271)(H,222,274)(H,223,269)(H,224,268)(H,225,260)(H,226,278)(H,227,279)(H,228,264)(H,229,275)(H,230,281)(H,231,276)(H,232,277)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)/t96-,97-,98-,99-,100-,101+,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125+,126-,127-,128?,129-,130-,140-,141-,142-,179?,180?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085771
(CHEMBL436657 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CSSC[C@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C65H81ClN16O12S2/c1-34(2)24-45-56(86)74-44(14-8-22-70-65(68)69)64(94)82-23-9-15-53(82)63(93)80-50(55(67)85)31-72-54(84)29-49-60(90)81-52(62(92)77-47(58(88)75-45)27-37-16-19-38-10-4-5-11-39(38)25-37)33-96-95-32-51(73-35(3)83)61(91)76-46(26-36-17-20-41(66)21-18-36)57(87)78-48(59(89)79-49)28-40-30-71-43-13-7-6-12-42(40)43/h4-7,10-13,16-21,25,30,34,44-53,71H,8-9,14-15,22-24,26-29,31-33H2,1-3H3,(H2,67,85)(H,72,84)(H,73,83)(H,74,86)(H,75,88)(H,76,91)(H,77,92)(H,78,87)(H,79,89)(H,80,93)(H,81,90)(H4,68,69,70)/t44-,45+,46-,47+,48+,49+,50+,51-,52+,53+/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153498
(CHEMBL3774682)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc1ccsc1)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C180H294N52O49S/c1-28-30-43-107(208-157(263)116(53-60-136(241)242)215-160(266)123(73-91(9)10)226-172(278)140(95(17)18)228-158(264)117(54-61-137(243)244)214-152(258)112(48-40-68-197-178(190)191)211-159(265)120(70-88(3)4)220-161(267)122(72-90(7)8)221-166(272)128(78-106-84-193-87-199-106)224-164(270)125(75-103-41-32-31-33-42-103)227-173(279)142(101(24)233)229-169(275)124(74-92(11)12)222-168(274)130(80-139(247)248)204-102(25)234)148(254)200-97(20)144(250)205-110(46-38-66-195-176(186)187)149(255)201-98(21)145(251)207-115(52-59-135(239)240)156(262)216-118(50-57-132(183)236)170(276)231-179(26,81-93(13)14)174(280)203-100(23)147(253)206-113(49-56-131(182)235)155(261)213-114-51-58-134(238)194-65-37-35-45-109(210-165(271)127(77-105-83-192-86-198-105)218-146(252)99(22)202-150(114)256)154(260)225-129(79-133(184)237)167(273)212-111(47-39-67-196-177(188)189)151(257)209-108(44-34-36-64-181)153(259)219-121(71-89(5)6)162(268)223-126(76-104-63-69-282-85-104)163(269)217-119(55-62-138(245)246)171(277)232-180(27,82-94(15)16)175(281)230-141(143(185)249)96(19)29-2/h31-33,41-42,63,69,83-101,107-130,140-142,233H,28-30,34-40,43-62,64-68,70-82,181H2,1-27H3,(H2,182,235)(H2,183,236)(H2,184,237)(H2,185,249)(H,192,198)(H,193,199)(H,194,238)(H,200,254)(H,201,255)(H,202,256)(H,203,280)(H,204,234)(H,205,250)(H,206,253)(H,207,251)(H,208,263)(H,209,257)(H,210,271)(H,211,265)(H,212,273)(H,213,261)(H,214,258)(H,215,266)(H,216,262)(H,217,269)(H,218,252)(H,219,259)(H,220,267)(H,221,272)(H,222,274)(H,223,268)(H,224,270)(H,225,260)(H,226,278)(H,227,279)(H,228,264)(H,229,275)(H,230,281)(H,231,276)(H,232,277)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)/t96-,97-,98-,99-,100-,101+,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125+,126?,127-,128-,129-,130-,140-,141-,142-,179?,180?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085810
(CHEMBL406809 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCCNC(=O)CC[C@@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C70H90ClN17O13/c1-38(2)30-51-63(95)81-50(17-10-28-76-70(73)74)69(101)88-29-11-18-57(88)68(100)87-56(60(72)92)37-78-59(91)35-55-67(99)80-48(61(93)84-53(65(97)82-51)33-41-19-22-42-12-4-5-13-43(42)31-41)16-8-9-27-75-58(90)26-25-49(79-39(3)89)62(94)83-52(32-40-20-23-45(71)24-21-40)64(96)85-54(66(98)86-55)34-44-36-77-47-15-7-6-14-46(44)47/h4-7,12-15,19-24,31,36,38,48-57,77H,8-11,16-18,25-30,32-35,37H2,1-3H3,(H2,72,92)(H,75,90)(H,78,91)(H,79,89)(H,80,99)(H,81,95)(H,82,97)(H,83,94)(H,84,93)(H,85,96)(H,86,98)(H,87,100)(H4,73,74,76)/t48-,49-,50+,51-,52+,53-,54-,55-,56-,57-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity of the compound for rat Gonadotropin-releasing hormone receptor membrane evaluated using HEK-293 cells transfected with rat Gonadotropin-rel... |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153579
(CHEMBL3774395)Show SMILES CCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C175H294N50O49/c1-29-33-37-56-128(231)197-123(84-133(240)241)161(266)214-119(80-91(13)14)162(267)221-136(98(22)226)166(271)218-120(81-99-47-38-36-39-48-99)158(263)215-121(82-100-85-187-86-192-100)159(264)213-117(78-89(9)10)157(262)212-116(77-88(7)8)155(260)204-106(55-46-75-191-172(185)186)147(252)207-112(62-69-131(236)237)153(258)220-134(92(15)16)165(270)217-118(79-90(11)12)156(261)208-111(61-68-130(234)235)152(257)201-101(49-34-30-2)142(247)193-94(18)138(243)198-104(53-44-73-189-170(181)182)143(248)194-95(19)139(244)200-110(60-67-129(232)233)151(256)209-113(58-65-125(178)228)163(268)224-173(23,24)167(272)196-96(20)140(245)199-108(57-64-124(177)227)150(255)206-109-59-66-127(230)188-72-43-41-52-107(219-168(273)174(25,26)223-141(246)97(21)195-144(109)249)149(254)216-122(83-126(179)229)160(265)205-105(54-45-74-190-171(183)184)146(251)202-103(51-40-42-71-176)148(253)211-115(76-87(5)6)154(259)203-102(50-35-31-3)145(250)210-114(63-70-132(238)239)164(269)225-175(27,28)169(274)222-135(137(180)242)93(17)32-4/h36,38-39,47-48,85-98,101-123,134-136,226H,29-35,37,40-46,49-84,176H2,1-28H3,(H2,177,227)(H2,178,228)(H2,179,229)(H2,180,242)(H,187,192)(H,188,230)(H,193,247)(H,194,248)(H,195,249)(H,196,272)(H,197,231)(H,198,243)(H,199,245)(H,200,244)(H,201,257)(H,202,251)(H,203,259)(H,204,260)(H,205,265)(H,206,255)(H,207,252)(H,208,261)(H,209,256)(H,210,250)(H,211,253)(H,212,262)(H,213,264)(H,214,266)(H,215,263)(H,216,254)(H,217,270)(H,218,271)(H,219,273)(H,220,258)(H,221,267)(H,222,274)(H,223,246)(H,224,268)(H,225,269)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H4,181,182,189)(H4,183,184,190)(H4,185,186,191)/t93-,94-,95-,96-,97-,98+,101?,102?,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121-,122-,123-,134-,135-,136-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1]-PD-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085732
(CHEMBL406094 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCCNC(=O)C(Cc3ccccc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C66H91ClN18O14/c1-5-42(75-37(4)86)57(91)81-48(31-39-19-21-41(67)22-20-39)61(95)82-49(32-40-15-9-25-71-34-40)62(96)83-50-33-54(88)74-35-51(55(68)89)84-64(98)52-18-12-28-85(52)65(99)45-17-11-26-72-56(90)47(30-38-13-7-6-8-14-38)76-53(87)24-23-44(78-63(50)97)59(93)77-43(16-10-27-73-66(69)70)58(92)80-46(29-36(2)3)60(94)79-45/h6-9,13-15,19-22,25,34,36,42-52H,5,10-12,16-18,23-24,26-33,35H2,1-4H3,(H2,68,89)(H,72,90)(H,74,88)(H,75,86)(H,76,87)(H,77,93)(H,78,97)(H,79,94)(H,80,92)(H,81,91)(H,82,95)(H,83,96)(H,84,98)(H4,69,70,73)/t42-,43-,44-,45?,46+,47?,48-,49-,50-,51?,52-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085768
(CHEMBL268538 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1C=CCN1C(C)=O |c:104| Show InChI InChI=1S/C73H87FN16O13/c1-40(2)31-53-64(95)81-52(15-8-28-78-73(76)77)72(103)90-30-10-17-61(90)71(102)88-59(63(75)94)39-80-62(93)37-58(69(100)83-54(34-43-21-26-49(92)27-22-43)65(96)84-56(67(98)82-53)35-44-18-23-45-11-4-5-12-46(45)32-44)86-68(99)57(36-47-38-79-51-14-7-6-13-50(47)51)85-66(97)55(33-42-19-24-48(74)25-20-42)87-70(101)60-16-9-29-89(60)41(3)91/h4-7,9,11-14,16,18-27,32,38,40,52-61,79,92H,8,10,15,17,28-31,33-37,39H2,1-3H3,(H2,75,94)(H,80,93)(H,81,95)(H,82,98)(H,83,100)(H,84,96)(H,85,97)(H,86,99)(H,87,101)(H,88,102)(H4,76,77,78)/t52-,53-,54-,55-,56-,57+,58-,59?,60-,61-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153579
(CHEMBL3774395)Show SMILES CCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C175H294N50O49/c1-29-33-37-56-128(231)197-123(84-133(240)241)161(266)214-119(80-91(13)14)162(267)221-136(98(22)226)166(271)218-120(81-99-47-38-36-39-48-99)158(263)215-121(82-100-85-187-86-192-100)159(264)213-117(78-89(9)10)157(262)212-116(77-88(7)8)155(260)204-106(55-46-75-191-172(185)186)147(252)207-112(62-69-131(236)237)153(258)220-134(92(15)16)165(270)217-118(79-90(11)12)156(261)208-111(61-68-130(234)235)152(257)201-101(49-34-30-2)142(247)193-94(18)138(243)198-104(53-44-73-189-170(181)182)143(248)194-95(19)139(244)200-110(60-67-129(232)233)151(256)209-113(58-65-125(178)228)163(268)224-173(23,24)167(272)196-96(20)140(245)199-108(57-64-124(177)227)150(255)206-109-59-66-127(230)188-72-43-41-52-107(219-168(273)174(25,26)223-141(246)97(21)195-144(109)249)149(254)216-122(83-126(179)229)160(265)205-105(54-45-74-190-171(183)184)146(251)202-103(51-40-42-71-176)148(253)211-115(76-87(5)6)154(259)203-102(50-35-31-3)145(250)210-114(63-70-132(238)239)164(269)225-175(27,28)169(274)222-135(137(180)242)93(17)32-4/h36,38-39,47-48,85-98,101-123,134-136,226H,29-35,37,40-46,49-84,176H2,1-28H3,(H2,177,227)(H2,178,228)(H2,179,229)(H2,180,242)(H,187,192)(H,188,230)(H,193,247)(H,194,248)(H,195,249)(H,196,272)(H,197,231)(H,198,243)(H,199,245)(H,200,244)(H,201,257)(H,202,251)(H,203,259)(H,204,260)(H,205,265)(H,206,255)(H,207,252)(H,208,261)(H,209,256)(H,210,250)(H,211,253)(H,212,262)(H,213,264)(H,214,266)(H,215,263)(H,216,254)(H,217,270)(H,218,271)(H,219,273)(H,220,258)(H,221,267)(H,222,274)(H,223,246)(H,224,268)(H,225,269)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H4,181,182,189)(H4,183,184,190)(H4,185,186,191)/t93-,94-,95-,96-,97-,98+,101?,102?,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121-,122-,123-,134-,135-,136-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1]-PD-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085735
(CHEMBL412681 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Pal...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)Nc2ccc(C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O)cc2 Show InChI InChI=1S/C61H83ClN16O14/c1-6-40(69-34(5)79)52(84)74-44(27-35-13-17-38(62)18-14-35)56(88)75-45(29-37-10-7-23-66-31-37)57(89)76-46(30-50(81)82)58(90)72-42-21-22-49(80)70-39-19-15-36(16-20-39)28-47(60(92)78-25-9-12-48(78)59(91)68-33(4)51(63)83)77-55(87)43(26-32(2)3)73-53(85)41(71-54(42)86)11-8-24-67-61(64)65/h7,10,13-20,23,31-33,40-48H,6,8-9,11-12,21-22,24-30H2,1-5H3,(H2,63,83)(H,68,91)(H,69,79)(H,70,80)(H,71,86)(H,72,90)(H,73,85)(H,74,84)(H,75,88)(H,76,89)(H,77,87)(H,81,82)(H4,64,65,67)/t33-,40-,41+,42+,43-,44-,45-,46-,47-,48+/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153577
(CHEMBL3774465)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)CCC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C173H290N50O49/c1-29-33-48-99(199-150(255)109(59-66-128(232)233)206-154(259)116(77-88(11)12)215-163(268)132(90(15)16)218-151(256)110(60-67-129(234)235)205-145(250)104(54-44-73-189-170(183)184)202-153(258)114(75-86(7)8)210-155(260)115(76-87(9)10)211-157(262)119(80-98-83-185-84-190-98)213-156(261)118(79-97-46-36-35-37-47-97)216-164(269)134(96(22)224)219-160(265)117(78-89(13)14)212-159(264)121(82-131(238)239)195-126(229)45-31-3)140(245)191-92(18)136(241)196-102(52-42-71-187-168(179)180)141(246)192-93(19)137(242)198-108(58-65-127(230)231)149(254)207-111(56-63-123(176)226)161(266)222-171(23,24)165(270)194-94(20)138(243)197-106(55-62-122(175)225)148(253)204-107-57-64-125(228)186-70-41-39-51-105(217-166(271)172(25,26)221-139(244)95(21)193-142(107)247)147(252)214-120(81-124(177)227)158(263)203-103(53-43-72-188-169(181)182)144(249)200-101(50-38-40-69-174)146(251)209-113(74-85(5)6)152(257)201-100(49-34-30-2)143(248)208-112(61-68-130(236)237)162(267)223-173(27,28)167(272)220-133(135(178)240)91(17)32-4/h35-37,46-47,83-96,99-121,132-134,224H,29-34,38-45,48-82,174H2,1-28H3,(H2,175,225)(H2,176,226)(H2,177,227)(H2,178,240)(H,185,190)(H,186,228)(H,191,245)(H,192,246)(H,193,247)(H,194,270)(H,195,229)(H,196,241)(H,197,243)(H,198,242)(H,199,255)(H,200,249)(H,201,257)(H,202,258)(H,203,263)(H,204,253)(H,205,250)(H,206,259)(H,207,254)(H,208,248)(H,209,251)(H,210,260)(H,211,262)(H,212,264)(H,213,261)(H,214,252)(H,215,268)(H,216,269)(H,217,271)(H,218,256)(H,219,265)(H,220,272)(H,221,244)(H,222,266)(H,223,267)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H4,179,180,187)(H4,181,182,188)(H4,183,184,189)/t91-,92-,93-,94-,95-,96+,99?,100?,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,132-,133-,134-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1]-PD-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153482
(CHEMBL3775357)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(C)(CC(C)C)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C180H304N50O49/c1-32-35-49-107(206-157(262)117(60-67-135(239)240)213-161(266)124(78-92(10)11)222-170(275)139(97(20)21)225-158(263)118(61-68-136(241)242)212-152(257)112(55-46-74-196-177(190)191)209-160(265)122(76-90(6)7)217-162(267)123(77-91(8)9)218-164(269)127(81-106-87-192-88-197-106)220-163(268)126(80-105-47-38-37-39-48-105)223-171(276)141(103(27)231)226-167(272)125(79-93(12)13)219-166(271)129(83-138(245)246)202-104(28)232)147(252)198-99(23)143(248)203-110(53-44-72-194-175(186)187)148(253)199-100(24)144(249)205-116(59-66-134(237)238)156(261)214-119(57-64-131(183)234)168(273)229-178(29,84-94(14)15)172(277)201-101(25)145(250)204-114(56-63-130(182)233)155(260)211-115-58-65-133(236)193-71-43-41-52-113(224-173(278)179(30,85-95(16)17)228-146(251)102(26)200-149(115)254)154(259)221-128(82-132(184)235)165(270)210-111(54-45-73-195-176(188)189)151(256)207-109(51-40-42-70-181)153(258)216-121(75-89(4)5)159(264)208-108(50-36-33-2)150(255)215-120(62-69-137(243)244)169(274)230-180(31,86-96(18)19)174(279)227-140(142(185)247)98(22)34-3/h37-39,47-48,87-103,107-129,139-141,231H,32-36,40-46,49-86,181H2,1-31H3,(H2,182,233)(H2,183,234)(H2,184,235)(H2,185,247)(H,192,197)(H,193,236)(H,198,252)(H,199,253)(H,200,254)(H,201,277)(H,202,232)(H,203,248)(H,204,250)(H,205,249)(H,206,262)(H,207,256)(H,208,264)(H,209,265)(H,210,270)(H,211,260)(H,212,257)(H,213,266)(H,214,261)(H,215,255)(H,216,258)(H,217,267)(H,218,269)(H,219,271)(H,220,268)(H,221,259)(H,222,275)(H,223,276)(H,224,278)(H,225,263)(H,226,272)(H,227,279)(H,228,251)(H,229,273)(H,230,274)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t98?,99?,100-,101-,102-,103+,107?,108?,109-,110-,111?,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126+,127-,128-,129-,139-,140-,141-,178?,179?,180?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153482
(CHEMBL3775357)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(C)(CC(C)C)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C180H304N50O49/c1-32-35-49-107(206-157(262)117(60-67-135(239)240)213-161(266)124(78-92(10)11)222-170(275)139(97(20)21)225-158(263)118(61-68-136(241)242)212-152(257)112(55-46-74-196-177(190)191)209-160(265)122(76-90(6)7)217-162(267)123(77-91(8)9)218-164(269)127(81-106-87-192-88-197-106)220-163(268)126(80-105-47-38-37-39-48-105)223-171(276)141(103(27)231)226-167(272)125(79-93(12)13)219-166(271)129(83-138(245)246)202-104(28)232)147(252)198-99(23)143(248)203-110(53-44-72-194-175(186)187)148(253)199-100(24)144(249)205-116(59-66-134(237)238)156(261)214-119(57-64-131(183)234)168(273)229-178(29,84-94(14)15)172(277)201-101(25)145(250)204-114(56-63-130(182)233)155(260)211-115-58-65-133(236)193-71-43-41-52-113(224-173(278)179(30,85-95(16)17)228-146(251)102(26)200-149(115)254)154(259)221-128(82-132(184)235)165(270)210-111(54-45-73-195-176(188)189)151(256)207-109(51-40-42-70-181)153(258)216-121(75-89(4)5)159(264)208-108(50-36-33-2)150(255)215-120(62-69-137(243)244)169(274)230-180(31,86-96(18)19)174(279)227-140(142(185)247)98(22)34-3/h37-39,47-48,87-103,107-129,139-141,231H,32-36,40-46,49-86,181H2,1-31H3,(H2,182,233)(H2,183,234)(H2,184,235)(H2,185,247)(H,192,197)(H,193,236)(H,198,252)(H,199,253)(H,200,254)(H,201,277)(H,202,232)(H,203,248)(H,204,250)(H,205,249)(H,206,262)(H,207,256)(H,208,264)(H,209,265)(H,210,270)(H,211,260)(H,212,257)(H,213,266)(H,214,261)(H,215,255)(H,216,258)(H,217,267)(H,218,269)(H,219,271)(H,220,268)(H,221,259)(H,222,275)(H,223,276)(H,224,278)(H,225,263)(H,226,272)(H,227,279)(H,228,251)(H,229,273)(H,230,274)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t98?,99?,100-,101-,102-,103+,107?,108?,109-,110-,111?,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126+,127-,128-,129-,139-,140-,141-,178?,179?,180?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153473
(CHEMBL3775796)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C179H298N52O49/c1-29-32-46-106(207-157(263)116(57-64-135(240)241)215-161(267)123(75-91(10)11)225-171(277)139(95(18)19)227-158(264)117(58-65-136(242)243)214-152(258)112(52-43-71-196-177(189)190)211-160(266)121(73-89(6)7)220-162(268)122(74-90(8)9)221-165(271)127(79-105-85-192-87-198-105)223-163(269)125(77-103-44-35-34-36-45-103)226-172(278)141(101(25)232)228-168(274)124(76-92(12)13)222-167(273)129(81-138(246)247)203-102(26)233)147(253)199-97(21)143(249)204-110(50-41-69-194-175(185)186)148(254)200-98(22)144(250)206-115(56-63-134(238)239)156(262)216-118(54-61-131(182)235)169(275)230-178(27,82-93(14)15)173(279)202-100(24)146(252)205-113(53-60-130(181)234)155(261)213-114-55-62-133(237)193-68-40-38-49-109(210-164(270)126(78-104-84-191-86-197-104)218-145(251)99(23)201-149(114)255)154(260)224-128(80-132(183)236)166(272)212-111(51-42-70-195-176(187)188)151(257)208-108(48-37-39-67-180)153(259)219-120(72-88(4)5)159(265)209-107(47-33-30-2)150(256)217-119(59-66-137(244)245)170(276)231-179(28,83-94(16)17)174(280)229-140(142(184)248)96(20)31-3/h34-36,44-45,84-101,106-129,139-141,232H,29-33,37-43,46-83,180H2,1-28H3,(H2,181,234)(H2,182,235)(H2,183,236)(H2,184,248)(H,191,197)(H,192,198)(H,193,237)(H,199,253)(H,200,254)(H,201,255)(H,202,279)(H,203,233)(H,204,249)(H,205,252)(H,206,250)(H,207,263)(H,208,257)(H,209,265)(H,210,270)(H,211,266)(H,212,272)(H,213,261)(H,214,258)(H,215,267)(H,216,262)(H,217,256)(H,218,251)(H,219,259)(H,220,268)(H,221,271)(H,222,273)(H,223,269)(H,224,260)(H,225,277)(H,226,278)(H,227,264)(H,228,274)(H,229,280)(H,230,275)(H,231,276)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H4,185,186,194)(H4,187,188,195)(H4,189,190,196)/t96-,97-,98-,99-,100-,101+,106?,107?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125+,126-,127-,128-,129-,139-,140-,141-,178?,179?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085772
(CHEMBL411964 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCNC(=O)CNC(=O)C[C@@H](NC(C)=O)C(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](CC(=O)NC[C@@H](NC(=O)[C@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)C(=O)N2 Show InChI InChI=1S/C70H89ClN18O14/c1-37(2)27-49-62(96)82-48(16-9-25-76-70(73)74)69(103)89-26-10-17-56(89)68(102)88-55(60(72)94)35-78-57(91)33-54-67(101)81-47(61(95)84-51(64(98)83-49)30-40-18-21-41-11-4-5-12-42(41)28-40)15-8-24-75-59(93)36-79-58(92)32-53(80-38(3)90)66(100)85-50(29-39-19-22-44(71)23-20-39)63(97)86-52(65(99)87-54)31-43-34-77-46-14-7-6-13-45(43)46/h4-7,11-14,18-23,28,34,37,47-56,77H,8-10,15-17,24-27,29-33,35-36H2,1-3H3,(H2,72,94)(H,75,93)(H,78,91)(H,79,92)(H,80,90)(H,81,101)(H,82,96)(H,83,98)(H,84,95)(H,85,100)(H,86,97)(H,87,99)(H,88,102)(H4,73,74,76)/t47-,48+,49-,50+,51-,52-,53-,54-,55-,56-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085753
(CHEMBL409996 | cyclo(1-3)Ac-D-Glu-D-Cpa-D-Dbu-Ser-...)Show SMILES CCCCC1CC(NC(=O)CCC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O Show InChI InChI=1S/C69H94ClN15O14/c1-6-7-14-47-36-55(78-58(89)28-27-49(76-40(5)87)60(91)81-52(61(92)77-47)33-41-18-23-46(70)24-19-41)65(96)84-56(37-86)66(97)83-53(34-42-20-25-48(88)26-21-42)63(94)82-54(35-43-17-22-44-12-8-9-13-45(44)32-43)64(95)80-51(31-38(2)3)62(93)79-50(15-10-29-74-69(72)73)68(99)85-30-11-16-57(85)67(98)75-39(4)59(71)90/h8-9,12-13,17-26,32,38-39,47,49-57,86,88H,6-7,10-11,14-16,27-31,33-37H2,1-5H3,(H2,71,90)(H,75,98)(H,76,87)(H,77,92)(H,78,89)(H,79,93)(H,80,95)(H,81,91)(H,82,94)(H,83,97)(H,84,96)(H4,72,73,74)/t39?,47?,49?,50-,51+,52+,53-,54?,55?,56-,57+/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293 |
J Med Chem 43: 797-806 (2000)
BindingDB Entry DOI: 10.7270/Q2DF6QD5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153578
(CHEMBL3775192)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)CCCC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C174H292N50O49/c1-29-33-48-100(200-151(256)110(60-67-129(233)234)207-155(260)117(78-89(11)12)216-164(269)133(91(15)16)219-152(257)111(61-68-130(235)236)206-146(251)105(54-45-74-190-171(184)185)203-154(259)115(76-87(7)8)211-156(261)116(77-88(9)10)212-158(263)120(81-99-84-186-85-191-99)214-157(262)119(80-98-46-37-36-38-47-98)217-165(270)135(97(22)225)220-161(266)118(79-90(13)14)213-160(265)122(83-132(239)240)196-127(230)55-35-31-3)141(246)192-93(18)137(242)197-103(52-43-72-188-169(180)181)142(247)193-94(19)138(243)199-109(59-66-128(231)232)150(255)208-112(57-64-124(177)227)162(267)223-172(23,24)166(271)195-95(20)139(244)198-107(56-63-123(176)226)149(254)205-108-58-65-126(229)187-71-42-40-51-106(218-167(272)173(25,26)222-140(245)96(21)194-143(108)248)148(253)215-121(82-125(178)228)159(264)204-104(53-44-73-189-170(182)183)145(250)201-102(50-39-41-70-175)147(252)210-114(75-86(5)6)153(258)202-101(49-34-30-2)144(249)209-113(62-69-131(237)238)163(268)224-174(27,28)168(273)221-134(136(179)241)92(17)32-4/h36-38,46-47,84-97,100-122,133-135,225H,29-35,39-45,48-83,175H2,1-28H3,(H2,176,226)(H2,177,227)(H2,178,228)(H2,179,241)(H,186,191)(H,187,229)(H,192,246)(H,193,247)(H,194,248)(H,195,271)(H,196,230)(H,197,242)(H,198,244)(H,199,243)(H,200,256)(H,201,250)(H,202,258)(H,203,259)(H,204,264)(H,205,254)(H,206,251)(H,207,260)(H,208,255)(H,209,249)(H,210,252)(H,211,261)(H,212,263)(H,213,265)(H,214,262)(H,215,253)(H,216,269)(H,217,270)(H,218,272)(H,219,257)(H,220,266)(H,221,273)(H,222,245)(H,223,267)(H,224,268)(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H,239,240)(H4,180,181,188)(H4,182,183,189)(H4,184,185,190)/t92-,93-,94-,95-,96-,97+,100?,101?,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119+,120-,121-,122-,133-,134-,135-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153576
(CHEMBL3774742)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C172H288N50O49/c1-29-33-47-98(198-149(254)108(58-65-127(231)232)205-153(258)115(76-87(11)12)214-162(267)131(89(15)16)217-150(255)109(59-66-128(233)234)204-144(249)103(53-44-72-188-169(182)183)201-152(257)113(74-85(7)8)209-154(259)114(75-86(9)10)210-156(261)118(79-97-82-184-83-189-97)212-155(260)117(78-96-45-36-35-37-46-96)215-163(268)133(95(22)223)218-159(264)116(77-88(13)14)211-158(263)120(81-130(237)238)194-124(227)32-4)139(244)190-91(18)135(240)195-101(51-42-70-186-167(178)179)140(245)191-92(19)136(241)197-107(57-64-126(229)230)148(253)206-110(55-62-122(175)225)160(265)221-170(23,24)164(269)193-93(20)137(242)196-105(54-61-121(174)224)147(252)203-106-56-63-125(228)185-69-41-39-50-104(216-165(270)171(25,26)220-138(243)94(21)192-141(106)246)146(251)213-119(80-123(176)226)157(262)202-102(52-43-71-187-168(180)181)143(248)199-100(49-38-40-68-173)145(250)208-112(73-84(5)6)151(256)200-99(48-34-30-2)142(247)207-111(60-67-129(235)236)161(266)222-172(27,28)166(271)219-132(134(177)239)90(17)31-3/h35-37,45-46,82-95,98-120,131-133,223H,29-34,38-44,47-81,173H2,1-28H3,(H2,174,224)(H2,175,225)(H2,176,226)(H2,177,239)(H,184,189)(H,185,228)(H,190,244)(H,191,245)(H,192,246)(H,193,269)(H,194,227)(H,195,240)(H,196,242)(H,197,241)(H,198,254)(H,199,248)(H,200,256)(H,201,257)(H,202,262)(H,203,252)(H,204,249)(H,205,258)(H,206,253)(H,207,247)(H,208,250)(H,209,259)(H,210,261)(H,211,263)(H,212,260)(H,213,251)(H,214,267)(H,215,268)(H,216,270)(H,217,255)(H,218,264)(H,219,271)(H,220,243)(H,221,265)(H,222,266)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H4,178,179,186)(H4,180,181,187)(H4,182,183,188)/t90-,91-,92-,93-,94-,95+,98?,99?,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117+,118-,119-,120-,131-,132-,133-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1]-PD-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085788
(CHEMBL405053 | Gonadotropin Releasing Hormone anal...)Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCC(=O)NCCCC[C@@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)NC(CNC(=O)C[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC(C)=O)C(=O)N2)C(N)=O Show InChI InChI=1S/C70H90FN17O13/c1-38(2)30-51-63(95)82-50-16-8-9-27-75-58(90)26-25-49(62(94)80-48(61(93)83-51)17-10-28-76-70(73)74)81-67(99)55(35-59(91)78-37-56(60(72)92)87-68(100)57-18-11-29-88(57)69(50)101)86-66(98)54(34-44-36-77-47-15-7-6-14-46(44)47)85-65(97)53(32-40-20-23-45(71)24-21-40)84-64(96)52(79-39(3)89)33-41-19-22-42-12-4-5-13-43(42)31-41/h4-7,12-15,19-24,31,36,38,48-57,77H,8-11,16-18,25-30,32-35,37H2,1-3H3,(H2,72,92)(H,75,90)(H,78,91)(H,79,89)(H,80,94)(H,81,99)(H,82,95)(H,83,93)(H,84,96)(H,85,97)(H,86,98)(H,87,100)(H4,73,74,76)/t48-,49-,50+,51-,52+,53-,54+,55-,56?,57-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 807-18 (2000)
BindingDB Entry DOI: 10.7270/Q28P5ZQW |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085704
(CHEMBL440436 | Cyclo (4-10) [Ac-D Nal, D Cpa, D Pa...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H]1CC(=O)N(CC(N)=O)C(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCC(O)=O)NC1=O Show InChI InChI=1S/C57H83ClN16O14/c1-5-36(65-32(4)75)48(80)70-41(26-33-15-17-35(58)18-16-33)52(84)71-42(27-34-11-8-22-63-29-34)53(85)72-43-28-46(77)74(30-45(60)76)56(88)44-14-10-24-73(44)55(87)39(12-6-7-21-59)68-51(83)40(25-31(2)3)69-49(81)37(13-9-23-64-57(61)62)66-50(82)38(67-54(43)86)19-20-47(78)79/h8,11,15-18,22,29,31,36-44H,5-7,9-10,12-14,19-21,23-28,30,59H2,1-4H3,(H2,60,76)(H,65,75)(H,66,82)(H,67,86)(H,68,83)(H,69,81)(H,70,80)(H,71,84)(H,72,85)(H,78,79)(H4,61,62,64)/t36-,37-,38+,39-,40+,41-,42-,43+,44+/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085711
(CHEMBL412682 | DiCyclo (4-10/5-8) [Ac-D Nal, D Cpa...)Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N2)C(N)=O Show InChI InChI=1S/C61H86ClN17O13/c1-5-38(70-33(4)80)52(84)75-44(27-34-17-19-36(62)20-18-34)56(88)76-45(28-35-30-68-39-13-7-6-12-37(35)39)57(89)77-46-29-50(82)69-31-47(51(63)83)78-59(91)48-16-11-25-79(48)60(92)42-14-8-9-23-66-49(81)22-21-41(72-58(46)90)54(86)71-40(15-10-24-67-61(64)65)53(85)74-43(26-32(2)3)55(87)73-42/h6-7,12-13,17-20,30,32,38,40-48,68H,5,8-11,14-16,21-29,31H2,1-4H3,(H2,63,83)(H,66,81)(H,69,82)(H,70,80)(H,71,86)(H,72,90)(H,73,87)(H,74,85)(H,75,84)(H,76,88)(H,77,89)(H,78,91)(H4,64,65,67)/t38-,40+,41-,42+,43-,44-,45-,46-,47?,48-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor |
J Med Chem 43: 784-96 (2000)
BindingDB Entry DOI: 10.7270/Q2J38RS2 |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085757
(CHEMBL427745 | cyclo(1,1'-3)Ac-D-Asp (beta-Ala)-D-...)Show SMILES CCCCC1C[C@@H](NC(=O)CCNC(=O)CC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O Show InChI InChI=1S/C71H97ClN16O15/c1-6-7-14-48-36-55(81-59(92)27-29-76-60(93)37-56(79-41(5)90)67(100)84-52(62(95)80-48)33-42-18-23-47(72)24-19-42)66(99)87-57(38-89)68(101)86-53(34-43-20-25-49(91)26-21-43)64(97)85-54(35-44-17-22-45-12-8-9-13-46(45)32-44)65(98)83-51(31-39(2)3)63(96)82-50(15-10-28-77-71(74)75)70(103)88-30-11-16-58(88)69(102)78-40(4)61(73)94/h8-9,12-13,17-26,32,39-40,48,50-58,89,91H,6-7,10-11,14-16,27-31,33-38H2,1-5H3,(H2,73,94)(H,76,93)(H,78,102)(H,79,90)(H,80,95)(H,81,92)(H,82,96)(H,83,98)(H,84,100)(H,85,97)(H,86,101)(H,87,99)(H4,74,75,77)/t40?,48?,50-,51+,52+,53-,54?,55+,56?,57-,58+/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293 |
J Med Chem 43: 797-806 (2000)
BindingDB Entry DOI: 10.7270/Q2DF6QD5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153575
(CHEMBL3775307)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC1CCCCC1)C(=O)NC(CC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C177H294N50O51/c1-27-29-47-103(204-155(261)113(58-65-133(238)239)211-158(264)119(75-89(9)10)221-169(275)137(92(15)16)223-156(262)114(59-66-134(240)241)210-149(255)108(52-42-71-193-175(187)188)207-157(263)116(72-86(3)4)214-159(265)118(74-88(7)8)215-163(269)123(79-102-84-189-85-194-102)218-162(268)122(78-101-45-34-31-35-46-101)222-170(276)139(98(22)228)224-166(272)120(76-90(11)12)216-165(271)125(81-135(242)243)199-99(23)229)145(251)195-94(18)141(247)200-106(50-40-69-191-173(183)184)146(252)196-95(19)142(248)203-112(57-64-132(236)237)154(260)212-115(54-61-128(180)231)167(273)226-176(24,25)171(277)198-97(21)144(250)201-109(53-60-127(179)230)152(258)209-110-55-62-130(233)190-68-39-37-49-105(206-153(259)111(56-63-131(234)235)202-143(249)96(20)197-147(110)253)151(257)219-124(80-129(181)232)164(270)208-107(51-41-70-192-174(185)186)148(254)205-104(48-36-38-67-178)150(256)213-117(73-87(5)6)160(266)217-121(77-100-43-32-30-33-44-100)161(267)220-126(82-136(244)245)168(274)227-177(26,83-91(13)14)172(278)225-138(140(182)246)93(17)28-2/h31,34-35,45-46,84-98,100,103-126,137-139,228H,27-30,32-33,36-44,47-83,178H2,1-26H3,(H2,179,230)(H2,180,231)(H2,181,232)(H2,182,246)(H,189,194)(H,190,233)(H,195,251)(H,196,252)(H,197,253)(H,198,277)(H,199,229)(H,200,247)(H,201,250)(H,202,249)(H,203,248)(H,204,261)(H,205,254)(H,206,259)(H,207,263)(H,208,270)(H,209,258)(H,210,255)(H,211,264)(H,212,260)(H,213,256)(H,214,265)(H,215,269)(H,216,271)(H,217,266)(H,218,268)(H,219,257)(H,220,267)(H,221,275)(H,222,276)(H,223,262)(H,224,272)(H,225,278)(H,226,273)(H,227,274)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H4,183,184,191)(H4,185,186,192)(H4,187,188,193)/t93-,94-,95?,96+,97-,98+,103?,104-,105-,106?,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121?,122+,123-,124-,125-,126-,137-,138-,139-,177?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50085746
(CHEMBL405223 | cyclo(1,1'-3)Ac-D-Asp (Gly)-D-Cpa-D...)Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O Show InChI InChI=1S/C67H89ClN16O15/c1-36(2)28-48(60(93)78-47(13-8-26-73-67(70)71)66(99)84-27-9-14-54(84)65(98)75-37(3)57(69)90)79-62(95)51(32-41-15-20-42-10-5-6-11-43(42)29-41)81-61(94)50(31-40-18-23-45(87)24-19-40)82-64(97)53(35-85)83-59(92)46-12-7-25-72-58(91)49(30-39-16-21-44(68)22-17-39)80-63(96)52(76-38(4)86)33-55(88)74-34-56(89)77-46/h5-6,10-11,15-24,29,36-37,46-54,85,87H,7-9,12-14,25-28,30-35H2,1-4H3,(H2,69,90)(H,72,91)(H,74,88)(H,75,98)(H,76,86)(H,77,89)(H,78,93)(H,79,95)(H,80,96)(H,81,94)(H,82,97)(H,83,92)(H4,70,71,73)/t37?,46-,47+,48-,49-,50+,51?,52?,53+,54-/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293 |
J Med Chem 43: 797-806 (2000)
BindingDB Entry DOI: 10.7270/Q2DF6QD5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50153494
(CHEMBL3775621)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C182H296N52O49/c1-28-30-48-109(210-159(265)118(58-65-138(243)244)217-162(268)125(76-93(9)10)228-174(280)142(97(17)18)230-160(266)119(59-66-139(245)246)216-154(260)114(53-43-72-199-180(192)193)213-161(267)122(73-90(3)4)222-163(269)124(75-92(7)8)223-168(274)130(81-108-87-195-89-201-108)226-166(272)128(79-106-46-35-32-36-47-106)229-175(281)144(103(24)235)231-171(277)126(77-94(11)12)224-170(276)132(83-141(249)250)206-104(25)236)150(256)202-99(20)146(252)207-112(51-41-70-197-178(188)189)151(257)203-100(21)147(253)209-117(57-64-137(241)242)158(264)218-120(55-62-134(185)238)172(278)233-181(26,84-95(13)14)176(282)205-102(23)149(255)208-115(54-61-133(184)237)157(263)215-116-56-63-136(240)196-69-40-38-50-111(212-167(273)129(80-107-86-194-88-200-107)220-148(254)101(22)204-152(116)258)156(262)227-131(82-135(186)239)169(275)214-113(52-42-71-198-179(190)191)153(259)211-110(49-37-39-68-183)155(261)221-123(74-91(5)6)164(270)225-127(78-105-44-33-31-34-45-105)165(271)219-121(60-67-140(247)248)173(279)234-182(27,85-96(15)16)177(283)232-143(145(187)251)98(19)29-2/h31-36,44-47,86-103,109-132,142-144,235H,28-30,37-43,48-85,183H2,1-27H3,(H2,184,237)(H2,185,238)(H2,186,239)(H2,187,251)(H,194,200)(H,195,201)(H,196,240)(H,202,256)(H,203,257)(H,204,258)(H,205,282)(H,206,236)(H,207,252)(H,208,255)(H,209,253)(H,210,265)(H,211,259)(H,212,273)(H,213,267)(H,214,275)(H,215,263)(H,216,260)(H,217,268)(H,218,264)(H,219,271)(H,220,254)(H,221,261)(H,222,269)(H,223,274)(H,224,276)(H,225,270)(H,226,272)(H,227,262)(H,228,280)(H,229,281)(H,230,266)(H,231,277)(H,232,283)(H,233,278)(H,234,279)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,188,189,197)(H4,190,191,198)(H4,192,193,199)/t98-,99-,100-,101-,102-,103+,109?,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128+,129-,130-,131-,132-,142-,143-,144-,181?,182?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in human CRF-R1 expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153477
(CHEMBL3775524)Show SMILES CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(C)(C)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O Show InChI InChI=1S/C177H298N50O49/c1-31-34-48-104(203-154(259)114(59-66-132(236)237)210-158(263)121(77-90(10)11)219-167(272)136(94(18)19)222-155(260)115(60-67-133(238)239)209-149(254)109(54-45-73-193-174(187)188)206-157(262)119(75-88(6)7)214-159(264)120(76-89(8)9)215-161(266)124(80-103-85-189-86-194-103)217-160(265)123(79-102-46-37-36-38-47-102)220-168(273)138(100(25)228)223-164(269)122(78-91(12)13)216-163(268)126(82-135(242)243)199-101(26)229)144(249)195-96(21)140(245)200-107(52-43-71-191-172(183)184)145(250)196-97(22)141(246)202-113(58-65-131(234)235)153(258)211-116(56-63-128(180)231)165(270)226-176(29,83-92(14)15)170(275)198-98(23)142(247)201-111(55-62-127(179)230)152(257)208-112-57-64-130(233)190-70-42-40-51-110(221-169(274)175(27,28)225-143(248)99(24)197-146(112)251)151(256)218-125(81-129(181)232)162(267)207-108(53-44-72-192-173(185)186)148(253)204-106(50-39-41-69-178)150(255)213-118(74-87(4)5)156(261)205-105(49-35-32-2)147(252)212-117(61-68-134(240)241)166(271)227-177(30,84-93(16)17)171(276)224-137(139(182)244)95(20)33-3/h36-38,46-47,85-100,104-126,136-138,228H,31-35,39-45,48-84,178H2,1-30H3,(H2,179,230)(H2,180,231)(H2,181,232)(H2,182,244)(H,189,194)(H,190,233)(H,195,249)(H,196,250)(H,197,251)(H,198,275)(H,199,229)(H,200,245)(H,201,247)(H,202,246)(H,203,259)(H,204,253)(H,205,261)(H,206,262)(H,207,267)(H,208,257)(H,209,254)(H,210,263)(H,211,258)(H,212,252)(H,213,255)(H,214,264)(H,215,266)(H,216,268)(H,217,265)(H,218,256)(H,219,272)(H,220,273)(H,221,274)(H,222,260)(H,223,269)(H,224,276)(H,225,248)(H,226,270)(H,227,271)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H4,183,184,191)(H4,185,186,192)(H4,187,188,193)/t95?,96?,97-,98-,99-,100+,104?,105?,106-,107-,108?,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123+,124-,125-,126-,136-,137-,138-,176?,177?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Mus musculus) | BDBM50153577
(CHEMBL3774465)Show SMILES CCCCC(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)CCC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)C(C)(C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O |r| Show InChI InChI=1S/C173H290N50O49/c1-29-33-48-99(199-150(255)109(59-66-128(232)233)206-154(259)116(77-88(11)12)215-163(268)132(90(15)16)218-151(256)110(60-67-129(234)235)205-145(250)104(54-44-73-189-170(183)184)202-153(258)114(75-86(7)8)210-155(260)115(76-87(9)10)211-157(262)119(80-98-83-185-84-190-98)213-156(261)118(79-97-46-36-35-37-47-97)216-164(269)134(96(22)224)219-160(265)117(78-89(13)14)212-159(264)121(82-131(238)239)195-126(229)45-31-3)140(245)191-92(18)136(241)196-102(52-42-71-187-168(179)180)141(246)192-93(19)137(242)198-108(58-65-127(230)231)149(254)207-111(56-63-123(176)226)161(266)222-171(23,24)165(270)194-94(20)138(243)197-106(55-62-122(175)225)148(253)204-107-57-64-125(228)186-70-41-39-51-105(217-166(271)172(25,26)221-139(244)95(21)193-142(107)247)147(252)214-120(81-124(177)227)158(263)203-103(53-43-72-188-169(181)182)144(249)200-101(50-38-40-69-174)146(251)209-113(74-85(5)6)152(257)201-100(49-34-30-2)143(248)208-112(61-68-130(236)237)162(267)223-173(27,28)167(272)220-133(135(178)240)91(17)32-4/h35-37,46-47,83-96,99-121,132-134,224H,29-34,38-45,48-82,174H2,1-28H3,(H2,175,225)(H2,176,226)(H2,177,227)(H2,178,240)(H,185,190)(H,186,228)(H,191,245)(H,192,246)(H,193,247)(H,194,270)(H,195,229)(H,196,241)(H,197,243)(H,198,242)(H,199,255)(H,200,249)(H,201,257)(H,202,258)(H,203,263)(H,204,253)(H,205,250)(H,206,259)(H,207,254)(H,208,248)(H,209,251)(H,210,260)(H,211,262)(H,212,264)(H,213,261)(H,214,252)(H,215,268)(H,216,269)(H,217,271)(H,218,256)(H,219,265)(H,220,272)(H,221,244)(H,222,266)(H,223,267)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H4,179,180,187)(H4,181,182,188)(H4,183,184,189)/t91-,92-,93-,94-,95-,96+,99?,100?,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,132-,133-,134-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay |
J Med Chem 59: 854-66 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00926
BindingDB Entry DOI: 10.7270/Q2WQ05NH |
More data for this
Ligand-Target Pair | |
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