Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor in rat brain | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216746 (3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor in rat brain | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50210964 (3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor in rat brain | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216746 (3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216762 (3-chloro-5-(2-methylquinolin-7-yl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216758 (3-methyl-5-(2-methylquinolin-7-yl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216749 (3-(methoxymethyl)-5-(2-methylquinolin-7-yl)benzoni...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216750 (5-(2-methylquinolin-7-yl)isophthalonitrile | CHEMB...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216761 (3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224920 (3-methoxy-5-(2-methyl-1,6-naphthyridin-7-yl)benzon...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.19 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50210964 (3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216741 (3-bromo-5-(2-methylquinolin-7-yl)benzonitrile | CH...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216770 (3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216745 (5-(2-methylquinolin-7-yl)nicotinonitrile | CHEMBL2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224924 (2-(3,4-dimethylphenyl)-1,8-naphthyridine | CHEMBL2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224929 (2-(3-bromophenyl)-7-methyl-1,8-naphthyridine | CHE...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 47.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224922 (2-(3,5-dimethoxyphenyl)-7-methyl-1,8-naphthyridine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 51.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224932 (3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224941 (2-(3,5-dimethoxyphenyl)-1,8-naphthyridine | CHEMBL...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224940 (3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216752 (3-(ethylthio)-5-(2-methylquinolin-7-yl)benzonitril...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216766 (3-(2-methylquinolin-7-yl)-5-(trifluoromethoxy)benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216768 (3-(2-methoxyethoxy)-5-(2-methylquinolin-7-yl)benzo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224923 (3-(1,8-naphthyridin-2-yl)benzonitrile | CHEMBL2353...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224936 (2-(3-chlorophenyl)-7-methyl-1,8-naphthyridine | CH...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224925 (2-(3,5-difluorophenyl)-7-methyl-1,8-naphthyridine ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 181 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224917 (2-m-tolyl-1,8-naphthyridine | CHEMBL395902) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224939 (2-methyl-7-m-tolyl-1,8-naphthyridine | CHEMBL23562...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216767 (3-isopropoxy-5-(2-methylquinolin-7-yl)benzonitrile...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224926 (7-(3,5-dimethoxyphenyl)-2-methyl-1,6-naphthyridine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 345 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216737 (3-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216769 (2-(3-(2-methylquinolin-7-yl)phenyl)acetonitrile | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224921 (3-(methoxymethoxy)-5-(1,6-naphthyridin-7-yl)benzon...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 468 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224931 (3-(7-methyl-1,8-naphthyridin-2-yl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216747 (2-methyl-7-(pyridin-3-yl)quinoline | CHEMBL231763) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50090686 (2-Methyl-7-phenyl-[1,8]naphthyridine | 2-methyl-7-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 664 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224938 (2-methyl-7-m-tolyl-1,6-naphthyridine | CHEMBL23643...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 676 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216748 (7-(3-methoxyphenyl)-2-methylquinoline | CHEMBL3948...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216764 (3-(ethylsulfonyl)-5-(2-methylquinolin-7-yl)benzoni...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224930 (7-m-tolyl-1,6-naphthyridine | CHEMBL238388) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224933 (3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216759 (7-(3-fluorophenyl)-2-methylquinoline | CHEMBL23176...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224918 (2-phenyl-1,8-naphthyridine | CHEMBL235396) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224943 (7-(3-fluoro-5-methylphenyl)-2-methyl-1,6-naphthyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216755 (2-methyl-7-m-tolylquinoline | CHEMBL231765) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216754 (7-(2-methoxyphenyl)-2-methylquinoline | CHEMBL2319...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216740 (1-(3-(2-methylquinolin-7-yl)phenyl)ethanone | CHEM...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50216757 (7-(3-(methoxymethyl)phenyl)-2-methylquinoline | CH...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 17: 4415-8 (2007) Article DOI: 10.1016/j.bmcl.2007.06.030 BindingDB Entry DOI: 10.7270/Q28G8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50224927 (7-(3,5-dimethoxyphenyl)-1,6-naphthyridine | CHEMBL...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Antagonist activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization | Bioorg Med Chem Lett 17: 6525-8 (2007) Article DOI: 10.1016/j.bmcl.2007.09.083 BindingDB Entry DOI: 10.7270/Q2V40TXS | |||||||||||
More data for this Ligand-Target Pair |
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