Found 133 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 8.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested in vitro for the inhibition constant against rat small intestinal sucrase |
Bioorg Med Chem Lett 7: 355-360 (1997)
Article DOI: 10.1016/S0960-894X(97)00012-7 BindingDB Entry DOI: 10.7270/Q2F18ZQ1 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
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| Article PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01673 BindingDB Entry DOI: 10.7270/Q23J3HVM |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
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| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase |
Bioorg Med Chem Lett 7: 355-360 (1997)
Article DOI: 10.1016/S0960-894X(97)00012-7 BindingDB Entry DOI: 10.7270/Q2F18ZQ1 |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 160 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Trehalose synthase/amylase TreS
(Mycobacterium tuberculosis) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| Article PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
| Assay Description The inhibition of TreS by a range of known alpha-glucosidase inhibitor was assayed. |
J Biol Chem 286: 35601-9 (2011)
Article DOI: 10.1074/jbc.M111.280362 BindingDB Entry DOI: 10.7270/Q2VM49V1 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Prunus avium) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/TrEMBL
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| 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against sweet almond Beta-glucosidase |
Bioorg Med Chem Lett 1: 667-672 (1991)
Article DOI: 10.1016/S0960-894X(01)81044-1 BindingDB Entry DOI: 10.7270/Q26W9BKM |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta glucosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta-glucosidase |
Bioorg Med Chem Lett 16: 2067-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.095 BindingDB Entry DOI: 10.7270/Q26Q1WV2 |
More data for this Ligand-Target Pair | |
Alpha-glucosidase MAL12
(Saccharomyces cerevisiae) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | Reactome pathway KEGG
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| 1.80E+4 | n/a | 3.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University
| Assay Description All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos... |
Chembiochem 11: 2125-31 (2010)
Article DOI: 10.1002/cbic.201000376 BindingDB Entry DOI: 10.7270/Q2542M33 |
More data for this Ligand-Target Pair | |
Alpha-galactosidase A
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hamburg
Curated by ChEMBL
| Assay Description Compound tested for inhibition of alpha-galactosidase from Aspergillus niger |
Bioorg Med Chem Lett 14: 73-5 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2925 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 6.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Berlin
Curated by ChEMBL
| Assay Description Inhibitory activity against alpha-glucosidase of yeast |
Bioorg Med Chem Lett 9: 615-8 (1999)
BindingDB Entry DOI: 10.7270/Q2V40VQH |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Berlin
Curated by ChEMBL
| Assay Description Inhibitory activity against beta-glucosidase of sweet almond |
Bioorg Med Chem Lett 9: 615-8 (1999)
BindingDB Entry DOI: 10.7270/Q2V40VQH |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | Reactome pathway KEGG
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| <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Competitive Inhibitory activity against Golgi Alpha-mannosidase II |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| 7.90E+4 | -24.4 | 2.40E+5 | n/a | n/a | n/a | n/a | 5.5 | 37 |
Hokuriku University
| Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4... |
Bioorg Med Chem 14: 7736-44 (2006)
Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| Article PubMed
| 7.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal beta-glucocerebrosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 2.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Inhibition of jack bean alpha-mannosidase using p-nitrophenyl-mannopyranoside as substrate measured every 2 mins |
Eur J Med Chem 123: 155-160 (2016)
Article DOI: 10.1016/j.ejmech.2016.07.021 BindingDB Entry DOI: 10.7270/Q2C24ZD6 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
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| 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on almonds beta Glucosidase at pH 5.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 4.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Tested for competitive inhibition of golgi alpha mannosidase II |
J Med Chem 37: 3701-6 (1994)
BindingDB Entry DOI: 10.7270/Q2ZC83H3 |
More data for this Ligand-Target Pair | |
Neutral alpha-glucosidase AB
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
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| 4.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
Curated by ChEMBL
| Assay Description Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 5.0 |
Bioorg Med Chem Lett 2: 27-32 (1992)
Article DOI: 10.1016/S0960-894X(00)80648-4 BindingDB Entry DOI: 10.7270/Q2TH8MKB |
More data for this Ligand-Target Pair | |
Beta-mannosidase
(Bacteroides thetaiotaomicron) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB MMDB
KEGG
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
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| Article PubMed
| 1.40E+7 | -11.0 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
The Medical School, Newcastle University
| Assay Description Putative mannosidase assay using wild-type protein Btman2A. Enzyme inhibition assay. |
Nat Chem Biol 4: 306-12 (2008)
Article DOI: 10.1038/nchembio.81 BindingDB Entry DOI: 10.7270/Q2X34VS6 |
More data for this Ligand-Target Pair | |
Tissue alpha-L-fucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article
| >1.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant against Alpha-Fucosidase |
Bioorg Med Chem Lett 2: 33-36 (1992)
Article DOI: 10.1016/S0960-894X(00)80649-6 BindingDB Entry DOI: 10.7270/Q2FF3SV0 |
More data for this Ligand-Target Pair | |
Putative alpha-glucosidase
(Oryza sativa subsp. japonica) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | Reactome pathway KEGG
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibitory concentration against rice alpha-glucosidase |
J Med Chem 48: 2036-44 (2005)
Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M |
More data for this Ligand-Target Pair | |
Maltase-glucoamylase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibitory concentration against human alpha-glucosidase |
J Med Chem 48: 2036-44 (2005)
Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M |
More data for this Ligand-Target Pair | |
Putative alpha-glucosidase
(Oryza sativa subsp. japonica) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | Reactome pathway KEGG
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibitory activity against alpha-Glucosidase from rice |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of maltase in human Caco-2 cell model system after 2 hrs |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal brush border membrane maltase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal brush border membrane isomaltase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Glycogen debranching enzyme
(Oryctolagus cuniculus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rabbit muscle amylo-1,6-glucosidase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of rat intestinal sucrase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113716 BindingDB Entry DOI: 10.7270/Q27W6H1P |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal sucrase using sucrose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibitory activity against rat intestinal sucrase using disaccharide |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal brush border membrane sucrase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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Patents
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| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal isomaltase using isomoltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibitory activity against rat intestinal isomaltase using disaccharide |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibitory activity against rat intestinal maltase using disaccharide |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Maltase-glucoamylase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Patents
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| PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test |
J Nat Prod 65: 1875-81 (2002)
Article DOI: 10.1021/np020296h BindingDB Entry DOI: 10.7270/Q2NC60Z4 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test |
J Nat Prod 65: 1875-81 (2002)
Article DOI: 10.1021/np020296h BindingDB Entry DOI: 10.7270/Q2NC60Z4 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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| | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry |
Bioorg Med Chem 19: 3558-68 (2011)
Article DOI: 10.1016/j.bmc.2011.04.011 BindingDB Entry DOI: 10.7270/Q2BC3ZWW |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of rat intestinal isomaltase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric ass... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113716 BindingDB Entry DOI: 10.7270/Q27W6H1P |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | UniProtKB/SwissProt
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Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibitory concentration against rat intestinal maltase |
J Med Chem 48: 2036-44 (2005)
Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M |
More data for this Ligand-Target Pair | |