Compile Data Set for Download or QSAR

Found 1266 hits Enz. Inhib. hit(s) with Target = 'Guanine nucleotide-binding protein subunit alpha-15'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213143 (US9278960, 8-50 | US9636337, 8-50) Show SMILES COc1ccc(cc1F)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O Show InChI InChI=1S/C24H21FN4O2/c1-14-27-12-16(13-28-14)4-3-15-5-7-18-19(11-22(24(26)30)29-21(18)9-15)17-6-8-23(31-2)20(25)10-17/h5-13H,3-4H2,1-2H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213133 (US9278960, 8-40 | US9278960, 8-41 | US9636337, 8-4...) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(C)Cc1cccnc1)C(N)=O Show InChI InChI=1S/C25H23N3O2/c1-16(12-17-4-3-11-27-15-17)19-7-10-21-22(18-5-8-20(30-2)9-6-18)14-24(25(26)29)28-23(21)13-19/h3-11,13-16H,12H2,1-2H3,(H2,26,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213144 (US9278960, 8-51 | US9636337, 8-51) Show SMILES COc1cc(F)c(c(F)c1)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O |(5.33,-6.16,;4,-5.39,;4,-3.85,;5.33,-3.08,;5.33,-1.54,;6.67,-.77,;4,-.77,;2.67,-1.54,;1.33,-.77,;2.67,-3.08,;4,.77,;5.33,1.54,;5.33,3.08,;4,3.85,;2.67,3.08,;1.33,3.85,;,3.08,;-1.33,3.85,;-2.67,3.08,;-4,3.85,;-4,5.39,;-5.33,6.16,;-6.67,5.39,;-8,6.16,;-6.67,3.85,;-5.33,3.08,;,1.54,;1.33,.77,;2.67,1.54,;6.67,3.85,;8,3.08,;6.67,5.39,)| Show InChI InChI=1S/C24H20F2N4O2/c1-13-28-11-15(12-29-13)4-3-14-5-6-17-18(10-22(24(27)31)30-21(17)7-14)23-19(25)8-16(32-2)9-20(23)26/h5-12H,3-4H2,1-2H3,(H2,27,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213110 (US9278960, 8-17 | US9278960, 8-18 | US9636337, 8-1...) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(cc2n1)C(O)Cc1cccnc1 Show InChI InChI=1S/C23H18FN3O2/c24-17-6-3-15(4-7-17)19-12-21(23(25)29)27-20-11-16(5-8-18(19)20)22(28)10-14-2-1-9-26-13-14/h1-9,11-13,22,28H,10H2,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213110 (US9278960, 8-17 | US9278960, 8-18 | US9636337, 8-1...) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(cc2n1)C(O)Cc1cccnc1 Show InChI InChI=1S/C23H18FN3O2/c24-17-6-3-15(4-7-17)19-12-21(23(25)29)27-20-11-16(5-8-18(19)20)22(28)10-14-2-1-9-26-13-14/h1-9,11-13,22,28H,10H2,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212882 (US9278960, 2-29 | US9663506, Example 2-29) Show SMILES Cc1ccc(cc1)-c1cc(nc2cc(CN3C(=O)CCC3=O)ccc12)C(N)=O Show InChI InChI=1S/C22H19N3O3/c1-13-2-5-15(6-3-13)17-11-19(22(23)28)24-18-10-14(4-7-16(17)18)12-25-20(26)8-9-21(25)27/h2-7,10-11H,8-9,12H2,1H3,(H2,23,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213113 (US9278960, 8-20 | US9278960, 8-27 | US9278960, 8-2...) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(O)Cc1ccc(Cl)nc1)C(N)=O Show InChI InChI=1S/C24H20ClN3O3/c1-31-17-6-3-15(4-7-17)19-12-21(24(26)30)28-20-11-16(5-8-18(19)20)22(29)10-14-2-9-23(25)27-13-14/h2-9,11-13,22,29H,10H2,1H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213074 (US9278960, 6-21 | US9663506, Example 6-21) Show SMILES Cn1cc(cn1)-c1cc(nc2cc(Cc3ccnc(c3)C(F)(F)F)ccc12)C(N)=O Show InChI InChI=1S/C21H16F3N5O/c1-29-11-14(10-27-29)16-9-18(20(25)30)28-17-7-12(2-3-15(16)17)6-13-4-5-26-19(8-13)21(22,23)24/h2-5,7-11H,6H2,1H3,(H2,25,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213126 (US9278960, 8-33 | US9636337, 8-33) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CCc3cnc(nc3)C#N)ccc12)C(N)=O Show InChI InChI=1S/C24H18FN5O2/c1-32-16-5-7-17(20(25)9-16)19-10-22(24(27)31)30-21-8-14(4-6-18(19)21)2-3-15-12-28-23(11-26)29-13-15/h4-10,12-13H,2-3H2,1H3,(H2,27,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213122 (US9278960, 8-29 | US9636337, 8-29) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O Show InChI InChI=1S/C24H21FN4O2/c1-14-27-12-16(13-28-14)4-3-15-5-7-19-20(11-23(24(26)30)29-22(19)9-15)18-8-6-17(31-2)10-21(18)25/h5-13H,3-4H2,1-2H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213104 (US9278960, 8-10 | US9278960, 8-11) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1cnc(C)nc1)C(N)=O Show InChI InChI=1S/C25H23FN4O2/c1-14(8-16-12-28-15(2)29-13-16)17-4-6-20-21(11-24(25(27)31)30-23(20)9-17)19-7-5-18(32-3)10-22(19)26/h4-7,9-14H,8H2,1-3H3,(H2,27,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213125 (US9278960, 8-32 | US9636337, 8-32) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(CCc3cnc(nc3)C#N)ccc12)C(N)=O Show InChI InChI=1S/C24H19N5O2/c1-31-18-7-5-17(6-8-18)20-11-22(24(26)30)29-21-10-15(4-9-19(20)21)2-3-16-13-27-23(12-25)28-14-16/h4-11,13-14H,2-3H2,1H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212880 (US9278960, 2-27 | US9663506, Example 2-27) Show SMILES CC1CCC(=CC1)c1cc(nc2cc(CN3C(=O)CCC3=O)ccc12)C(N)=O |c:4| Show InChI InChI=1S/C22H23N3O3/c1-13-2-5-15(6-3-13)17-11-19(22(23)28)24-18-10-14(4-7-16(17)18)12-25-20(26)8-9-21(25)27/h4-5,7,10-11,13H,2-3,6,8-9,12H2,1H3,(H2,23,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213128 (US9278960, 8-35 | US9636337, 8-35) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(CCc3cncnc3N)ccc12)C(N)=O Show InChI InChI=1S/C23H21N5O2/c1-30-17-7-5-15(6-8-17)19-11-21(23(25)29)28-20-10-14(3-9-18(19)20)2-4-16-12-26-13-27-22(16)24/h3,5-13H,2,4H2,1H3,(H2,25,29)(H2,24,26,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213104 (US9278960, 8-10 | US9278960, 8-11) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1cnc(C)nc1)C(N)=O Show InChI InChI=1S/C25H23FN4O2/c1-14(8-16-12-28-15(2)29-13-16)17-4-6-20-21(11-24(25(27)31)30-23(20)9-17)19-7-5-18(32-3)10-22(19)26/h4-7,9-14H,8H2,1-3H3,(H2,27,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213108 (US9278960, 8-15 | US9636337, 8-15) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3cncnc3)cc2n1 Show InChI InChI=1S/C22H17FN4O/c23-17-6-4-16(5-7-17)19-10-21(22(24)28)27-20-9-14(3-8-18(19)20)1-2-15-11-25-13-26-12-15/h3-13H,1-2H2,(H2,24,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213078 (US9278960, 6-25 | US9663506, Example 6-25) Show SMILES Cn1cc(cn1)-c1cc(nc2cc(Cc3cc(Cl)nc(c3)C(F)(F)F)ccc12)C(N)=O Show InChI InChI=1S/C21H15ClF3N5O/c1-30-10-13(9-27-30)15-8-17(20(26)31)28-16-5-11(2-3-14(15)16)4-12-6-18(21(23,24)25)29-19(22)7-12/h2-3,5-10H,4H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213091 (US9278960, 7-29 | US9636337, 7-29) Show SMILES CCC(O)(c1cn(Cc2ccc3c(cc(nc3c2F)C(N)=O)-c2ccc(OC)cc2F)cn1)C(F)(F)F Show InChI InChI=1S/C25H21F5N4O3/c1-3-24(36,25(28,29)30)20-11-34(12-32-20)10-13-4-6-16-17(15-7-5-14(37-2)8-18(15)26)9-19(23(31)35)33-22(16)21(13)27/h4-9,11-12,36H,3,10H2,1-2H3,(H2,31,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213127 (US9278960, 8-34 | US9636337, 8-34) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(C)Cc1cnc(nc1)C#N)C(N)=O Show InChI InChI=1S/C25H21N5O2/c1-15(9-16-13-28-24(12-26)29-14-16)18-5-8-20-21(17-3-6-19(32-2)7-4-17)11-23(25(27)31)30-22(20)10-18/h3-8,10-11,13-15H,9H2,1-2H3,(H2,27,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213139 (US9278960, 8-46 | US9278960, 8-47 | US9636337, 8-4...) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(C)Cc1ccc(CF)nc1)C(N)=O Show InChI InChI=1S/C26H24FN3O2/c1-16(11-17-3-7-20(14-27)29-15-17)19-6-10-22-23(18-4-8-21(32-2)9-5-18)13-25(26(28)31)30-24(22)12-19/h3-10,12-13,15-16H,11,14H2,1-2H3,(H2,28,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213051 (US9278960, 4-135 | US9663506, Example 4-135) Show SMILES C[C@@H]1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2cn(C)nc2C)C[C@@H](O1)C(F)(F)F |r| Show InChI InChI=1S/C22H24F3N5O2/c1-12-8-30(11-20(32-12)22(23,24)25)9-14-4-5-15-16(17-10-29(3)28-13(17)2)7-19(21(26)31)27-18(15)6-14/h4-7,10,12,20H,8-9,11H2,1-3H3,(H2,26,31)/t12-,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213012 (US9278960, 4-96 | US9663506, Example 4-96) Show SMILES Cn1cc(cn1)-c1cc(nc2cc(CN3C[C@@H](OCC3(C)C)C(F)(F)F)ccc12)C(N)=O |r| Show InChI InChI=1S/C22H24F3N5O2/c1-21(2)12-32-19(22(23,24)25)11-30(21)9-13-4-5-15-16(14-8-27-29(3)10-14)7-18(20(26)31)28-17(15)6-13/h4-8,10,19H,9,11-12H2,1-3H3,(H2,26,31)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213137 (US9278960, 8-44 | US9278960, 8-45 | US9636337, 8-4...) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1cccnc1)C(N)=O Show InChI InChI=1S/C25H22FN3O2/c1-15(10-16-4-3-9-28-14-16)17-5-7-20-21(13-24(25(27)30)29-23(20)11-17)19-8-6-18(31-2)12-22(19)26/h3-9,11-15H,10H2,1-2H3,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212892 (US9278960, 2-39 | US9663506, Example 2-39) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CN3C(=O)CCC3=O)ccc12)C(N)=O Show InChI InChI=1S/C22H18FN3O4/c1-30-13-3-5-14(17(23)9-13)16-10-19(22(24)29)25-18-8-12(2-4-15(16)18)11-26-20(27)6-7-21(26)28/h2-5,8-10H,6-7,11H2,1H3,(H2,24,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213006 (US9278960, 4-90 | US9663506, Example 4-90) Show SMILES C[C@@H]1CO[C@H](CN1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1cnn(C)c1)C(F)(F)F |r| Show InChI InChI=1S/C21H22F3N5O2/c1-12-11-31-19(21(22,23)24)10-29(12)8-13-3-4-15-16(14-7-26-28(2)9-14)6-18(20(25)30)27-17(15)5-13/h3-7,9,12,19H,8,10-11H2,1-2H3,(H2,25,30)/t12-,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213007 (US9278960, 4-91 | US9663506, Example 4-91) Show SMILES C[C@H]1CO[C@H](CN1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1cnn(C)c1)C(F)(F)F |r| Show InChI InChI=1S/C21H22F3N5O2/c1-12-11-31-19(21(22,23)24)10-29(12)8-13-3-4-15-16(14-7-26-28(2)9-14)6-18(20(25)30)27-17(15)5-13/h3-7,9,12,19H,8,10-11H2,1-2H3,(H2,25,30)/t12-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213060 (US9278960, 6-7 | US9663506, Example 6-7) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(Cc3ccnc(CO)c3)cc2n1 Show InChI InChI=1S/C23H18FN3O2/c24-17-4-2-16(3-5-17)20-12-22(23(25)29)27-21-11-14(1-6-19(20)21)9-15-7-8-26-18(10-15)13-28/h1-8,10-12,28H,9,13H2,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213123 (US9278960, 8-30 | US9636337, 8-30) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(CCc3cccnc3N)ccc12)C(N)=O Show InChI InChI=1S/C24H22N4O2/c1-30-18-9-7-16(8-10-18)20-14-22(24(26)29)28-21-13-15(5-11-19(20)21)4-6-17-3-2-12-27-23(17)25/h2-3,5,7-14H,4,6H2,1H3,(H2,25,27)(H2,26,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213141 (US9278960, 8-48 | US9278960, 8-49 | US9636337, 8-4...) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1ccc(CF)nc1)C(N)=O Show InChI InChI=1S/C26H23F2N3O2/c1-15(9-16-3-5-18(13-27)30-14-16)17-4-7-21-22(12-25(26(29)32)31-24(21)10-17)20-8-6-19(33-2)11-23(20)28/h3-8,10-12,14-15H,9,13H2,1-2H3,(H2,29,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212967 (US9278960, 4-51 | US9663506, Example 4-51) Show SMILES Cc1ncc(s1)-c1cc(nc2cc(CN3CCOC(C3)C(F)(F)F)ccc12)C(N)=O Show InChI InChI=1S/C20H19F3N4O2S/c1-11-25-8-17(30-11)14-7-16(19(24)28)26-15-6-12(2-3-13(14)15)9-27-4-5-29-18(10-27)20(21,22)23/h2-3,6-8,18H,4-5,9-10H2,1H3,(H2,24,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212937 (US9278960, 4-22-A | US9278960, 4-22-B) Show SMILES C[C@H]1CNC(CN1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H22F4N4O/c1-13-10-29-21(23(25,26)27)12-31(13)11-14-2-7-17-18(15-3-5-16(24)6-4-15)9-20(22(28)32)30-19(17)8-14/h2-9,13,21,29H,10-12H2,1H3,(H2,28,32)/t13-,21?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213124 (US9278960, 8-31 | US9636337, 8-31) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(CCc3cccnc3N)ccc12)C(N)=O Show InChI InChI=1S/C24H21FN4O2/c1-31-16-7-9-17(20(25)12-16)19-13-22(24(27)30)29-21-11-14(5-8-18(19)21)4-6-15-3-2-10-28-23(15)26/h2-3,5,7-13H,4,6H2,1H3,(H2,26,28)(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212860 (US9278960, 2-7 | US9663506, Example 2-7) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1 Show InChI InChI=1S/C21H16FN3O3/c22-14-4-2-13(3-5-14)16-10-18(21(23)28)24-17-9-12(1-6-15(16)17)11-25-19(26)7-8-20(25)27/h1-6,9-10H,7-8,11H2,(H2,23,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213002 (US9278960, 4-86 | US9663506, Example 4-86) Show SMILES NC(=O)c1cc(-c2cnn(CF)c2)c2ccc(CN3CCO[C@H](C3)C(F)(F)F)cc2n1 |r| Show InChI InChI=1S/C20H19F4N5O2/c21-11-29-9-13(7-26-29)15-6-17(19(25)30)27-16-5-12(1-2-14(15)16)8-28-3-4-31-18(10-28)20(22,23)24/h1-2,5-7,9,18H,3-4,8,10-11H2,(H2,25,30)/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213085 (US9278960, 7-23 | US9636337, 7-23) Show SMILES COc1ncc(Cc2ccc3c(cc(nc3c2F)C(N)=O)-c2ccc(F)cc2)cn1 Show InChI InChI=1S/C22H16F2N4O2/c1-30-22-26-10-12(11-27-22)8-14-4-7-16-17(13-2-5-15(23)6-3-13)9-18(21(25)29)28-20(16)19(14)24/h2-7,9-11H,8H2,1H3,(H2,25,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213133 (US9278960, 8-40 | US9278960, 8-41 | US9636337, 8-4...) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(C)Cc1cccnc1)C(N)=O Show InChI InChI=1S/C25H23N3O2/c1-16(12-17-4-3-11-27-15-17)19-7-10-21-22(18-5-8-20(30-2)9-6-18)14-24(25(26)29)28-23(21)13-19/h3-11,13-16H,12H2,1-2H3,(H2,26,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213135 (US9278960, 8-42 | US9278960, 8-43 | US9636337, 8-4...) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(C)Cc1ccc(C)nc1)C(N)=O Show InChI InChI=1S/C26H25N3O2/c1-16(12-18-5-4-17(2)28-15-18)20-8-11-22-23(19-6-9-21(31-3)10-7-19)14-25(26(27)30)29-24(22)13-20/h4-11,13-16H,12H2,1-3H3,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213137 (US9278960, 8-44 | US9278960, 8-45 | US9636337, 8-4...) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1cccnc1)C(N)=O Show InChI InChI=1S/C25H22FN3O2/c1-15(10-16-4-3-9-28-14-16)17-5-7-20-21(13-24(25(27)30)29-23(20)11-17)19-8-6-18(31-2)12-22(19)26/h3-9,11-15H,10H2,1-2H3,(H2,27,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213017 (US9278960, 4-101 | US9278960, 4-102 | US9663506, E...) Show SMILES C[C@@H]1CNC(CN1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H22F4N4O/c1-13-10-29-21(23(25,26)27)12-31(13)11-14-2-7-17-18(15-3-5-16(24)6-4-15)9-20(22(28)32)30-19(17)8-14/h2-9,13,21,29H,10-12H2,1H3,(H2,28,32)/t13-,21?/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213017 (US9278960, 4-101 | US9278960, 4-102 | US9663506, E...) Show SMILES C[C@@H]1CNC(CN1Cc1ccc2c(cc(nc2c1)C(N)=O)-c1ccc(F)cc1)C(F)(F)F |r| Show InChI InChI=1S/C23H22F4N4O/c1-13-10-29-21(23(25,26)27)12-31(13)11-14-2-7-17-18(15-3-5-16(24)6-4-15)9-20(22(28)32)30-19(17)8-14/h2-9,13,21,29H,10-12H2,1H3,(H2,28,32)/t13-,21?/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM212932 (US9278960, 3-51 | US9663506, Example 3-51) Show SMILES CCC(O)(c1cn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(OC)cc2)cn1)C(F)(F)F Show InChI InChI=1S/C25H23F3N4O3/c1-3-24(34,25(26,27)28)22-13-32(14-30-22)12-15-4-9-18-19(16-5-7-17(35-2)8-6-16)11-21(23(29)33)31-20(18)10-15/h4-11,13-14,34H,3,12H2,1-2H3,(H2,29,33)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213090 (US9278960, 7-28 | US9636337, 7-28) Show SMILES CCC(O)(c1cn(Cc2ccc3c(cc(nc3c2F)C(N)=O)-c2ccc(OC)c(F)c2)cn1)C(F)(F)F Show InChI InChI=1S/C25H21F5N4O3/c1-3-24(36,25(28,29)30)20-11-34(12-32-20)10-14-4-6-15-16(13-5-7-19(37-2)17(26)8-13)9-18(23(31)35)33-22(15)21(14)27/h4-9,11-12,36H,3,10H2,1-2H3,(H2,31,35)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213101 (US9278960, 8-1 | US9636337, 8-1) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(cc2n1)[C@@H](O)Cc1ccc(Cl)nc1 |r| Show InChI InChI=1S/C23H17ClFN3O2/c24-22-8-1-13(12-27-22)9-21(29)15-4-7-17-18(14-2-5-16(25)6-3-14)11-20(23(26)30)28-19(17)10-15/h1-8,10-12,21,29H,9H2,(H2,26,30)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213109 (US9278960, 8-16 | US9636337, 8-16) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3cccnc3)cc2n1 Show InChI InChI=1S/C23H18FN3O/c24-18-8-6-17(7-9-18)20-13-22(23(25)28)27-21-12-15(5-10-19(20)21)3-4-16-2-1-11-26-14-16/h1-2,5-14H,3-4H2,(H2,25,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213139 (US9278960, 8-46 | US9278960, 8-47 | US9636337, 8-4...) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(C)Cc1ccc(CF)nc1)C(N)=O Show InChI InChI=1S/C26H24FN3O2/c1-16(11-17-3-7-20(14-27)29-15-17)19-6-10-22-23(18-4-8-21(32-2)9-5-18)13-25(26(28)31)30-24(22)12-19/h3-10,12-13,15-16H,11,14H2,1-2H3,(H2,28,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213141 (US9278960, 8-48 | US9278960, 8-49 | US9636337, 8-4...) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(ccc12)C(C)Cc1ccc(CF)nc1)C(N)=O Show InChI InChI=1S/C26H23F2N3O2/c1-15(9-16-3-5-18(13-27)30-14-16)17-4-7-21-22(12-25(26(29)32)31-24(21)10-17)20-8-6-19(33-2)11-23(20)28/h3-8,10-12,14-15H,9,13H2,1-2H3,(H2,29,32)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213062 (US9278960, 6-11 | US9278960, 6-9 | US9663506, Exam...) Show SMILES COc1ncc(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)cn1 Show InChI InChI=1S/C22H17FN4O2/c1-29-22-25-11-14(12-26-22)8-13-2-7-17-18(15-3-5-16(23)6-4-15)10-20(21(24)28)27-19(17)9-13/h2-7,9-12H,8H2,1H3,(H2,24,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213113 (US9278960, 8-20 | US9278960, 8-27 | US9278960, 8-2...) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(ccc12)C(O)Cc1ccc(Cl)nc1)C(N)=O Show InChI InChI=1S/C24H20ClN3O3/c1-31-17-6-3-15(4-7-17)19-12-21(24(26)30)28-20-11-16(5-8-18(19)20)22(29)10-14-2-9-23(25)27-13-14/h2-9,11-13,22,29H,10H2,1H3,(H2,26,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213147 (US9278960, 8-54 | US9636337, 8-54) Show SMILES COc1c(F)cc(cc1F)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O Show InChI InChI=1S/C24H20F2N4O2/c1-13-28-11-15(12-29-13)4-3-14-5-6-17-18(10-22(24(27)31)30-21(17)7-14)16-8-19(25)23(32-2)20(26)9-16/h5-12H,3-4H2,1-2H3,(H2,27,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM213011 (US9278960, 4-95 | US9663506, Example 4-95) Show SMILES Cn1cc(cn1)-c1cc(nc2cc(CN3C[C@@H](OC(C)(C)C3)C(F)(F)F)ccc12)C(N)=O |r| Show InChI InChI=1S/C22H24F3N5O2/c1-21(2)12-30(11-19(32-21)22(23,24)25)9-13-4-5-15-16(14-8-27-29(3)10-14)7-18(20(26)31)28-17(15)6-13/h4-8,10,19H,9,11-12H2,1-3H3,(H2,26,31)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...				US Patent US9278960 (2016) BindingDB Entry DOI: 10.7270/Q2MK6BQW
					More data for this Ligand-Target Pair

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