Found 1125 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Sgk1' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50402020
(CHEMBL2205426)Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of recombinant SGK after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP |
Bioorg Med Chem Lett 22: 7615-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM7393
(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)Show InChI InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,13,17H,(H,18,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by PDSP Ki Database
| |
Biochem J 371: 199-204 (2003)
Article DOI: 10.1042/BJ20021535
BindingDB Entry DOI: 10.7270/Q2KH0KV9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50540597
(CHEMBL4638374)Show SMILES OCCNc1nc(NCCc2ccccc2)c2cnn(\C=C\c3ccccc3)c2n1 Show InChI InChI=1S/C23H24N6O/c30-16-14-25-23-27-21(24-13-11-18-7-3-1-4-8-18)20-17-26-29(22(20)28-23)15-12-19-9-5-2-6-10-19/h1-10,12,15,17,30H,11,13-14,16H2,(H2,24,25,27,28)/b15-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His6-tagged N-truncated human SGK1 harboring S422D mutant expressed in Sf21 cells using Sgktide-peptide as substrate i... |
ACS Med Chem Lett 11: 657-663 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00530
BindingDB Entry DOI: 10.7270/Q2V128CQ |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50341519
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1 |r| Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals (Europe) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of SGK1 |
J Med Chem 54: 2341-50 (2011)
Article DOI: 10.1021/jm101499u
BindingDB Entry DOI: 10.7270/Q2KH0NPW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50463479
(CHEMBL4249925)Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Inhibition of SGK1 (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50463484
(CHEMBL4248525)Show SMILES CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(cs3)-c3c[nH]c4ncccc34)c2)CC1 Show InChI InChI=1S/C26H30N6O2S/c1-31-10-12-32(13-11-31)9-4-14-34-20-6-2-5-19(15-20)16-24(33)30-26-29-23(18-35-26)22-17-28-25-21(22)7-3-8-27-25/h2-3,5-8,15,17-18H,4,9-14,16H2,1H3,(H,27,28)(H,29,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Inhibition of SGK (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50463483
(CHEMBL4245242)Show SMILES O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Inhibition of SGK1 (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50463479
(CHEMBL4249925)Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Inhibition of SGK (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50224883
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of SGK |
Bioorg Med Chem Lett 17: 6593-601 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM269150
(US9718825, Example 596)Show SMILES CCOc1nc(cc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1 Show InChI InChI=1S/C21H20FN5O3S/c1-3-30-21-19-17(25-26-20(19)23)11-16(24-21)13-5-7-14(8-6-13)27-31(28,29)18-10-12(2)4-9-15(18)22/h4-11,27H,3H2,1-2H3,(H3,23,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM269143
(US9718825, Example 589)Show SMILES CC(C)N1CC(COc2nc(cc3[nH]nc(C)c23)-c2ccc(NS(=O)(=O)c3cc(C)ccc3F)cc2)C1 Show InChI InChI=1S/C27H30FN5O3S/c1-16(2)33-13-19(14-33)15-36-27-26-18(4)30-31-24(26)12-23(29-27)20-6-8-21(9-7-20)32-37(34,35)25-11-17(3)5-10-22(25)28/h5-12,16,19,32H,13-15H2,1-4H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM269083
(US9718825, Example 527)Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1ncc2c(N)n[nH]c2n1 Show InChI InChI=1S/C18H15FN6O3S/c1-28-12-6-7-14(19)15(8-12)29(26,27)25-11-4-2-10(3-5-11)17-21-9-13-16(20)23-24-18(13)22-17/h2-9,25H,1H3,(H3,20,21,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <0.510 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM268829
(US9718825, Example 234)Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1 Show InChI InChI=1S/C23H23FN6O5S/c1-33-16-6-7-18(24)19(8-16)36(31,32)30-15-4-2-14(3-5-15)20-27-21-17(9-26-29-21)22(28-20)35-13-23(10-25)11-34-12-23/h2-9,30H,10-13,25H2,1H3,(H,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <0.510 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM269008
(US9718825, Example 451)Show SMILES CCOc1nc(nc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1 Show InChI InChI=1S/C19H15ClF2N6O3S/c1-2-31-19-15-16(23)26-27-18(15)24-17(25-19)9-3-5-10(6-4-9)28-32(29,30)14-7-11(20)12(21)8-13(14)22/h3-8,28H,2H2,1H3,(H3,23,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM268860
(US9718825, Example 265)Show SMILES CN1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C23H22ClFN6O3S/c1-31-10-8-17(9-11-31)34-23-18-13-26-29-22(18)27-21(28-23)14-2-5-16(6-3-14)30-35(32,33)20-12-15(24)4-7-19(20)25/h2-7,12-13,17,30H,8-11H2,1H3,(H,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM268850
(US9718825, Example 255 | US9718825, Example 261)Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM268828
(US9718825, Example 233)Show SMILES COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1 Show InChI InChI=1S/C23H23ClN6O5S/c1-33-16-6-7-18(24)19(8-16)36(31,32)30-15-4-2-14(3-5-15)20-27-21-17(9-26-29-21)22(28-20)35-13-23(10-25)11-34-12-23/h2-9,30H,10-13,25H2,1H3,(H,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9718825 (2017)
BindingDB Entry DOI: 10.7270/Q2VM4F82 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043877
(CHEMBL3356033)Show SMILES COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1ccc2c(N)n[nH]c2c1 Show InChI InChI=1S/C20H17ClN4O3S/c1-28-15-7-9-17(21)19(11-15)29(26,27)25-14-5-2-12(3-6-14)13-4-8-16-18(10-13)23-24-20(16)22/h2-11,25H,1H3,(H3,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043878
(CHEMBL3356034)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2cc(Br)ccc2Cl)cc1 Show InChI InChI=1S/C19H14BrClN4O2S/c20-13-4-8-16(21)18(10-13)28(26,27)25-14-5-1-11(2-6-14)12-3-7-15-17(9-12)23-24-19(15)22/h1-10,25H,(H3,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
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Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043894
(CHEMBL3356037)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C19H14ClFN4O2S/c20-13-4-8-16(21)18(10-13)28(26,27)25-14-5-1-11(2-6-14)12-3-7-15-17(9-12)23-24-19(15)22/h1-10,25H,(H3,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
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| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50443628
(CHEMBL3092468 | US9174993, 35 | US9221828, 35)Show SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043926
(CHEMBL3356021)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1 Show InChI InChI=1S/C17H12Cl2N4O2S2/c18-15-8-14(16(19)26-15)27(24,25)23-11-4-1-9(2-5-11)10-3-6-12-13(7-10)21-22-17(12)20/h1-8,23H,(H3,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043928
(CHEMBL3356023)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C19H15ClN4O2S/c20-16-3-1-2-4-18(16)27(25,26)24-14-8-5-12(6-9-14)13-7-10-15-17(11-13)22-23-19(15)21/h1-11,24H,(H3,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043930
(CHEMBL3356025)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 Show InChI InChI=1S/C19H14Cl2N4O2S/c20-13-4-8-16(21)18(10-13)28(26,27)25-14-5-1-11(2-6-14)12-3-7-15-17(9-12)23-24-19(15)22/h1-10,25H,(H3,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043934
(CHEMBL3356029)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2cc(ccc2F)C(F)(F)F)cc1 Show InChI InChI=1S/C20H14F4N4O2S/c21-16-8-4-13(20(22,23)24)10-18(16)31(29,30)28-14-5-1-11(2-6-14)12-3-7-15-17(9-12)26-27-19(15)25/h1-10,28H,(H3,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
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UniChem
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043935
(CHEMBL3356030)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2ccccc2F)cc1 Show InChI InChI=1S/C19H15FN4O2S/c20-16-3-1-2-4-18(16)27(25,26)24-14-8-5-12(6-9-14)13-7-10-15-17(11-13)22-23-19(15)21/h1-11,24H,(H3,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043937
(CHEMBL3356032)Show SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(NS(=O)(=O)c2cc(F)ccc2F)cc1 Show InChI InChI=1S/C19H14F2N4O2S/c20-13-4-8-16(21)18(10-13)28(26,27)25-14-5-1-11(2-6-14)12-3-7-15-17(9-12)23-24-19(15)22/h1-10,25H,(H3,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence... |
ACS Med Chem Lett 6: 73-8 (2015)
Article DOI: 10.1021/ml5003376
BindingDB Entry DOI: 10.7270/Q28S4RJT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50443628
(CHEMBL3092468 | US9174993, 35 | US9221828, 35)Show SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human SGK-1 expressed in baculovirus expression system using (5(6)-carboxyfluorescein)-RPRAATF-NH2 as substrate preincubate... |
ACS Med Chem Lett 4: 1022-4 (2013)
Article DOI: 10.1021/ml400389a
BindingDB Entry DOI: 10.7270/Q2XS5WVS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50443628
(CHEMBL3092468 | US9174993, 35 | US9221828, 35)Show SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... |
US Patent US9174993 (2015)
BindingDB Entry DOI: 10.7270/Q2MK6BPF |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50443628
(CHEMBL3092468 | US9174993, 35 | US9221828, 35)Show SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 Show InChI InChI=1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 24 |
SANOFI
US Patent
| Assay Description
The enzyme reaction was carried out in a buffer containing 25 mM
Tris-HCl (pH 7.4), 5 mM MgCl2, 2 mM MnCl2, 2 mM DTT, and 0.03% bovine
serum albumi... |
US Patent US9221828 (2015)
BindingDB Entry DOI: 10.7270/Q2GX49DW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50043019
(CHEMBL3355029)Show SMILES O[C@H]1CC[C@@H](CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |r,wU:4.7,wD:1.0,(43,-11.27,;41.45,-11.27,;40.68,-9.93,;39.13,-9.93,;38.37,-11.26,;39.14,-12.6,;40.68,-12.61,;36.83,-11.26,;36.06,-12.6,;34.52,-12.6,;33.75,-13.93,;34.52,-15.27,;36.05,-15.27,;37.07,-16.42,;38.48,-15.8,;38.34,-14.27,;36.83,-13.94,;32.21,-13.93,;31.43,-15.26,;29.89,-15.26,;29.13,-13.92,;27.59,-13.91,;26.81,-15.24,;28.15,-16.01,;26.81,-16.78,;25.27,-15.25,;24.5,-13.91,;22.96,-13.92,;22.18,-12.58,;22.2,-15.25,;22.96,-16.57,;24.5,-16.58,;25.27,-17.91,;29.9,-12.59,;31.44,-12.59,)| | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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| Article
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| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584096
(CHEMBL5078023)Show SMILES Clc1cccc(c1Cl)S(=O)(=O)Nc1ccc(cc1)-c1cc(C(=O)N[C@@H]2CCNC2)c2cn[nH]c2n1 |r| | PDB
MMDB
Reactome pathway
KEGG
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| Article
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| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584107
(CHEMBL5077567)Show SMILES NCCNC(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584109
(CHEMBL5071237)Show SMILES CN1CC(C1)NC(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584122
(CHEMBL5074684)Show SMILES Cc1n[nH]c2nc(nc(OCC3(CN)COC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584127
(CHEMBL5087162)Show SMILES CC(C)N1CC(COc2nc(nc3[nH]nc(C)c23)-c2ccc(NS(=O)(=O)c3cc(Cl)ccc3F)cc2)C1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM268914
(US9718825, Example 339)Show SMILES Cc1n[nH]c2nc(nc(OC3CCCNC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584128
(CHEMBL5083625)Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM268850
(US9718825, Example 255 | US9718825, Example 261)Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584131
(CHEMBL5070612)Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3F)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584096
(CHEMBL5078023)Show SMILES Clc1cccc(c1Cl)S(=O)(=O)Nc1ccc(cc1)-c1cc(C(=O)N[C@@H]2CCNC2)c2cn[nH]c2n1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584097
(CHEMBL5084696)Show SMILES CN1CCC(C1)NC(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584100
(CHEMBL5093306)Show SMILES OCCN1CCC(C1)NC(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584101
(CHEMBL5087657)Show SMILES Clc1cccc(c1Cl)S(=O)(=O)Nc1ccc(cc1)-c1cc(C(=O)NC2CCN(CC3CC3)C2)c2cn[nH]c2n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584102
(CHEMBL5075992)Show SMILES NC(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584106
(CHEMBL5080922)Show SMILES CN(CCO)C(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584107
(CHEMBL5077567)Show SMILES NCCNC(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584109
(CHEMBL5071237)Show SMILES CN1CC(C1)NC(=O)c1cc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584111
(CHEMBL5090286)Show SMILES CCN1CCC(CNC(=O)c2cc(nc3[nH]ncc23)-c2ccc(NS(=O)(=O)c3cccc(Cl)c3Cl)cc2)C1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50584112
(CHEMBL5079183)Show SMILES Clc1cccc(c1Cl)S(=O)(=O)Nc1ccc(cc1)-c1cc(C(=O)NCc2ncc[nH]2)c2cn[nH]c2n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01601
BindingDB Entry DOI: 10.7270/Q2P55SCW |
More data for this
Ligand-Target Pair | |
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