Compile Data Set for Download or QSAR

Found 864 hits Enz. Inhib. hit(s) with Target = 'N-acylethanolamine-hydrolyzing acid amidase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538919 (CHEMBL4633233) Show SMILES COc1ccc(cc1F)-c1ccc(COC2(CN(C2)C#N)C2CC2)c(F)c1 Show InChI InChI=1S/C21H20F2N2O2/c1-26-20-7-4-15(9-19(20)23)14-2-3-16(18(22)8-14)10-27-21(17-5-6-17)11-25(12-21)13-24/h2-4,7-9,17H,5-6,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393375 (3-((4'-Methyl-[1,1'-biphenyl]-4-yl)methoxy)azetidi...) Show SMILES Cc1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C18H18N2O/c1-14-2-6-16(7-3-14)17-8-4-15(5-9-17)12-21-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393377 (3-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)metho...) Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)c(F)c1 Show InChI InChI=1S/C18H17FN2O2/c1-22-16-4-2-3-13(7-16)14-5-6-15(18(19)8-14)11-23-17-9-21(10-17)12-20/h2-8,17H,9-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393376 (3-((4'-Fluoro-[1,1'-biphenyl]-4-yl)methoxy)azetidi...) Show SMILES Fc1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C17H15FN2O/c18-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-21-17-9-20(10-17)12-19/h1-8,17H,9-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393378 (3-((3'-Methoxy-3-(trifluoromethyl)-[1,1'-biphenyl]...) Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)c(c1)C(F)(F)F Show InChI InChI=1S/C19H17F3N2O2/c1-25-16-4-2-3-13(7-16)14-5-6-15(18(8-14)19(20,21)22)11-26-17-9-24(10-17)12-23/h2-8,17H,9-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393368 (3-((2',3'-Dimethoxy-[1,1'-biphenyl]-4-yl)methoxy)a...) Show SMILES COc1cccc(-c2ccc(COC3CN(C3)C#N)cc2)c1OC Show InChI InChI=1S/C19H20N2O3/c1-22-18-5-3-4-17(19(18)23-2)15-8-6-14(7-9-15)12-24-16-10-21(11-16)13-20/h3-9,16H,10-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393366 (3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)azetid...) Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C18H18N2O2/c1-21-17-4-2-3-16(9-17)15-7-5-14(6-8-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.890	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393366 (3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)azetid...) Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C18H18N2O2/c1-21-17-4-2-3-16(9-17)15-7-5-14(6-8-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of NAAA (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393362 (US9963444, Example 63) Show SMILES COc1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C18H18N2O2/c1-21-17-8-6-16(7-9-17)15-4-2-14(3-5-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538909 (CHEMBL4637701) Show SMILES Brc1cc(Oc2ccccc2)ccc1COC1CN(C1)C#N Show InChI InChI=1S/C17H15BrN2O2/c18-17-8-15(22-14-4-2-1-3-5-14)7-6-13(17)11-21-16-9-20(10-16)12-19/h1-8,16H,9-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393380 (3-((4-Phenoxybenzyl)oxy)azetidine-1-carbonitrile |...) Show SMILES N#CN1CC(C1)OCc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C17H16N2O2/c18-13-19-10-17(11-19)20-12-14-6-8-16(9-7-14)21-15-4-2-1-3-5-15/h1-9,17H,10-12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393384 (US9963444, Example 85) Show SMILES N#CN1CC(C1)OCc1ccc(cc1)-c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C24H22N2O2/c25-18-26-14-24(15-26)28-17-20-9-11-21(12-10-20)22-7-4-8-23(13-22)27-16-19-5-2-1-3-6-19/h1-13,24H,14-17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538910 (CHEMBL4645560) Show SMILES COc1ccc(cc1F)-c1ccc2CN(Cc2c1)C1CN(C1)C#N Show InChI InChI=1S/C19H18FN3O/c1-24-19-5-4-14(7-18(19)20)13-2-3-15-8-23(9-16(15)6-13)17-10-22(11-17)12-21/h2-7,17H,8-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538911 (CHEMBL4635238) Show SMILES COc1cccc(c1)-c1ccc(cc1)C(=O)NC1(C)CN(C1)C#N Show InChI InChI=1S/C19H19N3O2/c1-19(11-22(12-19)13-20)21-18(23)15-8-6-14(7-9-15)16-4-3-5-17(10-16)24-2/h3-10H,11-12H2,1-2H3,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538916 (CHEMBL4646586) Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C18H15F3N2O/c19-18(20,21)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-24-17-9-23(10-17)12-22/h1-8,17H,9-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393394 (US9963444, Example 95) Show SMILES COc1cccc(c1)-c1ccc(COC2(C)CN(C2)C#N)cc1 Show InChI InChI=1S/C19H20N2O2/c1-19(12-21(13-19)14-20)23-11-15-6-8-16(9-7-15)17-4-3-5-18(10-17)22-2/h3-10H,11-13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM447488 (US10689357, Example 25) Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:18.19,20.24,(-9.61,-3.62,;-8.28,-4.39,;-6.94,-3.62,;-6.94,-2.08,;-5.61,-1.31,;-4.28,-2.08,;-4.28,-3.62,;-5.61,-4.39,;-2.94,-1.31,;-2.94,.23,;-1.61,1,;-.28,.23,;-.28,-1.31,;-1.61,-2.08,;1.06,1,;.29,2.33,;1.83,2.33,;2.39,.23,;3.72,1,;4.12,2.48,;5.61,2.08,;5.21,.6,;6.94,2.85,;8.28,3.62,;9.61,4.39,)| Show InChI InChI=1S/C18H18N2O3S2/c1-23-17-6-2-13(3-7-17)14-4-8-18(9-5-14)25(21,22)20-16-10-15(11-16)19-12-24/h2-9,15-16,20H,10-11H2,1H3/t15-,16+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393391 (3-((4'-Cyano-5-phenoxy-[1,1'-biphenyl]-2-yl)methox...) Show SMILES N#CN1CC(C1)OCc1ccc(Oc2ccccc2)cc1-c1ccc(cc1)C#N Show InChI InChI=1S/C24H19N3O2/c25-13-18-6-8-19(9-7-18)24-12-22(29-21-4-2-1-3-5-21)11-10-20(24)16-28-23-14-27(15-23)17-26/h1-12,23H,14-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393363 (3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carboni...) Show SMILES N#CN1CC(C1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O/c18-13-19-10-17(11-19)20-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538914 (CHEMBL4637755) Show SMILES COc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCC11CN(C1)C#N Show InChI InChI=1S/C19H19N3O3S/c1-25-17-4-2-3-16(11-17)15-5-7-18(8-6-15)26(23,24)22-10-9-19(22)12-21(13-19)14-20/h2-8,11H,9-10,12-13H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393379 (3-((3,3'-Dimethoxy-[1,1'-biphenyl]-4-yl)methoxy)az...) Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)c(OC)c1 Show InChI InChI=1S/C19H20N2O3/c1-22-17-5-3-4-14(8-17)15-6-7-16(19(9-15)23-2)12-24-18-10-21(11-18)13-20/h3-9,18H,10-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393363 (3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carboni...) Show SMILES N#CN1CC(C1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O/c18-13-19-10-17(11-19)20-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of NAAA (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538912 (CHEMBL4643588) Show SMILES COc1cccc(c1)-c1ccc(cc1)S(=O)(=O)NC1(C)CN(C1)C#N Show InChI InChI=1S/C18H19N3O3S/c1-18(11-21(12-18)13-19)20-25(22,23)17-8-6-14(7-9-17)15-4-3-5-16(10-15)24-2/h3-10,20H,11-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM447493 (US10689357, Example 30) Show SMILES COc1ccc(cc1F)-c1ccc(cc1)S(=O)(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:19.20,21.25,(-11.93,2.49,;-11.4,1.04,;-9.86,1.04,;-9.09,2.37,;-7.55,2.37,;-6.78,1.04,;-7.55,-.3,;-9.09,-.3,;-9.86,-1.63,;-5.24,1.04,;-4.47,-.3,;-2.93,-.3,;-2.16,1.04,;-2.93,2.37,;-4.47,2.37,;-.62,1.04,;-.62,-.5,;-.62,2.58,;.92,1.04,;2.46,1.04,;3.54,2.13,;5.14,1.04,;3.54,-.05,;7.03,1.04,;7.98,2.68,;8.93,4.32,)| Show InChI InChI=1S/C18H17FN2O3S2/c1-24-18-7-4-13(8-17(18)19)12-2-5-16(6-3-12)26(22,23)21-15-9-14(10-15)20-11-25/h2-8,14-15,21H,9-10H2,1H3/t14-,15+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393385 (US9963444, Example 86) Show SMILES N#CN1CC(COCc2ccc(cc2)-c2ccccc2)C1 Show InChI InChI=1S/C18H18N2O/c19-14-20-10-16(11-20)13-21-12-15-6-8-18(9-7-15)17-4-2-1-3-5-17/h1-9,16H,10-13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM233790 (US9353075, 47) Show SMILES CC[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1 |r| Show InChI InChI=1S/C17H23NO4/c1-2-14-15(16(19)22-14)18-17(20)21-12-8-4-7-11-13-9-5-3-6-10-13/h3,5-6,9-10,14-15H,2,4,7-8,11-12H2,1H3,(H,18,20)/t14-,15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	4.5	n/a
The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo” US Patent					Assay Description The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...				US Patent US9353075 (2016) BindingDB Entry DOI: 10.7270/Q23N229Q
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50576137 (CHEMBL4863412) Show SMILES Fc1cc(ccc1CO[C@H]1C[C@H](C1)N=C=S)-c1ccc2OCCc2c1 |r,wU:9.9,11.14,(13.46,-17.55,;12.7,-18.88,;11.16,-18.9,;10.4,-20.24,;11.19,-21.57,;12.73,-21.55,;13.49,-20.22,;15.02,-20.2,;15.81,-21.53,;17.35,-21.52,;18.42,-20.42,;19.52,-21.5,;18.44,-22.59,;21.06,-21.48,;21.84,-22.81,;22.6,-24.13,;8.86,-20.26,;8.09,-18.93,;6.55,-18.94,;5.78,-20.28,;4.27,-20.63,;4.13,-22.17,;5.56,-22.78,;6.58,-21.61,;8.12,-21.59,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538918 (CHEMBL4638402) Show SMILES COc1ccc(cc1F)-c1ccc(COC2(CN(C2)C#N)c2cccnc2)c(F)c1 Show InChI InChI=1S/C23H19F2N3O2/c1-29-22-7-6-17(10-21(22)25)16-4-5-18(20(24)9-16)12-30-23(13-28(14-23)15-26)19-3-2-8-27-11-19/h2-11H,12-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50439649 (CHEMBL2419811 | US9353075, 7) Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O |r| Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	4.5	37
The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo” US Patent					Assay Description NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...				US Patent US9353075 (2016) BindingDB Entry DOI: 10.7270/Q23N229Q
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50439649 (CHEMBL2419811 | US9353075, 7) Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O |r| Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells				J Med Chem 56: 6917-34 (2013) Article DOI: 10.1021/jm400739u BindingDB Entry DOI: 10.7270/Q2F47QK0
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50439653 (CHEMBL2419830 | US9353075, 35) Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1 |r| Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	4.5	37
The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo” US Patent					Assay Description NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...				US Patent US9353075 (2016) BindingDB Entry DOI: 10.7270/Q23N229Q
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50439653 (CHEMBL2419830 | US9353075, 35) Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1 |r| Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells				J Med Chem 56: 6917-34 (2013) Article DOI: 10.1021/jm400739u BindingDB Entry DOI: 10.7270/Q2F47QK0
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393389 (3-((4'-Methoxy-5-phenoxy-[1,1'-biphenyl]-2-yl)meth...) Show SMILES COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1COC1CN(C1)C#N Show InChI InChI=1S/C24H22N2O3/c1-27-20-10-7-18(8-11-20)24-13-22(29-21-5-3-2-4-6-21)12-9-19(24)16-28-23-14-26(15-23)17-25/h2-13,23H,14-16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393373 (3-((4-(2-Methoxypyridin-3-yl)benzyl)oxy)azetidine-...) Show SMILES COc1ncccc1-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C17H17N3O2/c1-21-17-16(3-2-8-19-17)14-6-4-13(5-7-14)11-22-15-9-20(10-15)12-18/h2-8,15H,9-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538922 (CHEMBL4647961) Show SMILES C[C@H]1[C@H](NC(=O)OCCCCC2CCCCC2)C(=O)N1c1cccc(c1)S(C)(=O)=O |r| Show InChI InChI=1S/C22H32N2O5S/c1-16-20(21(25)24(16)18-12-8-13-19(15-18)30(2,27)28)23-22(26)29-14-7-6-11-17-9-4-3-5-10-17/h8,12-13,15-17,20H,3-7,9-11,14H2,1-2H3,(H,23,26)/t16-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of NAAA (unknown origin)				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538922 (CHEMBL4647961) Show SMILES C[C@H]1[C@H](NC(=O)OCCCCC2CCCCC2)C(=O)N1c1cccc(c1)S(C)(=O)=O |r| Show InChI InChI=1S/C22H32N2O5S/c1-16-20(21(25)24(16)18-12-8-13-19(15-18)30(2,27)28)23-22(26)29-14-7-6-11-17-9-4-3-5-10-17/h8,12-13,15-17,20H,3-7,9-11,14H2,1-2H3,(H,23,26)/t16-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of NAAA (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM233791 (US9353075, 48) Show SMILES CC[C@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C19H19NO4/c1-2-16-17(18(21)24-16)20-19(22)23-12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17H,2,12H2,1H3,(H,20,22)/t16-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	4.5	n/a
The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo” US Patent					Assay Description The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...				US Patent US9353075 (2016) BindingDB Entry DOI: 10.7270/Q23N229Q
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50151057 (CHEMBL3770726) Show SMILES O=C(N[C@H]1CNC1=O)OCCCCC1CCCCC1 |r| Show InChI InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human NAAA				J Med Chem 63: 7475-7490 (2020) Article DOI: 10.1021/acs.jmedchem.0c00191 BindingDB Entry DOI: 10.7270/Q2V98CM4
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50234746 (CHEMBL4093333) Show SMILES C[C@H]1[C@H](NC(=O)OCCCCC2CCCCC2)C(=O)N1Oc1ccccc1S(C)(=O)=O |r| Show InChI InChI=1S/C22H32N2O6S/c1-16-20(23-22(26)29-15-9-8-12-17-10-4-3-5-11-17)21(25)24(16)30-18-13-6-7-14-19(18)31(2,27)28/h6-7,13-14,16-17,20H,3-5,8-12,15H2,1-2H3,(H,23,26)/t16-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human spleen NAAA expressed in HEK293 cells using PAMCA as substrate preincubated for 10 mins followed by substrate additio...				Eur J Med Chem 126: 561-575 (2017) Article DOI: 10.1016/j.ejmech.2016.11.039 BindingDB Entry DOI: 10.7270/Q25H7JHB
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50234744 (CHEMBL4101070) Show SMILES C[C@H]1[C@H](NC(=O)OCCCCC2CCCCC2)C(=O)N1Oc1ccc(cc1)S(C)(=O)=O |r| Show InChI InChI=1S/C22H32N2O6S/c1-16-20(23-22(26)29-15-7-6-10-17-8-4-3-5-9-17)21(25)24(16)30-18-11-13-19(14-12-18)31(2,27)28/h11-14,16-17,20H,3-10,15H2,1-2H3,(H,23,26)/t16-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of recombinant human spleen NAAA expressed in HEK293 cells using PAMCA as substrate preincubated for 10 mins followed by substrate additio...				Eur J Med Chem 126: 561-575 (2017) Article DOI: 10.1016/j.ejmech.2016.11.039 BindingDB Entry DOI: 10.7270/Q25H7JHB
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393397 (3-((4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)...) Show SMILES N#CN1CC(C1)(OCc1ccc(cc1)-c1ccc2OCCOc2c1)c1ccccc1 Show InChI InChI=1S/C25H22N2O3/c26-18-27-16-25(17-27,22-4-2-1-3-5-22)30-15-19-6-8-20(9-7-19)21-10-11-23-24(14-21)29-13-12-28-23/h1-11,14H,12-13,15-17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM447489 (US10689357, Example 26) Show SMILES COc1ccc(cc1)-c1ccc(nc1)S(=O)(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:18.19,20.24,(-9.61,-3.62,;-8.28,-4.39,;-6.94,-3.62,;-6.94,-2.08,;-5.61,-1.31,;-4.28,-2.08,;-4.28,-3.62,;-5.61,-4.39,;-2.94,-1.31,;-2.94,.23,;-1.61,1,;-.28,.23,;-.28,-1.31,;-1.61,-2.08,;1.06,1,;.29,2.33,;1.83,2.33,;2.39,.23,;3.72,1,;4.12,2.48,;5.61,2.08,;5.21,.6,;6.94,2.85,;8.28,3.62,;9.61,4.39,)| Show InChI InChI=1S/C17H17N3O3S2/c1-23-16-5-2-12(3-6-16)13-4-7-17(18-10-13)25(21,22)20-15-8-14(9-15)19-11-24/h2-7,10,14-15,20H,8-9H2,1H3/t14-,15+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50538913 (CHEMBL4649749) Show SMILES COc1cccc(c1)-c1ccc(cc1)C(=O)N1CCC11CN(C1)C#N Show InChI InChI=1S/C20H19N3O2/c1-25-18-4-2-3-17(11-18)15-5-7-16(8-6-15)19(24)23-10-9-20(23)12-22(13-20)14-21/h2-8,11H,9-10,12-13H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
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N-acylethanolamine-hydrolyzing acid amidase (Rattus norvegicus (Rat))	BDBM50032458 (CHEMBL3354144 | US9353075, 42) Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)C1CCCCC1 |r| Show InChI InChI=1S/C18H23NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h7-10,12,14,16H,2-6,11H2,1H3,(H,19,21)/t12-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method				J Med Chem 57: 10101-11 (2014) Article DOI: 10.1021/jm501455s BindingDB Entry DOI: 10.7270/Q26111W8
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N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393392 (3-((2'-Cyano-5-phenoxy-[1,1'-biphenyl]-2-yl)methox...) Show SMILES N#CN1CC(C1)OCc1ccc(Oc2ccccc2)cc1-c1ccccc1C#N Show InChI InChI=1S/C24H19N3O2/c25-13-18-6-4-5-9-23(18)24-12-21(29-20-7-2-1-3-8-20)11-10-19(24)16-28-22-14-27(15-22)17-26/h1-12,22H,14-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2019.115195 BindingDB Entry DOI: 10.7270/Q2K35Z63
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50151154 (CHEMBL3770896) Show SMILES CCCCc1ccc(COC(=O)N[C@H]2CNC2=O)cc1 |r| Show InChI InChI=1S/C15H20N2O3/c1-2-3-4-11-5-7-12(8-6-11)10-20-15(19)17-13-9-16-14(13)18/h5-8,13H,2-4,9-10H2,1H3,(H,16,18)(H,17,19)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Italian Institute of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysis				Eur J Med Chem 111: 138-59 (2016) Article DOI: 10.1016/j.ejmech.2016.01.046 BindingDB Entry DOI: 10.7270/Q2GQ70MX
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50389023 (CHEMBL2064166 | US9353075, 6) Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1 |r| Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	4.5	37
The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo” US Patent					Assay Description NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...				US Patent US9353075 (2016) BindingDB Entry DOI: 10.7270/Q23N229Q
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50439664 (CHEMBL2419814 | US9353075, 17) Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	4.5	37
The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo” US Patent					Assay Description NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...				US Patent US9353075 (2016) BindingDB Entry DOI: 10.7270/Q23N229Q
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50389023 (CHEMBL2064166 | US9353075, 6) Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1 |r| Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells				J Med Chem 56: 6917-34 (2013) Article DOI: 10.1021/jm400739u BindingDB Entry DOI: 10.7270/Q2F47QK0
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM50389023 (CHEMBL2064166 | US9353075, 6) Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1 |r| Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of NAAA (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00076 BindingDB Entry DOI: 10.7270/Q2C25175
					More data for this Ligand-Target Pair

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