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Found 60 hits Enz. Inhib. hit(s) with Target = 'Chymotrypsin-like protease CTRL-1' AND taxid = 9606   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441773
PNG
(US10640533, Identification number CX13-103 | US106...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccncc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)[C@]1(C)CO1 |r|
Show InChI InChI=1S/C36H46N6O7/c1-24(2)19-29(32(43)36(3)23-48-36)39-34(45)30(20-26-11-13-37-14-12-26)40-33(44)28(10-9-25-7-5-4-6-8-25)38-35(46)31-21-27(49-41-31)22-42-15-17-47-18-16-42/h4-8,11-14,21,24,28-30H,9-10,15-20,22-23H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t28-,29-,30-,36+/m1/s1
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n/an/a 0.920n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441775
PNG
(US10640533, Identification number CX13-105 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C37H47N5O7/c1-25(2)20-31(35(45)39-30(33(43)37(3)24-48-37)21-27-12-8-5-9-13-27)40-34(44)29(15-14-26-10-6-4-7-11-26)38-36(46)32-22-28(49-41-32)23-42-16-18-47-19-17-42/h4-13,22,25,29-31H,14-21,23-24H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t29-,30-,31-,37+/m0/s1
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n/an/a 0.970n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441773
PNG
(US10640533, Identification number CX13-103 | US106...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccncc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)[C@]1(C)CO1 |r|
Show InChI InChI=1S/C36H46N6O7/c1-24(2)19-29(32(43)36(3)23-48-36)39-34(45)30(20-26-11-13-37-14-12-26)40-33(44)28(10-9-25-7-5-4-6-8-25)38-35(46)31-21-27(49-41-31)22-42-15-17-47-18-16-42/h4-8,11-14,21,24,28-30H,9-10,15-20,22-23H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t28-,29-,30-,36+/m1/s1
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n/an/a 1.09n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441775
PNG
(US10640533, Identification number CX13-105 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C37H47N5O7/c1-25(2)20-31(35(45)39-30(33(43)37(3)24-48-37)21-27-12-8-5-9-13-27)40-34(44)29(15-14-26-10-6-4-7-11-26)38-36(46)32-22-28(49-41-32)23-42-16-18-47-19-17-42/h4-13,22,25,29-31H,14-21,23-24H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t29-,30-,31-,37+/m0/s1
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n/an/a 1.34n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50031442
PNG
(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Show SMILES CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCN1C(=O)c2ccccc2C1=O)C1CCCC1)C=O |w:12.11|
Show InChI InChI=1S/C35H53N7O7/c1-24(2)22-26(23-43)38-32(45)30(19-13-20-37-35(36)40-42(48)49)39-31(44)27(25-14-8-9-15-25)16-7-5-3-4-6-12-21-41-33(46)28-17-10-11-18-29(28)34(41)47/h10-11,17-18,23-27,30H,3-9,12-16,19-22H2,1-2H3,(H,38,45)(H,39,44)(H3,36,37,40)
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brain

Bioorg Med Chem Lett 6: 287-290 (1996)


Article DOI: 10.1016/0960-894X(96)00014-5
BindingDB Entry DOI: 10.7270/Q2JQ1112
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441779
PNG
(US10640533, Identification number CX13-133 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)Cc1ccc(CN2CCOCC2)cc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C40H51N5O6/c1-28(2)23-34(37(47)40(3)27-51-40)43-39(49)35(24-31-15-17-41-18-16-31)44-38(48)33(14-13-29-7-5-4-6-8-29)42-36(46)25-30-9-11-32(12-10-30)26-45-19-21-50-22-20-45/h4-12,15-18,28,33-35H,13-14,19-27H2,1-3H3,(H,42,46)(H,43,49)(H,44,48)/t33-,34-,35-,40+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441789
PNG
(US10640533, Identification number CX13-608 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)Cc1ccc(CN2CCOCC2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C39H48N4O7/c1-39(27-50-39)36(45)33(23-29-11-7-4-8-12-29)41-38(47)34(26-48-2)42-37(46)32(18-17-28-9-5-3-6-10-28)40-35(44)24-30-13-15-31(16-14-30)25-43-19-21-49-22-20-43/h3-16,32-34H,17-27H2,1-2H3,(H,40,44)(H,41,47)(H,42,46)/t32-,33-,34-,39+/m0/s1
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n/an/a 3.73n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441789
PNG
(US10640533, Identification number CX13-608 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)Cc1ccc(CN2CCOCC2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C39H48N4O7/c1-39(27-50-39)36(45)33(23-29-11-7-4-8-12-29)41-38(47)34(26-48-2)42-37(46)32(18-17-28-9-5-3-6-10-28)40-35(44)24-30-13-15-31(16-14-30)25-43-19-21-49-22-20-43/h3-16,32-34H,17-27H2,1-2H3,(H,40,44)(H,41,47)(H,42,46)/t32-,33-,34-,39+/m0/s1
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n/an/a 4.26n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441784
PNG
(US10640533, Identification number CX13-600 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C37H47N5O7/c1-25(2)20-30(33(43)37(3)24-48-37)39-35(45)31(21-27-12-8-5-9-13-27)40-34(44)29(15-14-26-10-6-4-7-11-26)38-36(46)32-22-28(49-41-32)23-42-16-18-47-19-17-42/h4-13,22,25,29-31H,14-21,23-24H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t29-,30-,31-,37+/m0/s1
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n/an/a 4.28n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441779
PNG
(US10640533, Identification number CX13-133 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)Cc1ccc(CN2CCOCC2)cc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C40H51N5O6/c1-28(2)23-34(37(47)40(3)27-51-40)43-39(49)35(24-31-15-17-41-18-16-31)44-38(48)33(14-13-29-7-5-4-6-8-29)42-36(46)25-30-9-11-32(12-10-30)26-45-19-21-50-22-20-45/h4-12,15-18,28,33-35H,13-14,19-27H2,1-3H3,(H,42,46)(H,43,49)(H,44,48)/t33-,34-,35-,40+/m0/s1
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n/an/a 4.65n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441776
PNG
(US10640533, Identification number CX13-107 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C34H46N4O6/c1-24(2)20-29(33(42)36-28(31(40)34(3)23-44-34)21-26-12-8-5-9-13-26)37-32(41)27(15-14-25-10-6-4-7-11-25)35-30(39)22-38-16-18-43-19-17-38/h4-13,24,27-29H,14-23H2,1-3H3,(H,35,39)(H,36,42)(H,37,41)/t27-,28-,29-,34+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441776
PNG
(US10640533, Identification number CX13-107 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C34H46N4O6/c1-24(2)20-29(33(42)36-28(31(40)34(3)23-44-34)21-26-12-8-5-9-13-26)37-32(41)27(15-14-25-10-6-4-7-11-25)35-30(39)22-38-16-18-43-19-17-38/h4-13,24,27-29H,14-23H2,1-3H3,(H,35,39)(H,36,42)(H,37,41)/t27-,28-,29-,34+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50031440
PNG
(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Show SMILES CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCC#N)C1CCCC1)C=O |w:12.11|
Show InChI InChI=1S/C28H49N7O5/c1-21(2)19-23(20-36)32-27(38)25(16-12-18-31-28(30)34-35(39)40)33-26(37)24(22-13-9-10-14-22)15-8-6-4-3-5-7-11-17-29/h20-25H,3-16,18-19H2,1-2H3,(H,32,38)(H,33,37)(H3,30,31,34)
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TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brain

Bioorg Med Chem Lett 6: 287-290 (1996)


Article DOI: 10.1016/0960-894X(96)00014-5
BindingDB Entry DOI: 10.7270/Q2JQ1112
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441788
PNG
(US10640533, Identification number CX13-606 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)Cc1ccc(CN2CCOCC2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C36H50N4O7/c1-25(2)20-30(33(42)36(3)24-47-36)38-35(44)31(23-45-4)39-34(43)29(15-14-26-8-6-5-7-9-26)37-32(41)21-27-10-12-28(13-11-27)22-40-16-18-46-19-17-40/h5-13,25,29-31H,14-24H2,1-4H3,(H,37,41)(H,38,44)(H,39,43)/t29-,30-,31-,36+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441780
PNG
(US10640533, Identification number CX13-135 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(C)on1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C32H39N5O6/c1-20(2)16-25(28(38)32(4)19-42-32)35-30(40)26(18-23-12-14-33-15-13-23)36-29(39)24(11-10-22-8-6-5-7-9-22)34-31(41)27-17-21(3)43-37-27/h5-9,12-15,17,20,24-26H,10-11,16,18-19H2,1-4H3,(H,34,41)(H,35,40)(H,36,39)/t24-,25-,26-,32+/m0/s1
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n/an/a 6.56n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441787
PNG
(US10640533, Identification number CX13-605 | US106...)
Show SMILES C[C@@]1(CO1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cscn1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1 |r|
Show InChI InChI=1S/C37H42N6O7S/c1-37(23-49-37)33(44)30(18-26-10-6-3-7-11-26)40-35(46)31(19-27-22-51-24-38-27)41-34(45)29(13-12-25-8-4-2-5-9-25)39-36(47)32-20-28(50-42-32)21-43-14-16-48-17-15-43/h2-11,20,22,24,29-31H,12-19,21,23H2,1H3,(H,39,47)(H,40,46)(H,41,45)/t29-,30-,31-,37+/m0/s1
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n/an/a 6.81n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441784
PNG
(US10640533, Identification number CX13-600 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C37H47N5O7/c1-25(2)20-30(33(43)37(3)24-48-37)39-35(45)31(21-27-12-8-5-9-13-27)40-34(44)29(15-14-26-10-6-4-7-11-26)38-36(46)32-22-28(49-41-32)23-42-16-18-47-19-17-42/h4-13,22,25,29-31H,14-21,23-24H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t29-,30-,31-,37+/m0/s1
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n/an/a 7.41n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50288611
PNG
(Alpha-ketocarbonyl boronic ester derivative | CHEM...)
Show SMILES CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCC#N)C1CCCC1)B1OC(C)(C)C(C)(C)O1 |w:12.11|
Show InChI InChI=1S/C33H60BN7O6/c1-24(2)23-28(34-46-32(3,4)33(5,6)47-34)39-30(43)27(20-16-22-37-31(36)40-41(44)45)38-29(42)26(25-17-13-14-18-25)19-12-10-8-7-9-11-15-21-35/h24-28H,7-20,22-23H2,1-6H3,(H,38,42)(H,39,43)(H3,36,37,40)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brain

Bioorg Med Chem Lett 6: 287-290 (1996)


Article DOI: 10.1016/0960-894X(96)00014-5
BindingDB Entry DOI: 10.7270/Q2JQ1112
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441790
PNG
(US10640533, Identification number CX13-705 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C31H36N4O6S/c1-20-32-17-26(42-20)30(39)33-23(15-14-21-10-6-4-7-11-21)28(37)35-25(18-40-3)29(38)34-24(27(36)31(2)19-41-31)16-22-12-8-5-9-13-22/h4-13,17,23-25H,14-16,18-19H2,1-3H3,(H,33,39)(H,34,38)(H,35,37)/t23-,24-,25-,31+/m0/s1
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n/an/a 9.75n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441786
PNG
(US10640533, Identification number CX13-603 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C35H43N5O8/c1-35(23-47-35)31(41)28(19-25-11-7-4-8-12-25)37-34(44)30(22-45-2)38-32(42)27(14-13-24-9-5-3-6-10-24)36-33(43)29-20-26(48-39-29)21-40-15-17-46-18-16-40/h3-12,20,27-28,30H,13-19,21-23H2,1-2H3,(H,36,43)(H,37,44)(H,38,42)/t27-,28-,30-,35+/m0/s1
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US Patent
n/an/a 11.1n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441787
PNG
(US10640533, Identification number CX13-605 | US106...)
Show SMILES C[C@@]1(CO1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cscn1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1 |r|
Show InChI InChI=1S/C37H42N6O7S/c1-37(23-49-37)33(44)30(18-26-10-6-3-7-11-26)40-35(46)31(19-27-22-51-24-38-27)41-34(45)29(13-12-25-8-4-2-5-9-25)39-36(47)32-20-28(50-42-32)21-43-14-16-48-17-15-43/h2-11,20,22,24,29-31H,12-19,21,23H2,1H3,(H,39,47)(H,40,46)(H,41,45)/t29-,30-,31-,37+/m0/s1
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US Patent
n/an/a 12.2n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441781
PNG
(US10640533, Identification number CX13-137 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cnc(C)s1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C32H39N5O5S/c1-20(2)16-25(28(38)32(4)19-42-32)36-30(40)26(17-23-12-14-33-15-13-23)37-29(39)24(11-10-22-8-6-5-7-9-22)35-31(41)27-18-34-21(3)43-27/h5-9,12-15,18,20,24-26H,10-11,16-17,19H2,1-4H3,(H,35,41)(H,36,40)(H,37,39)/t24-,25-,26-,32+/m0/s1
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US Patent
n/an/a 13.5n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441786
PNG
(US10640533, Identification number CX13-603 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C35H43N5O8/c1-35(23-47-35)31(41)28(19-25-11-7-4-8-12-25)37-34(44)30(22-45-2)38-32(42)27(14-13-24-9-5-3-6-10-24)36-33(43)29-20-26(48-39-29)21-40-15-17-46-18-16-40/h3-12,20,27-28,30H,13-19,21-23H2,1-2H3,(H,36,43)(H,37,44)(H,38,42)/t27-,28-,30-,35+/m0/s1
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US Patent
n/an/a 14.2n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441790
PNG
(US10640533, Identification number CX13-705 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C31H36N4O6S/c1-20-32-17-26(42-20)30(39)33-23(15-14-21-10-6-4-7-11-21)28(37)35-25(18-40-3)29(38)34-24(27(36)31(2)19-41-31)16-22-12-8-5-9-13-22/h4-13,17,23-25H,14-16,18-19H2,1-3H3,(H,33,39)(H,34,38)(H,35,37)/t23-,24-,25-,31+/m0/s1
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US Patent
n/an/a 15.3n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441785
PNG
(US10640533, Identification number CX13-601 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C32H45N5O8/c1-21(2)16-25(28(38)32(3)20-44-32)34-31(41)27(19-42-4)35-29(39)24(11-10-22-8-6-5-7-9-22)33-30(40)26-17-23(45-36-26)18-37-12-14-43-15-13-37/h5-9,17,21,24-25,27H,10-16,18-20H2,1-4H3,(H,33,40)(H,34,41)(H,35,39)/t24-,25-,27-,32+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50288609
PNG
(Alpha-ketocarbonyl derivative | CHEMBL317337)
Show SMILES CCNC(=O)C(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCC#N)C1CCCC1 |w:19.18|
Show InChI InChI=1S/C31H54N8O6/c1-4-34-30(43)27(40)26(21-22(2)3)37-29(42)25(18-14-20-35-31(33)38-39(44)45)36-28(41)24(23-15-11-12-16-23)17-10-8-6-5-7-9-13-19-32/h22-26H,4-18,20-21H2,1-3H3,(H,34,43)(H,36,41)(H,37,42)(H3,33,35,38)
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n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brain

Bioorg Med Chem Lett 6: 287-290 (1996)


Article DOI: 10.1016/0960-894X(96)00014-5
BindingDB Entry DOI: 10.7270/Q2JQ1112
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50288609
PNG
(Alpha-ketocarbonyl derivative | CHEMBL317337)
Show SMILES CCNC(=O)C(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCC#N)C1CCCC1 |w:19.18|
Show InChI InChI=1S/C31H54N8O6/c1-4-34-30(43)27(40)26(21-22(2)3)37-29(42)25(18-14-20-35-31(33)38-39(44)45)36-28(41)24(23-15-11-12-16-23)17-10-8-6-5-7-9-13-19-32/h22-26H,4-18,20-21H2,1-3H3,(H,34,43)(H,36,41)(H,37,42)(H3,33,35,38)
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n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brain

Bioorg Med Chem Lett 6: 287-290 (1996)


Article DOI: 10.1016/0960-894X(96)00014-5
BindingDB Entry DOI: 10.7270/Q2JQ1112
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441780
PNG
(US10640533, Identification number CX13-135 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(C)on1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C32H39N5O6/c1-20(2)16-25(28(38)32(4)19-42-32)35-30(40)26(18-23-12-14-33-15-13-23)36-29(39)24(11-10-22-8-6-5-7-9-22)34-31(41)27-17-21(3)43-37-27/h5-9,12-15,17,20,24-26H,10-11,16,18-19H2,1-4H3,(H,34,41)(H,35,40)(H,36,39)/t24-,25-,26-,32+/m0/s1
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US Patent
n/an/a 28.1n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441785
PNG
(US10640533, Identification number CX13-601 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C32H45N5O8/c1-21(2)16-25(28(38)32(3)20-44-32)34-31(41)27(19-42-4)35-29(39)24(11-10-22-8-6-5-7-9-22)33-30(40)26-17-23(45-36-26)18-37-12-14-43-15-13-37/h5-9,17,21,24-25,27H,10-16,18-20H2,1-4H3,(H,33,40)(H,34,41)(H,35,39)/t24-,25-,27-,32+/m0/s1
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n/an/a 31.7n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441774
PNG
(US10640533, Identification number CX13-104 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccncc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C36H46N6O7/c1-24(2)19-30(34(45)39-29(32(43)36(3)23-48-36)20-26-11-13-37-14-12-26)40-33(44)28(10-9-25-7-5-4-6-8-25)38-35(46)31-21-27(49-41-31)22-42-15-17-47-18-16-42/h4-8,11-14,21,24,28-30H,9-10,15-20,22-23H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t28-,29-,30-,36+/m0/s1
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n/an/a 33.3n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441774
PNG
(US10640533, Identification number CX13-104 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccncc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C36H46N6O7/c1-24(2)19-30(34(45)39-29(32(43)36(3)23-48-36)20-26-11-13-37-14-12-26)40-33(44)28(10-9-25-7-5-4-6-8-25)38-35(46)31-21-27(49-41-31)22-42-15-17-47-18-16-42/h4-8,11-14,21,24,28-30H,9-10,15-20,22-23H2,1-3H3,(H,38,46)(H,39,45)(H,40,44)/t28-,29-,30-,36+/m0/s1
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n/an/a 33.6n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441788
PNG
(US10640533, Identification number CX13-606 | US106...)
Show SMILES COC[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)Cc1ccc(CN2CCOCC2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C36H50N4O7/c1-25(2)20-30(33(42)36(3)24-47-36)38-35(44)31(23-45-4)39-34(43)29(15-14-26-8-6-5-7-9-26)37-32(41)21-27-10-12-28(13-11-27)22-40-16-18-46-19-17-40/h5-13,25,29-31H,14-24H2,1-4H3,(H,37,41)(H,38,44)(H,39,43)/t29-,30-,31-,36+/m0/s1
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n/an/a 59.3n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441781
PNG
(US10640533, Identification number CX13-137 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)c1cnc(C)s1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C32H39N5O5S/c1-20(2)16-25(28(38)32(4)19-42-32)36-30(40)26(17-23-12-14-33-15-13-23)37-29(39)24(11-10-22-8-6-5-7-9-22)35-31(41)27-18-34-21(3)43-27/h5-9,12-15,18,20,24-26H,10-11,16-17,19H2,1-4H3,(H,35,41)(H,36,40)(H,37,39)/t24-,25-,26-,32+/m0/s1
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n/an/a 60.4n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441778
PNG
(US10640533, Identification number CX13-130 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(C)=O)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C29H38N4O5/c1-19(2)16-24(26(35)29(4)18-38-29)32-28(37)25(17-22-12-14-30-15-13-22)33-27(36)23(31-20(3)34)11-10-21-8-6-5-7-9-21/h5-9,12-15,19,23-25H,10-11,16-18H2,1-4H3,(H,31,34)(H,32,37)(H,33,36)/t23-,24-,25-,29+/m0/s1
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n/an/a 62.4n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50484478
PNG
(CHEMBL1929019 | jm5b01461, Compound 47)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](Cc1c[nH]cn1)C=O |r|
Show InChI InChI=1S/C28H45N7O7/c1-16(2)24(35-25(39)17(3)31-27(41)23(14-37)32-18(4)38)28(42)34-22(10-19-8-6-5-7-9-19)26(40)33-21(13-36)11-20-12-29-15-30-20/h12-13,15-17,19,21-24,37H,5-11,14H2,1-4H3,(H,29,30)(H,31,41)(H,32,38)(H,33,40)(H,34,42)(H,35,39)/t17-,21-,22-,23-,24-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like protease R188I mutant using peptide substrate SO1 measured after 60 mins by HPLC analysis

J Med Chem 54: 7962-73 (2011)


Article DOI: 10.1021/jm200870n
BindingDB Entry DOI: 10.7270/Q29G5QNB
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50484484
PNG
(CHEMBL1929023)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](Cc1c[nH]cn1)C=O |r|
Show InChI InChI=1S/C26H42N6O6/c1-15(2)22(32-26(38)23(16(3)34)29-17(4)35)25(37)31-21(10-18-8-6-5-7-9-18)24(36)30-20(13-33)11-19-12-27-14-28-19/h12-16,18,20-23,34H,5-11H2,1-4H3,(H,27,28)(H,29,35)(H,30,36)(H,31,37)(H,32,38)/t16-,20+,21+,22+,23+/m1/s1
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Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like protease R188I mutant using peptide substrate SO1 measured after 60 mins by HPLC analysis

J Med Chem 54: 7962-73 (2011)


Article DOI: 10.1021/jm200870n
BindingDB Entry DOI: 10.7270/Q29G5QNB
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441783
PNG
(US10640533, Identification number CX13-501 | US106...)
Show SMILES COC[C@H](NC(=O)c1cc(C)on1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C26H35N5O7/c1-15(2)10-18(22(32)26(4)14-37-26)28-23(33)19(12-17-6-8-27-9-7-17)29-25(35)21(13-36-5)30-24(34)20-11-16(3)38-31-20/h6-9,11,15,18-19,21H,10,12-14H2,1-5H3,(H,28,33)(H,29,35)(H,30,34)/t18-,19-,21-,26+/m0/s1
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n/an/a 113n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441782
PNG
(US10640533, Identification number CX13-500 | US106...)
Show SMILES COC[C@H](NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C30H42N6O8/c1-19(2)13-22(26(37)30(3)18-43-30)32-27(38)23(14-20-5-7-31-8-6-20)33-29(40)25(17-41-4)34-28(39)24-15-21(44-35-24)16-36-9-11-42-12-10-36/h5-8,15,19,22-23,25H,9-14,16-18H2,1-4H3,(H,32,38)(H,33,40)(H,34,39)/t22-,23-,25-,30+/m0/s1
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n/an/a 121n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50398607
PNG
(ONX 0912 | OPROZOMIB | US10640533, Identification ...)
Show SMILES COC[C@H](NC(=O)[C@H](COC)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1
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n/an/a 124n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441782
PNG
(US10640533, Identification number CX13-500 | US106...)
Show SMILES COC[C@H](NC(=O)c1cc(CN2CCOCC2)on1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C30H42N6O8/c1-19(2)13-22(26(37)30(3)18-43-30)32-27(38)23(14-20-5-7-31-8-6-20)33-29(40)25(17-41-4)34-28(39)24-15-21(44-35-24)16-36-9-11-42-12-10-36/h5-8,15,19,22-23,25H,9-14,16-18H2,1-4H3,(H,32,38)(H,33,40)(H,34,39)/t22-,23-,25-,30+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441778
PNG
(US10640533, Identification number CX13-130 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(C)=O)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C29H38N4O5/c1-19(2)16-24(26(35)29(4)18-38-29)32-28(37)25(17-22-12-14-30-15-13-22)33-27(36)23(31-20(3)34)11-10-21-8-6-5-7-9-21/h5-9,12-15,19,23-25H,10-11,16-18H2,1-4H3,(H,31,34)(H,32,37)(H,33,36)/t23-,24-,25-,29+/m0/s1
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n/an/a 248n/an/an/an/an/an/a



CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50398607
PNG
(ONX 0912 | OPROZOMIB | US10640533, Identification ...)
Show SMILES COC[C@H](NC(=O)[C@H](COC)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50484483
PNG
(CHEMBL1929020 | acs.jmedchem.1c00409_ST.132)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](Cc1c[nH]cn1)C=O |r|
Show InChI InChI=1S/C25H40N6O5/c1-15(2)22(31-23(34)16(3)28-17(4)33)25(36)30-21(10-18-8-6-5-7-9-18)24(35)29-20(13-32)11-19-12-26-14-27-19/h12-16,18,20-22H,5-11H2,1-4H3,(H,26,27)(H,28,33)(H,29,35)(H,30,36)(H,31,34)/t16-,20-,21-,22-/m0/s1
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Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like protease R188I mutant using peptide substrate SO1 measured after 60 mins by HPLC analysis

J Med Chem 54: 7962-73 (2011)


Article DOI: 10.1021/jm200870n
BindingDB Entry DOI: 10.7270/Q29G5QNB
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50484491
PNG
(CHEMBL1929022 | acs.jmedchem.1c00409_ST.144)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](Cc1c[nH]cn1)C=O |r|
Show InChI InChI=1S/C25H40N6O6/c1-15(2)22(31-24(36)21(13-33)28-16(3)34)25(37)30-20(9-17-7-5-4-6-8-17)23(35)29-19(12-32)10-18-11-26-14-27-18/h11-12,14-15,17,19-22,33H,4-10,13H2,1-3H3,(H,26,27)(H,28,34)(H,29,35)(H,30,37)(H,31,36)/t19-,20-,21-,22-/m0/s1
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Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like protease R188I mutant using peptide substrate SO1 measured after 60 mins by HPLC analysis

J Med Chem 54: 7962-73 (2011)


Article DOI: 10.1021/jm200870n
BindingDB Entry DOI: 10.7270/Q29G5QNB
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50484487
PNG
(CHEMBL1929018 | acs.jmedchem.1c00409_ST.150)
Show SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C=O |r|
Show InChI InChI=1S/C28H39N7O7/c1-16(2)24(35-25(39)17(3)31-27(41)23(14-37)32-18(4)38)28(42)34-22(10-19-8-6-5-7-9-19)26(40)33-21(13-36)11-20-12-29-15-30-20/h5-9,12-13,15-17,21-24,37H,10-11,14H2,1-4H3,(H,29,30)(H,31,41)(H,32,38)(H,33,40)(H,34,42)(H,35,39)/t17-,21-,22-,23-,24-/m0/s1
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Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like protease R188I mutant using peptide substrate SO1 measured after 60 mins by HPLC analysis

J Med Chem 54: 7962-73 (2011)


Article DOI: 10.1021/jm200870n
BindingDB Entry DOI: 10.7270/Q29G5QNB
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441783
PNG
(US10640533, Identification number CX13-501 | US106...)
Show SMILES COC[C@H](NC(=O)c1cc(C)on1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C26H35N5O7/c1-15(2)10-18(22(32)26(4)14-37-26)28-23(33)19(12-17-6-8-27-9-7-17)29-25(35)21(13-36-5)30-24(34)20-11-16(3)38-31-20/h6-9,11,15,18-19,21H,10,12-14H2,1-5H3,(H,28,33)(H,29,35)(H,30,34)/t18-,19-,21-,26+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441777
PNG
(US10640533, Identification number CX13-109 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccncc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C33H45N5O6/c1-23(2)19-28(32(42)36-27(30(40)33(3)22-44-33)20-25-11-13-34-14-12-25)37-31(41)26(10-9-24-7-5-4-6-8-24)35-29(39)21-38-15-17-43-18-16-38/h4-8,11-14,23,26-28H,9-10,15-22H2,1-3H3,(H,35,39)(H,36,42)(H,37,41)/t26-,27-,28-,33+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM441777
PNG
(US10640533, Identification number CX13-109 | US106...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccncc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C33H45N5O6/c1-23(2)19-28(32(42)36-27(30(40)33(3)22-44-33)20-25-11-13-34-14-12-25)37-31(41)26(10-9-24-7-5-4-6-8-24)35-29(39)21-38-15-17-43-18-16-38/h4-8,11-14,23,26-28H,9-10,15-22H2,1-3H3,(H,35,39)(H,36,42)(H,37,41)/t26-,27-,28-,33+/m0/s1
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CENTRAX INTERNATIONAL, INC.

US Patent


Assay Description
Inhibition of the chymotrypsin-like (CT-L), peptidylglutamyl peptide hydrolyzing activity (PGPH), and trypsin-like (T-L) activities of the 20S protea...

US Patent US10640533 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PQN
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50288610
PNG
(Alpha-ketocarbonyl derivative | CHEMBL98937)
Show SMILES CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCC#N)C1CCCC1)C(=O)CCl |w:12.11|
Show InChI InChI=1S/C29H50ClN7O5/c1-21(2)19-25(26(38)20-30)35-28(40)24(16-12-18-33-29(32)36-37(41)42)34-27(39)23(22-13-9-10-14-22)15-8-6-4-3-5-7-11-17-31/h21-25H,3-16,18-20H2,1-2H3,(H,34,39)(H,35,40)(H3,32,33,36)
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UniProtKB/SwissProt

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Article
n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for thromboxane TXA2 synthase inhibitory activity using human platelet

Bioorg Med Chem Lett 6: 287-290 (1996)


Article DOI: 10.1016/0960-894X(96)00014-5
BindingDB Entry DOI: 10.7270/Q2JQ1112
More data for this
Ligand-Target Pair
Chymotrypsin-like protease CTRL-1


(Homo sapiens (Human))		BDBM50288610
PNG
(Alpha-ketocarbonyl derivative | CHEMBL98937)
Show SMILES CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCC#N)C1CCCC1)C(=O)CCl |w:12.11|
Show InChI InChI=1S/C29H50ClN7O5/c1-21(2)19-25(26(38)20-30)35-28(40)24(16-12-18-33-29(32)36-37(41)42)34-27(39)23(22-13-9-10-14-22)15-8-6-4-3-5-7-11-17-31/h21-25H,3-16,18-20H2,1-2H3,(H,34,39)(H,35,40)(H3,32,33,36)
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UniProtKB/SwissProt

antibodypedia
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brain

Bioorg Med Chem Lett 6: 287-290 (1996)


Article DOI: 10.1016/0960-894X(96)00014-5
BindingDB Entry DOI: 10.7270/Q2JQ1112
More data for this
Ligand-Target Pair
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