Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50277866![]() (2,4-dichloro-N-((3-(cyclopropylmethyl)-1-(1-methyl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation counting | Bioorg Med Chem Lett 19: 2235-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.102 BindingDB Entry DOI: 10.7270/Q23R0SSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50277942![]() (2,4-dichloro-N-((3-(3-fluoropyridin-2-yl)-1-(1-met...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation counting | Bioorg Med Chem Lett 19: 2235-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.102 BindingDB Entry DOI: 10.7270/Q23R0SSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50149871![]() ((R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)pro...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagasaki University Curated by ChEMBL | Assay Description Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillat... | Bioorg Med Chem 19: 6245-53 (2011) Article DOI: 10.1016/j.bmc.2011.09.010 BindingDB Entry DOI: 10.7270/Q20V8D7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50178415![]() ((2S)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phe...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1 | Bioorg Med Chem Lett 16: 1388-91 (2006) Article DOI: 10.1016/j.bmcl.2005.11.041 BindingDB Entry DOI: 10.7270/Q29C6X13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50277943![]() (2,4-dichloro-N-((4-(3-fluoropyridin-2-yl)-1-(1-met...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation counting | Bioorg Med Chem Lett 19: 2235-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.102 BindingDB Entry DOI: 10.7270/Q23R0SSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533742![]() (CHEMBL4593786) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.671 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533732![]() (CHEMBL4526580) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.726 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533748![]() (CHEMBL4468117) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.733 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM327829![]() (2-((R)-4-((S)-(3-bromophenyl)(phenyl)methyl)-2-met...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.934 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor... | US Patent US9663476 (2017) BindingDB Entry DOI: 10.7270/Q2KK9DWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50178423![]() (2-((2-(4,5-dichloro-2-(4-fluorophenyl)-6-methoxy-1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1 | Bioorg Med Chem Lett 16: 1388-91 (2006) Article DOI: 10.1016/j.bmcl.2005.11.041 BindingDB Entry DOI: 10.7270/Q29C6X13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM327832![]() (2-((R)-2-methyl-4-((R)-phenyl(3-(trifluoromethyl)p...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor... | US Patent US9663476 (2017) BindingDB Entry DOI: 10.7270/Q2KK9DWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460356![]() (CHEMBL4224734) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM201090![]() (US9233953, 51) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Cells expressing either endogenously the GlyT1 transporter like JAR cells (human placental choriocarcinoma cells; e.g. WO 2008/002583) or SK-N-MC cel... | US Patent US9233953 (2016) BindingDB Entry DOI: 10.7270/Q2Q81BVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460344![]() (CHEMBL4228859) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460368![]() (CHEMBL4226039) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460371![]() (CHEMBL4228975) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460377![]() (CHEMBL4225587) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460357![]() (CHEMBL4226364) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM201186![]() (US9233953, 148) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Cells expressing either endogenously the GlyT1 transporter like JAR cells (human placental choriocarcinoma cells; e.g. WO 2008/002583) or SK-N-MC cel... | US Patent US9233953 (2016) BindingDB Entry DOI: 10.7270/Q2Q81BVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM201161![]() (US9233953, 121) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Cells expressing either endogenously the GlyT1 transporter like JAR cells (human placental choriocarcinoma cells; e.g. WO 2008/002583) or SK-N-MC cel... | US Patent US9233953 (2016) BindingDB Entry DOI: 10.7270/Q2Q81BVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533727![]() (CHEMBL4456392) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533730![]() (CHEMBL4582587) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533749![]() (CHEMBL4516089) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533723![]() (CHEMBL4572086) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM327844![]() (2-((R)-4-(cyclopropyl(3-(trifluoromethyl)phenyl)me...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor... | US Patent US9663476 (2017) BindingDB Entry DOI: 10.7270/Q2KK9DWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533725![]() (CHEMBL4579165) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM327827![]() ((R)-2-(4-benzhydryl-2-methylpiperazin-1-yl)acetic ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.51 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor... | US Patent US9663476 (2017) BindingDB Entry DOI: 10.7270/Q2KK9DWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50277795![]() (2,4-dichloro-N-((4-(3-fluoropyridin-2-yl)-1-(1-met...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation counting | Bioorg Med Chem Lett 19: 2235-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.102 BindingDB Entry DOI: 10.7270/Q23R0SSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50278041![]() (2,4-dichloro-N-(((trans)-1-(cyclopropylmethyl)-4-(...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation counting | Bioorg Med Chem Lett 19: 2235-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.102 BindingDB Entry DOI: 10.7270/Q23R0SSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50278041![]() (2,4-dichloro-N-(((trans)-1-(cyclopropylmethyl)-4-(...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human GlyT1a after 15 mins | ACS Med Chem Lett 1: 350-354 (2010) Article DOI: 10.1021/ml1001085 BindingDB Entry DOI: 10.7270/Q2W09700 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50178418![]() (2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phenyl-2...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1 | Bioorg Med Chem Lett 16: 1388-91 (2006) Article DOI: 10.1016/j.bmcl.2005.11.041 BindingDB Entry DOI: 10.7270/Q29C6X13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50277757![]() (2,4-dichloro-N-((1-(cyclopropylmethylsulfonyl)-4-(...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation counting | Bioorg Med Chem Lett 19: 2235-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.102 BindingDB Entry DOI: 10.7270/Q23R0SSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460353![]() (CHEMBL4225116) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM201081![]() (US9233953, 42) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Cells expressing either endogenously the GlyT1 transporter like JAR cells (human placental choriocarcinoma cells; e.g. WO 2008/002583) or SK-N-MC cel... | US Patent US9233953 (2016) BindingDB Entry DOI: 10.7270/Q2Q81BVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533736![]() (CHEMBL4462009) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM327833![]() ((S)-2-((R)-4-(bis(4-chlorophenyl)methyl)-3-methylp...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.14 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor... | US Patent US9663476 (2017) BindingDB Entry DOI: 10.7270/Q2KK9DWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50533733![]() (CHEMBL4532784) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin... | J Med Chem 59: 8473-94 (2016) Article DOI: 10.1021/acs.jmedchem.6b00914 BindingDB Entry DOI: 10.7270/Q23R0XC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50361576![]() (CHEMBL1939497 | CHEMBL1939498) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagasaki University Curated by ChEMBL | Assay Description Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillat... | Bioorg Med Chem 19: 6245-53 (2011) Article DOI: 10.1016/j.bmc.2011.09.010 BindingDB Entry DOI: 10.7270/Q20V8D7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50195169![]() (2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co. Curated by ChEMBL | Assay Description Inhibition of human GlyT1 | Bioorg Med Chem Lett 16: 5968-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.131 BindingDB Entry DOI: 10.7270/Q2C82B31 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50447893![]() (CHEMBL3114792) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake | Bioorg Med Chem Lett 24: 1067-70 (2014) Article DOI: 10.1016/j.bmcl.2014.01.013 BindingDB Entry DOI: 10.7270/Q2K64KK4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50361575![]() (CHEMBL1939495) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagasaki University Curated by ChEMBL | Assay Description Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillat... | Bioorg Med Chem 19: 6245-53 (2011) Article DOI: 10.1016/j.bmc.2011.09.010 BindingDB Entry DOI: 10.7270/Q20V8D7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50248651![]() (2,4-dichloro-N-((4-(6-methylpyridin-2-yl)-1-(propy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of human glycine transporter 1 | Bioorg Med Chem Lett 19: 1488-91 (2009) Article DOI: 10.1016/j.bmcl.2008.12.115 BindingDB Entry DOI: 10.7270/Q2V124P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50277944![]() (2,4-dichloro-N-((3-(cyclopropylmethyl)-1-(1-ethyl-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation counting | Bioorg Med Chem Lett 19: 2235-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.102 BindingDB Entry DOI: 10.7270/Q23R0SSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50248641![]() (2-amino-6-chloro-N-((4-phenyl-1-(propylsulfonyl)pi...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of glycine transporter 1 (unknown origin) by HTS assay | Bioorg Med Chem Lett 19: 1488-91 (2009) Article DOI: 10.1016/j.bmcl.2008.12.115 BindingDB Entry DOI: 10.7270/Q2V124P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM327842![]() (2-((R)-2-methyl-4-((R)-phenyl(4-(2-phenylethynyl)p...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC. US Patent | Assay Description This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor... | US Patent US9663476 (2017) BindingDB Entry DOI: 10.7270/Q2KK9DWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50248064![]() (2,4-dichloro-N-((4-(2-hydroxycyclohexyl)-1-(propyl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of Glyt1 | Bioorg Med Chem Lett 19: 1492-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.015 BindingDB Entry DOI: 10.7270/Q2B27V5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50178424![]() ((2S)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phe...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1 | Bioorg Med Chem Lett 16: 1388-91 (2006) Article DOI: 10.1016/j.bmcl.2005.11.041 BindingDB Entry DOI: 10.7270/Q29C6X13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50248062![]() (2,4-dichloro-N-((1-(propylsulfonyl)-4-((tetrahydro...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of Glyt1 | Bioorg Med Chem Lett 19: 1492-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.015 BindingDB Entry DOI: 10.7270/Q2B27V5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM50460354![]() (CHEMBL4228817) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci... | Bioorg Med Chem Lett 28: 1043-1049 (2018) Article DOI: 10.1016/j.bmcl.2018.02.029 BindingDB Entry DOI: 10.7270/Q26112ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human)) | BDBM201162![]() (US9233953, 122) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Cells expressing either endogenously the GlyT1 transporter like JAR cells (human placental choriocarcinoma cells; e.g. WO 2008/002583) or SK-N-MC cel... | US Patent US9233953 (2016) BindingDB Entry DOI: 10.7270/Q2Q81BVM | |||||||||||
More data for this Ligand-Target Pair |
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