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Compile Data Set for Download or QSAR

Found 5828 hits of ic50 data for polymerid = 2112,9137   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM602735
PNG
((5Z)-5-[[1-(3-chlorophenyl)pyrazol-4-yl]methylene]...)
Show SMILES Clc1cccc(c1)-n1cc(\C=C2/SC(=S)NC2=O)cn1
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n/an/a 0n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2CR5Z94
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Mus musculus (Mouse))		BDBM36609
PNG
(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O |c:14,33,t:29,31|
Show InChI InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
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n/an/a 0.0500n/an/an/an/an/an/a



Therachem Research Medilab, LLC.

Curated by ChEMBL


Assay Description
Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assay

ACS Med Chem Lett 10: 843-845 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00215
BindingDB Entry DOI: 10.7270/Q2SQ93XR
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM116089
PNG
(US8633183, E-238)
Show SMILES CCc1ncnc(-c2cc(F)c(C(=O)N3CCN4CCC[C@H]4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 |r|
Show InChI InChI=1S/C27H26ClFN6O/c1-2-23-20(7-5-17-6-8-24(30)31-14-17)26(33-16-32-23)18-12-21(28)25(22(29)13-18)27(36)35-11-10-34-9-3-4-19(34)15-35/h6,8,12-14,16,19H,2-4,9-11,15H2,1H3,(H2,30,31)/t19-/m0/s1
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n/an/a 0.0700n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...

US Patent US8633183 (2014)


BindingDB Entry DOI: 10.7270/Q2SX6BW4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM35595
PNG
(pyrazolo pyrimidine, 28)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CCOCC1
Show InChI InChI=1S/C30H34N8O5/c1-42-30(41)37-12-10-24(11-13-37)38-28-25(18-31-38)27(36-14-16-43-17-15-36)34-26(35-28)21-4-8-23(9-5-21)33-29(40)32-22-6-2-20(19-39)3-7-22/h2-9,18,24,39H,10-17,19H2,1H3,(H2,32,33,40)
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n/an/a 0.0800n/an/an/an/a7.423



Wyeth Research



Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...

J Med Chem 52: 5013-6 (2009)


Article DOI: 10.1021/jm900851f
BindingDB Entry DOI: 10.7270/Q2SJ1HZD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM36609
PNG
(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O |c:14,33,t:29,31|
Show InChI InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Stanford University

Curated by ChEMBL


Assay Description
Inhibition of mTOR kinase expressed in human HEK293 cells by western blot analysis

J Biol Chem 282: 13395-401 (2007)


Article DOI: 10.1074/jbc.M700498200
BindingDB Entry DOI: 10.7270/Q2J1042G
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM36609
PNG
(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O |c:14,33,t:29,31|
Show InChI InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of mTOR in HEK293 cells

J Med Chem 63: 10135-10157 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02038
BindingDB Entry DOI: 10.7270/Q2S46WJB
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM36609
PNG
(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Show SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O |c:14,33,t:29,31|
Show InChI InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50303282
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CC2CCC(C1)O2 |TLB:6:27:34:30.31|
Show InChI InChI=1S/C25H26N8O2/c1-2-33-24-21(13-27-33)23(32-14-19-9-10-20(15-32)35-19)30-22(31-24)16-5-7-17(8-6-16)28-25(34)29-18-4-3-11-26-12-18/h3-8,11-13,19-20H,2,9-10,14-15H2,1H3,(H2,28,29,34)
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA

Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50316254
PNG
(CHEMBL1098245 | methyl 4-(6-(4-(3-(4-(2-hydroxyeth...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CCO)cc2)cc1)N1CCOCC1
Show InChI InChI=1S/C31H36N8O5/c1-43-31(42)38-13-10-25(11-14-38)39-29-26(20-32-39)28(37-15-18-44-19-16-37)35-27(36-29)22-4-8-24(9-5-22)34-30(41)33-23-6-2-21(3-7-23)12-17-40/h2-9,20,25,40H,10-19H2,1H3,(H2,33,34,41)
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells

J Med Chem 52: 8010-24 (2009)


Article DOI: 10.1021/jm9013828
BindingDB Entry DOI: 10.7270/Q28W3DGF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50303298
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:29:36:32.33|
Show InChI InChI=1S/C27H29N7O3/c1-2-34-26-23(13-28-34)25(33-14-21-11-12-22(15-33)37-21)31-24(32-26)18-5-9-20(10-6-18)30-27(36)29-19-7-3-17(16-35)4-8-19/h3-10,13,21-22,35H,2,11-12,14-16H2,1H3,(H2,29,30,36)
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA

Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50303299
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CCO)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:30:37:33.34|
Show InChI InChI=1S/C28H31N7O3/c1-2-35-27-24(15-29-35)26(34-16-22-11-12-23(17-34)38-22)32-25(33-27)19-5-9-21(10-6-19)31-28(37)30-20-7-3-18(4-8-20)13-14-36/h3-10,15,22-23,36H,2,11-14,16-17H2,1H3,(H2,30,31,37)
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA

Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50315080
PNG
(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NCCN(C)C)cc1)N1C2CCC1COC2 |r|
Show InChI InChI=1S/C32H41N9O4/c1-21-18-44-17-16-40(21)30-36-28(37-31(38-30)41-26-12-13-27(41)20-45-19-26)22-4-8-24(9-5-22)34-32(43)35-25-10-6-23(7-11-25)29(42)33-14-15-39(2)3/h4-11,21,26-27H,12-20H2,1-3H3,(H,33,42)(H2,34,35,43)/t21-,26?,27?/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 2648-53 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.031
BindingDB Entry DOI: 10.7270/Q2DZ08GK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300067
PNG
(CHEMBL573157 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C30H33N9O4/c1-42-30(41)37-13-10-22(11-14-37)39-28-25(16-32-39)27(38-17-23-8-9-24(18-38)43-23)35-26(36-28)19-4-6-20(7-5-19)33-29(40)34-21-3-2-12-31-15-21/h2-7,12,15-16,22-24H,8-11,13-14,17-18H2,1H3,(H2,33,34,40)
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n/an/a 0.110n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306624
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-is...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C(C)C)c2n1
Show InChI InChI=1S/C22H27N7O2/c1-13(2)29-21-18(10-24-29)20(28-11-16-8-9-17(12-28)31-16)26-19(27-21)14-4-6-15(7-5-14)25-22(30)23-3/h4-7,10,13,16-17H,8-9,11-12H2,1-3H3,(H2,23,25,30)
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n/an/a 0.120n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306640
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES O=C(Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1)Nc1cccnc1
Show InChI InChI=1S/C31H34N8O4/c40-30(35-22-2-1-13-32-16-22)34-21-5-3-20(4-6-21)27-36-28(38-18-24-7-8-25(19-38)43-24)26-17-33-39(29(26)37-27)23-9-11-31(12-10-23)41-14-15-42-31/h1-6,13,16-17,23-25H,7-12,14-15,18-19H2,(H2,34,35,40)
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n/an/a 0.120n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306639
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES O=C(Nc1ccncc1)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C31H34N8O4/c40-30(35-22-9-13-32-14-10-22)34-21-3-1-20(2-4-21)27-36-28(38-18-24-5-6-25(19-38)43-24)26-17-33-39(29(26)37-27)23-7-11-31(12-8-23)41-15-16-42-31/h1-4,9-10,13-14,17,23-25H,5-8,11-12,15-16,18-19H2,(H2,32,34,35,40)
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n/an/a 0.120n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50348452
PNG
(AZD-8055 | CHEMBL1801204 | US9102670, 1a)
Show SMILES COc1ccc(cc1CO)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1
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n/an/a 0.130n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cells

Bioorg Med Chem Lett 23: 1212-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.019
BindingDB Entry DOI: 10.7270/Q2N29Z97
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50348452
PNG
(AZD-8055 | CHEMBL1801204 | US9102670, 1a)
Show SMILES COc1ccc(cc1CO)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1
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n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria

Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50315071
PNG
(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Show SMILES CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2C3CCC2COC3)C2CCOCC2)cc1
Show InChI InChI=1S/C32H40N8O4/c1-39(2)16-15-33-30(41)23-5-9-25(10-6-23)35-32(42)34-24-7-3-21(4-8-24)28-36-29(22-13-17-43-18-14-22)38-31(37-28)40-26-11-12-27(40)20-44-19-26/h3-10,22,26-27H,11-20H2,1-2H3,(H,33,41)(H2,34,35,42)
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n/an/a 0.140n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 2648-53 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.031
BindingDB Entry DOI: 10.7270/Q2DZ08GK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM174595
PNG
(US9102670, 14a)
Show SMILES COc1ccc(cc1C(O)=O)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C25H29N5O5/c1-15-13-34-10-8-29(15)23-18-5-6-20(17-4-7-21(33-3)19(12-17)24(31)32)26-22(18)27-25(28-23)30-9-11-35-14-16(30)2/h4-7,12,15-16H,8-11,13-14H2,1-3H3,(H,31,32)/t15-,16-/m0/s1
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US Patent
n/an/a 0.150n/an/an/an/an/a25



KUDOS PHARMACEUTICALS LIMITED

US Patent


Assay Description
The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...

US Patent US9102670 (2015)


BindingDB Entry DOI: 10.7270/Q26M35MZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300072
PNG
(CHEMBL573202 | methyl 4-(4-(3-oxa-8-azabicyclo[3.2...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1C2CCC1COC2
Show InChI InChI=1S/C30H33N9O4/c1-42-30(41)37-13-10-22(11-14-37)39-28-25(16-32-39)27(38-23-8-9-24(38)18-43-17-23)35-26(36-28)19-4-6-20(7-5-19)33-29(40)34-21-3-2-12-31-15-21/h2-7,12,15-16,22-24H,8-11,13-14,17-18H2,1H3,(H2,33,34,40)
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n/an/a 0.160n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306638
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C32H35N7O4/c40-31(34-22-4-2-1-3-5-22)35-23-8-6-21(7-9-23)28-36-29(38-19-25-10-11-26(20-38)43-25)27-18-33-39(30(27)37-28)24-12-14-32(15-13-24)41-16-17-42-32/h1-9,18,24-26H,10-17,19-20H2,(H2,34,35,40)
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n/an/a 0.160n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300077
PNG
(CHEMBL578645 | ethyl 4-(6-(4-(3-ethylureido)phenyl...)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OCC)c2n1
Show InChI InChI=1S/C26H34N8O4/c1-3-27-25(35)29-19-7-5-18(6-8-19)22-30-23(32-13-15-37-16-14-32)21-17-28-34(24(21)31-22)20-9-11-33(12-10-20)26(36)38-4-2/h5-8,17,20H,3-4,9-16H2,1-2H3,(H2,27,29,35)
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n/an/a 0.170n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Mus musculus (Mouse))		BDBM50535638
PNG
(CHEMBL4529771)
Show SMILES [H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\C(C2)N1CCS1(=O)=O)[C@H](C)C[C@@H]1CC[C@@H](O)[C@@H](C1)OC |r,c:31,50,t:46,48|
Show InChI InChI=1S/C52H82N2O13S/c1-32-15-11-10-12-16-34(3)42(54-25-26-68(54,62)63)31-40-21-19-38(7)52(61,67-40)49(58)50(59)53-24-14-13-17-41(53)51(60)66-44(35(4)29-39-20-22-43(55)45(30-39)64-8)23-18-33(2)28-37(6)47(57)48(65-9)46(56)36(5)27-32/h10-12,15-16,28,32-33,35-36,38-45,47-48,55,57,61H,13-14,17-27,29-31H2,1-9H3/b12-10+,15-11+,34-16+,37-28+/t32-,33+,35-,36-,38-,39+,40+,41+,42?,43-,44+,45-,47-,48+,52-/m1/s1
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n/an/a 0.170n/an/an/an/an/an/a



Therachem Research Medilab, LLC.

Curated by ChEMBL


Assay Description
Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assay

ACS Med Chem Lett 10: 843-845 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00215
BindingDB Entry DOI: 10.7270/Q2SQ93XR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50315056
PNG
(1-(4-(4,6-di(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Show SMILES OCc1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2C3CCC2COC3)N2C3CCC2COC3)cc1
Show InChI InChI=1S/C29H33N7O4/c37-13-18-1-5-20(6-2-18)30-29(38)31-21-7-3-19(4-8-21)26-32-27(35-22-9-10-23(35)15-39-14-22)34-28(33-26)36-24-11-12-25(36)17-40-16-24/h1-8,22-25,37H,9-17H2,(H2,30,31,38)
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n/an/a 0.180n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 2648-53 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.031
BindingDB Entry DOI: 10.7270/Q2DZ08GK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50145416
PNG
(GSK2126458 | Omipalisib)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nccc(-c3ccnnc3)c2c1
Show InChI InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
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n/an/a 0.180n/an/an/an/an/an/a



Temple University

Curated by ChEMBL


Assay Description
Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding method

Bioorg Med Chem Lett 27: 3117-3122 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.044
BindingDB Entry DOI: 10.7270/Q2Z89FTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306633
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
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n/an/a 0.190n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300070
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Show SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C25H23F3N8O2/c26-25(27,28)14-36-23-20(11-30-36)22(35-12-18-7-8-19(13-35)38-18)33-21(34-23)15-3-5-16(6-4-15)31-24(37)32-17-2-1-9-29-10-17/h1-6,9-11,18-19H,7-8,12-14H2,(H2,31,32,37)
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n/an/a 0.190n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306620
PNG
(CHEMBL606423 | isopropyl 4-(4-(8-oxa-3-azabicyclo[...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCN(CC3)C(=O)OC(C)C)c2n1
Show InChI InChI=1S/C28H36N8O4/c1-17(2)39-28(38)34-12-10-20(11-13-34)36-26-23(14-30-36)25(35-15-21-8-9-22(16-35)40-21)32-24(33-26)18-4-6-19(7-5-18)31-27(37)29-3/h4-7,14,17,20-22H,8-13,15-16H2,1-3H3,(H2,29,31,37)
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n/an/a 0.190n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50341056
PNG
(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Show SMILES Cc1nc(N)nc(n1)-n1c(Nc2cc(O)cc(O)c2)nc2ccccc12
Show InChI InChI=1S/C17H15N7O2/c1-9-19-15(18)23-16(20-9)24-14-5-3-2-4-13(14)22-17(24)21-10-6-11(25)8-12(26)7-10/h2-8,25-26H,1H3,(H,21,22)(H2,18,19,20,23)
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assay

Bioorg Med Chem Lett 21: 2064-70 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.007
BindingDB Entry DOI: 10.7270/Q2FT8MBW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300074
PNG
(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Show SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)14-34-21-18(13-28-34)20(33-8-10-36-11-9-33)31-19(32-21)15-3-5-16(6-4-15)29-22(35)30-17-2-1-7-27-12-17/h1-7,12-13H,8-11,14H2,(H2,29,30,35)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR in HEK293 cells by DELFIA assay

Bioorg Med Chem Lett 20: 640-3 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.050
BindingDB Entry DOI: 10.7270/Q2C829DN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50316255
PNG
(CHEMBL1095932 | Isopropyl 4-(6-(4-(3-Methylureido)...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC(C)C)c2n1
Show InChI InChI=1S/C26H34N8O4/c1-17(2)38-26(36)33-10-8-20(9-11-33)34-24-21(16-28-34)23(32-12-14-37-15-13-32)30-22(31-24)18-4-6-19(7-5-18)29-25(35)27-3/h4-7,16-17,20H,8-15H2,1-3H3,(H2,27,29,35)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells

J Med Chem 52: 8010-24 (2009)


Article DOI: 10.1021/jm9013828
BindingDB Entry DOI: 10.7270/Q28W3DGF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50089318
PNG
(CHEMBL3577911)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncnc(-c3ccncc3)c2c1
Show InChI InChI=1S/C25H17F2N5O3S/c1-35-25-22(32-36(33,34)23-5-3-18(26)12-20(23)27)11-17(13-29-25)16-2-4-21-19(10-16)24(31-14-30-21)15-6-8-28-9-7-15/h2-14,32H,1H3
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n/an/a 0.200n/an/an/an/an/an/a



PKUCare Pharmaceutical R&D Center

Curated by ChEMBL


Assay Description
Inhibition of mTOR (unknown origin) using GFP-4E-BP1 as substrate after 1 hr by TR-FRET assay

ACS Med Chem Lett 6: 434-8 (2015)


Article DOI: 10.1021/ml5005014
BindingDB Entry DOI: 10.7270/Q29Z96M1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50303280
PNG
(4-(3-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)NN2CCCC2)cc1)N1CC2CCC(C1)O2 |TLB:6:35:42:38.39|
Show InChI InChI=1S/C31H35N9O3/c1-2-40-29-26(17-32-40)28(38-18-24-13-14-25(19-38)43-24)35-27(36-29)20-5-9-22(10-6-20)33-31(42)34-23-11-7-21(8-12-23)30(41)37-39-15-3-4-16-39/h5-12,17,24-25H,2-4,13-16,18-19H2,1H3,(H,37,41)(H2,33,34,42)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA

Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50303281
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2)cc1)N1CC2CCC(C1)O2 |TLB:6:33:40:36.37|
Show InChI InChI=1S/C30H34N8O3/c1-2-38-29-26(17-31-38)28(37-18-24-11-12-25(19-37)41-24)34-27(35-29)20-3-5-21(6-4-20)32-30(39)33-22-7-9-23(10-8-22)36-13-15-40-16-14-36/h3-10,17,24-25H,2,11-16,18-19H2,1H3,(H2,32,33,39)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA

Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM116093
PNG
(US8633183, E-242)
Show SMILES CCc1ncnc(-c2cc(F)c(C(=O)N3CCC(CO)CC3)c(Cl)c2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C26H25ClFN5O2/c1-2-22-19(5-3-16-4-6-23(29)30-13-16)25(32-15-31-22)18-11-20(27)24(21(28)12-18)26(35)33-9-7-17(14-34)8-10-33/h4,6,11-13,15,17,34H,2,7-10,14H2,1H3,(H2,29,30)
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n/an/a 0.200n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...

US Patent US8633183 (2014)


BindingDB Entry DOI: 10.7270/Q2SX6BW4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50303295
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Show SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CN)cc2)cc1)N1CC2CCC(C1)O2 |TLB:6:29:36:32.33|
Show InChI InChI=1S/C27H30N8O2/c1-2-35-26-23(14-29-35)25(34-15-21-11-12-22(16-34)37-21)32-24(33-26)18-5-9-20(10-6-18)31-27(36)30-19-7-3-17(13-28)4-8-19/h3-10,14,21-22H,2,11-13,15-16,28H2,1H3,(H2,30,31,36)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA

Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM35592
PNG
(pyrazolo pyrimidine, 24)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H31N9O4/c1-40-28(39)36-11-8-22(9-12-36)37-26-23(18-30-37)25(35-13-15-41-16-14-35)33-24(34-26)19-4-6-20(7-5-19)31-27(38)32-21-3-2-10-29-17-21/h2-7,10,17-18,22H,8-9,11-16H2,1H3,(H2,31,32,38)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300071
PNG
(CHEMBL577137 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Show InChI InChI=1S/C27H34N8O4/c1-3-28-26(36)30-18-6-4-17(5-7-18)23-31-24(34-15-20-8-9-21(16-34)39-20)22-14-29-35(25(22)32-23)19-10-12-33(13-11-19)27(37)38-2/h4-7,14,19-21H,3,8-13,15-16H2,1-2H3,(H2,28,30,36)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300075
PNG
(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...)
Show SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1C2CCC1COC2
Show InChI InChI=1S/C25H23F3N8O2/c26-25(27,28)14-35-22-20(11-30-35)23(36-18-7-8-19(36)13-38-12-18)34-21(33-22)15-3-5-16(6-4-15)31-24(37)32-17-2-1-9-29-10-17/h1-6,9-11,18-19H,7-8,12-14H2,(H2,31,32,37)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM35592
PNG
(pyrazolo pyrimidine, 24)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1
Show InChI InChI=1S/C28H31N9O4/c1-40-28(39)36-11-8-22(9-12-36)37-26-23(18-30-37)25(35-13-15-41-16-14-35)33-24(34-26)19-4-6-20(7-5-19)31-27(38)32-21-3-2-10-29-17-21/h2-7,10,17-18,22H,8-9,11-16H2,1H3,(H2,31,32,38)
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n/an/a 0.200n/an/an/an/a7.423



Wyeth Research



Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...

J Med Chem 52: 5013-6 (2009)


Article DOI: 10.1021/jm900851f
BindingDB Entry DOI: 10.7270/Q2SJ1HZD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50303292
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Show SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCNCC2)cc1)N1CC2CCC(C1)O2 |TLB:9:36:43:39.40|
Show InChI InChI=1S/C30H32F3N9O2/c31-30(32,33)18-42-28-25(15-35-42)27(41-16-23-9-10-24(17-41)44-23)38-26(39-28)19-1-3-20(4-2-19)36-29(43)37-21-5-7-22(8-6-21)40-13-11-34-12-14-40/h1-8,15,23-24,34H,9-14,16-18H2,(H2,36,37,43)
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA

Bioorg Med Chem Lett 19: 6830-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.096
BindingDB Entry DOI: 10.7270/Q2BV7GPR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM116143
PNG
(US8633183, E-297)
Show SMILES CCc1ncnc(-c2cc(F)c(C(=O)N3CCN(Cc4cc(C)no4)CC3)c(F)c2)c1C#Cc1ccc(N)nc1
Show InChI InChI=1S/C29H27F2N7O2/c1-3-25-22(6-4-19-5-7-26(32)33-15-19)28(35-17-34-25)20-13-23(30)27(24(31)14-20)29(39)38-10-8-37(9-11-38)16-21-12-18(2)36-40-21/h5,7,12-15,17H,3,8-11,16H2,1-2H3,(H2,32,33)
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US Patent
n/an/a 0.210n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...

US Patent US8633183 (2014)


BindingDB Entry DOI: 10.7270/Q2SX6BW4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306633
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
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n/an/a 0.210n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300078
PNG
(CHEMBL574012 | methyl 4-(4-(3-oxa-8-azabicyclo[3.2...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2C3CCC2COC3)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Show InChI InChI=1S/C26H32N8O4/c1-27-25(35)29-17-5-3-16(4-6-17)22-30-23(33-19-7-8-20(33)15-38-14-19)21-13-28-34(24(21)31-22)18-9-11-32(12-10-18)26(36)37-2/h3-6,13,18-20H,7-12,14-15H2,1-2H3,(H2,27,29,35)
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n/an/a 0.220n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300066
PNG
(CHEMBL568259 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Show InChI InChI=1S/C26H32N8O4/c1-27-25(35)29-17-5-3-16(4-6-17)22-30-23(33-14-19-7-8-20(15-33)38-19)21-13-28-34(24(21)31-22)18-9-11-32(12-10-18)26(36)37-2/h3-6,13,18-20H,7-12,14-15H2,1-2H3,(H2,27,29,35)
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n/an/a 0.220n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50300066
PNG
(CHEMBL568259 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Show InChI InChI=1S/C26H32N8O4/c1-27-25(35)29-17-5-3-16(4-6-17)22-30-23(33-14-19-7-8-20(15-33)38-19)21-13-28-34(24(21)31-22)18-9-11-32(12-10-18)26(36)37-2/h3-6,13,18-20H,7-12,14-15H2,1-2H3,(H2,27,29,35)
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n/an/a 0.220n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Flag-tagged human mTOR by DELFIA method

J Med Chem 52: 7942-5 (2009)


Article DOI: 10.1021/jm901415x
BindingDB Entry DOI: 10.7270/Q2WM1DGH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306636
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES FCCNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C28H34FN7O4/c29-11-12-30-27(37)32-19-3-1-18(2-4-19)24-33-25(35-16-21-5-6-22(17-35)40-21)23-15-31-36(26(23)34-24)20-7-9-28(10-8-20)38-13-14-39-28/h1-4,15,20-22H,5-14,16-17H2,(H2,30,32,37)
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n/an/a 0.220n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306637
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Show SMILES O=C(NC1CC1)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC4(CC3)OCCO4)c2n1
Show InChI InChI=1S/C29H35N7O4/c37-28(32-20-5-6-20)31-19-3-1-18(2-4-19)25-33-26(35-16-22-7-8-23(17-35)40-22)24-15-30-36(27(24)34-25)21-9-11-29(12-10-21)38-13-14-39-29/h1-4,15,20-23H,5-14,16-17H2,(H2,31,32,37)
PDB
MMDB

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Article
PubMed
n/an/a 0.220n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50306627
PNG
(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(4...)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn(C3CCC(=O)CC3)c2n1
Show InChI InChI=1S/C25H29N7O3/c1-26-25(34)28-16-4-2-15(3-5-16)22-29-23(31-13-19-10-11-20(14-31)35-19)21-12-27-32(24(21)30-22)17-6-8-18(33)9-7-17/h2-5,12,17,19-20H,6-11,13-14H2,1H3,(H2,26,28,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.220n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR

Bioorg Med Chem Lett 20: 1440-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.086
BindingDB Entry DOI: 10.7270/Q2S46S2T
More data for this
Ligand-Target Pair
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