Compile Data Set for Download or QSAR

Found 987 hits of ki for UniProtKB: P10721   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342153 (6-(4-fluorophenyl)-4-[4-(4-methyl-5- phenyl-1H-imi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C27H25FN6/c1-17-24(19-5-3-2-4-6-19)33-25(31-17)20-11-13-34(14-12-20)27-22-15-23(32-26(22)29-16-30-27)18-7-9-21(28)10-8-18/h2-10,15-16,20H,11-14H2,1H3,(H,31,33)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342154 (6-(2-methoxy-4-pyridyl)-4-[4-(4- methyl-5-phenyl-1...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C27H27N7O/c1-17-24(18-6-4-3-5-7-18)33-25(31-17)19-9-12-34(13-10-19)27-21-15-22(32-26(21)29-16-30-27)20-8-11-28-23(14-20)35-2/h3-8,11,14-16,19H,9-10,12-13H2,1-2H3,(H,31,33)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342158 (6-(4-fluorophenyl)-4-[4-[5-(4- fluorophenyl)-4-met...) Show SMILES Cc1nc([nH]c1-c1ccc(F)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C27H24F2N6/c1-16-24(18-4-8-21(29)9-5-18)34-25(32-16)19-10-12-35(13-11-19)27-22-14-23(33-26(22)30-15-31-27)17-2-6-20(28)7-3-17/h2-9,14-15,19H,10-13H2,1H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342159 (4-[4-[5-(4-fluorophenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H26FN7O/c1-16-24(17-3-5-20(28)6-4-17)34-25(32-16)18-8-11-35(12-9-18)27-21-14-22(33-26(21)30-15-31-27)19-7-10-29-23(13-19)36-2/h3-7,10,13-15,18H,8-9,11-12H2,1-2H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342162 (4-[4-(4-cyclopropyl-5-phenyl-1H- imidazol-2-yl)-1-...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C2CC2)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C29H29N7O/c1-37-24-15-21(9-12-30-24)23-16-22-28(33-23)31-17-32-29(22)36-13-10-20(11-14-36)27-34-25(18-5-3-2-4-6-18)26(35-27)19-7-8-19/h2-6,9,12,15-17,19-20H,7-8,10-11,13-14H2,1H3,(H,34,35)(H,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342163 (4-[4-(4-cyclopropyl-5-phenyl-1H- imidazol-2-yl)-1-...) Show SMILES Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C2CC2)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C29H27FN6/c30-22-10-8-18(9-11-22)24-16-23-28(33-24)31-17-32-29(23)36-14-12-21(13-15-36)27-34-25(19-4-2-1-3-5-19)26(35-27)20-6-7-20/h1-5,8-11,16-17,20-21H,6-7,12-15H2,(H,34,35)(H,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342164 (4-[4-[4-(4-cyclopropyl-5-phenyl-1H- imidazol-2-yl)...) Show SMILES N#Cc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C2CC2)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C30H27N7/c31-17-19-6-8-20(9-7-19)25-16-24-29(34-25)32-18-33-30(24)37-14-12-23(13-15-37)28-35-26(21-4-2-1-3-5-21)27(36-28)22-10-11-22/h1-9,16,18,22-23H,10-15H2,(H,35,36)(H,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342165 (4-[4-[5-[3-(difluoromethoxy)phenyl]- 4H-1,2,4-tria...) Show SMILES FC(F)Oc1cccc(c1)-c1nnc([nH]1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C26H22F3N7O/c27-18-6-4-15(5-7-18)21-13-20-24(32-21)30-14-31-25(20)36-10-8-16(9-11-36)22-33-23(35-34-22)17-2-1-3-19(12-17)37-26(28)29/h1-7,12-14,16,26H,8-11H2,(H,30,31,32)(H,33,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342169 (6-(4-fluorophenyl)-4-[4-[4-methyl-5-[3- (trifluoro...) Show SMILES Cc1nc([nH]c1-c1cccc(OC(F)(F)F)c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H24F4N6O/c1-16-24(19-3-2-4-21(13-19)39-28(30,31)32)37-25(35-16)18-9-11-38(12-10-18)27-22-14-23(36-26(22)33-15-34-27)17-5-7-20(29)8-6-17/h2-8,13-15,18H,9-12H2,1H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342172 (6-(4-fluorophenyl)-4-[4-[5-(4- fluorophenyl)-4H-1,...) Show SMILES Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nnc([nH]1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H21F2N7/c26-18-5-1-15(2-6-18)21-13-20-24(30-21)28-14-29-25(20)34-11-9-17(10-12-34)23-31-22(32-33-23)16-3-7-19(27)8-4-16/h1-8,13-14,17H,9-12H2,(H,28,29,30)(H,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342175 (6-(2-methoxy-4-pyridyl)-4-[4-[4- methyl-5-[3-(trif...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C28H26F3N7O2/c1-16-24(19-4-3-5-20(12-19)40-28(29,30)31)37-25(35-16)17-7-10-38(11-8-17)27-21-14-22(36-26(21)33-15-34-27)18-6-9-32-23(13-18)39-2/h3-6,9,12-15,17H,7-8,10-11H2,1-2H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342176 (4-[4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C29H27N7O/c1-18-26(21-7-9-23(37-2)10-8-21)35-27(33-18)22-11-13-36(14-12-22)29-24-15-25(34-28(24)31-17-32-29)20-5-3-19(16-30)4-6-20/h3-10,15,17,22H,11-14H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342177 (4-[4-[4-[5-(3-fluorophenyl)-4-methyl- 1H-imidazol-...) Show SMILES Cc1nc([nH]c1-c1cccc(F)c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H24FN7/c1-17-25(21-3-2-4-22(29)13-21)35-26(33-17)20-9-11-36(12-10-20)28-23-14-24(34-27(23)31-16-32-28)19-7-5-18(15-30)6-8-19/h2-8,13-14,16,20H,9-12H2,1H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342178 (4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol-2-...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C28H29N7O2/c1-17-25(18-4-6-21(36-2)7-5-18)34-26(32-17)19-9-12-35(13-10-19)28-22-15-23(33-27(22)30-16-31-28)20-8-11-29-24(14-20)37-3/h4-8,11,14-16,19H,9-10,12-13H2,1-3H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342179 (4-[4-[4-[5-(3-fluoro-4-methoxy-phenyl)- 4-methyl-1...) Show SMILES COc1ccc(cc1F)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C29H26FN7O/c1-17-26(21-7-8-25(38-2)23(30)13-21)36-27(34-17)20-9-11-37(12-10-20)29-22-14-24(35-28(22)32-16-33-29)19-5-3-18(15-31)4-6-19/h3-8,13-14,16,20H,9-12H2,1-2H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342180 (4-[4-[5-(3-fluorophenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1cccc(F)c1 Show InChI InChI=1S/C27H26FN7O/c1-16-24(19-4-3-5-20(28)12-19)34-25(32-16)17-7-10-35(11-8-17)27-21-14-22(33-26(21)30-15-31-27)18-6-9-29-23(13-18)36-2/h3-6,9,12-15,17H,7-8,10-11H2,1-2H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342181 (4-[4-[4-[5-(4-fluorophenyl)-4-methyl- 1H-imidazol-...) Show SMILES Cc1nc([nH]c1-c1ccc(F)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H24FN7/c1-17-25(20-6-8-22(29)9-7-20)35-26(33-17)21-10-12-36(13-11-21)28-23-14-24(34-27(23)31-16-32-28)19-4-2-18(15-30)3-5-19/h2-9,14,16,21H,10-13H2,1H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342182 (4-[4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol...) Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C29H27N7O/c1-18-26(22-4-3-5-23(14-22)37-2)35-27(33-18)21-10-12-36(13-11-21)29-24-15-25(34-28(24)31-17-32-29)20-8-6-19(16-30)7-9-20/h3-9,14-15,17,21H,10-13H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342183 (4-[4-[5-(3-methoxyphenyl)-4-methyl- 1H-imidazol-2-...) Show SMILES COc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C28H29N7O2/c1-17-25(20-5-4-6-21(13-20)36-2)34-26(32-17)18-8-11-35(12-9-18)28-22-15-23(33-27(22)30-16-31-28)19-7-10-29-24(14-19)37-3/h4-7,10,13-16,18H,8-9,11-12H2,1-3H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342184 (4-[4-[5-(4-methoxy-3-methyl-phenyl)-4- methyl-1H-i...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccc(OC)c(C)c1 Show InChI InChI=1S/C29H31N7O2/c1-17-13-21(5-6-24(17)37-3)26-18(2)33-27(35-26)19-8-11-36(12-9-19)29-22-15-23(34-28(22)31-16-32-29)20-7-10-30-25(14-20)38-4/h5-7,10,13-16,19H,8-9,11-12H2,1-4H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342185 (4-[4-[5-(3-ethoxyphenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES CCOc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6O/c1-3-37-23-6-4-5-21(15-23)26-18(2)33-27(35-26)20-11-13-36(14-12-20)29-24-16-25(34-28(24)31-17-32-29)19-7-9-22(30)10-8-19/h4-10,15-17,20H,3,11-14H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342186 (4-[4-[4-[5-(3-ethoxyphenyl)-4-methyl- 1H-imidazol-...) Show SMILES CCOc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O/c1-3-38-24-6-4-5-23(15-24)27-19(2)34-28(36-27)22-11-13-37(14-12-22)30-25-16-26(35-29(25)32-18-33-30)21-9-7-20(17-31)8-10-21/h4-10,15-16,18,22H,3,11-14H2,1-2H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342187 (4-[4-[5-(4-ethoxyphenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES CCOc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6O/c1-3-37-23-10-6-20(7-11-23)26-18(2)33-27(35-26)21-12-14-36(15-13-21)29-24-16-25(34-28(24)31-17-32-29)19-4-8-22(30)9-5-19/h4-11,16-17,21H,3,12-15H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342188 (4-[4-[4-[5-(4-ethoxyphenyl)-4-methyl- 1H-imidazol-...) Show SMILES CCOc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O/c1-3-38-24-10-8-22(9-11-24)27-19(2)34-28(36-27)23-12-14-37(15-13-23)30-25-16-26(35-29(25)32-18-33-30)21-6-4-20(17-31)5-7-21/h4-11,16,18,23H,3,12-15H2,1-2H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342190 (6-(4-fluorophenyl)-4-[4-[5-(4- methoxyphenyl)-4-me...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H27FN6O/c1-17-25(19-5-9-22(36-2)10-6-19)34-26(32-17)20-11-13-35(14-12-20)28-23-15-24(33-27(23)30-16-31-28)18-3-7-21(29)8-4-18/h3-10,15-16,20H,11-14H2,1-2H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342191 (6-(4-fluorophenyl)-4-[4-[5-(4-methoxy- 3-methyl-ph...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6O/c1-17-14-21(6-9-25(17)37-3)26-18(2)33-27(35-26)20-10-12-36(13-11-20)29-23-15-24(34-28(23)31-16-32-29)19-4-7-22(30)8-5-19/h4-9,14-16,20H,10-13H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342192 (4-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O/c1-18-14-23(8-9-26(18)38-3)27-19(2)34-28(36-27)22-10-12-37(13-11-22)30-24-15-25(35-29(24)32-17-33-30)21-6-4-20(16-31)5-7-21/h4-9,14-15,17,22H,10-13H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342193 (4-[4-[5-(4-ethoxyphenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES CCOc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C29H31N7O2/c1-4-38-22-7-5-19(6-8-22)26-18(2)33-27(35-26)20-10-13-36(14-11-20)29-23-16-24(34-28(23)31-17-32-29)21-9-12-30-25(15-21)37-3/h5-9,12,15-17,20H,4,10-11,13-14H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342197 (6-(4-fluorophenyl)-4-[4-methyl-4-(4- methyl-5-phen...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H27FN6/c1-18-24(20-6-4-3-5-7-20)34-27(32-18)28(2)12-14-35(15-13-28)26-22-16-23(33-25(22)30-17-31-26)19-8-10-21(29)11-9-19/h3-11,16-17H,12-15H2,1-2H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342198 (6-(2-methoxy-4-pyridyl)-4-[4-methyl-4- (4-methyl-5...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C28H29N7O/c1-18-24(19-7-5-4-6-8-19)34-27(32-18)28(2)10-13-35(14-11-28)26-21-16-22(33-25(21)30-17-31-26)20-9-12-29-23(15-20)36-3/h4-9,12,15-17H,10-11,13-14H2,1-3H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342200 (4-[4-[5-(3-ethoxyphenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES CCOc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C29H31N7O2/c1-4-38-22-7-5-6-21(14-22)26-18(2)33-27(35-26)19-9-12-36(13-10-19)29-23-16-24(34-28(23)31-17-32-29)20-8-11-30-25(15-20)37-3/h5-8,11,14-17,19H,4,9-10,12-13H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342201 (4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C27H24ClFN6/c1-16-24(18-2-6-20(28)7-3-18)34-25(32-16)19-10-12-35(13-11-19)27-22-14-23(33-26(22)30-15-31-27)17-4-8-21(29)9-5-17/h2-9,14-15,19H,10-13H2,1H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342202 (4-[4-[5-(3,4-dimethoxyphenyl)-4- methyl-1H-imidazo...) Show SMILES COc1ccc(cc1OC)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6O2/c1-17-26(20-6-9-24(37-2)25(14-20)38-3)35-27(33-17)19-10-12-36(13-11-19)29-22-15-23(34-28(22)31-16-32-29)18-4-7-21(30)8-5-18/h4-9,14-16,19H,10-13H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342203 (4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C27H26ClN7O/c1-16-24(17-3-5-20(28)6-4-17)34-25(32-16)18-8-11-35(12-9-18)27-21-14-22(33-26(21)30-15-31-27)19-7-10-29-23(13-19)36-2/h3-7,10,13-15,18H,8-9,11-12H2,1-2H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342204 (4-[4-[4-[5-(4-chlorophenyl)-4-methyl- 1H-imidazol-...) Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H24ClN7/c1-17-25(20-6-8-22(29)9-7-20)35-26(33-17)21-10-12-36(13-11-21)28-23-14-24(34-27(23)31-16-32-28)19-4-2-18(15-30)3-5-19/h2-9,14,16,21H,10-13H2,1H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342205 (4-[4-[4-[5-(3,4-dimethoxyphenyl)-4- methyl-1H-imid...) Show SMILES COc1ccc(cc1OC)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O2/c1-18-27(22-8-9-25(38-2)26(14-22)39-3)36-28(34-18)21-10-12-37(13-11-21)30-23-15-24(35-29(23)32-17-33-30)20-6-4-19(16-31)5-7-20/h4-9,14-15,17,21H,10-13H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342208 (6-(4-fluorophenyl)-4-[4-[5-(4- methoxyphenyl)-4-me...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6O/c1-18-25(20-6-10-22(37-3)11-7-20)35-28(33-18)29(2)12-14-36(15-13-29)27-23-16-24(34-26(23)31-17-32-27)19-4-8-21(30)9-5-19/h4-11,16-17H,12-15H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342209 (4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol-2-...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C29H31N7O2/c1-18-25(19-5-7-21(37-3)8-6-19)35-28(33-18)29(2)10-13-36(14-11-29)27-22-16-23(34-26(22)31-17-32-27)20-9-12-30-24(15-20)38-4/h5-9,12,15-17H,10-11,13-14H2,1-4H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342210 (4-[4-[5-(3,4-dimethoxyphenyl)-4- methyl-1H-imidazo...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C29H31N7O3/c1-17-26(20-5-6-23(37-2)24(13-20)38-3)35-27(33-17)18-8-11-36(12-9-18)29-21-15-22(34-28(21)31-16-32-29)19-7-10-30-25(14-19)39-4/h5-7,10,13-16,18H,8-9,11-12H2,1-4H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342211 (4-[4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O/c1-19-26(22-8-10-23(38-3)11-9-22)36-29(34-19)30(2)12-14-37(15-13-30)28-24-16-25(35-27(24)32-18-33-28)21-6-4-20(17-31)5-7-21/h4-11,16,18H,12-15H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342212 (4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C28H27N7O/c1-17-24(19-5-3-2-4-6-19)34-26(32-17)21-11-13-35(14-12-21)28-22-15-23(33-27(22)30-16-31-28)18-7-9-20(10-8-18)25(29)36/h2-10,15-16,21H,11-14H2,1H3,(H2,29,36)(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342213 (6-(2-methoxypyrimidin-5-yl)-4-[4-(4- methyl-5-phen...) Show SMILES COc1ncc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C26H26N8O/c1-16-22(17-6-4-3-5-7-17)33-23(31-16)18-8-10-34(11-9-18)25-20-12-21(32-24(20)29-15-30-25)19-13-27-26(35-2)28-14-19/h3-7,12-15,18H,8-11H2,1-2H3,(H,31,33)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342214 (4-[4-(4-methyl-5-phenyl-1H-imidazol-2- yl)-1-piper...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 Show InChI InChI=1S/C25H26N8/c1-16-22(17-6-4-3-5-7-17)31-23(29-16)18-8-10-33(11-9-18)25-20-12-21(19-13-28-32(2)14-19)30-24(20)26-15-27-25/h3-7,12-15,18H,8-11H2,1-2H3,(H,29,31)(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342215 (4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H25N7/c1-18-25(21-5-3-2-4-6-21)34-26(32-18)22-11-13-35(14-12-22)28-23-15-24(33-27(23)30-17-31-28)20-9-7-19(16-29)8-10-20/h2-10,15,17,22H,11-14H2,1H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342216 (4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)S(N)(=O)=O Show InChI InChI=1S/C27H27N7O2S/c1-17-24(19-5-3-2-4-6-19)33-25(31-17)20-11-13-34(14-12-20)27-22-15-23(32-26(22)29-16-30-27)18-7-9-21(10-8-18)37(28,35)36/h2-10,15-16,20H,11-14H2,1H3,(H,31,33)(H2,28,35,36)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342217 (N-methyl-3-[4-[4-(4-methyl-5-phenyl- 1H-imidazol-2...) Show SMILES CNC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C29H29N7O/c1-18-25(19-7-4-3-5-8-19)35-26(33-18)20-11-13-36(14-12-20)28-23-16-24(34-27(23)31-17-32-28)21-9-6-10-22(15-21)29(37)30-2/h3-10,15-17,20H,11-14H2,1-2H3,(H,30,37)(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342218 (6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- (4-methyl...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F Show InChI InChI=1S/C25H24F2N8/c1-15-21(16-5-3-2-4-6-16)33-22(31-15)17-7-9-34(10-8-17)24-19-11-20(32-23(19)28-14-29-24)18-12-30-35(13-18)25(26)27/h2-6,11-14,17,25H,7-10H2,1H3,(H,31,33)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342219 (3-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccc(c1)S(N)(=O)=O Show InChI InChI=1S/C27H27N7O2S/c1-17-24(18-6-3-2-4-7-18)33-25(31-17)19-10-12-34(13-11-19)27-22-15-23(32-26(22)29-16-30-27)20-8-5-9-21(14-20)37(28,35)36/h2-9,14-16,19H,10-13H2,1H3,(H,31,33)(H2,28,35,36)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342220 (6-(4-fluorophenyl)-4-[4-[5-(4-methoxy- 3-methyl-ph...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C30H31FN6O/c1-18-15-21(7-10-25(18)38-4)26-19(2)34-29(36-26)30(3)11-13-37(14-12-30)28-23-16-24(35-27(23)32-17-33-28)20-5-8-22(31)9-6-20/h5-10,15-17H,11-14H2,1-4H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342221 (4-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H31N7O/c1-19-15-23(9-10-26(19)39-4)27-20(2)35-30(37-27)31(3)11-13-38(14-12-31)29-24-16-25(36-28(24)33-18-34-29)22-7-5-21(17-32)6-8-22/h5-10,15-16,18H,11-14H2,1-4H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair

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