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Compile Data Set for Download or QSAR

Found 174 hits of ki for UniProtKB: P35353   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219966
PNG
(CHEMBL23959)
Show SMILES CC[C@H](C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H21Cl2N3/c1-3-17(12-5-6-12)25-18(4-2)24-19-15(9-10-23-20(19)25)14-8-7-13(21)11-16(14)22/h7-12,17H,3-6H2,1-2H3/t17-/m1/s1
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 0.200n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219965
PNG
(CHEMBL430913)
Show SMILES CC[C@@H](C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H21Cl2N3/c1-3-17(12-5-6-12)25-18(4-2)24-19-15(9-10-23-20(19)25)14-8-7-13(21)11-16(14)22/h7-12,17H,3-6H2,1-2H3/t17-/m0/s1
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 0.400n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222124
PNG
(CHEMBL97340)
Show SMILES CCC(C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C22H27N3O/c1-5-19(15-7-8-15)25-20(6-2)24-21-18(11-12-23-22(21)25)17-10-9-16(26-4)13-14(17)3/h9-13,15,19H,5-8H2,1-4H3
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 0.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220479
PNG
(CHEMBL23342)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H21Cl2N3/c1-4-6-12(3)24-17(5-2)23-18-15(9-10-22-19(18)24)14-8-7-13(20)11-16(14)21/h7-12H,4-6H2,1-3H3
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 0.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220478
PNG
(CHEMBL22622)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1cc(C)c(OC)cc1C
Show InChI InChI=1S/C22H29N3O/c1-7-9-16(5)25-20(8-2)24-21-17(10-11-23-22(21)25)18-12-15(4)19(26-6)13-14(18)3/h10-13,16H,7-9H2,1-6H3
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 0.600n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219957
PNG
(CHEMBL3085294)
Show SMILES CCc1nc2c(ccnc2n1[C@H](C)C1CC1)-c1ccc(Cl)cc1Cl |r|
Show InChI InChI=1S/C19H19Cl2N3/c1-3-17-23-18-15(14-7-6-13(20)10-16(14)21)8-9-22-19(18)24(17)11(2)12-4-5-12/h6-12H,3-5H2,1-2H3/t11-/m1/s1
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 0.600n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222115
PNG
(CHEMBL100157)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)nc1C(F)(F)F
Show InChI InChI=1S/C20H23F3N4O/c1-5-7-12(3)27-15(6-2)25-17-13(10-11-24-19(17)27)14-8-9-16(28-4)26-18(14)20(21,22)23/h8-12H,5-7H2,1-4H3
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 0.600n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219969
PNG
(CHEMBL23439)
Show SMILES CCC(CCOC)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C21H23ClF3N3O/c1-4-14(9-11-29-3)28-18(5-2)27-19-16(8-10-26-20(19)28)15-7-6-13(12-17(15)22)21(23,24)25/h6-8,10,12,14H,4-5,9,11H2,1-3H3
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 0.700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219962
PNG
(CHEMBL431105)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)cc1C(F)(F)F
Show InChI InChI=1S/C21H24F3N3O/c1-5-7-13(3)27-18(6-2)26-19-16(10-11-25-20(19)27)15-9-8-14(28-4)12-17(15)21(22,23)24/h8-13H,5-7H2,1-4H3
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 0.700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219954
PNG
(CHEMBL283993)
Show SMILES CCc1nc2c(ccnc2n1C(C)C1CCC1)-c1ccc(OC(F)F)cc1Cl
Show InChI InChI=1S/C21H22ClF2N3O/c1-3-18-26-19-16(15-8-7-14(11-17(15)22)28-21(23)24)9-10-25-20(19)27(18)12(2)13-5-4-6-13/h7-13,21H,3-6H2,1-2H3
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 0.700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222119
PNG
(CHEMBL316624)
Show SMILES CCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)nc1C(F)(F)F
Show InChI InChI=1S/C19H21F3N4O/c1-5-11(3)26-14(6-2)24-16-12(9-10-23-18(16)26)13-7-8-15(27-4)25-17(13)19(20,21)22/h7-11H,5-6H2,1-4H3
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 0.700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222117
PNG
(CHEMBL328163)
Show SMILES CCC(C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(OC)nc1C(F)(F)F
Show InChI InChI=1S/C21H23F3N4O/c1-4-15(12-6-7-12)28-16(5-2)26-18-13(10-11-25-20(18)28)14-8-9-17(29-3)27-19(14)21(22,23)24/h8-12,15H,4-7H2,1-3H3
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 0.700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219962
PNG
(CHEMBL431105)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)cc1C(F)(F)F
Show InChI InChI=1S/C21H24F3N3O/c1-5-7-13(3)27-18(6-2)26-19-16(10-11-25-20(19)27)15-9-8-14(28-4)12-17(15)21(22,23)24/h8-13H,5-7H2,1-4H3
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 0.740n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220480
PNG
(CHEMBL22433)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H27N3O/c1-6-8-15(4)24-19(7-2)23-20-18(11-12-22-21(20)24)17-10-9-16(25-5)13-14(17)3/h9-13,15H,6-8H2,1-5H3
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 0.800n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50087556
PNG
((4-Fluoro-butyl)-propyl-[2,5,6-trimethyl-7-(2,4,6-...)
Show SMILES CCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(7.65,-.09,;7.16,-1.55,;8.19,-2.71,;7.72,-4.17,;6.2,-4.5,;5.18,-3.35,;3.67,-3.67,;2.64,-2.53,;1.13,-2.84,;8.75,-5.32,;8.28,-6.79,;9.31,-7.93,;8.85,-9.41,;10.81,-7.61,;11.29,-6.15,;12.7,-5.53,;12.54,-3.98,;13.69,-2.95,;11.02,-3.67,;10.4,-2.25,;10.26,-5,;14.04,-6.29,;14.04,-7.84,;12.7,-8.61,;15.37,-8.61,;16.7,-7.84,;18.05,-8.61,;16.7,-6.29,;15.37,-5.52,;15.36,-3.97,)|
Show InChI InChI=1S/C25H35FN4/c1-8-12-29(13-10-9-11-26)24-22-19(5)20(6)30(25(22)28-21(7)27-24)23-17(3)14-16(2)15-18(23)4/h14-15H,8-13H2,1-7H3
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 0.910n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum

Bioorg Med Chem Lett 10: 707-10 (2000)


BindingDB Entry DOI: 10.7270/Q2SB44ZX
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220485
PNG
(CHEMBL23354)
Show SMILES CCc1nc2c(ccnc2n1C(C)C1CCC1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H21Cl2N3/c1-3-18-24-19-16(15-8-7-14(21)11-17(15)22)9-10-23-20(19)25(18)12(2)13-5-4-6-13/h7-13H,3-6H2,1-2H3
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Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219967
PNG
(CHEMBL423475)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(C)=O
Show InChI InChI=1S/C21H24ClN3O/c1-5-7-13(3)25-19(6-2)24-20-17(10-11-23-21(20)25)16-9-8-15(14(4)26)12-18(16)22/h8-13H,5-7H2,1-4H3
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 1n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219961
PNG
(CHEMBL23483)
Show SMILES CCC(CC)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H21Cl2N3/c1-4-13(5-2)24-17(6-3)23-18-15(9-10-22-19(18)24)14-8-7-12(20)11-16(14)21/h7-11,13H,4-6H2,1-3H3
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 1n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074501
PNG
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(4.9,1.82,;3.57,2.56,;2.24,1.79,;.91,2.55,;-.44,1.78,;-1.76,2.55,;-3.1,1.78,;-.42,.25,;-1.75,-.52,;-1.75,-2.06,;-3.08,-2.83,;-.42,-2.83,;.91,-2.06,;2.38,-2.54,;3.31,-1.29,;4.85,-1.29,;2.38,-.03,;2.86,1.43,;.91,-.52,;2.86,-4.02,;4.37,-4.33,;5.39,-3.17,;4.85,-5.78,;3.82,-6.93,;4.31,-8.4,;2.32,-6.61,;1.84,-5.14,;.33,-4.82,)|
Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
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 1n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brain

J Med Chem 46: 3559-62 (2003)


Article DOI: 10.1021/jm034077k
BindingDB Entry DOI: 10.7270/Q2NS0VN9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074439
PNG
(1-(2-Bromo-4,6-dimethoxy-phenyl)-4,6-dimethyl-1H-p...)
Show SMILES COc1cc(Br)c(c(OC)c1)-n1ccc2c(C)cc(C)nc12 |(12.47,-15.06,;10.97,-14.75,;10.48,-13.3,;11.5,-12.14,;11.01,-10.69,;12.02,-9.53,;9.5,-10.37,;8.48,-11.53,;6.98,-11.21,;5.96,-12.35,;8.97,-12.98,;9.03,-8.92,;9.92,-7.66,;9.01,-6.42,;7.54,-6.91,;6.21,-6.14,;6.21,-4.6,;4.88,-6.91,;4.88,-8.45,;3.55,-9.22,;6.21,-9.22,;7.56,-8.45,)|
Show InChI InChI=1S/C17H17BrN2O2/c1-10-7-11(2)19-17-13(10)5-6-20(17)16-14(18)8-12(21-3)9-15(16)22-4/h5-9H,1-4H3
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 1n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1

J Med Chem 42: 819-32 (1999)


Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM35723
PNG
(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1
Show InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
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 1n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo

Curated by PDSP Ki Database




J Pharmacol Exp Ther 301: 322-32 (2002)


Article DOI: 10.1124/jpet.301.1.322
BindingDB Entry DOI: 10.7270/Q2MP51VM
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219963
PNG
(CHEMBL276971)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C20H21ClF3N3/c1-4-6-12(3)27-17(5-2)26-18-15(9-10-25-19(18)27)14-8-7-13(11-16(14)21)20(22,23)24/h7-12H,4-6H2,1-3H3
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 1.10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222122
PNG
(CHEMBL99286)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C20H26N4O/c1-6-8-13(3)24-17(7-2)23-19-16(11-12-21-20(19)24)15-9-10-18(25-5)22-14(15)4/h9-13H,6-8H2,1-5H3
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 1.10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219963
PNG
(CHEMBL276971)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C20H21ClF3N3/c1-4-6-12(3)27-17(5-2)26-18-15(9-10-25-19(18)27)14-8-7-13(11-16(14)21)20(22,23)24/h7-12H,4-6H2,1-3H3
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 1.10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219970
PNG
(CHEMBL23950)
Show SMILES CCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H19Cl2N3/c1-4-11(3)23-16(5-2)22-17-14(8-9-21-18(17)23)13-7-6-12(19)10-15(13)20/h6-11H,4-5H2,1-3H3
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 1.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219956
PNG
(CHEMBL282289)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(SC)cc1C(F)(F)F
Show InChI InChI=1S/C21H24F3N3S/c1-5-7-13(3)27-18(6-2)26-19-16(10-11-25-20(19)27)15-9-8-14(28-4)12-17(15)21(22,23)24/h8-13H,5-7H2,1-4H3
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 1.40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219971
PNG
(CHEMBL23291)
Show SMILES CCc1nc2c(ccnc2n1C(CCOC)C1CC1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-19-25-20-16(15-7-6-14(22)12-17(15)23)8-10-24-21(20)26(19)18(9-11-27-2)13-4-5-13/h6-8,10,12-13,18H,3-5,9,11H2,1-2H3
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 1.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM35723
PNG
(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1
Show InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
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 1.70n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo

Curated by PDSP Ki Database




J Pharmacol Exp Ther 301: 322-32 (2002)


Article DOI: 10.1124/jpet.301.1.322
BindingDB Entry DOI: 10.7270/Q2MP51VM
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220483
PNG
(CHEMBL22213)
Show SMILES CCc1nc2c(ncnc2n1C(C1CC1)C1CC1)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N4/c1-2-16-28-18-17(14-8-7-13(9-15(14)22)21(23,24)25)26-10-27-20(18)29(16)19(11-3-4-11)12-5-6-12/h7-12,19H,2-6H2,1H3
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 1.80n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220483
PNG
(CHEMBL22213)
Show SMILES CCc1nc2c(ncnc2n1C(C1CC1)C1CC1)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N4/c1-2-16-28-18-17(14-8-7-13(9-15(14)22)21(23,24)25)26-10-27-20(18)29(16)19(11-3-4-11)12-5-6-12/h7-12,19H,2-6H2,1H3
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 1.80n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 129-31 (2003)


BindingDB Entry DOI: 10.7270/Q2DZ0BGD
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50058163
PNG
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)|
Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
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 1.80n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)


BindingDB Entry DOI: 10.7270/Q2GM85VG
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222120
PNG
(CHEMBL420442)
Show SMILES CCc1nc2c(ncnc2n1C(C1CC1)C1CC1)-c1ccc(OC)nc1C
Show InChI InChI=1S/C21H25N5O/c1-4-16-25-19-18(15-9-10-17(27-3)24-12(15)2)22-11-23-21(19)26(16)20(13-5-6-13)14-7-8-14/h9-11,13-14,20H,4-8H2,1-3H3
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 1.80n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220476
PNG
(CHEMBL280666)
Show SMILES CCC(CCOC)n1c(OC)nc2c(ccnc12)-c1ccc(OC(F)(F)F)cc1Cl
Show InChI InChI=1S/C20H21ClF3N3O3/c1-4-12(8-10-28-2)27-18-17(26-19(27)29-3)15(7-9-25-18)14-6-5-13(11-16(14)21)30-20(22,23)24/h5-7,9,11-12H,4,8,10H2,1-3H3
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 1.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220492
PNG
(CHEMBL25256)
Show SMILES CCC[C@@H](C)n1c(CC)nc2c(nccc12)-c1ccc(OC(F)(F)F)cc1Cl
Show InChI InChI=1S/C20H21ClF3N3O/c1-4-6-12(3)27-16-9-10-25-18(19(16)26-17(27)5-2)14-8-7-13(11-15(14)21)28-20(22,23)24/h7-12H,4-6H2,1-3H3/t12-/m1/s1
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 1.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 129-31 (2003)


BindingDB Entry DOI: 10.7270/Q2DZ0BGD
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50131716
PNG
(CHEMBL430892 | [3-(4-Bromo-2-chloro-phenyl)-2,5-di...)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1ccc(Br)cc1Cl |(2.5,2.36,;1.17,3.13,;-.17,2.36,;-1.5,3.12,;-2.85,2.35,;-4.18,3.11,;-5.51,2.34,;-6.84,3.11,;-8.17,2.34,;-2.83,.81,;-4.16,.04,;-4.16,-1.51,;-5.51,-2.28,;-2.83,-2.28,;-1.49,-1.5,;-.03,-1.98,;.88,-.73,;2.42,-.73,;-.03,.52,;-1.49,.04,;.44,-3.44,;-.59,-4.58,;-.12,-6.04,;1.39,-6.36,;1.87,-7.83,;2.43,-5.21,;1.94,-3.75,;2.96,-2.61,)|
Show InChI InChI=1S/C19H23BrClN5O2/c1-12-17(15-6-5-14(20)11-16(15)21)18-22-13(2)23-19(26(18)24-12)25(7-9-27-3)8-10-28-4/h5-6,11H,7-10H2,1-4H3
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 1.90n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brain

J Med Chem 46: 3559-62 (2003)


Article DOI: 10.1021/jm034077k
BindingDB Entry DOI: 10.7270/Q2NS0VN9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222112
PNG
(CHEMBL98093)
Show SMILES CCc1nc2c(ccnc2n1C(C)C1CC1)-c1ccc(OC)nc1C
Show InChI InChI=1S/C20H24N4O/c1-5-17-23-19-16(15-8-9-18(25-4)22-12(15)2)10-11-21-20(19)24(17)13(3)14-6-7-14/h8-11,13-14H,5-7H2,1-4H3
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 2n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222123
PNG
(CHEMBL99239)
Show SMILES CCc1nc2c(ccnc2n1C(C)C1CCC1)-c1ccc(OC)nc1C
Show InChI InChI=1S/C21H26N4O/c1-5-18-24-20-17(16-9-10-19(26-4)23-13(16)2)11-12-22-21(20)25(18)14(3)15-7-6-8-15/h9-12,14-15H,5-8H2,1-4H3
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 2.10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220491
PNG
(CHEMBL422223)
Show SMILES CCC[C@H](C)n1c(CC)nc2c(nccc12)-c1ccc(OC(F)(F)F)cc1Cl
Show InChI InChI=1S/C20H21ClF3N3O/c1-4-6-12(3)27-16-9-10-25-18(19(16)26-17(27)5-2)14-8-7-13(11-15(14)21)28-20(22,23)24/h7-12H,4-6H2,1-3H3/t12-/m0/s1
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 2.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 129-31 (2003)


BindingDB Entry DOI: 10.7270/Q2DZ0BGD
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50087559
PNG
(CHEMBL164206 | Cyclopropylmethyl-propyl-[2,5,6-tri...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(2.88,-3.62,;4.39,-3.31,;5.41,-4.46,;6.91,-4.14,;7.4,-2.67,;6.37,-1.52,;6.03,-.01,;4.9,-1.05,;7.96,-5.28,;7.47,-6.74,;8.52,-7.89,;8.03,-9.36,;10.01,-7.57,;10.48,-6.1,;11.88,-5.48,;11.72,-3.95,;12.86,-2.92,;10.22,-3.62,;9.6,-2.22,;9.46,-4.95,;13.21,-6.25,;13.21,-7.79,;11.88,-8.56,;14.54,-8.56,;15.89,-7.79,;17.23,-8.56,;15.89,-6.24,;14.54,-5.47,;14.54,-3.93,)|
Show InChI InChI=1S/C25H34N4/c1-8-11-28(14-21-9-10-21)24-22-18(5)19(6)29(25(22)27-20(7)26-24)23-16(3)12-15(2)13-17(23)4/h12-13,21H,8-11,14H2,1-7H3
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 2.30n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum

Bioorg Med Chem Lett 10: 707-10 (2000)


BindingDB Entry DOI: 10.7270/Q2SB44ZX
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220475
PNG
(CHEMBL431886)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(\C)=N/OC
Show InChI InChI=1S/C22H27ClN4O/c1-6-8-14(3)27-20(7-2)25-21-18(11-12-24-22(21)27)17-10-9-16(13-19(17)23)15(4)26-28-5/h9-14H,6-8H2,1-5H3/b26-15-
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 2.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220481
PNG
(CHEMBL23178)
Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C19H20ClF2N3/c1-4-6-11(3)25-17(5-2)24-18-12(7-8-23-19(18)25)13-9-15(21)16(22)10-14(13)20/h7-11H,4-6H2,1-3H3
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 2.40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50219964
PNG
(CHEMBL23105)
Show SMILES CCc1nc2c(ccnc2n1C(CCOC)C1CCC1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H25Cl2N3O/c1-3-20-26-21-17(16-8-7-15(23)13-18(16)24)9-11-25-22(21)27(20)19(10-12-28-2)14-5-4-6-14/h7-9,11,13-14,19H,3-6,10,12H2,1-2H3
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 2.40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 125-8 (2003)


BindingDB Entry DOI: 10.7270/Q2JM2CV9
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074501
PNG
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(4.9,1.82,;3.57,2.56,;2.24,1.79,;.91,2.55,;-.44,1.78,;-1.76,2.55,;-3.1,1.78,;-.42,.25,;-1.75,-.52,;-1.75,-2.06,;-3.08,-2.83,;-.42,-2.83,;.91,-2.06,;2.38,-2.54,;3.31,-1.29,;4.85,-1.29,;2.38,-.03,;2.86,1.43,;.91,-.52,;2.86,-4.02,;4.37,-4.33,;5.39,-3.17,;4.85,-5.78,;3.82,-6.93,;4.31,-8.4,;2.32,-6.61,;1.84,-5.14,;.33,-4.82,)|
Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
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 2.5n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum

Bioorg Med Chem Lett 10: 707-10 (2000)


BindingDB Entry DOI: 10.7270/Q2SB44ZX
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220495
PNG
(CHEMBL26610)
Show SMILES CCCC(C)n1c(CC)nc2c(nccc12)-c1ccc(OC(F)(F)F)cc1Cl
Show InChI InChI=1S/C20H21ClF3N3O/c1-4-6-12(3)27-16-9-10-25-18(19(16)26-17(27)5-2)14-8-7-13(11-15(14)21)28-20(22,23)24/h7-12H,4-6H2,1-3H3
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 2.80n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 129-31 (2003)


BindingDB Entry DOI: 10.7270/Q2DZ0BGD
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220496
PNG
(CHEMBL24803)
Show SMILES CCC(C1CC1)n1c(CC)nc2c(nccc12)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C21H21ClF3N3/c1-3-16(12-5-6-12)28-17-9-10-26-19(20(17)27-18(28)4-2)14-8-7-13(11-15(14)22)21(23,24)25/h7-12,16H,3-6H2,1-2H3
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 2.90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 129-31 (2003)


BindingDB Entry DOI: 10.7270/Q2DZ0BGD
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50096721
PNG
(5-Chloro-N-cyclopropylmethyl-N'-(2,6-dichloro-4-tr...)
Show SMILES CCCC[Sn](CCCC)(CCCC)c1cc(Cl)c(Nc2nc(C)nc(N(CCC)CC3CC3)c2Cl)c(Cl)c1
Show InChI InChI=1S/C18H20Cl3N4.3C4H9.Sn/c1-3-9-25(10-12-7-8-12)18-15(21)17(22-11(2)23-18)24-16-13(19)5-4-6-14(16)20;3*1-3-4-2;/h5-6,12H,3,7-10H2,1-2H3,(H,22,23,24);3*1,3-4H2,2H3;
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 3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand.

Bioorg Med Chem Lett 11: 331-3 (2001)


BindingDB Entry DOI: 10.7270/Q21G0KHH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220497
PNG
(CHEMBL285666)
Show SMILES CCCC(C)n1c(CC)nc2c(nccc12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H21Cl2N3/c1-4-6-12(3)24-16-9-10-22-18(19(16)23-17(24)5-2)14-8-7-13(20)11-15(14)21/h7-12H,4-6H2,1-3H3
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 3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 129-31 (2003)


BindingDB Entry DOI: 10.7270/Q2DZ0BGD
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50222116
PNG
(CHEMBL318051)
Show SMILES CCC(C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)nc1C
Show InChI InChI=1S/C20H23ClN4/c1-4-16(13-6-7-13)25-18(5-2)24-19-15(10-11-22-20(19)25)14-8-9-17(21)23-12(14)3/h8-11,13,16H,4-7H2,1-3H3
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 3.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity at Corticotropin releasing factor receptor of rat cortical homogenates.

Bioorg Med Chem Lett 13: 289-91 (2003)


BindingDB Entry DOI: 10.7270/Q2765HJ4
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1/2


(Rattus norvegicus (rat)-RAT)		BDBM50220487
PNG
(CHEMBL26347)
Show SMILES CCCC(C)n1c(CC)nc2c(nccc12)-c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C20H21ClF3N3/c1-4-6-12(3)27-16-9-10-25-18(19(16)26-17(27)5-2)14-8-7-13(11-15(14)21)20(22,23)24/h7-12H,4-6H2,1-3H3
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 3.5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates

Bioorg Med Chem Lett 13: 129-31 (2003)


BindingDB Entry DOI: 10.7270/Q2DZ0BGD
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50087560
PNG
(CHEMBL348967 | Ethyl-(4-fluoro-butyl)-[2,5,6-trime...)
Show SMILES CCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(6.4,-1.55,;7.43,-2.71,;6.95,-4.16,;5.44,-4.49,;4.42,-3.34,;2.9,-3.66,;1.87,-2.52,;.37,-2.83,;7.98,-5.3,;7.5,-6.77,;8.54,-7.91,;8.07,-9.38,;10.04,-7.59,;10.5,-6.13,;11.92,-5.51,;11.76,-3.97,;12.9,-2.95,;10.25,-3.66,;9.62,-2.25,;9.48,-4.99,;13.25,-6.27,;13.25,-7.82,;11.9,-8.59,;14.58,-8.59,;15.92,-7.82,;17.24,-8.59,;15.92,-6.27,;14.58,-5.5,;14.56,-3.97,)|
Show InChI InChI=1S/C24H33FN4/c1-8-28(12-10-9-11-25)23-21-18(5)19(6)29(24(21)27-20(7)26-23)22-16(3)13-15(2)14-17(22)4/h13-14H,8-12H2,1-7H3
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 3.5n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum

Bioorg Med Chem Lett 10: 707-10 (2000)


BindingDB Entry DOI: 10.7270/Q2SB44ZX
More data for this
Ligand-Target Pair
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