Compile Data Set for Download or QSAR

Found 114 hits Enz. Inhib. hit(s) with all data for entry = 126   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164395 (US9669029, 98 8-Methoxy-5-methyl-2-{2-[1-(2-morpho...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)NC12 |t:2,4,8| Show InChI InChI=1S/C23H30N6O2S/c1-17-5-6-19(30-2)23-25-21(26-29(17)23)7-8-22-24-18(20-4-3-15-32-20)16-28(22)10-9-27-11-13-31-14-12-27/h3-6,15-16,23H,7-14H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164399 (US9669029, 102 5,8-Dimethyl-2-[2-(1-methyl-4-thiop...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3ccco3)=NN12 |c:23,t:1,3| Show InChI InChI=1S/C17H20N6O/c1-11-9-18-12(2)17-20-15(21-23(11)17)6-7-16-19-13(10-22(16)3)14-5-4-8-24-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164544 (US9669029, 115 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...) Show SMILES CC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cscn3)NC12 |t:1,3,7| Show InChI InChI=1S/C17H20N6S/c1-11-4-5-12(2)23-17(11)20-15(21-23)6-7-16-19-13(8-22(16)3)14-9-24-10-18-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164545 (US9669029, 116 5,8-Dimethyl-2-[2-(1-methyl-4-pyrim...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cncnc3)=NN12 |c:24,t:1,3| Show InChI InChI=1S/C17H20N8/c1-11-6-20-12(2)17-22-15(23-25(11)17)4-5-16-21-14(9-24(16)3)13-7-18-10-19-8-13/h6-10,17H,4-5H2,1-3H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164549 (US9669029, 117 5,8-Dimethyl-2-[2-(1-methyl-4-pyraz...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cnccn3)=NN12 |c:24,t:1,3| Show InChI InChI=1S/C17H20N8/c1-11-8-20-12(2)17-22-15(23-25(11)17)4-5-16-21-14(10-24(16)3)13-9-18-6-7-19-13/h6-10,17H,4-5H2,1-3H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164283 (US9669029, 33 5-Methyl-2-[2-(4-thiophen-2-yl-1H-im...) Show SMILES CC1=CC=CC2NC(CCc3nc(c[nH]3)-c3cccs3)=NN12 |c:3,21,t:1| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164560 (US9669029, 118 5,8-Dimethyl-2-[2-(1-methyl-4-pyrid...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3ccncc3)=NN12 |c:24,t:1,3| Show InChI InChI=1S/C18H21N7/c1-12-10-20-13(2)18-22-16(23-25(12)18)4-5-17-21-15(11-24(17)3)14-6-8-19-9-7-14/h6-11,18H,4-5H2,1-3H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164284 (US9669029, 34 8-Methyl-2-[2-(4-thiophen-2-yl-1H-im...) Show SMILES CC1=CC=CN2N=C(CCc3nc(c[nH]3)-c3cccs3)NC12 |c:3,t:1,6| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.990	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164391 (US9669029, 94 5,8-Dimethyl-2-[2-(1-methyl-4-thioph...) Show SMILES CC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cccs3)NC12 |t:1,3,7| Show InChI InChI=1S/C18H21N5S/c1-12-6-7-13(2)23-18(12)20-16(21-23)8-9-17-19-14(11-22(17)3)15-5-4-10-24-15/h4-7,10-11,18H,8-9H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164354 (US9669029, 62 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cccs3)NC12 |t:2,4,8| Show InChI InChI=1S/C18H21N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-7,10-11,18H,8-9H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164392 (US9669029, 95 8-Methoxy-5-methyl-2-[2-(1-propyl-4-...) Show SMILES CCCn1cc(nc1CCC1=NN2C(N1)C(OC)=CC=C2C)-c1cccs1 |c:19,21,t:11| Show InChI InChI=1S/C20H25N5OS/c1-4-11-24-13-15(17-6-5-12-27-17)21-19(24)10-9-18-22-20-16(26-3)8-7-14(2)25(20)23-18/h5-8,12-13,20H,4,9-11H2,1-3H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164543 (US9669029, 114 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cscn3)=NN12 |c:23,t:1,3| Show InChI InChI=1S/C16H19N7S/c1-10-6-17-11(2)16-20-14(21-23(10)16)4-5-15-19-12(7-22(15)3)13-8-24-9-18-13/h6-9,16H,4-5H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.29	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164354 (US9669029, 62 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cccs3)NC12 |t:2,4,8| Show InChI InChI=1S/C18H21N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-7,10-11,18H,8-9H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164394 (US9669029, 97 4-{2-[2-(8-Methoxy-5-methyl-[1,2,4]t...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3CCCC#N)-c3cncs3)NC12 |t:2,4,8| Show InChI InChI=1S/C20H23N7OS/c1-14-5-6-16(28-2)20-24-18(25-27(14)20)7-8-19-23-15(17-11-22-13-29-17)12-26(19)10-4-3-9-21/h5-6,11-13,20H,3-4,7-8,10H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164396 (US9669029, 99 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3ccsc3)NC12 |t:2,4,8| Show InChI InChI=1S/C18H21N5OS/c1-12-4-5-15(24-3)18-20-16(21-23(12)18)6-7-17-19-14(10-22(17)2)13-8-9-25-11-13/h4-5,8-11,18H,6-7H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164495 (US9669029, 103 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...) Show SMILES CC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3nccs3)NC12 |t:1,3,7| Show InChI InChI=1S/C17H20N6S/c1-11-4-5-12(2)23-16(11)20-14(21-23)6-7-15-19-13(10-22(15)3)17-18-8-9-24-17/h4-5,8-10,16H,6-7H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164501 (US9669029, 104 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3nccs3)=NN12 |c:23,t:1,3| Show InChI InChI=1S/C16H19N7S/c1-10-8-18-11(2)15-20-13(21-23(10)15)4-5-14-19-12(9-22(14)3)16-17-6-7-24-16/h6-9,15H,4-5H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164316 (US9669029, 50 8-Methoxy-5-methyl-2-[(E)-2-(1-methy...) Show SMILES COC1=CC=C(C)N2N=C(NC12)\C=C/c1nc(cn1C)-c1cccs1 |c:8,t:2,4| Show InChI InChI=1S/C18H19N5OS/c1-12-6-7-14(24-3)18-20-16(21-23(12)18)8-9-17-19-13(11-22(17)2)15-5-4-10-25-15/h4-11,18H,1-3H3,(H,20,21)/b9-8-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164350 (US9669029, 59 (R)-1-Chloro-3-{2-[2-(5-methyl-[1,2,...) Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C[C@@H](O)CCl)-c3cccs3)=NN12 |r,c:3,26,t:1| Show InChI InChI=1S/C19H22ClN5OS/c1-13-4-2-6-19-22-17(23-25(13)19)7-8-18-21-15(16-5-3-9-27-16)12-24(18)11-14(26)10-20/h2-6,9,12,14,19,26H,7-8,10-11H2,1H3,(H,22,23)/t14-,19?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164536 (US9669029, 111 2-[2-(4-Furan-3-yl-1-methyl-1H-imid...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3ccoc3)=NN12 |c:23,t:1,3| Show InChI InChI=1S/C17H20N6O/c1-11-8-18-12(2)17-20-15(21-23(11)17)4-5-16-19-14(9-22(16)3)13-6-7-24-10-13/h6-10,17H,4-5H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164511 (US9669029, 105 8-Methoxy-5-methyl-2-{2-[1-methyl-4...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cocc3C)NC12 |t:2,4,8| Show InChI InChI=1S/C19H23N5O2/c1-12-10-26-11-14(12)15-9-23(3)18(20-15)8-7-17-21-19-16(25-4)6-5-13(2)24(19)22-17/h5-6,9-11,19H,7-8H2,1-4H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173102 (US9096589, 5,7-Dimethyl-2-[2-(1-propyl-4-thiophen-...) Show SMILES CCCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C20H23N5S/c1-4-9-24-13-17(18-6-5-10-26-18)23-19(24)8-7-16-12-25-15(3)11-14(2)21-20(25)22-16/h5-6,10-13H,4,7-9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164397 (US9669029, 100 2-[2-(4-Furan-3-yl-1-methyl-1H-imid...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3ccoc3)NC12 |t:2,4,8| Show InChI InChI=1S/C18H21N5O2/c1-12-4-5-15(24-3)18-20-16(21-23(12)18)6-7-17-19-14(10-22(17)2)13-8-9-25-11-13/h4-5,8-11,18H,6-7H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164393 (US9669029, 96 8-Methoxy-5-methyl-2-[2-(1-prop-2-yn...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3CC#C)-c3cncs3)NC12 |t:2,4,8| Show InChI InChI=1S/C19H20N6OS/c1-4-9-24-11-14(16-10-20-12-27-16)21-18(24)8-7-17-22-19-15(26-3)6-5-13(2)25(19)23-17/h1,5-6,10-12,19H,7-9H2,2-3H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164534 (US9669029, 109 5,8-Dimethyl-2-{2-[1-methyl-4-(5-me...) Show SMILES Cc1ccc(o1)-c1cn(C)c(CCC2=NN3C(N2)C(C)=CC=C3C)n1 |c:21,23,t:14| Show InChI InChI=1S/C19H23N5O/c1-12-5-6-13(2)24-19(12)21-17(22-24)9-10-18-20-15(11-23(18)4)16-8-7-14(3)25-16/h5-8,11,19H,9-10H2,1-4H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164317 (US9669029, 51 5,7-Dimethyl-2-[2-(1-methyl-4-thioph...) Show SMILES CC1=NC2NC(CCc3nc(cn3C)-c3cccs3)=NN2C(C)=C1 |c:20,25,t:1| Show InChI InChI=1S/C17H20N6S/c1-11-9-12(2)23-17(18-11)20-15(21-23)6-7-16-19-13(10-22(16)3)14-5-4-8-24-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164328 (US9669029, 52 8-Methoxy-2-[2-(1-methyl-4-thiophen-...) Show SMILES COC1=CC=CN2N=C(CCc3nc(cn3C)-c3cccs3)NC12 |c:4,t:2,7| Show InChI InChI=1S/C17H19N5OS/c1-21-11-12(14-6-4-10-24-14)18-16(21)8-7-15-19-17-13(23-2)5-3-9-22(17)20-15/h3-6,9-11,17H,7-8H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164290 (US9669029, 40 5-Methyl-2-[2-(4-thiophen-3-yl-1H-im...) Show SMILES CC1=CC=CC2NC(CCc3ncc(n3)-c3ccsc3)=NN12 |c:3,21,t:1| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164282 (US9669029, 32 1-(4-Chloro-phenyl)-2-{2-[2-(5,7-dim...) Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3C(C)(O)c3ccc(Cl)cc3)-c3cncs3)nc2n1 Show InChI InChI=1S/C24H23ClN6OS/c1-15-10-16(2)30-12-19(28-23(30)27-15)8-9-22-29-20(21-11-26-14-33-21)13-31(22)24(3,32)17-4-6-18(25)7-5-17/h4-7,10-14,32H,8-9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164532 (US9669029, 107 5,8-Dimethyl-2-[2-(1-methyl-4-pyrid...) Show SMILES CCCn1cc(nc1CCC1=NN2C(N1)C(C)=CC=C2C)-c1cccnc1 |c:18,20,t:11| Show InChI InChI=1S/C21H26N6/c1-4-12-26-14-18(17-6-5-11-22-13-17)23-20(26)10-9-19-24-21-15(2)7-8-16(3)27(21)25-19/h5-8,11,13-14,21H,4,9-10,12H2,1-3H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164285 (US9669029, 35 (S)-2-{2-[2-(5-Methyl-[1,2,4]triazol...) Show SMILES CC[C@@H](O)n1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1 |r,c:18,20,t:12| Show InChI InChI=1S/C19H23N5OS/c1-3-19(25)23-12-14(15-7-5-11-26-15)20-17(23)10-9-16-21-18-8-4-6-13(2)24(18)22-16/h4-8,11-12,18-19,25H,3,9-10H2,1-2H3,(H,21,22)/t18?,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164398 (US9669029, 101 5,8-Dimethyl-2-{2-[1-methyl-4-(5-me...) Show SMILES Cc1ccc(o1)-c1cn(C)c(CCC2=NN3C(N2)C(C)=NC=C3C)n1 |c:21,23,t:14| Show InChI InChI=1S/C18H22N6O/c1-11-9-19-13(3)18-21-16(22-24(11)18)7-8-17-20-14(10-23(17)4)15-6-5-12(2)25-15/h5-6,9-10,18H,7-8H2,1-4H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173105 (US9096589, 5,7-Dimethyl-2-{2-[1-(3-methyl-butyl)-4...) Show SMILES CC(C)CCn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C22H27N5S/c1-15(2)9-10-26-14-19(20-6-5-11-28-20)25-21(26)8-7-18-13-27-17(4)12-16(3)23-22(27)24-18/h5-6,11-15H,7-10H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164539 (US9669029, 113 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cncs3)=NN12 |c:23,t:1,3| Show InChI InChI=1S/C16H19N7S/c1-10-6-18-11(2)16-20-14(21-23(10)16)4-5-15-19-12(8-22(15)3)13-7-17-9-24-13/h6-9,16H,4-5H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164286 (US9669029, 36 1-Methoxy-3-{2-[2-(5-methyl-[1,2,4]t...) Show SMILES COCC(O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1 |c:20,22,t:14| Show InChI InChI=1S/C20H25N5O2S/c1-14-5-3-7-20-22-18(23-25(14)20)8-9-19-21-16(17-6-4-10-28-17)12-24(19)11-15(26)13-27-2/h3-7,10,12,15,20,26H,8-9,11,13H2,1-2H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173096 (US9096589, 5,7-Dimethyl-2-[2-(4-thiophen-2-yl-1H-i...) Show SMILES Cc1cc(C)n2cc(CCc3nc(c[nH]3)-c3cccs3)nc2n1 Show InChI InChI=1S/C17H17N5S/c1-11-8-12(2)22-10-13(20-17(22)19-11)5-6-16-18-9-14(21-16)15-4-3-7-23-15/h3-4,7-10H,5-6H2,1-2H3,(H,18,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164272 (US9669029, 22 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]...) Show SMILES CCOCC(O)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C22H27N5O2S/c1-4-29-14-18(28)12-26-13-19(20-6-5-9-30-20)25-21(26)8-7-17-11-27-16(3)10-15(2)23-22(27)24-17/h5-6,9-11,13,18,28H,4,7-8,12,14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164380 (US9669029, 83 1-Methoxy-3-{2-[2-(8-methyl-[1,2,4]t...) Show SMILES COCC(O)Cn1cc(nc1CCC1=NN2C=CC=C(C)C2N1)-c1cccs1 |c:17,t:14,19| Show InChI InChI=1S/C20H25N5O2S/c1-14-5-3-9-25-20(14)22-18(23-25)7-8-19-21-16(17-6-4-10-28-17)12-24(19)11-15(26)13-27-2/h3-6,9-10,12,15,20,26H,7-8,11,13H2,1-2H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164372 (US9669029, 75 [((S)-2-Hydroxy-3-{2-[2-(5-methyl-[1...) Show SMILES CN(CC#N)C[C@H](O)Cn1cc(nc1CCC1=NN2C(N1)C=CC=C2C)-c1cccs1 |r,c:23,25,t:17| Show InChI InChI=1S/C22H27N7OS/c1-16-5-3-7-22-25-20(26-29(16)22)8-9-21-24-18(19-6-4-12-31-19)15-28(21)14-17(30)13-27(2)11-10-23/h3-7,12,15,17,22,30H,8-9,11,13-14H2,1-2H3,(H,25,26)/t17-,22?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173083 (US9096589, 5,7-Dimethyl-2-[(E)-2-(1-methyl-4-thiop...) Show SMILES Cc1cc(C)n2cc(\C=C\c3nc(cn3C)-c3cccs3)nc2n1 Show InChI InChI=1S/C18H17N5S/c1-12-9-13(2)23-10-14(20-18(23)19-12)6-7-17-21-15(11-22(17)3)16-5-4-8-24-16/h4-11H,1-3H3/b7-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173100 (US9096589, (S)-2-{2-[2-(5,7-Dimethyl-imidazo[1,2-a...) Show SMILES C[C@@H](CO)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C20H23N5OS/c1-13-9-14(2)25-10-16(22-20(25)21-13)6-7-19-23-17(18-5-4-8-27-18)11-24(19)15(3)12-26/h4-5,8-11,15,26H,6-7,12H2,1-3H3/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164533 (US9669029, 108 5,8-Dimethyl-2-[2-(1-methyl-4-pyrid...) Show SMILES CC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cccnc3)=NN12 |c:24,t:1,3| Show InChI InChI=1S/C18H21N7/c1-12-9-20-13(2)18-22-16(23-25(12)18)6-7-17-21-15(11-24(17)3)14-5-4-8-19-10-14/h4-5,8-11,18H,6-7H2,1-3H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164381 (US9669029, 84 5-Methyl-2-[2-(1-methyl-4-thiophen-2...) Show SMILES CC1=CC=CC2NC(CCc3nc(cn3C)-c3cccs3)=NN12 |c:3,22,t:1| Show InChI InChI=1S/C17H19N5S/c1-12-5-3-7-17-19-15(20-22(12)17)8-9-16-18-13(11-21(16)2)14-6-4-10-23-14/h3-7,10-11,17H,8-9H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164388 (US9669029, 91 8-Methoxy-5-methyl-2-[2-(1-methyl-4-...) Show SMILES COC1=CC=C(C)N2N=C(CCc3nc(cn3C)-c3cncs3)NC12 |t:2,4,8| Show InChI InChI=1S/C17H20N6OS/c1-11-4-5-13(24-3)17-20-15(21-23(11)17)6-7-16-19-12(9-22(16)2)14-8-18-10-25-14/h4-5,8-10,17H,6-7H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164266 (US9669029, 16 5,7-Dimethyl-2-{2-[4-thiophen-2-yl-1...) Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3COCC[Si](C)(C)C)-c3-[s]ccc3)nc2n1 Show InChI InChI=1S/C23H31N5OSSi/c1-17-13-18(2)28-14-19(25-23(28)24-17)8-9-22-26-20(21-7-6-11-30-21)15-27(22)16-29-10-12-31(3,4)5/h6-7,11,13-15H,8-10,12,16H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164291 (US9669029, 41 5-Methyl-2-[2-(4-pyridin-3-yl-1H-imi...) Show SMILES CC1=CC=CC2NC(CCc3ncc(n3)-c3cccnc3)=NN12 |c:3,22,t:1| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164291 (US9669029, 41 5-Methyl-2-[2-(4-pyridin-3-yl-1H-imi...) Show SMILES CC1=CC=CC2NC(CCc3ncc(n3)-c3cccnc3)=NN12 |c:3,22,t:1| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164531 (US9669029, 106 5,8-Dimethyl-2-[2-(1-methyl-4-thiaz...) Show SMILES CC1=CN=C(C)N2N=C(CCc3nc(cn3C)-c3nccs3)NC12 |t:1,3,7| Show InChI InChI=1S/C16H19N7S/c1-10-8-18-11(2)23-15(10)20-13(21-23)4-5-14-19-12(9-22(14)3)16-17-6-7-24-16/h6-9,15H,4-5H2,1-3H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM164277 (US9669029, 27 2-[2-(1-Isobutyl-4-thiophen-2-yl-1H-...) Show SMILES CCC(C)n1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1 Show InChI InChI=1S/C21H25N5S/c1-5-15(3)25-13-18(19-7-6-10-27-19)24-20(25)9-8-17-12-26-16(4)11-14(2)22-21(26)23-17/h6-7,10-13,15H,5,8-9H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM173108 (US9096589, 1-{2-[2-(5,7-Dimethyl-imidazo[1,2-a]pyr...) Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3CC(O)CF)-c3cccs3)nc2n1 Show InChI InChI=1S/C20H22FN5OS/c1-13-8-14(2)26-10-15(23-20(26)22-13)5-6-19-24-17(18-4-3-7-28-18)12-25(19)11-16(27)9-21/h3-4,7-8,10,12,16,27H,5-6,9,11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	25
TBA US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9669029 (2017) BindingDB Entry DOI: 10.7270/Q2BG2M4J
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 114 total )  |  Next  |  Last  >>

Jump to: