Found 59 hits Enz. Inhib. hit(s) with all data for entry = 50018075 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190877
(2-(6-(3-cyanophenyl)-1-(1-(tetrahydro-2H-pyran-4-y...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCOCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C34H36Cl2N4O2/c35-28-18-29(36)20-30(19-28)38-33(41)22-40-13-8-27-17-26(25-3-1-2-23(16-25)21-37)4-5-32(27)34(40)24-6-11-39(12-7-24)31-9-14-42-15-10-31/h1-5,16-20,24,31,34H,6-15,22H2,(H,38,41) | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190869
(2-(6-(3-cyanophenyl)-1-(1-(5-hydroxypentyl)piperid...)Show SMILES OCCCCCN1CCC(CC1)C1N(CC(=O)Nc2cc(Cl)cc(Cl)c2)CCc2cc(ccc12)-c1cccc(c1)C#N Show InChI InChI=1S/C34H38Cl2N4O2/c35-29-19-30(36)21-31(20-29)38-33(42)23-40-15-11-28-18-27(26-6-4-5-24(17-26)22-37)7-8-32(28)34(40)25-9-13-39(14-10-25)12-2-1-3-16-41/h4-8,17-21,25,34,41H,1-3,9-16,23H2,(H,38,42) | Reactome pathway
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UniChem
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| Article
PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190851
(2-(6-(3-cyanophenyl)-1-(1-(tetrahydrothiophen-3-yl...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCSC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C33H34Cl2N4OS/c34-27-16-28(35)18-29(17-27)37-32(40)20-39-12-8-26-15-25(24-3-1-2-22(14-24)19-36)4-5-31(26)33(39)23-6-10-38(11-7-23)30-9-13-41-21-30/h1-5,14-18,23,30,33H,6-13,20-21H2,(H,37,40) | Reactome pathway
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| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190884
(2-(6-(3-cyanophenyl)-1-(1-(cyclopropylmethyl)piper...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC3CC3)CC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C33H34Cl2N4O/c34-28-16-29(35)18-30(17-28)37-32(40)21-39-13-10-27-15-26(25-3-1-2-23(14-25)19-36)6-7-31(27)33(39)24-8-11-38(12-9-24)20-22-4-5-22/h1-3,6-7,14-18,22,24,33H,4-5,8-13,20-21H2,(H,37,40) | Reactome pathway
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PubMed
| 9.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190889
(2-(6-(3-cyanophenyl)-1-(1-cycloheptylpiperidin-4-y...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCCCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C36H40Cl2N4O/c37-30-20-31(38)22-32(21-30)40-35(43)24-42-17-14-29-19-28(27-7-5-6-25(18-27)23-39)10-11-34(29)36(42)26-12-15-41(16-13-26)33-8-3-1-2-4-9-33/h5-7,10-11,18-22,26,33,36H,1-4,8-9,12-17,24H2,(H,40,43) | Reactome pathway
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PubMed
| 9.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190883
(2-(6-(3-cyanophenyl)-1-(1-cyclohexylpiperidin-4-yl...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C35H38Cl2N4O/c36-29-19-30(37)21-31(20-29)39-34(42)23-41-16-13-28-18-27(26-6-4-5-24(17-26)22-38)9-10-33(28)35(41)25-11-14-40(15-12-25)32-7-2-1-3-8-32/h4-6,9-10,17-21,25,32,35H,1-3,7-8,11-16,23H2,(H,39,42) | Reactome pathway
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| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190896
(2-(6-(3-cyanophenyl)-1-(1-cyclopentylpiperidin-4-y...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C34H36Cl2N4O/c35-28-18-29(36)20-30(19-28)38-33(41)22-40-15-12-27-17-26(25-5-3-4-23(16-25)21-37)8-9-32(27)34(40)24-10-13-39(14-11-24)31-6-1-2-7-31/h3-5,8-9,16-20,24,31,34H,1-2,6-7,10-15,22H2,(H,38,41) | Reactome pathway
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PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190902
(2-[6-(3-cyano-phenyl)-1'-cycloheptyl-3,4-dihydro-s...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC2)C2CCCCCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C35H38Cl2N4O/c36-29-20-30(37)22-31(21-29)39-34(42)24-41-15-12-28-19-27(26-7-5-6-25(18-26)23-38)10-11-33(28)35(41)13-16-40(17-14-35)32-8-3-1-2-4-9-32/h5-7,10-11,18-22,32H,1-4,8-9,12-17,24H2,(H,39,42) | Reactome pathway
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PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190886
(2-[6-(3-cyano-phenyl)-1'-cyclobutyl-3,4-dihydro-sp...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC2)C2CCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C32H32Cl2N4O/c33-26-17-27(34)19-28(18-26)36-31(39)21-38-12-9-25-16-24(23-4-1-3-22(15-23)20-35)7-8-30(25)32(38)10-13-37(14-11-32)29-5-2-6-29/h1,3-4,7-8,15-19,29H,2,5-6,9-14,21H2,(H,36,39) | Reactome pathway
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PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190874
(2-(6-(3-cyanophenyl)-1-(1-(furan-3-ylmethyl)piperi...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(Cc3ccoc3)CC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C34H32Cl2N4O2/c35-29-16-30(36)18-31(17-29)38-33(41)21-40-12-8-28-15-27(26-3-1-2-23(14-26)19-37)4-5-32(28)34(40)25-6-10-39(11-7-25)20-24-9-13-42-22-24/h1-5,9,13-18,22,25,34H,6-8,10-12,20-21H2,(H,38,41) | Reactome pathway
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190903
(2-(6-(3-cyanophenyl)-1-(1-cyclobutylpiperidin-4-yl...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C33H34Cl2N4O/c34-27-17-28(35)19-29(18-27)37-32(40)21-39-14-11-26-16-25(24-4-1-3-22(15-24)20-36)7-8-31(26)33(39)23-9-12-38(13-10-23)30-5-2-6-30/h1,3-4,7-8,15-19,23,30,33H,2,5-6,9-14,21H2,(H,37,40) | Reactome pathway
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PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190863
(2-[6-(3-cyano-phenyl)-1'-cyclopropylmethyl-3,4-dih...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C32H32Cl2N4O/c33-27-16-28(34)18-29(17-27)36-31(39)21-38-11-8-26-15-25(24-3-1-2-23(14-24)19-35)6-7-30(26)32(38)9-12-37(13-10-32)20-22-4-5-22/h1-3,6-7,14-18,22H,4-5,8-13,20-21H2,(H,36,39) | Reactome pathway
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190887
(2-[6-(3-cyano-phenyl)-1'-cyclopentyl-3,4-dihydro-s...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC2)C2CCCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C33H34Cl2N4O/c34-27-18-28(35)20-29(19-27)37-32(40)22-39-13-10-26-17-25(24-5-3-4-23(16-24)21-36)8-9-31(26)33(39)11-14-38(15-12-33)30-6-1-2-7-30/h3-5,8-9,16-20,30H,1-2,6-7,10-15,22H2,(H,37,40) | Reactome pathway
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190858
(2-[6-(3-cyano-phenyl)-1'-(tetrahydro-pyran-4-yl)-3...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC2)C2CCOCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C33H34Cl2N4O2/c34-27-18-28(35)20-29(19-27)37-32(40)22-39-11-6-26-17-25(24-3-1-2-23(16-24)21-36)4-5-31(26)33(39)9-12-38(13-10-33)30-7-14-41-15-8-30/h1-5,16-20,30H,6-15,22H2,(H,37,40) | Reactome pathway
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190901
(2-(1-(1-(2-methoxybenzyl)piperidin-4-yl)-6-(3-cyan...)Show SMILES COc1ccccc1CN1CCC(CC1)C1N(CC(=O)Nc2cc(Cl)cc(Cl)c2)CCc2cc(ccc12)-c1cccc(c1)C#N Show InChI InChI=1S/C37H36Cl2N4O2/c1-45-35-8-3-2-6-30(35)23-42-14-11-26(12-15-42)37-34-10-9-28(27-7-4-5-25(17-27)22-40)18-29(34)13-16-43(37)24-36(44)41-33-20-31(38)19-32(39)21-33/h2-10,17-21,26,37H,11-16,23-24H2,1H3,(H,41,44) | Reactome pathway
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190852
(2-(6-(3-cyanophenyl)-1-(1-methylpiperidin-4-yl)-3,...)Show SMILES CN1CCC(CC1)C1N(CC(=O)Nc2cc(Cl)cc(Cl)c2)CCc2cc(ccc12)-c1cccc(c1)C#N Show InChI InChI=1S/C30H30Cl2N4O/c1-35-10-7-21(8-11-35)30-28-6-5-23(22-4-2-3-20(13-22)18-33)14-24(28)9-12-36(30)19-29(37)34-27-16-25(31)15-26(32)17-27/h2-6,13-17,21,30H,7-12,19H2,1H3,(H,34,37) | Reactome pathway
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PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190871
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(pyridin-3-yl...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2cccnc2)c1 Show InChI InChI=1S/C32H36Cl2N4O/c33-26-17-27(34)19-28(18-26)36-31(39)21-38-15-11-24-16-23(25-4-3-12-35-20-25)7-8-30(24)32(38)22-9-13-37(14-10-22)29-5-1-2-6-29/h3-4,7-8,12,16-20,22,29,32H,1-2,5-6,9-11,13-15,21H2,(H,36,39) | Reactome pathway
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PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190860
(2-(1-(1-benzylpiperidin-4-yl)-6-(3-cyanophenyl)-3,...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(Cc3ccccc3)CC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C36H34Cl2N4O/c37-31-19-32(38)21-33(20-31)40-35(43)24-42-16-13-30-18-29(28-8-4-7-26(17-28)22-39)9-10-34(30)36(42)27-11-14-41(15-12-27)23-25-5-2-1-3-6-25/h1-10,17-21,27,36H,11-16,23-24H2,(H,40,43) | Reactome pathway
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| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190857
(CHEMBL212756 | N-(3-chloro-4-fluoro-phenyl)-2-[6-(...)Show SMILES Fc1ccc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)cc1Cl Show InChI InChI=1S/C32H32ClFN4O/c33-29-18-27(7-9-30(29)34)36-31(39)21-38-13-10-26-17-25(24-3-1-2-23(16-24)19-35)6-8-28(26)32(38)11-14-37(15-12-32)20-22-4-5-22/h1-3,6-9,16-18,22H,4-5,10-15,20-21H2,(H,36,39) | Reactome pathway
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| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190876
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(pyridin-4-yl...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2ccncc2)c1 Show InChI InChI=1S/C32H36Cl2N4O/c33-26-18-27(34)20-28(19-26)36-31(39)21-38-16-11-25-17-24(22-7-12-35-13-8-22)5-6-30(25)32(38)23-9-14-37(15-10-23)29-3-1-2-4-29/h5-8,12-13,17-20,23,29,32H,1-4,9-11,14-16,21H2,(H,36,39) | Reactome pathway
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| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190865
(2-[6-(3-cyano-phenyl)-1'-cyclopropylmethyl-3,4-dih...)Show SMILES Fc1ccc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)cc1C(F)(F)F Show InChI InChI=1S/C33H32F4N4O/c34-30-9-7-27(18-29(30)33(35,36)37)39-31(42)21-41-13-10-26-17-25(24-3-1-2-23(16-24)19-38)6-8-28(26)32(41)11-14-40(15-12-32)20-22-4-5-22/h1-3,6-9,16-18,22H,4-5,10-15,20-21H2,(H,39,42) | Reactome pathway
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190880
(2-(6-(3-cyanophenyl)-1-(piperidin-4-yl)-3,4-dihydr...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCNCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C29H28Cl2N4O/c30-24-14-25(31)16-26(15-24)34-28(36)18-35-11-8-23-13-22(21-3-1-2-19(12-21)17-32)4-5-27(23)29(35)20-6-9-33-10-7-20/h1-5,12-16,20,29,33H,6-11,18H2,(H,34,36) | Reactome pathway
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190905
(2-[6-(3-cyano-phenyl)-1'-isopropyl-3,4-dihydro-spi...)Show SMILES CC(C)N1CCC2(CC1)N(CC(=O)Nc1cc(Cl)cc(Cl)c1)CCc1cc(ccc21)-c1cccc(c1)C#N Show InChI InChI=1S/C31H32Cl2N4O/c1-21(2)36-12-9-31(10-13-36)29-7-6-24(23-5-3-4-22(14-23)19-34)15-25(29)8-11-37(31)20-30(38)35-28-17-26(32)16-27(33)18-28/h3-7,14-18,21H,8-13,20H2,1-2H3,(H,35,38) | Reactome pathway
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190867
(2-[6-(3-cyano-phenyl)-1'-(tetrahydro-thiophen-3-yl...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC2)C2CCSC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C32H32Cl2N4OS/c33-26-16-27(34)18-28(17-26)36-31(39)20-38-10-6-25-15-24(23-3-1-2-22(14-23)19-35)4-5-30(25)32(38)8-11-37(12-9-32)29-7-13-40-21-29/h1-5,14-18,29H,6-13,20-21H2,(H,36,39) | Reactome pathway
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| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190898
(2-[6-(3-cyano-phenyl)-1'-cyclopropylmethyl-3,4-dih...)Show SMILES Fc1ccc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)cc1F Show InChI InChI=1S/C32H32F2N4O/c33-29-9-7-27(18-30(29)34)36-31(39)21-38-13-10-26-17-25(24-3-1-2-23(16-24)19-35)6-8-28(26)32(38)11-14-37(15-12-32)20-22-4-5-22/h1-3,6-9,16-18,22H,4-5,10-15,20-21H2,(H,36,39) | Reactome pathway
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| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190888
(2-(6-(3-cyanophenyl)-1-(1-isopropylpiperidin-4-yl)...)Show SMILES CC(C)N1CCC(CC1)C1N(CC(=O)Nc2cc(Cl)cc(Cl)c2)CCc2cc(ccc12)-c1cccc(c1)C#N Show InChI InChI=1S/C32H34Cl2N4O/c1-21(2)37-11-8-23(9-12-37)32-30-7-6-25(24-5-3-4-22(14-24)19-35)15-26(30)10-13-38(32)20-31(39)36-29-17-27(33)16-28(34)18-29/h3-7,14-18,21,23,32H,8-13,20H2,1-2H3,(H,36,39) | Reactome pathway
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| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190875
(2-[6-(3-cyano-phenyl)-1'-furan-3-ylmethyl-3,4-dihy...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(Cc3ccoc3)CC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C33H30Cl2N4O2/c34-28-16-29(35)18-30(17-28)37-32(40)21-39-10-6-27-15-26(25-3-1-2-23(14-25)19-36)4-5-31(27)33(39)8-11-38(12-9-33)20-24-7-13-41-22-24/h1-5,7,13-18,22H,6,8-12,20-21H2,(H,37,40) | Reactome pathway
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| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190850
(2-[6-(3-cyano-phenyl)-1'-methyl-3,4-dihydro-spiro[...)Show SMILES CN1CCC2(CC1)N(CC(=O)Nc1cc(Cl)cc(Cl)c1)CCc1cc(ccc21)-c1cccc(c1)C#N Show InChI InChI=1S/C29H28Cl2N4O/c1-34-11-8-29(9-12-34)27-6-5-22(21-4-2-3-20(13-21)18-32)14-23(27)7-10-35(29)19-28(36)33-26-16-24(30)15-25(31)17-26/h2-6,13-17H,7-12,19H2,1H3,(H,33,36) | Reactome pathway
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190879
(2-[6-(3-cyano-phenyl)-1'-ethyl-3,4-dihydro-spiro[i...)Show SMILES CCN1CCC2(CC1)N(CC(=O)Nc1cc(Cl)cc(Cl)c1)CCc1cc(ccc21)-c1cccc(c1)C#N Show InChI InChI=1S/C30H30Cl2N4O/c1-2-35-12-9-30(10-13-35)28-7-6-23(22-5-3-4-21(14-22)19-33)15-24(28)8-11-36(30)20-29(37)34-27-17-25(31)16-26(32)18-27/h3-7,14-18H,2,8-13,20H2,1H3,(H,34,37) | Reactome pathway
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190862
(2-[6-(3-cyano-phenyl)-1'-(1-hydroxy-ethyl)-3,4-dih...)Show SMILES CC(O)N1CCC2(CC1)N(CC(=O)Nc1cc(Cl)cc(Cl)c1)CCc1cc(ccc21)-c1cccc(c1)C#N Show InChI InChI=1S/C30H30Cl2N4O2/c1-20(37)35-11-8-30(9-12-35)28-6-5-23(22-4-2-3-21(13-22)18-33)14-24(28)7-10-36(30)19-29(38)34-27-16-25(31)15-26(32)17-27/h2-6,13-17,20,37H,7-12,19H2,1H3,(H,34,38) | Reactome pathway
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190908
(2-(6-(3-chlorophenyl)-1-(1-cyclopentylpiperidin-4-...)Show SMILES Clc1cccc(c1)-c1ccc2C(C3CCN(CC3)C3CCCC3)N(CC(=O)Nc3cc(Cl)cc(Cl)c3)CCc2c1 Show InChI InChI=1S/C33H36Cl3N3O/c34-26-5-3-4-23(17-26)24-8-9-31-25(16-24)12-15-39(21-32(40)37-29-19-27(35)18-28(36)20-29)33(31)22-10-13-38(14-11-22)30-6-1-2-7-30/h3-5,8-9,16-20,22,30,33H,1-2,6-7,10-15,21H2,(H,37,40) | Reactome pathway
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| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190853
(CHEMBL263975 | N-(3-chloro-phenyl)-2-[6-(3-cyano-p...)Show SMILES Clc1cccc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C32H33ClN4O/c33-28-5-2-6-29(19-28)35-31(38)22-37-14-11-27-18-26(25-4-1-3-24(17-25)20-34)9-10-30(27)32(37)12-15-36(16-13-32)21-23-7-8-23/h1-6,9-10,17-19,23H,7-8,11-16,21-22H2,(H,35,38) | Reactome pathway
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| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190878
(2-(6-(3-(1H-imidazol-2-yl)phenyl)-1-(1-cyclopentyl...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2cccc(c2)-c2ncc[nH]2)c1 Show InChI InChI=1S/C36H39Cl2N5O/c37-29-20-30(38)22-31(21-29)41-34(44)23-43-17-12-27-18-26(25-4-3-5-28(19-25)36-39-13-14-40-36)8-9-33(27)35(43)24-10-15-42(16-11-24)32-6-1-2-7-32/h3-5,8-9,13-14,18-22,24,32,35H,1-2,6-7,10-12,15-17,23H2,(H,39,40)(H,41,44) | Reactome pathway
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| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190881
(2-[6-(3-cyano-phenyl)-1'-cyclopropylmethyl-3,4-dih...)Show SMILES Fc1cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)cc(c1)C(F)(F)F Show InChI InChI=1S/C33H32F4N4O/c34-28-16-27(33(35,36)37)17-29(18-28)39-31(42)21-41-11-8-26-15-25(24-3-1-2-23(14-24)19-38)6-7-30(26)32(41)9-12-40(13-10-32)20-22-4-5-22/h1-3,6-7,14-18,22H,4-5,8-13,20-21H2,(H,39,42) | Reactome pathway
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| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190855
(2-[6-(3-cyano-phenyl)-3,4-dihydro-spiro[isoquinoli...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C22CCNCC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C28H26Cl2N4O/c29-23-14-24(30)16-25(15-23)33-27(35)18-34-11-6-22-13-21(20-3-1-2-19(12-20)17-31)4-5-26(22)28(34)7-9-32-10-8-28/h1-5,12-16,32H,6-11,18H2,(H,33,35) | Reactome pathway
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| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190891
(2-[6-(3-cyano-phenyl)-1'-cyclopropylmethyl-3,4-dih...)Show SMILES Fc1cc(F)cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C32H32F2N4O/c33-27-16-28(34)18-29(17-27)36-31(39)21-38-11-8-26-15-25(24-3-1-2-23(14-24)19-35)6-7-30(26)32(38)9-12-37(13-10-32)20-22-4-5-22/h1-3,6-7,14-18,22H,4-5,8-13,20-21H2,(H,36,39) | Reactome pathway
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| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190904
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(3-fluorophen...)Show SMILES Fc1cccc(c1)-c1ccc2C(C3CCN(CC3)C3CCCC3)N(CC(=O)Nc3cc(Cl)cc(Cl)c3)CCc2c1 Show InChI InChI=1S/C33H36Cl2FN3O/c34-26-18-27(35)20-29(19-26)37-32(40)21-39-15-12-25-16-24(23-4-3-5-28(36)17-23)8-9-31(25)33(39)22-10-13-38(14-11-22)30-6-1-2-7-30/h3-5,8-9,16-20,22,30,33H,1-2,6-7,10-15,21H2,(H,37,40) | Reactome pathway
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| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190906
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(3-(trifluoro...)Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc2C(C3CCN(CC3)C3CCCC3)N(CC(=O)Nc3cc(Cl)cc(Cl)c3)CCc2c1 Show InChI InChI=1S/C34H36Cl2F3N3O2/c35-26-18-27(36)20-28(19-26)40-32(43)21-42-15-12-25-16-24(23-4-3-7-30(17-23)44-34(37,38)39)8-9-31(25)33(42)22-10-13-41(14-11-22)29-5-1-2-6-29/h3-4,7-9,16-20,22,29,33H,1-2,5-6,10-15,21H2,(H,40,43) | Reactome pathway
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190864
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(3-formylphen...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2cccc(C=O)c2)c1 Show InChI InChI=1S/C34H37Cl2N3O2/c35-28-18-29(36)20-30(19-28)37-33(41)21-39-15-12-27-17-26(25-5-3-4-23(16-25)22-40)8-9-32(27)34(39)24-10-13-38(14-11-24)31-6-1-2-7-31/h3-5,8-9,16-20,22,24,31,34H,1-2,6-7,10-15,21H2,(H,37,41) | Reactome pathway
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190873
(3-(2-((6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)...)Show SMILES Fc1cc2[nH]c(CN3CCc4cc(ccc4C3C3CCN(CC4CC4)CC3)-c3cccc(c3)C#N)nc2cc1Cl Show InChI InChI=1S/C33H33ClFN5/c34-28-16-30-31(17-29(28)35)38-32(37-30)20-40-13-10-26-15-25(24-3-1-2-22(14-24)18-36)6-7-27(26)33(40)23-8-11-39(12-9-23)19-21-4-5-21/h1-3,6-7,14-17,21,23,33H,4-5,8-13,19-20H2,(H,37,38) | Reactome pathway
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| 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190894
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(2,5-dichloro...)Show SMILES Clc1ccc(Cl)c(c1)-c1ccc2C(C3CCN(CC3)C3CCCC3)N(CC(=O)Nc3cc(Cl)cc(Cl)c3)CCc2c1 Show InChI InChI=1S/C33H35Cl4N3O/c34-24-6-8-31(37)30(19-24)22-5-7-29-23(15-22)11-14-40(20-32(41)38-27-17-25(35)16-26(36)18-27)33(29)21-9-12-39(13-10-21)28-3-1-2-4-28/h5-8,15-19,21,28,33H,1-4,9-14,20H2,(H,38,41) | Reactome pathway
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| 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190872
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(3-methoxyphe...)Show SMILES COc1cccc(c1)-c1ccc2C(C3CCN(CC3)C3CCCC3)N(CC(=O)Nc3cc(Cl)cc(Cl)c3)CCc2c1 Show InChI InChI=1S/C34H39Cl2N3O2/c1-41-31-8-4-5-24(18-31)25-9-10-32-26(17-25)13-16-39(22-33(40)37-29-20-27(35)19-28(36)21-29)34(32)23-11-14-38(15-12-23)30-6-2-3-7-30/h4-5,8-10,17-21,23,30,34H,2-3,6-7,11-16,22H2,1H3,(H,37,40) | Reactome pathway
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| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190861
(2-(6-(4-cyanophenyl)-1-(1-cyclopentylpiperidin-4-y...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2ccc(cc2)C#N)c1 Show InChI InChI=1S/C34H36Cl2N4O/c35-28-18-29(36)20-30(19-28)38-33(41)22-40-16-13-27-17-26(24-7-5-23(21-37)6-8-24)9-10-32(27)34(40)25-11-14-39(15-12-25)31-3-1-2-4-31/h5-10,17-20,25,31,34H,1-4,11-16,22H2,(H,38,41) | Reactome pathway
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| 108 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190856
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(thiophen-3-y...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2ccsc2)c1 Show InChI InChI=1S/C31H35Cl2N3OS/c32-25-16-26(33)18-27(17-25)34-30(37)19-36-13-9-23-15-22(24-10-14-38-20-24)5-6-29(23)31(36)21-7-11-35(12-8-21)28-3-1-2-4-28/h5-6,10,14-18,20-21,28,31H,1-4,7-9,11-13,19H2,(H,34,37) | Reactome pathway
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| 115 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190899
(CHEMBL212142 | N-(4-chloro-3-trifluoromethyl-pheny...)Show SMILES FC(F)(F)c1cc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)ccc1Cl Show InChI InChI=1S/C33H32ClF3N4O/c34-30-9-7-27(18-29(30)33(35,36)37)39-31(42)21-41-13-10-26-17-25(24-3-1-2-23(16-24)19-38)6-8-28(26)32(41)11-14-40(15-12-32)20-22-4-5-22/h1-3,6-9,16-18,22H,4-5,10-15,20-21H2,(H,39,42) | Reactome pathway
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| 119 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190866
(3-(1-(1-(cyclopropylmethyl)piperidin-4-yl)-2-((5,6...)Show SMILES Clc1cc2nc(CN3CCc4cc(ccc4C3C3CCN(CC4CC4)CC3)-c3cccc(c3)C#N)[nH]c2cc1Cl Show InChI InChI=1S/C33H33Cl2N5/c34-28-16-30-31(17-29(28)35)38-32(37-30)20-40-13-10-26-15-25(24-3-1-2-22(14-24)18-36)6-7-27(26)33(40)23-8-11-39(12-9-23)19-21-4-5-21/h1-3,6-7,14-17,21,23,33H,4-5,8-13,19-20H2,(H,37,38) | Reactome pathway
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| 133 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190854
(CHEMBL212136 | N-(4-chloro-phenyl)-2-[6-(3-cyano-p...)Show SMILES Clc1ccc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)cc1 Show InChI InChI=1S/C32H33ClN4O/c33-28-7-9-29(10-8-28)35-31(38)22-37-15-12-27-19-26(25-3-1-2-24(18-25)20-34)6-11-30(27)32(37)13-16-36(17-14-32)21-23-4-5-23/h1-3,6-11,18-19,23H,4-5,12-17,21-22H2,(H,35,38) | Reactome pathway
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| 138 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190868
(2-[6-(3-cyano-phenyl)-1'-cyclopropylmethyl-3,4-dih...)Show SMILES Clc1ccc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)cc1Cl Show InChI InChI=1S/C32H32Cl2N4O/c33-29-9-7-27(18-30(29)34)36-31(39)21-38-13-10-26-17-25(24-3-1-2-23(16-24)19-35)6-8-28(26)32(38)11-14-37(15-12-32)20-22-4-5-22/h1-3,6-9,16-18,22H,4-5,10-15,20-21H2,(H,36,39) | Reactome pathway
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| 138 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190892
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-phenyl-3,4-di...)Show SMILES Clc1cc(Cl)cc(NC(=O)CN2CCc3cc(ccc3C2C2CCN(CC2)C2CCCC2)-c2ccccc2)c1 Show InChI InChI=1S/C33H37Cl2N3O/c34-27-19-28(35)21-29(20-27)36-32(39)22-38-17-14-26-18-25(23-6-2-1-3-7-23)10-11-31(26)33(38)24-12-15-37(16-13-24)30-8-4-5-9-30/h1-3,6-7,10-11,18-21,24,30,33H,4-5,8-9,12-17,22H2,(H,36,39) | Reactome pathway
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| 168 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190907
(2-(1-(1-cyclopentylpiperidin-4-yl)-6-(3-(trifluoro...)Show SMILES FC(F)(F)c1cccc(c1)-c1ccc2C(C3CCN(CC3)C3CCCC3)N(CC(=O)Nc3cc(Cl)cc(Cl)c3)CCc2c1 Show InChI InChI=1S/C34H36Cl2F3N3O/c35-27-18-28(36)20-29(19-27)40-32(43)21-42-15-12-25-16-24(23-4-3-5-26(17-23)34(37,38)39)8-9-31(25)33(42)22-10-13-41(14-11-22)30-6-1-2-7-30/h3-5,8-9,16-20,22,30,33H,1-2,6-7,10-15,21H2,(H,40,43) | Reactome pathway
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| 191 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHR1 |
Bioorg Med Chem Lett 16: 4917-21 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.055
BindingDB Entry DOI: 10.7270/Q2WW7H83 |
More data for this
Ligand-Target Pair | |
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