Found 76 hits Enz. Inhib. hit(s) with all data for entry = 50032578 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331363
((S)-3'-cyclopropyl-4'-(4-(1,1,1-trifluoro-2-hydrox...)Show SMILES C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1C1CC1)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C25H20F3NO3S/c1-24(30,25(26,27)28)20-9-11-21(12-10-20)33(31,32)23-13-8-19(14-22(23)18-6-7-18)17-4-2-16(15-29)3-5-17/h2-5,8-14,18,30H,6-7H2,1H3/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50248569
((1-(((R)-3-methyl-4-(4-((S)-1,1,1-trifluoro-2-hydr...)Show SMILES C[C@@H]1CN(CC2(CC2)C(N)=O)CCN1S(=O)(=O)c1ccc(cc1)[C@](C)(O)C(F)(F)F |r| Show InChI InChI=1S/C19H26F3N3O4S/c1-13-11-24(12-18(7-8-18)16(23)26)9-10-25(13)30(28,29)15-5-3-14(4-6-15)17(2,27)19(20,21)22/h3-6,13,27H,7-12H2,1-2H3,(H2,23,26)/t13-,17+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331361
((S)-3'-chloro-4'-(4-(1,1,1-trifluoro-2-hydroxyprop...)Show SMILES C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C22H15ClF3NO3S/c1-21(28,22(24,25)26)17-7-9-18(10-8-17)31(29,30)20-11-6-16(12-19(20)23)15-4-2-14(13-27)3-5-15/h2-12,28H,1H3/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331365
((S)-3'-(2-fluoroethyl)-4'-(4-(1,1,1-trifluoro-2-hy...)Show SMILES C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1CCF)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C24H19F4NO3S/c1-23(30,24(26,27)28)20-7-9-21(10-8-20)33(31,32)22-11-6-18(14-19(22)12-13-25)17-4-2-16(15-29)3-5-17/h2-11,14,30H,12-13H2,1H3/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331343
(CHEMBL1290164 | rac-2-(4-(2-cyclopropylphenylsulfo...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3O3S/c1-17(22,18(19,20)21)13-8-10-14(11-9-13)25(23,24)16-5-3-2-4-15(16)12-6-7-12/h2-5,8-12,22H,6-7H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331341
(CHEMBL1290057 | rac-2-(4-(2-ethylphenylsulfonyl)ph...)Show SMILES CCc1ccccc1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F Show InChI InChI=1S/C17H17F3O3S/c1-3-12-6-4-5-7-15(12)24(22,23)14-10-8-13(9-11-14)16(2,21)17(18,19)20/h4-11,21H,3H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331350
(CHEMBL1290502 | rac-2-(4-(4-bromo-2-chlorophenylsu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(Br)cc1Cl)C(F)(F)F Show InChI InChI=1S/C15H11BrClF3O3S/c1-14(21,15(18,19)20)9-2-5-11(6-3-9)24(22,23)13-7-4-10(16)8-12(13)17/h2-8,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331349
(CHEMBL1290501 | rac-2-(4-(2,4-dichlorophenylsulfon...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(Cl)cc1Cl)C(F)(F)F Show InChI InChI=1S/C15H11Cl2F3O3S/c1-14(21,15(18,19)20)9-2-5-11(6-3-9)24(22,23)13-7-4-10(16)8-12(13)17/h2-8,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331363
((S)-3'-cyclopropyl-4'-(4-(1,1,1-trifluoro-2-hydrox...)Show SMILES C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1C1CC1)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C25H20F3NO3S/c1-24(30,25(26,27)28)20-9-11-21(12-10-20)33(31,32)23-13-8-19(14-22(23)18-6-7-18)17-4-2-16(15-29)3-5-17/h2-5,8-14,18,30H,6-7H2,1H3/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331351
(CHEMBL1290610 | rac-3-chloro-4-(4-(1,1,1-trifluoro...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)C#N)C(F)(F)F Show InChI InChI=1S/C16H11ClF3NO3S/c1-15(22,16(18,19)20)11-3-5-12(6-4-11)25(23,24)14-7-2-10(9-21)8-13(14)17/h2-8,22H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331352
(CHEMBL1290611 | rac-2-(4-(2-chloro-4-nitrophenylsu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)[N+]([O-])=O)C(F)(F)F Show InChI InChI=1S/C15H11ClF3NO5S/c1-14(21,15(17,18)19)9-2-5-11(6-3-9)26(24,25)13-7-4-10(20(22)23)8-12(13)16/h2-8,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331342
(CHEMBL1290163 | rac-1,1,1-trifluoro-2-(4-(2-isopro...)Show SMILES CC(C)c1ccccc1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F Show InChI InChI=1S/C18H19F3O3S/c1-12(2)15-6-4-5-7-16(15)25(23,24)14-10-8-13(9-11-14)17(3,22)18(19,20)21/h4-12,22H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331330
(CHEMBL1289839 | rac-1,1,1-trifluoro-2-(4-(o-tolyls...)Show SMILES Cc1ccccc1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F Show InChI InChI=1S/C16H15F3O3S/c1-11-5-3-4-6-14(11)23(21,22)13-9-7-12(8-10-13)15(2,20)16(17,18)19/h3-10,20H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331329
(CHEMBL1289838 | rac-2-(4-(2-chlorophenylsulfonyl)p...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C15H12ClF3O3S/c1-14(20,15(17,18)19)10-6-8-11(9-7-10)23(21,22)13-5-3-2-4-12(13)16/h2-9,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331354
(CHEMBL1290730 | rac-2-(4-(2-chloro-4-(pyridin-4-yl...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)-c1ccncc1)C(F)(F)F Show InChI InChI=1S/C20H15ClF3NO3S/c1-19(26,20(22,23)24)15-3-5-16(6-4-15)29(27,28)18-7-2-14(12-17(18)21)13-8-10-25-11-9-13/h2-12,26H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50248569
((1-(((R)-3-methyl-4-(4-((S)-1,1,1-trifluoro-2-hydr...)Show SMILES C[C@@H]1CN(CC2(CC2)C(N)=O)CCN1S(=O)(=O)c1ccc(cc1)[C@](C)(O)C(F)(F)F |r| Show InChI InChI=1S/C19H26F3N3O4S/c1-13-11-24(12-18(7-8-18)16(23)26)9-10-25(13)30(28,29)15-5-3-14(4-6-15)17(2,27)19(20,21)22/h3-6,13,27H,7-12H2,1-2H3,(H2,23,26)/t13-,17+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331340
(CHEMBL1290056 | rac-1,1,1-trifluoro-2-(4-(2-(trifl...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C16H12F6O3S/c1-14(23,16(20,21)22)10-6-8-11(9-7-10)26(24,25)13-5-3-2-4-12(13)15(17,18)19/h2-9,23H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331358
(CHEMBL1289178 | rac-1-(3-chloro-4-(4-(1,1,1-triflu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(CC2(CC2)C#N)cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H17ClF3NO3S/c1-18(26,20(22,23)24)14-3-5-15(6-4-14)29(27,28)17-7-2-13(10-16(17)21)11-19(12-25)8-9-19/h2-7,10,26H,8-9,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331344
(CHEMBL1290273 | rac-2-(4-(2-tert-butylphenylsulfon...)Show SMILES CC(C)(C)c1ccccc1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F Show InChI InChI=1S/C19H21F3O3S/c1-17(2,3)15-7-5-6-8-16(15)26(24,25)14-11-9-13(10-12-14)18(4,23)19(20,21)22/h5-12,23H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331339
(CHEMBL1290055 | rac-1,1,1-trifluoro-2-(4-(2-fluoro...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1F)C(F)(F)F Show InChI InChI=1S/C15H12F4O3S/c1-14(20,15(17,18)19)10-6-8-11(9-7-10)23(21,22)13-5-3-2-4-12(13)16/h2-9,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331361
((S)-3'-chloro-4'-(4-(1,1,1-trifluoro-2-hydroxyprop...)Show SMILES C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C22H15ClF3NO3S/c1-21(28,22(24,25)26)17-7-9-18(10-8-17)31(29,30)20-11-6-16(12-19(20)23)15-4-2-14(13-27)3-5-15/h2-12,28H,1H3/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331362
((R)-3'-cyclopropyl-4'-(4-(1,1,1-trifluoro-2-hydrox...)Show SMILES C[C@@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1C1CC1)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C25H20F3NO3S/c1-24(30,25(26,27)28)20-9-11-21(12-10-20)33(31,32)23-13-8-19(14-22(23)18-6-7-18)17-4-2-16(15-29)3-5-17/h2-5,8-14,18,30H,6-7H2,1H3/t24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331360
((R)-3'-chloro-4'-(4-(1,1,1-trifluoro-2-hydroxyprop...)Show SMILES C[C@@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C22H15ClF3NO3S/c1-21(28,22(24,25)26)17-7-9-18(10-8-17)31(29,30)20-11-6-16(12-19(20)23)15-4-2-14(13-27)3-5-15/h2-12,28H,1H3/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331356
(CHEMBL1289061 | rac-3-chloro-4-(4-(1,1,1-trifluoro...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)C(N)=O)C(F)(F)F Show InChI InChI=1S/C16H13ClF3NO4S/c1-15(23,16(18,19)20)10-3-5-11(6-4-10)26(24,25)13-7-2-9(14(21)22)8-12(13)17/h2-8,23H,1H3,(H2,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331331
(CHEMBL1289840 | rac-2-(4-(3-chlorophenylsulfonyl)p...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1cccc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C15H12ClF3O3S/c1-14(20,15(17,18)19)10-5-7-12(8-6-10)23(21,22)13-4-2-3-11(16)9-13/h2-9,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331337
(CHEMBL1288908 | rac-1-(4-tert-butylphenylsulfonyl)...)Show InChI InChI=1S/C16H17ClO2S/c1-16(2,3)12-8-10-13(11-9-12)20(18,19)15-7-5-4-6-14(15)17/h4-11H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331365
((S)-3'-(2-fluoroethyl)-4'-(4-(1,1,1-trifluoro-2-hy...)Show SMILES C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1CCF)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C24H19F4NO3S/c1-23(30,24(26,27)28)20-7-9-21(10-8-20)33(31,32)22-11-6-18(14-19(22)12-13-25)17-4-2-16(15-29)3-5-17/h2-11,14,30H,12-13H2,1H3/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331334
(CHEMBL1289958 | rac-1,1,1-trifluoro-2-(4-(4-nitrop...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O)C(F)(F)F Show InChI InChI=1S/C15H12F3NO5S/c1-14(20,15(16,17)18)10-2-6-12(7-3-10)25(23,24)13-8-4-11(5-9-13)19(21)22/h2-9,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331353
(CHEMBL1290729 | rac-3'-chloro-4'-(4-(1,1,1-trifluo...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)-c1ccc(cc1)C#N)C(F)(F)F Show InChI InChI=1S/C22H15ClF3NO3S/c1-21(28,22(24,25)26)17-7-9-18(10-8-17)31(29,30)20-11-6-16(12-19(20)23)15-4-2-14(13-27)3-5-15/h2-12,28H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331343
(CHEMBL1290164 | rac-2-(4-(2-cyclopropylphenylsulfo...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3O3S/c1-17(22,18(19,20)21)13-8-10-14(11-9-13)25(23,24)16-5-3-2-4-15(16)12-6-7-12/h2-5,8-12,22H,6-7H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331332
(CHEMBL1289956 | rac-1,1,1-trifluoro-2-(4-(4-methox...)Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F Show InChI InChI=1S/C16H15F3O4S/c1-15(20,16(17,18)19)11-3-7-13(8-4-11)24(21,22)14-9-5-12(23-2)6-10-14/h3-10,20H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331336
(CHEMBL1288907 | rac-1-chloro-2-(4-(2-fluoropropan-...)Show InChI InChI=1S/C15H14ClFO2S/c1-15(2,17)11-7-9-12(10-8-11)20(18,19)14-6-4-3-5-13(14)16/h3-10H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331359
(CHEMBL1289291 | rac-1-(3-chloro-4-(4-(1,1,1-triflu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(CC2(CC2)C(N)=O)cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H19ClF3NO4S/c1-18(27,20(22,23)24)13-3-5-14(6-4-13)30(28,29)16-7-2-12(10-15(16)21)11-19(8-9-19)17(25)26/h2-7,10,27H,8-9,11H2,1H3,(H2,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331355
(CHEMBL1289060 | rac-2-(4-(4-amino-2-chlorophenylsu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(N)cc1Cl)C(F)(F)F Show InChI InChI=1S/C15H13ClF3NO3S/c1-14(21,15(17,18)19)9-2-5-11(6-3-9)24(22,23)13-7-4-10(20)8-12(13)16/h2-8,21H,20H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331364
((R)-3'-(2-fluoroethyl)-4'-(4-(1,1,1-trifluoro-2-hy...)Show SMILES C[C@@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1CCF)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C24H19F4NO3S/c1-23(30,24(26,27)28)20-7-9-21(10-8-20)33(31,32)22-11-6-18(14-19(22)12-13-25)17-4-2-16(15-29)3-5-17/h2-11,14,30H,12-13H2,1H3/t23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331333
(CHEMBL1289957 | rac-1,1,1-trifluoro-2-(4-(4-fluoro...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C15H12F4O3S/c1-14(20,15(17,18)19)10-2-6-12(7-3-10)23(21,22)13-8-4-11(16)5-9-13/h2-9,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331351
(CHEMBL1290610 | rac-3-chloro-4-(4-(1,1,1-trifluoro...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)C#N)C(F)(F)F Show InChI InChI=1S/C16H11ClF3NO3S/c1-15(22,16(18,19)20)11-3-5-12(6-4-11)25(23,24)14-7-2-10(9-21)8-13(14)17/h2-8,22H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331349
(CHEMBL1290501 | rac-2-(4-(2,4-dichlorophenylsulfon...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(Cl)cc1Cl)C(F)(F)F Show InChI InChI=1S/C15H11Cl2F3O3S/c1-14(21,15(18,19)20)9-2-5-11(6-3-9)24(22,23)13-7-4-10(16)8-12(13)17/h2-8,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331345
(CHEMBL1290274 | rac-2-(4-(1,1,1-trifluoro-2-hydrox...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1C#N)C(F)(F)F Show InChI InChI=1S/C16H12F3NO3S/c1-15(21,16(17,18)19)12-6-8-13(9-7-12)24(22,23)14-5-3-2-4-11(14)10-20/h2-9,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331329
(CHEMBL1289838 | rac-2-(4-(2-chlorophenylsulfonyl)p...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C15H12ClF3O3S/c1-14(20,15(17,18)19)10-6-8-11(9-7-10)23(21,22)13-5-3-2-4-12(13)16/h2-9,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331330
(CHEMBL1289839 | rac-1,1,1-trifluoro-2-(4-(o-tolyls...)Show SMILES Cc1ccccc1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F Show InChI InChI=1S/C16H15F3O3S/c1-11-5-3-4-6-14(11)23(21,22)13-9-7-12(8-10-13)15(2,20)16(17,18)19/h3-10,20H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331350
(CHEMBL1290502 | rac-2-(4-(4-bromo-2-chlorophenylsu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(Br)cc1Cl)C(F)(F)F Show InChI InChI=1S/C15H11BrClF3O3S/c1-14(21,15(18,19)20)9-2-5-11(6-3-9)24(22,23)13-7-4-10(16)8-12(13)17/h2-8,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331328
(CHEMBL1289734 | rac-1,1,1-trifluoro-2-(4-(phenylsu...)Show InChI InChI=1S/C15H13F3O3S/c1-14(19,15(16,17)18)11-7-9-13(10-8-11)22(20,21)12-5-3-2-4-6-12/h2-10,19H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331357
(CHEMBL1289177 | rac-1-(3-chloro-4-(4-(1,1,1-triflu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(NC(N)=O)cc1Cl)C(F)(F)F Show InChI InChI=1S/C16H14ClF3N2O4S/c1-15(24,16(18,19)20)9-2-5-11(6-3-9)27(25,26)13-7-4-10(8-12(13)17)22-14(21)23/h2-8,24H,1H3,(H3,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331341
(CHEMBL1290057 | rac-2-(4-(2-ethylphenylsulfonyl)ph...)Show SMILES CCc1ccccc1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F Show InChI InChI=1S/C17H17F3O3S/c1-3-12-6-4-5-7-15(12)24(22,23)14-10-8-13(9-11-14)16(2,21)17(18,19)20/h4-11,21H,3H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331335
(CHEMBL1288906 | rac-2-(4-(2-chlorophenylsulfonyl)p...)Show InChI InChI=1S/C15H15ClO3S/c1-15(2,17)11-7-9-12(10-8-11)20(18,19)14-6-4-3-5-13(14)16/h3-10,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331352
(CHEMBL1290611 | rac-2-(4-(2-chloro-4-nitrophenylsu...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)[N+]([O-])=O)C(F)(F)F Show InChI InChI=1S/C15H11ClF3NO5S/c1-14(21,15(17,18)19)9-2-5-11(6-3-9)26(24,25)13-7-4-10(20(22)23)8-12(13)16/h2-8,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331346
(CHEMBL1290389 | rac-1,1,1-trifluoro-2-(4-(4'-fluor...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C21H16F4O3S/c1-20(26,21(23,24)25)15-8-12-17(13-9-15)29(27,28)19-5-3-2-4-18(19)14-6-10-16(22)11-7-14/h2-13,26H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331354
(CHEMBL1290730 | rac-2-(4-(2-chloro-4-(pyridin-4-yl...)Show SMILES CC(O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1Cl)-c1ccncc1)C(F)(F)F Show InChI InChI=1S/C20H15ClF3NO3S/c1-19(26,20(22,23)24)15-3-5-16(6-4-15)29(27,28)18-7-2-14(12-17(18)21)13-8-10-25-11-9-13/h2-12,26H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50331362
((R)-3'-cyclopropyl-4'-(4-(1,1,1-trifluoro-2-hydrox...)Show SMILES C[C@@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1C1CC1)-c1ccc(cc1)C#N)C(F)(F)F |r| Show InChI InChI=1S/C25H20F3NO3S/c1-24(30,25(26,27)28)20-9-11-21(12-10-20)33(31,32)23-13-8-19(14-22(23)18-6-7-18)17-4-2-16(15-29)3-5-17/h2-5,8-14,18,30H,6-7H2,1H3/t24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 transfected in HEK293 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7071-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.097
BindingDB Entry DOI: 10.7270/Q21G0MHX |
More data for this
Ligand-Target Pair | |
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