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Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with all data for entry = 50042481   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426652
PNG
(CHEMBL2326178)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccc(F)cc2F)c1C
Show InChI InChI=1S/C19H19F2N5O2S/c1-11-12(2)28-24-17(11)23-18(27)25-5-7-26(8-6-25)19-22-16(10-29-19)14-4-3-13(20)9-15(14)21/h3-4,9-10H,5-8H2,1-2H3,(H,23,24,27)
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n/an/a 0.430n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426652
PNG
(CHEMBL2326178)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccc(F)cc2F)c1C
Show InChI InChI=1S/C19H19F2N5O2S/c1-11-12(2)28-24-17(11)23-18(27)25-5-7-26(8-6-25)19-22-16(10-29-19)14-4-3-13(20)9-15(14)21/h3-4,9-10H,5-8H2,1-2H3,(H,23,24,27)
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n/an/a 0.460n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426651
PNG
(CHEMBL2326194)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccccc2F)c1C
Show InChI InChI=1S/C19H20FN5O2S/c1-12-13(2)27-23-17(12)22-18(26)24-7-9-25(10-8-24)19-21-16(11-28-19)14-5-3-4-6-15(14)20/h3-6,11H,7-10H2,1-2H3,(H,22,23,26)
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n/an/a 0.670n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426650
PNG
(CHEMBL2326177)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccc(F)cc2)c1C
Show InChI InChI=1S/C19H20FN5O2S/c1-12-13(2)27-23-17(12)22-18(26)24-7-9-25(10-8-24)19-21-16(11-28-19)14-3-5-15(20)6-4-14/h3-6,11H,7-10H2,1-2H3,(H,22,23,26)
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n/an/a 0.710n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426651
PNG
(CHEMBL2326194)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccccc2F)c1C
Show InChI InChI=1S/C19H20FN5O2S/c1-12-13(2)27-23-17(12)22-18(26)24-7-9-25(10-8-24)19-21-16(11-28-19)14-5-3-4-6-15(14)20/h3-6,11H,7-10H2,1-2H3,(H,22,23,26)
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n/an/a 0.75n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426648
PNG
(CHEMBL2326197)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2ccc(F)cc2)c1C
Show InChI InChI=1S/C18H19FN6O2S/c1-11-12(2)27-22-15(11)20-17(26)24-7-9-25(10-8-24)18-21-16(23-28-18)13-3-5-14(19)6-4-13/h3-6H,7-10H2,1-2H3,(H,20,22,26)
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n/an/a 0.800n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426650
PNG
(CHEMBL2326177)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccc(F)cc2)c1C
Show InChI InChI=1S/C19H20FN5O2S/c1-12-13(2)27-23-17(12)22-18(26)24-7-9-25(10-8-24)19-21-16(11-28-19)14-3-5-15(20)6-4-14/h3-6,11H,7-10H2,1-2H3,(H,22,23,26)
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n/an/a 0.860n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426649
PNG
(CHEMBL2326192)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccccc2)c1C
Show InChI InChI=1S/C19H21N5O2S/c1-13-14(2)26-22-17(13)21-18(25)23-8-10-24(11-9-23)19-20-16(12-27-19)15-6-4-3-5-7-15/h3-7,12H,8-11H2,1-2H3,(H,21,22,25)
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n/an/a 0.920n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426649
PNG
(CHEMBL2326192)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2ccccc2)c1C
Show InChI InChI=1S/C19H21N5O2S/c1-13-14(2)26-22-17(13)21-18(25)23-8-10-24(11-9-23)19-20-16(12-27-19)15-6-4-3-5-7-15/h3-7,12H,8-11H2,1-2H3,(H,21,22,25)
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n/an/a 0.960n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426647
PNG
(CHEMBL2326196)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2cccc(F)c2)c1C
Show InChI InChI=1S/C19H20FN5O2S/c1-12-13(2)27-23-17(12)22-18(26)24-6-8-25(9-7-24)19-21-16(11-28-19)14-4-3-5-15(20)10-14/h3-5,10-11H,6-9H2,1-2H3,(H,22,23,26)
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n/an/a 1.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426645
PNG
(CHEMBL2326193)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2ccccc2F)c1C
Show InChI InChI=1S/C18H19FN6O2S/c1-11-12(2)27-22-15(11)20-17(26)24-7-9-25(10-8-24)18-21-16(23-28-18)13-5-3-4-6-14(13)19/h3-6H,7-10H2,1-2H3,(H,20,22,26)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426648
PNG
(CHEMBL2326197)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2ccc(F)cc2)c1C
Show InChI InChI=1S/C18H19FN6O2S/c1-11-12(2)27-22-15(11)20-17(26)24-7-9-25(10-8-24)18-21-16(23-28-18)13-3-5-14(19)6-4-13/h3-6H,7-10H2,1-2H3,(H,20,22,26)
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n/an/a 1.30n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426646
PNG
(CHEMBL2326189)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2ccccc2)c1C
Show InChI InChI=1S/C18H20N6O2S/c1-12-13(2)26-21-15(12)19-17(25)23-8-10-24(11-9-23)18-20-16(22-27-18)14-6-4-3-5-7-14/h3-7H,8-11H2,1-2H3,(H,19,21,25)
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n/an/a 1.30n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426647
PNG
(CHEMBL2326196)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(cs2)-c2cccc(F)c2)c1C
Show InChI InChI=1S/C19H20FN5O2S/c1-12-13(2)27-23-17(12)22-18(26)24-6-8-25(9-7-24)19-21-16(11-28-19)14-4-3-5-15(20)10-14/h3-5,10-11H,6-9H2,1-2H3,(H,22,23,26)
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n/an/a 1.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426646
PNG
(CHEMBL2326189)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2ccccc2)c1C
Show InChI InChI=1S/C18H20N6O2S/c1-12-13(2)26-21-15(12)19-17(25)23-8-10-24(11-9-23)18-20-16(22-27-18)14-6-4-3-5-7-14/h3-7H,8-11H2,1-2H3,(H,19,21,25)
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n/an/a 1.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426644
PNG
(CHEMBL2326195)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2cccc(F)c2)c1C
Show InChI InChI=1S/C18H19FN6O2S/c1-11-12(2)27-22-15(11)20-17(26)24-6-8-25(9-7-24)18-21-16(23-28-18)13-4-3-5-14(19)10-13/h3-5,10H,6-9H2,1-2H3,(H,20,22,26)
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n/an/a 2n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426645
PNG
(CHEMBL2326193)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2ccccc2F)c1C
Show InChI InChI=1S/C18H19FN6O2S/c1-11-12(2)27-22-15(11)20-17(26)24-7-9-25(10-8-24)18-21-16(23-28-18)13-5-3-4-6-14(13)19/h3-6H,7-10H2,1-2H3,(H,20,22,26)
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n/an/a 2.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50244993
PNG
(4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridin-3-yl...)
Show SMILES O=C(Nc1cccnc1)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C18H18N6OS/c25-17(20-15-7-4-8-19-13-15)23-9-11-24(12-10-23)18-21-16(22-26-18)14-5-2-1-3-6-14/h1-8,13H,9-12H2,(H,20,25)
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n/an/a 2.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426643
PNG
(CHEMBL2326190)
Show SMILES O=C(Nc1cccnn1)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C17H17N7OS/c25-16(19-14-7-4-8-18-21-14)23-9-11-24(12-10-23)17-20-15(22-26-17)13-5-2-1-3-6-13/h1-8H,9-12H2,(H,19,21,25)
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n/an/a 2.90n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426644
PNG
(CHEMBL2326195)
Show SMILES Cc1onc(NC(=O)N2CCN(CC2)c2nc(ns2)-c2cccc(F)c2)c1C
Show InChI InChI=1S/C18H19FN6O2S/c1-11-12(2)27-22-15(11)20-17(26)24-6-8-25(9-7-24)18-21-16(23-28-18)13-4-3-5-14(19)10-13/h3-5,10H,6-9H2,1-2H3,(H,20,22,26)
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n/an/a 3.20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426643
PNG
(CHEMBL2326190)
Show SMILES O=C(Nc1cccnn1)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C17H17N7OS/c25-16(19-14-7-4-8-18-21-14)23-9-11-24(12-10-23)17-20-15(22-26-17)13-5-2-1-3-6-13/h1-8H,9-12H2,(H,19,21,25)
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n/an/a 3.30n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426641
PNG
(CHEMBL2326181)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2S/c27-20(23-19-16-8-4-5-9-18(16)28-24-19)25-10-12-26(13-11-25)21-22-17(14-29-21)15-6-2-1-3-7-15/h1-9,14H,10-13H2,(H,23,24,27)
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n/an/a 3.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50244993
PNG
(4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridin-3-yl...)
Show SMILES O=C(Nc1cccnc1)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C18H18N6OS/c25-17(20-15-7-4-8-19-13-15)23-9-11-24(12-10-23)18-21-16(22-26-18)14-5-2-1-3-6-14/h1-8,13H,9-12H2,(H,20,25)
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n/an/a 3.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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n/an/a 4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of FAAH (unknown origin)

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426642
PNG
(CHEMBL459152)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O2S/c27-19(21-18-15-8-4-5-9-16(15)28-23-18)25-10-12-26(13-11-25)20-22-17(24-29-20)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,23,27)
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n/an/a 4.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426642
PNG
(CHEMBL459152)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O2S/c27-19(21-18-15-8-4-5-9-16(15)28-23-18)25-10-12-26(13-11-25)20-22-17(24-29-20)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,23,27)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426641
PNG
(CHEMBL2326181)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2S/c27-20(23-19-16-8-4-5-9-18(16)28-24-19)25-10-12-26(13-11-25)21-22-17(14-29-21)15-6-2-1-3-7-15/h1-9,14H,10-13H2,(H,23,24,27)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50244718
PNG
(CHEMBL460273 | JNJ-1661010 | N-phenyl-4-(3-phenyl-...)
Show SMILES O=C(Nc1ccccc1)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM26736
PNG
(CHEMBL509860 | LY2183240 | N,N-dimethyl-5-[(4-phen...)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of FAAH (unknown origin)

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM26740
PNG
(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Show SMILES O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C22H23N3O/c26-22(24-20-7-2-1-3-8-20)25-12-10-17(11-13-25)14-18-15-19-6-4-5-9-21(19)23-16-18/h1-9,15-17H,10-14H2,(H,24,26)
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n/an/a 16n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of FAAH (unknown origin)

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426639
PNG
(CHEMBL2326184)
Show SMILES O=C(Nc1noc2ccccc12)N1CCC(CC1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H20N4O2S/c27-22(24-20-17-8-4-5-9-19(17)28-25-20)26-12-10-16(11-13-26)21-23-18(14-29-21)15-6-2-1-3-7-15/h1-9,14,16H,10-13H2,(H,24,25,27)
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n/an/a 43n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426640
PNG
(CHEMBL2326179)
Show SMILES CN(C)C(=O)Oc1noc2ccc(Cl)cc12
Show InChI InChI=1S/C10H9ClN2O3/c1-13(2)10(14)15-9-7-5-6(11)3-4-8(7)16-12-9/h3-5H,1-2H3
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n/an/a 45n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426638
PNG
(CHEMBL2326191)
Show SMILES O=C(Nc1ccccn1)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C18H18N6OS/c25-17(20-15-8-4-5-9-19-15)23-10-12-24(13-11-23)18-21-16(22-26-18)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,19,20,25)
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n/an/a 48n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426639
PNG
(CHEMBL2326184)
Show SMILES O=C(Nc1noc2ccccc12)N1CCC(CC1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H20N4O2S/c27-22(24-20-17-8-4-5-9-19(17)28-25-20)26-12-10-16(11-13-26)21-23-18(14-29-21)15-6-2-1-3-7-15/h1-9,14,16H,10-13H2,(H,24,25,27)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426637
PNG
(CHEMBL2326180)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1nc(no1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O3/c27-19(21-18-15-8-4-5-9-16(15)28-24-18)25-10-12-26(13-11-25)20-22-17(23-29-20)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,24,27)
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n/an/a 87n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426636
PNG
(CHEMBL2326182)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1cc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H20N4O2S/c27-22(23-21-18-8-4-5-9-19(18)28-24-21)26-12-10-25(11-13-26)20-14-17(15-29-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,23,24,27)
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n/an/a 110n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426638
PNG
(CHEMBL2326191)
Show SMILES O=C(Nc1ccccn1)N1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C18H18N6OS/c25-17(20-15-8-4-5-9-19-15)23-10-12-24(13-11-23)18-21-16(22-26-18)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,19,20,25)
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n/an/a 120n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426637
PNG
(CHEMBL2326180)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1nc(no1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O3/c27-19(21-18-15-8-4-5-9-16(15)28-24-18)25-10-12-26(13-11-25)20-22-17(23-29-20)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,24,27)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426636
PNG
(CHEMBL2326182)
Show SMILES O=C(Nc1noc2ccccc12)N1CCN(CC1)c1cc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H20N4O2S/c27-22(23-21-18-8-4-5-9-19(18)28-24-21)26-12-10-25(11-13-26)20-14-17(15-29-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,23,24,27)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426634
PNG
(CHEMBL2326185)
Show SMILES O=C(NCCNc1nc(ns1)-c1ccccc1)Nc1noc2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c25-17(21-16-13-8-4-5-9-14(13)26-23-16)19-10-11-20-18-22-15(24-27-18)12-6-2-1-3-7-12/h1-9H,10-11H2,(H,20,22,24)(H2,19,21,23,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426633
PNG
(CHEMBL2326186)
Show SMILES O=C(Nc1noc2ccccc12)N1CCCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C21H20N6O2S/c28-20(22-19-16-9-4-5-10-17(16)29-24-19)26-11-6-12-27(14-13-26)21-23-18(25-30-21)15-7-2-1-3-8-15/h1-5,7-10H,6,11-14H2,(H,22,24,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426632
PNG
(CHEMBL2326187)
Show SMILES O=C(NC1CCN(CC1)c1nc(ns1)-c1ccccc1)Nc1noc2ccccc12
Show InChI InChI=1S/C21H20N6O2S/c28-20(23-19-16-8-4-5-9-17(16)29-25-19)22-15-10-12-27(13-11-15)21-24-18(26-30-21)14-6-2-1-3-7-14/h1-9,15H,10-13H2,(H2,22,23,25,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426631
PNG
(CHEMBL2326188)
Show SMILES O=C(Nc1noc2ccccc12)N1CC2CC1CN2c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C21H18N6O2S/c28-20(22-19-16-8-4-5-9-17(16)29-24-19)26-11-15-10-14(26)12-27(15)21-23-18(25-30-21)13-6-2-1-3-7-13/h1-9,14-15H,10-12H2,(H,22,24,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426634
PNG
(CHEMBL2326185)
Show SMILES O=C(NCCNc1nc(ns1)-c1ccccc1)Nc1noc2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c25-17(21-16-13-8-4-5-9-14(13)26-23-16)19-10-11-20-18-22-15(24-27-18)12-6-2-1-3-7-12/h1-9H,10-11H2,(H,20,22,24)(H2,19,21,23,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426633
PNG
(CHEMBL2326186)
Show SMILES O=C(Nc1noc2ccccc12)N1CCCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C21H20N6O2S/c28-20(22-19-16-9-4-5-10-17(16)29-24-19)26-11-6-12-27(14-13-26)21-23-18(25-30-21)15-7-2-1-3-8-15/h1-5,7-10H,6,11-14H2,(H,22,24,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426632
PNG
(CHEMBL2326187)
Show SMILES O=C(NC1CCN(CC1)c1nc(ns1)-c1ccccc1)Nc1noc2ccccc12
Show InChI InChI=1S/C21H20N6O2S/c28-20(23-19-16-8-4-5-9-17(16)29-25-19)22-15-10-12-27(13-11-15)21-24-18(26-30-21)14-6-2-1-3-7-14/h1-9,15H,10-13H2,(H2,22,23,25,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426631
PNG
(CHEMBL2326188)
Show SMILES O=C(Nc1noc2ccccc12)N1CC2CC1CN2c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C21H18N6O2S/c28-20(22-19-16-8-4-5-9-17(16)29-24-19)26-11-15-10-14(26)12-27(15)21-23-18(25-30-21)13-6-2-1-3-7-13/h1-9,14-15H,10-12H2,(H,22,24,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50426635
PNG
(CHEMBL2326183)
Show SMILES O=C(Nc1noc2ccccc12)C1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2S/c27-20(22-19-16-8-4-5-9-17(16)28-24-19)15-10-12-26(13-11-15)21-23-18(25-29-21)14-6-2-1-3-7-14/h1-9,15H,10-13H2,(H,22,24,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50426635
PNG
(CHEMBL2326183)
Show SMILES O=C(Nc1noc2ccccc12)C1CCN(CC1)c1nc(ns1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2S/c27-20(22-19-16-8-4-5-9-17(16)28-24-19)15-10-12-26(13-11-15)21-23-18(25-29-21)14-6-2-1-3-7-14/h1-9,15H,10-13H2,(H,22,24,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH after 30 mins

Bioorg Med Chem 21: 28-41 (2012)


Article DOI: 10.1016/j.bmc.2012.11.006
BindingDB Entry DOI: 10.7270/Q2FN17H6
More data for this
Ligand-Target Pair