Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM25142 ((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29589 (Faridak | LBH-589 | LBH-589B | Panobinostat | US10...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29602 (benzylidenehydrazine derivative, 19) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29593 (benzylidenehydrazine derivative, 10) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29595 (benzylidenehydrazine derivative, 12) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29603 (benzylidenehydrazine derivative, 20) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29596 (benzylidenehydrazine derivative, 13) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29599 (benzylidenehydrazine derivative, 16) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29597 (benzylidenehydrazine derivative, 14) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29594 (benzylidenehydrazine derivative, 11) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29607 (benzylidenehydrazine derivative, 24) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 45 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29598 (benzylidenehydrazine derivative, 15) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29591 (benzylidenehydrazine derivative, 8) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM19149 (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29606 (benzylidenehydrazine derivative, 23) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29600 (benzylidenehydrazine derivative, 17) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29605 (benzylidenehydrazine derivative, 22) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 89 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29601 (benzylidenehydrazine derivative, 18) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29604 (benzylidenehydrazine derivative, 21) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 106 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29592 (benzylidenehydrazine derivative, 9) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM19410 (CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 940 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase (Plasmodium falciparum (isolate 3D7)) | BDBM29590 (1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one | CHEMBL8...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Harvard Medical School | Assay Description Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c... | J Med Chem 52: 2185-7 (2009) Article DOI: 10.1021/jm801654y BindingDB Entry DOI: 10.7270/Q26H4FRD | |||||||||||
More data for this Ligand-Target Pair |