Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31592 (PF-2545920 | US9138494, MP-10 | substituted pyraz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31591 (pyrazole, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31606 (methyl substituted pyrazole, 27) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31594 (substituted pyrazole, 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31605 (methyl substituted pyrazole, 26) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.29 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31596 (substituted pyrazole, 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.41 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31593 (substituted pyrazole, 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.54 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31607 (methyl substituted pyrazole, 28) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31595 (substituted pyrazole, 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.76 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31604 (methyl substituted pyrazole, 25) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.09 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31590 (pyrazole, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 11.5 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31597 (isoxazole, 14) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31600 (pyrazole, 17) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11.9 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31599 (pyrazole, 16) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27.2 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31589 (triaryl imidazole, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31601 (pyrazole, 18) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 258 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31602 (pyrazole, 19) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 371 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31603 (pyrazole, 20) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 413 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM31598 (pyrimidine, 15) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Pfizer | Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c... | J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B | |||||||||||
More data for this Ligand-Target Pair |