Compile Data Set for Download or QSAR

Found 26 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 50044541   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020165 (CHEMBL3288526 | US9914707, I-4) Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12 Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020166 (CHEMBL3288505 | US9914707, I-8) Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C25H20N4O/c1-15-8-11-18(12-9-15)27-25(30)21-6-2-4-16-14-17(10-13-19(16)21)20-5-3-7-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020169 (CHEMBL3288506 | US9914707, I-9) Show SMILES CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C26H22N4O/c1-2-16-6-3-8-19(14-16)28-26(31)22-10-4-7-17-15-18(12-13-20(17)22)21-9-5-11-23-24(21)25(27)30-29-23/h3-15H,2H2,1H3,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020193 (CHEMBL3288515 | US9914707, I-14) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(F)cc(F)c3)c12 Show InChI InChI=1S/C24H16F2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020194 (CHEMBL3288504 | US9914707, I-7) Show SMILES Cc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C25H20N4O/c1-15-5-2-7-18(13-15)27-25(30)21-9-3-6-16-14-17(11-12-19(16)21)20-8-4-10-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020195 (CHEMBL3288512 | US9914707, I-11) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c12 Show InChI InChI=1S/C24H17FN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020223 (CHEMBL3288514 | US9914707, I-13) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3F)c12 Show InChI InChI=1S/C24H16F2N4O/c25-15-8-10-20(19(26)12-15)28-24(31)18-5-1-3-13-11-14(7-9-16(13)18)17-4-2-6-21-22(17)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020225 (CHEMBL3288523 | US9914707, I-27) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12 Show InChI InChI=1S/C21H18N4O/c22-20-19-16(4-2-6-18(19)24-25-20)13-7-10-15-12(11-13)3-1-5-17(15)21(26)23-14-8-9-14/h1-7,10-11,14H,8-9H2,(H,23,26)(H3,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020227 (CHEMBL3288516 | US9914707, I-15) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c12 Show InChI InChI=1S/C24H17ClN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020228 (CHEMBL3288509 | US9914707, I-22) Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c(F)c1 Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-21(20(26)12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-22-23(18)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020170 (CHEMBL3288502 | US9914707, I-1) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12 Show InChI InChI=1S/C24H18N4O/c25-23-22-19(9-5-11-21(22)27-28-23)16-12-13-18-15(14-16)6-4-10-20(18)24(29)26-17-7-2-1-3-8-17/h1-14H,(H,26,29)(H3,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020230 (CHEMBL3288517 | US9914707, I-16) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Br)c3)c12 Show InChI InChI=1S/C24H17BrN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020233 (CHEMBL3288510 | US9914707, I-23) Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1F Show InChI InChI=1S/C25H19FN4O/c1-14-8-10-17(13-21(14)26)28-25(31)20-6-2-4-15-12-16(9-11-18(15)20)19-5-3-7-22-23(19)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020234 (CHEMBL3288520 | US9914707, I-24) Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1 Show InChI InChI=1S/C22H17N5O2/c1-12-10-19(27-29-12)24-22(28)17-6-2-4-13-11-14(8-9-15(13)17)16-5-3-7-18-20(16)21(23)26-25-18/h2-11H,1H3,(H3,23,25,26)(H,24,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020229 (CHEMBL3288508 | US9914707, I-20) Show SMILES Cc1ccc(F)c(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-20(26)22(12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-21-23(18)24(27)30-29-21/h2-13H,1H3,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020235 (CHEMBL3288511 | US9914707, I-10) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3F)c12 Show InChI InChI=1S/C24H17FN4O/c25-19-8-1-2-9-20(19)27-24(30)18-7-3-5-14-13-15(11-12-16(14)18)17-6-4-10-21-22(17)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020238 (CHEMBL3288522 | US9914707, I-26) Show SMILES CCNC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12 Show InChI InChI=1S/C20H18N4O/c1-2-22-20(25)16-7-3-5-12-11-13(9-10-14(12)16)15-6-4-8-17-18(15)19(21)24-23-17/h3-11H,2H2,1H3,(H,22,25)(H3,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020249 (CHEMBL3288527) Show SMILES Nc1n[nH]c2cccc(-c3ccc4N(CCOc4c3)C(=O)Nc3ccccc3)c12 Show InChI InChI=1S/C22H19N5O2/c23-21-20-16(7-4-8-17(20)25-26-21)14-9-10-18-19(13-14)29-12-11-27(18)22(28)24-15-5-2-1-3-6-15/h1-10,13H,11-12H2,(H,24,28)(H3,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020245 (CHEMBL3288513 | US9914707, I-12) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3)c12 Show InChI InChI=1S/C24H17FN4O/c25-16-8-10-17(11-9-16)27-24(30)20-5-1-3-14-13-15(7-12-18(14)20)19-4-2-6-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020239 (CHEMBL3288525 | US9914707, I-3) Show SMILES Nc1nccc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12 Show InChI InChI=1S/C24H17N3OS/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020236 (CHEMBL3288524 | US9914707, I-2) Show SMILES Nc1nccc2occ(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12 Show InChI InChI=1S/C24H17N3O2/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020248 (CHEMBL3288503 | US9914707, I-6) Show SMILES Cc1ccccc1NC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12 Show InChI InChI=1S/C25H20N4O/c1-15-6-2-3-10-21(15)27-25(30)20-9-4-7-16-14-17(12-13-18(16)20)19-8-5-11-22-23(19)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020242 (CHEMBL3288507 | US9914707, I-19) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12 Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)16-5-2-6-17(13-16)30-24(33)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(29)32-31-21/h1-13H,(H,30,33)(H3,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020167 (CHEMBL3288518 | US9914707, I-17) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c12 Show InChI InChI=1S/C24H16Cl2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50020210 (CHEMBL3288519 | US9914707, I-18) Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Br)cc(Br)c3)c12 Show InChI InChI=1S/C24H16Br2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...				ACS Med Chem Lett 5: 592-7 (2014) Article DOI: 10.1021/ml5000417 BindingDB Entry DOI: 10.7270/Q2TB18GG
					More data for this Ligand-Target Pair