Found 39 hits Enz. Inhib. hit(s) with all data for assayid = 4 entry = 50047188 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155671
(CHEMBL3780239)Show SMILES COc1ccc(F)cc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H21FN6O/c1-30-20-8-7-16(23)13-19(20)27-9-11-28(12-10-27)21-18-14-26-29(22(18)25-15-24-21)17-5-3-2-4-6-17/h2-8,13-15H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155656
(CHEMBL3781331)Show SMILES COc1ccc(cc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1)C(N)=O Show InChI InChI=1S/C23H23N7O2/c1-32-20-8-7-16(21(24)31)13-19(20)28-9-11-29(12-10-28)22-18-14-27-30(23(18)26-15-25-22)17-5-3-2-4-6-17/h2-8,13-15H,9-12H2,1H3,(H2,24,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155715
(CHEMBL3781149)Show SMILES Oc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C26H28Br2ClN5O/c27-19-12-18-6-5-17-13-20(29)14-21(28)23(17)25(24(18)32-15-19)34-10-2-1-4-22(34)26(35)31-7-3-9-33-11-8-30-16-33/h8,11-16,22,25H,1-7,9-10H2,(H,31,35)/t22-,25?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155751
(CHEMBL3780460)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1cc(F)cc(F)c1 Show InChI InChI=1S/C22H20F2N6O/c1-31-20-5-3-2-4-19(20)28-6-8-29(9-7-28)21-18-13-27-30(22(18)26-14-25-21)17-11-15(23)10-16(24)12-17/h2-5,10-14H,6-9H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155585
(CHEMBL3780372)Show SMILES COc1ccncc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C21H21N7O/c1-29-19-7-8-22-14-18(19)26-9-11-27(12-10-26)20-17-13-25-28(21(17)24-15-23-20)16-5-3-2-4-6-16/h2-8,13-15H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155673
(CHEMBL3780972)Show SMILES COc1cc(F)ccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H21FN6O/c1-30-20-13-16(23)7-8-19(20)27-9-11-28(12-10-27)21-18-14-26-29(22(18)25-15-24-21)17-5-3-2-4-6-17/h2-8,13-15H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155747
(CHEMBL3781194)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-5-3-2-4-20(21)28-10-12-29(13-11-28)22-19-15-27-30(23(19)26-16-25-22)18-8-6-17(14-24)7-9-18/h2-9,15-16H,10-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155746
(CHEMBL3781151)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccc(F)cc1 Show InChI InChI=1S/C22H21FN6O/c1-30-20-5-3-2-4-19(20)27-10-12-28(13-11-27)21-18-14-26-29(22(18)25-15-24-21)17-8-6-16(23)7-9-17/h2-9,14-15H,10-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155670
(CHEMBL3780144)Show SMILES COc1ccc(cc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-8-7-17(14-24)13-20(21)28-9-11-29(12-10-28)22-19-15-27-30(23(19)26-16-25-22)18-5-3-2-4-6-18/h2-8,13,15-16H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155714
(CHEMBL3781157)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C26H25Br2ClN4O/c27-19-10-18-7-6-17-11-20(29)12-21(28)23(17)25(24(18)31-15-19)33-9-2-1-5-22(33)26(34)32-14-16-4-3-8-30-13-16/h3-4,8,10-13,15,22,25H,1-2,5-7,9,14H2,(H,32,34)/t22-,25?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155753
(CHEMBL3780470)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1cc(F)ccc1OC Show InChI InChI=1S/C23H23FN6O2/c1-31-20-6-4-3-5-18(20)28-9-11-29(12-10-28)22-17-14-27-30(23(17)26-15-25-22)19-13-16(24)7-8-21(19)32-2/h3-8,13-15H,9-12H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155677
(CHEMBL3780765)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1cccc(c1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-8-3-2-7-20(21)28-9-11-29(12-10-28)22-19-15-27-30(23(19)26-16-25-22)18-6-4-5-17(13-18)14-24/h2-8,13,15-16H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155680
(CHEMBL3780717)Show SMILES N#Cc1cccc(c1)N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H19N7/c23-14-17-5-4-8-19(13-17)27-9-11-28(12-10-27)21-20-15-26-29(22(20)25-16-24-21)18-6-2-1-3-7-18/h1-8,13,15-16H,9-12H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155752
(CHEMBL3780527)Show InChI InChI=1S/C21H26N6O/c1-28-19-9-5-4-8-18(19)25-10-12-26(13-11-25)20-17-14-24-27(16-6-2-3-7-16)21(17)23-15-22-20/h4-5,8-9,14-16H,2-3,6-7,10-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155745
(CHEMBL3780043)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1cccc(C)c1 Show InChI InChI=1S/C23H24N6O/c1-17-6-5-7-18(14-17)29-23-19(15-26-29)22(24-16-25-23)28-12-10-27(11-13-28)20-8-3-4-9-21(20)30-2/h3-9,14-16H,10-13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155583
(CHEMBL3781835)Show SMILES COc1cccnc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C21H21N7O/c1-29-18-8-5-9-22-21(18)27-12-10-26(11-13-27)19-17-14-25-28(20(17)24-15-23-19)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155748
(CHEMBL3781535)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ncccc1F Show InChI InChI=1S/C21H20FN7O/c1-30-18-7-3-2-6-17(18)27-9-11-28(12-10-27)19-15-13-26-29(20(15)25-14-24-19)21-16(22)5-4-8-23-21/h2-8,13-14H,9-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155750
(CHEMBL3780595)Show SMILES COc1ccc(cn1)-n1ncc2c(ncnc12)N1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C22H23N7O2/c1-30-19-6-4-3-5-18(19)27-9-11-28(12-10-27)21-17-14-26-29(22(17)25-15-24-21)16-7-8-20(31-2)23-13-16/h3-8,13-15H,9-12H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155591
(CHEMBL3781654)Show SMILES COc1cccc(F)c1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H21FN6O/c1-30-19-9-5-8-18(23)20(19)27-10-12-28(13-11-27)21-17-14-26-29(22(17)25-15-24-21)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155672
(CHEMBL3781183)Show SMILES COc1cc(ccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-13-17(14-24)7-8-20(21)28-9-11-29(12-10-28)22-19-15-27-30(23(19)26-16-25-22)18-5-3-2-4-6-18/h2-8,13,15-16H,9-12H2,1H3 | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155681
(CHEMBL3781827)Show SMILES COc1cccc(c1)N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H22N6O/c1-29-19-9-5-8-18(14-19)26-10-12-27(13-11-26)21-20-15-25-28(22(20)24-16-23-21)17-6-3-2-4-7-17/h2-9,14-16H,10-13H2,1H3 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155587
(CHEMBL3780764)Show SMILES COc1ncccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C21H21N7O/c1-29-21-18(8-5-9-22-21)26-10-12-27(13-11-26)19-17-14-25-28(20(17)24-15-23-19)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155679
(CHEMBL3780772)Show SMILES COc1cccc(c1)-n1ncc2c(ncnc12)N1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C23H24N6O2/c1-30-18-7-5-6-17(14-18)29-23-19(15-26-29)22(24-16-25-23)28-12-10-27(11-13-28)20-8-3-4-9-21(20)31-2/h3-9,14-16H,10-13H2,1-2H3 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155749
(CHEMBL3781625)Show SMILES COc1ccc(cc1)-n1ncc2c(ncnc12)N1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C23H24N6O2/c1-30-18-9-7-17(8-10-18)29-23-19(15-26-29)22(24-16-25-23)28-13-11-27(12-14-28)20-5-3-4-6-21(20)31-2/h3-10,15-16H,11-14H2,1-2H3 | PDB
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| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155586
(CHEMBL3781847)Show SMILES COc1cnccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C21H21N7O/c1-29-19-14-22-8-7-18(19)26-9-11-27(12-10-26)20-17-13-25-28(21(17)24-15-23-20)16-5-3-2-4-6-16/h2-8,13-15H,9-12H2,1H3 | PDB
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| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155674
(CHEMBL3780459)Show SMILES Fc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C21H19FN6/c22-18-8-4-5-9-19(18)26-10-12-27(13-11-26)20-17-14-25-28(21(17)24-15-23-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2 | PDB
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Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155682
(CHEMBL3781994)Show SMILES Fc1cccc(c1)N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C21H19FN6/c22-16-5-4-8-18(13-16)26-9-11-27(12-10-26)20-19-14-25-28(21(19)24-15-23-20)17-6-2-1-3-7-17/h1-8,13-15H,9-12H2 | PDB
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| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155754
(CHEMBL3780729)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)C(C)c1ccccc1 Show InChI InChI=1S/C24H26N6O/c1-18(19-8-4-3-5-9-19)30-24-20(16-27-30)23(25-17-26-24)29-14-12-28(13-15-29)21-10-6-7-11-22(21)31-2/h3-11,16-18H,12-15H2,1-2H3 | PDB
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| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155755
(CHEMBL3780349)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccn1 Show InChI InChI=1S/C21H21N7O/c1-29-18-7-3-2-6-17(18)26-10-12-27(13-11-26)20-16-14-25-28(21(16)24-15-23-20)19-8-4-5-9-22-19/h2-9,14-15H,10-13H2,1H3 | PDB
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| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155756
(CHEMBL3781797)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1cccnc1 Show InChI InChI=1S/C21H21N7O/c1-29-19-7-3-2-6-18(19)26-9-11-27(12-10-26)20-17-14-25-28(21(17)24-15-23-20)16-5-4-8-22-13-16/h2-8,13-15H,9-12H2,1H3 | PDB
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| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155757
(CHEMBL3780845)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccncc1 Show InChI InChI=1S/C21H21N7O/c1-29-19-5-3-2-4-18(19)26-10-12-27(13-11-26)20-17-14-25-28(21(17)24-15-23-20)16-6-8-22-9-7-16/h2-9,14-15H,10-13H2,1H3 | PDB
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155675
(CHEMBL3781447)Show SMILES COc1c(cccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1)C#N Show InChI InChI=1S/C23H21N7O/c1-31-21-17(14-24)6-5-9-20(21)28-10-12-29(13-11-28)22-19-15-27-30(23(19)26-16-25-22)18-7-3-2-4-8-18/h2-9,15-16H,10-13H2,1H3 | PDB
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155584
(CHEMBL1551510)Show SMILES COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccc(C)cc1 Show InChI InChI=1S/C23H24N6O/c1-17-7-9-18(10-8-17)29-23-19(15-26-29)22(24-16-25-23)28-13-11-27(12-14-28)20-5-3-4-6-21(20)30-2/h3-10,15-16H,11-14H2,1-2H3 | PDB
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| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155678
(CHEMBL3780534)Show SMILES COc1ccc(cc1)N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H22N6O/c1-29-19-9-7-17(8-10-19)26-11-13-27(14-12-26)21-20-15-25-28(22(20)24-16-23-21)18-5-3-2-4-6-18/h2-10,15-16H,11-14H2,1H3 | PDB
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| n/a | n/a | 1.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155684
(CHEMBL3781094)Show SMILES N#Cc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H19N7/c23-14-17-6-4-5-9-20(17)27-10-12-28(13-11-27)21-19-15-26-29(22(19)25-16-24-21)18-7-2-1-3-8-18/h1-9,15-16H,10-13H2 | PDB
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| n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155676
(CHEMBL3781161)Show SMILES COc1c(F)cccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H21FN6O/c1-30-20-18(23)8-5-9-19(20)27-10-12-28(13-11-27)21-17-14-26-29(22(17)25-15-24-21)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3 | PDB
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155685
(CHEMBL3780403)Show SMILES FC(F)(F)Oc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H19F3N6O/c23-22(24,25)32-19-9-5-4-8-18(19)29-10-12-30(13-11-29)20-17-14-28-31(21(17)27-15-26-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155683
(CHEMBL3781573)Show SMILES FC(F)(F)c1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C22H19F3N6/c23-22(24,25)18-8-4-5-9-19(18)29-10-12-30(13-11-29)20-17-14-28-31(21(17)27-15-26-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
More data for this
Ligand-Target Pair | |
Solute carrier family 2, facilitated glucose transporter member 1
(Homo sapiens (Human)) | BDBM50155582
(CHEMBL3781086)Show SMILES OC1CCCCC1N1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1 Show InChI InChI=1S/C21H26N6O/c28-19-9-5-4-8-18(19)25-10-12-26(13-11-25)20-17-14-24-27(21(17)23-15-22-20)16-6-2-1-3-7-16/h1-3,6-7,14-15,18-19,28H,4-5,8-13H2 | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human GLUT1 expressed in DLD1 cells assessed as ATP production co-incubated with 100 mM glucose for 16 hrs by CellTiter-Glo assay in pr... |
Bioorg Med Chem Lett 26: 1732-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.050
BindingDB Entry DOI: 10.7270/Q2639RM3 |
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Ligand-Target Pair | |
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