Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM203919 (US9242988, 1) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ... | US Patent US9242988 (2016) BindingDB Entry DOI: 10.7270/Q22B8WVP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM35554 (thiophene scaffold, 21) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.5 | 23 |
IRBM-MRL Rome | Assay Description Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi... | J Med Chem 52: 5217-27 (2009) Article DOI: 10.1021/jm900517t BindingDB Entry DOI: 10.7270/Q2X928P4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM50081634 (CHEMBL3422106) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b BK NS5B expressed in Escherichia coli BL21 (DE3) after 1 hr | Eur J Med Chem 94: 218-28 (2015) Article DOI: 10.1016/j.ejmech.2015.03.012 BindingDB Entry DOI: 10.7270/Q2KD20N9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30466 (benzothiazine-containing analog, 4a) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <10 | n/a | 1.5 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4628-32 (2008) Article DOI: 10.1016/j.bmcl.2008.07.014 BindingDB Entry DOI: 10.7270/Q2T43RFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30544 (5,6-Dihydro-1H-pyridin-2-one, 4ap) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 55 | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30543 (5,6-Dihydro-1H-pyridin-2-one, 4ao) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 45 | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30542 (5,6-Dihydro-1H-pyridin-2-one, 4an) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 34 | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30541 (5,6-Dihydro-1H-pyridin-2-one, 4am) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 160 | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30538 (5,6-Dihydro-1H-pyridin-2-one, 4aj) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 9 | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30537 (5,6-Dihydro-1H-pyridin-2-one, 4ai) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 32 | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30452 (Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | <10 | n/a | 34 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30418 (BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 12 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30530 (5,6-Dihydro-1H-pyridin-2-one, 4ad) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 16 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30516 (5,6-Dihydro-1H-pyridin-2-one, 4p) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 60 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30508 (5,6-Dihydro-1H-pyridin-2-one, 4h) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 24 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30504 (5,6-Dihydro-1H-pyridin-2-one, 4d) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 23 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30490 (1,1-dioxoisothiazole analog., 34) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | <10 | n/a | 70 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4181-5 (2008) Article DOI: 10.1016/j.bmcl.2008.05.083 BindingDB Entry DOI: 10.7270/Q2PC30Q5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30458 (benzothiazine-containing analog, 3b) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <10 | n/a | 2.70 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4628-32 (2008) Article DOI: 10.1016/j.bmcl.2008.07.014 BindingDB Entry DOI: 10.7270/Q2T43RFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30407 (5-hydroxy- 3(2H)-pyridazinone, 2 | BMCL185002 Comp...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | <10 | n/a | 5 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 3616-21 (2008) Article DOI: 10.1016/j.bmcl.2008.04.066 BindingDB Entry DOI: 10.7270/Q26D5R9N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30410 (pyrrolo[1,2-b]pyridazin-2-one analog., 3c) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | <10 | n/a | 8.5 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 3616-21 (2008) Article DOI: 10.1016/j.bmcl.2008.04.066 BindingDB Entry DOI: 10.7270/Q26D5R9N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30415 (pyrrolo[1,2-b]pyridazin-2-one analog., 3h) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 5 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 3616-21 (2008) Article DOI: 10.1016/j.bmcl.2008.04.066 BindingDB Entry DOI: 10.7270/Q26D5R9N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30418 (BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 12 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 3616-21 (2008) Article DOI: 10.1016/j.bmcl.2008.04.066 BindingDB Entry DOI: 10.7270/Q26D5R9N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30407 (5-hydroxy- 3(2H)-pyridazinone, 2 | BMCL185002 Comp...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | <10 | n/a | 5 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30448 (benzothiazine-containing analog, 3a | pyridazin-3-...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | <10 | n/a | 11 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30418 (BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 12 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30450 (hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4a) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | <10 | n/a | 190 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30452 (Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | <10 | n/a | 34 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30448 (benzothiazine-containing analog, 3a | pyridazin-3-...) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | <10 | n/a | 1.10 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4628-32 (2008) Article DOI: 10.1016/j.bmcl.2008.07.014 BindingDB Entry DOI: 10.7270/Q2T43RFH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM50081636 (CHEMBL3422108) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b BK NS5B expressed in Escherichia coli BL21 (DE3) after 1 hr | Eur J Med Chem 94: 218-28 (2015) Article DOI: 10.1016/j.ejmech.2015.03.012 BindingDB Entry DOI: 10.7270/Q2KD20N9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30451 (hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4b) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | 160 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM35570 (1H-benzo[de]isoquinoline-1,3(2H)-dione, 19) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <14 | n/a | 2.20E+3 | n/a | n/a | 7.5 | 23 |
IRBM-MRL Rome | Assay Description Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi... | J Med Chem 52: 5217-27 (2009) Article DOI: 10.1021/jm900517t BindingDB Entry DOI: 10.7270/Q2X928P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30460 (benzothiazine-containing analog, 3d) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | 3.5 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4628-32 (2008) Article DOI: 10.1016/j.bmcl.2008.07.014 BindingDB Entry DOI: 10.7270/Q2T43RFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30456 (hexahydro-1H-pyrido[1,2-b]pyridazin-2-one, 4g) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | 300 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30495 (1,1-dioxoisothiazole analog., 39) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | 350 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4181-5 (2008) Article DOI: 10.1016/j.bmcl.2008.05.083 BindingDB Entry DOI: 10.7270/Q2PC30Q5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30461 (benzothiazine-containing analog, 3e) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | 36 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4628-32 (2008) Article DOI: 10.1016/j.bmcl.2008.07.014 BindingDB Entry DOI: 10.7270/Q2T43RFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM35563 (1H-benzo[de]isoquinoline-1,3(2H)-dione, 12) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | 3.80E+3 | n/a | n/a | 7.5 | 23 |
IRBM-MRL Rome | Assay Description Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi... | J Med Chem 52: 5217-27 (2009) Article DOI: 10.1021/jm900517t BindingDB Entry DOI: 10.7270/Q2X928P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM50081635 (CHEMBL3422107) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b BK NS5B expressed in Escherichia coli BL21 (DE3) after 1 hr | Eur J Med Chem 94: 218-28 (2015) Article DOI: 10.1016/j.ejmech.2015.03.012 BindingDB Entry DOI: 10.7270/Q2KD20N9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM35553 (1H-benzo[de]isoquinoline-1,3(2H)-dione, 1) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 20 | n/a | 7.10E+3 | n/a | n/a | 7.5 | 23 |
IRBM-MRL Rome | Assay Description Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi... | J Med Chem 52: 5217-27 (2009) Article DOI: 10.1021/jm900517t BindingDB Entry DOI: 10.7270/Q2X928P4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30523 (5,6-Dihydro-1H-pyridin-2-one, 4w) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | 170 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30505 (5,6-Dihydro-1H-pyridin-2-one, 4e) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | 150 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30491 (1,1-dioxoisothiazole analog., 35) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | 90 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4181-5 (2008) Article DOI: 10.1016/j.bmcl.2008.05.083 BindingDB Entry DOI: 10.7270/Q2PC30Q5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM35560 (1H-benzo[de]isoquinoline-1,3(2H)-dione, 9) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.5 | 23 |
IRBM-MRL Rome | Assay Description Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi... | J Med Chem 52: 5217-27 (2009) Article DOI: 10.1021/jm900517t BindingDB Entry DOI: 10.7270/Q2X928P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30419 (pyrrolo[1,2-b]pyridazin-2-one analog., 3l) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | 22 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 3616-21 (2008) Article DOI: 10.1016/j.bmcl.2008.04.066 BindingDB Entry DOI: 10.7270/Q26D5R9N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30411 (pyrrolo[1,2-b]pyridazin-2-one analog., 3d) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 27 | n/a | 19 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 3616-21 (2008) Article DOI: 10.1016/j.bmcl.2008.04.066 BindingDB Entry DOI: 10.7270/Q26D5R9N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30467 (benzothiazine-containing analog, 4b) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | 13 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 4628-32 (2008) Article DOI: 10.1016/j.bmcl.2008.07.014 BindingDB Entry DOI: 10.7270/Q2T43RFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30534 (5,6-Dihydro-1H-pyridin-2-one, 4af) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 27 | n/a | 120 | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30522 (5,6-Dihydro-1H-pyridin-2-one, 4v) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | 880 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM35558 (1H-benzo[de]isoquinoline-1,3(2H)-dione, 7) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | 7.5 | 23 |
IRBM-MRL Rome | Assay Description Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi... | J Med Chem 52: 5217-27 (2009) Article DOI: 10.1021/jm900517t BindingDB Entry DOI: 10.7270/Q2X928P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM35569 (1H-benzo[de]isoquinoline-1,3(2H)-dione, 18) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | 1.90E+3 | n/a | n/a | 7.5 | 23 |
IRBM-MRL Rome | Assay Description Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi... | J Med Chem 52: 5217-27 (2009) Article DOI: 10.1021/jm900517t BindingDB Entry DOI: 10.7270/Q2X928P4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30531 (5,6-Dihydro-1H-pyridin-2-one, 4ae) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 31 | n/a | 220 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0 | |||||||||||
More data for this Ligand-Target Pair |
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