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PubMed code 11527737

Compile data set for download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 32n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103948
PNG
(2-Isopropoxy-3-[4-(5-p-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(C)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-6-10-18(11-7-16)27-13-20-23-21(29-24-20)17-8-4-15(3)5-9-17/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 16n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103950
PNG
(2-Isopropoxy-3-{4-[5-(4-isopropyl-phenyl)-[1,2,4]o...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(C)C)cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O5/c1-15(2)18-7-9-19(10-8-18)23-25-22(26-31-23)14-29-20-11-5-17(6-12-20)13-21(24(27)28)30-16(3)4/h5-12,15-16,21H,13-14H2,1-4H3,(H,27,28)
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n/an/an/an/a 13n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103939
PNG
(2-Isopropoxy-3-[4-(5-o-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccccc2C)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-8-10-17(11-9-16)27-13-20-23-21(29-24-20)18-7-5-4-6-15(18)3/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103952
PNG
(3-(4-((5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21FN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103958
PNG
(3-(4-((5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cccc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C21H21FN2O5/c1-13(2)28-18(21(25)26)10-14-6-8-17(9-7-14)27-12-19-23-20(29-24-19)15-4-3-5-16(22)11-15/h3-9,11,13,18H,10,12H2,1-2H3,(H,25,26)
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n/an/an/an/a 7.90E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103955
PNG
(3-(4-((5-(4-tert-butylphenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(C)(C)C)cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O5/c1-16(2)31-21(24(28)29)14-17-6-12-20(13-7-17)30-15-22-26-23(32-27-22)18-8-10-19(11-9-18)25(3,4)5/h6-13,16,21H,14-15H2,1-5H3,(H,28,29)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103951
PNG
(3-(4-(2-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccc(F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H23FN2O5/c1-14(2)29-19(22(26)27)13-15-3-9-18(10-4-15)28-12-11-20-24-21(30-25-20)16-5-7-17(23)8-6-16/h3-10,14,19H,11-13H2,1-2H3,(H,26,27)
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n/an/an/an/a 790n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103945
PNG
(2-Isopropoxy-3-(4-{2-[5-(2-trifluoromethyl-phenyl)...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccccc2C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H23F3N2O5/c1-14(2)32-19(22(29)30)13-15-7-9-16(10-8-15)31-12-11-20-27-21(33-28-20)17-5-3-4-6-18(17)23(24,25)26/h3-10,14,19H,11-13H2,1-2H3,(H,29,30)
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n/an/an/an/a 2.50E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human Peroxisome proliferator activated receptor delta in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103945
PNG
(2-Isopropoxy-3-(4-{2-[5-(2-trifluoromethyl-phenyl)...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccccc2C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H23F3N2O5/c1-14(2)32-19(22(29)30)13-15-7-9-16(10-8-15)31-12-11-20-27-21(33-28-20)17-5-3-4-6-18(17)23(24,25)26/h3-10,14,19H,11-13H2,1-2H3,(H,29,30)
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n/an/an/an/a 400n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human Peroxisome proliferator activated receptor alpha in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103951
PNG
(3-(4-(2-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccc(F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H23FN2O5/c1-14(2)29-19(22(26)27)13-15-3-9-18(10-4-15)28-12-11-20-24-21(30-25-20)16-5-7-17(23)8-6-16/h3-10,14,19H,11-13H2,1-2H3,(H,26,27)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103953
PNG
(3-(4-(2-(5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(Cl)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O5/c1-14(2)29-19(22(26)27)12-15-6-8-18(9-7-15)28-11-10-20-24-21(30-25-20)16-4-3-5-17(23)13-16/h3-9,13-14,19H,10-12H2,1-2H3,(H,26,27)
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n/an/an/an/a 320n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103950
PNG
(2-Isopropoxy-3-{4-[5-(4-isopropyl-phenyl)-[1,2,4]o...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(C)C)cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O5/c1-15(2)18-7-9-19(10-8-18)23-25-22(26-31-23)14-29-20-11-5-17(6-12-20)13-21(24(27)28)30-16(3)4/h5-12,15-16,21H,13-14H2,1-4H3,(H,27,28)
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n/an/an/an/a 4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103949
PNG
(2-Isopropoxy-3-{4-[5-(4-trifluoromethyl-phenyl)-[1...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C22H21F3N2O5/c1-13(2)31-18(21(28)29)11-14-3-9-17(10-4-14)30-12-19-26-20(32-27-19)15-5-7-16(8-6-15)22(23,24)25/h3-10,13,18H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 25n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103938
PNG
(2-Isopropoxy-3-[4-(5-phenyl-[1,2,4]oxadiazol-3-ylm...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C21H22N2O5/c1-14(2)27-18(21(24)25)12-15-8-10-17(11-9-15)26-13-19-22-20(28-23-19)16-6-4-3-5-7-16/h3-11,14,18H,12-13H2,1-2H3,(H,24,25)
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103941
PNG
(2-Isopropoxy-3-(4-{2-[5-(3-trifluoromethyl-phenyl)...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(c2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H23F3N2O5/c1-14(2)32-19(22(29)30)12-15-6-8-18(9-7-15)31-11-10-20-27-21(33-28-20)16-4-3-5-17(13-16)23(24,25)26/h3-9,13-14,19H,10-12H2,1-2H3,(H,29,30)
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n/an/an/an/a 500n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103943
PNG
(3-(4-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 500n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 32n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human peroxisome proliferator activated receptor gamma in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 320n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human peroxisome proliferator activated receptor gamma in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 6n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human Peroxisome proliferator activated receptor alpha in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human Peroxisome proliferator activated receptor alpha in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103943
PNG
(3-(4-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 20n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 630n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103941
PNG
(2-Isopropoxy-3-(4-{2-[5-(3-trifluoromethyl-phenyl)...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(c2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H23F3N2O5/c1-14(2)32-19(22(29)30)12-15-6-8-18(9-7-15)31-11-10-20-27-21(33-28-20)16-4-3-5-17(13-16)23(24,25)26/h3-9,13-14,19H,10-12H2,1-2H3,(H,29,30)
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n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103942
PNG
(3-(4-((5-cyclohexyl-1,2,4-oxadiazol-3-yl)methoxy)p...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)C2CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C21H28N2O5/c1-14(2)27-18(21(24)25)12-15-8-10-17(11-9-15)26-13-19-22-20(28-23-19)16-6-4-3-5-7-16/h8-11,14,16,18H,3-7,12-13H2,1-2H3,(H,24,25)
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n/an/an/an/a 240n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103944
PNG
(3-(4-(2-(5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O5/c1-14(2)29-19(22(26)27)13-15-3-9-18(10-4-15)28-12-11-20-24-21(30-25-20)16-5-7-17(23)8-6-16/h3-10,14,19H,11-13H2,1-2H3,(H,26,27)
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n/an/an/an/a 25n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103949
PNG
(2-Isopropoxy-3-{4-[5-(4-trifluoromethyl-phenyl)-[1...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C22H21F3N2O5/c1-13(2)31-18(21(28)29)11-14-3-9-17(10-4-14)30-12-19-26-20(32-27-19)15-5-7-16(8-6-15)22(23,24)25/h3-10,13,18H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 32n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103956
PNG
(2-Isopropoxy-3-[4-(5-m-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cccc(C)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-7-9-18(10-8-16)27-13-20-23-21(29-24-20)17-6-4-5-15(3)11-17/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 79n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103952
PNG
(3-(4-((5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21FN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 160n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103958
PNG
(3-(4-((5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cccc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C21H21FN2O5/c1-13(2)28-18(21(25)26)10-14-6-8-17(9-7-14)27-12-19-23-20(29-24-19)15-4-3-5-16(22)11-15/h3-9,11,13,18H,10,12H2,1-2H3,(H,25,26)
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n/an/an/an/a 79n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103956
PNG
(2-Isopropoxy-3-[4-(5-m-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cccc(C)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-7-9-18(10-8-16)27-13-20-23-21(29-24-20)17-6-4-5-15(3)11-17/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 1.60E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103947
PNG
(3-(4-((5-(4-bromophenyl)-1,2,4-oxadiazol-3-yl)meth...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(Br)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21BrN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 32n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103939
PNG
(2-Isopropoxy-3-[4-(5-o-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccccc2C)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-8-10-17(11-9-16)27-13-20-23-21(29-24-20)18-7-5-4-6-15(18)3/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 1.60E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103943
PNG
(3-(4-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21ClN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 13n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103946
PNG
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27)
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n/an/an/an/a 160n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103948
PNG
(2-Isopropoxy-3-[4-(5-p-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(C)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-6-10-18(11-7-16)27-13-20-23-21(29-24-20)17-8-4-15(3)5-9-17/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 2.50E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103948
PNG
(2-Isopropoxy-3-[4-(5-p-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(C)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-6-10-18(11-7-16)27-13-20-23-21(29-24-20)17-8-4-15(3)5-9-17/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 25n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103954
PNG
(2-Isopropoxy-3-{4-[2-(5-phenyl-[1,2,4]oxadiazol-3-...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-15(2)28-19(22(25)26)14-16-8-10-18(11-9-16)27-13-12-20-23-21(29-24-20)17-6-4-3-5-7-17/h3-11,15,19H,12-14H2,1-2H3,(H,25,26)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103960
PNG
(3-(4-(2-(5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H23FN2O5/c1-14(2)29-19(22(26)27)12-15-6-8-18(9-7-15)28-11-10-20-24-21(30-25-20)16-4-3-5-17(23)13-16/h3-9,13-14,19H,10-12H2,1-2H3,(H,26,27)
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n/an/an/an/a 4.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103958
PNG
(3-(4-((5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cccc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C21H21FN2O5/c1-13(2)28-18(21(25)26)10-14-6-8-17(9-7-14)27-12-19-23-20(29-24-19)15-4-3-5-16(22)11-15/h3-9,11,13,18H,10,12H2,1-2H3,(H,25,26)
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103939
PNG
(2-Isopropoxy-3-[4-(5-o-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccccc2C)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-8-10-17(11-9-16)27-13-20-23-21(29-24-20)18-7-5-4-6-15(18)3/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103938
PNG
(2-Isopropoxy-3-[4-(5-phenyl-[1,2,4]oxadiazol-3-ylm...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C21H22N2O5/c1-14(2)27-18(21(24)25)12-15-8-10-17(11-9-15)26-13-19-22-20(28-23-19)16-6-4-3-5-7-16/h3-11,14,18H,12-13H2,1-2H3,(H,24,25)
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n/an/an/an/a 160n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103947
PNG
(3-(4-((5-(4-bromophenyl)-1,2,4-oxadiazol-3-yl)meth...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(Br)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21BrN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 790n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103942
PNG
(3-(4-((5-cyclohexyl-1,2,4-oxadiazol-3-yl)methoxy)p...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)C2CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C21H28N2O5/c1-14(2)27-18(21(24)25)12-15-8-10-17(11-9-15)26-13-19-22-20(28-23-19)16-6-4-3-5-7-16/h8-11,14,16,18H,3-7,12-13H2,1-2H3,(H,24,25)
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n/an/an/an/a 230n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103945
PNG
(2-Isopropoxy-3-(4-{2-[5-(2-trifluoromethyl-phenyl)...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccccc2C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H23F3N2O5/c1-14(2)32-19(22(29)30)13-15-7-9-16(10-8-15)31-12-11-20-27-21(33-28-20)17-5-3-4-6-18(17)23(24,25)26/h3-10,14,19H,11-13H2,1-2H3,(H,29,30)
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n/an/an/an/a 600n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human peroxisome proliferator activated receptor gamma in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103954
PNG
(2-Isopropoxy-3-{4-[2-(5-phenyl-[1,2,4]oxadiazol-3-...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-15(2)28-19(22(25)26)14-16-8-10-18(11-9-16)27-13-12-20-23-21(29-24-20)17-6-4-3-5-7-17/h3-11,15,19H,12-14H2,1-2H3,(H,25,26)
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n/an/an/an/a 13n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 32n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human Peroxisome proliferator activated receptor delta in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103959
PNG
(2-Isopropoxy-3-{4-[5-(4-trifluoromethoxy-phenyl)-[...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(OC(F)(F)F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H21F3N2O6/c1-13(2)31-18(21(28)29)11-14-3-7-16(8-4-14)30-12-19-26-20(33-27-19)15-5-9-17(10-6-15)32-22(23,24)25/h3-10,13,18H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 7.90E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103959
PNG
(2-Isopropoxy-3-{4-[5-(4-trifluoromethoxy-phenyl)-[...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(OC(F)(F)F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H21F3N2O6/c1-13(2)31-18(21(28)29)11-14-3-7-16(8-4-14)30-12-19-26-20(33-27-19)15-5-9-17(10-6-15)32-22(23,24)25/h3-10,13,18H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 63n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103940
PNG
(3-(4-((5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-ox...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H20F6N2O5/c1-12(2)35-18(21(32)33)7-13-3-5-17(6-4-13)34-11-19-30-20(36-31-19)14-8-15(22(24,25)26)10-16(9-14)23(27,28)29/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,32,33)
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n/an/an/an/a 630n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human Peroxisome proliferator activated receptor delta in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103947
PNG
(3-(4-((5-(4-bromophenyl)-1,2,4-oxadiazol-3-yl)meth...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(Br)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21BrN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103949
PNG
(2-Isopropoxy-3-{4-[5-(4-trifluoromethyl-phenyl)-[1...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C22H21F3N2O5/c1-13(2)31-18(21(28)29)11-14-3-9-17(10-4-14)30-12-19-26-20(32-27-19)15-5-7-16(8-6-15)22(23,24)25/h3-10,13,18H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 500n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103959
PNG
(2-Isopropoxy-3-{4-[5-(4-trifluoromethoxy-phenyl)-[...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(OC(F)(F)F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H21F3N2O6/c1-13(2)31-18(21(28)29)11-14-3-7-16(8-4-14)30-12-19-26-20(33-27-19)15-5-9-17(10-6-15)32-22(23,24)25/h3-10,13,18H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 20n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103946
PNG
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103953
PNG
(3-(4-(2-(5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(Cl)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O5/c1-14(2)29-19(22(26)27)12-15-6-8-18(9-7-15)28-11-10-20-24-21(30-25-20)16-4-3-5-17(23)13-16/h3-9,13-14,19H,10-12H2,1-2H3,(H,26,27)
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103960
PNG
(3-(4-(2-(5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H23FN2O5/c1-14(2)29-19(22(26)27)12-15-6-8-18(9-7-15)28-11-10-20-24-21(30-25-20)16-4-3-5-17(23)13-16/h3-9,13-14,19H,10-12H2,1-2H3,(H,26,27)
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n/an/an/an/a 500n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103944
PNG
(3-(4-(2-(5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2ccc(Cl)cc2)cc1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O5/c1-14(2)29-19(22(26)27)13-15-3-9-18(10-4-15)28-12-11-20-24-21(30-25-20)16-5-7-17(23)8-6-16/h3-10,14,19H,11-13H2,1-2H3,(H,26,27)
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n/an/an/an/a 400n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103938
PNG
(2-Isopropoxy-3-[4-(5-phenyl-[1,2,4]oxadiazol-3-ylm...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C21H22N2O5/c1-14(2)27-18(21(24)25)12-15-8-10-17(11-9-15)26-13-19-22-20(28-23-19)16-6-4-3-5-7-16/h3-11,14,18H,12-13H2,1-2H3,(H,24,25)
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n/an/an/an/a 79n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103946
PNG
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27)
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103950
PNG
(2-Isopropoxy-3-{4-[5-(4-isopropyl-phenyl)-[1,2,4]o...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(C)C)cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O5/c1-15(2)18-7-9-19(10-8-18)23-25-22(26-31-23)14-29-20-11-5-17(6-12-20)13-21(24(27)28)30-16(3)4/h5-12,15-16,21H,13-14H2,1-4H3,(H,27,28)
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n/an/an/an/a 7.90E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103952
PNG
(3-(4-((5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(F)cc2)cc1)C(O)=O
Show InChI InChI=1S/C21H21FN2O5/c1-13(2)28-18(21(25)26)11-14-3-9-17(10-4-14)27-12-19-23-20(29-24-19)15-5-7-16(22)8-6-15/h3-10,13,18H,11-12H2,1-2H3,(H,25,26)
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n/an/an/an/a 7.90E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103955
PNG
(3-(4-((5-(4-tert-butylphenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(C)(C)C)cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O5/c1-16(2)31-21(24(28)29)14-17-6-12-20(13-7-17)30-15-22-26-23(32-27-22)18-8-10-19(11-9-18)25(3,4)5/h6-13,16,21H,14-15H2,1-5H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))		BDBM50103955
PNG
(3-(4-((5-(4-tert-butylphenyl)-1,2,4-oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2ccc(cc2)C(C)(C)C)cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O5/c1-16(2)31-21(24(28)29)14-17-6-12-20(13-7-17)30-15-22-26-23(32-27-22)18-8-10-19(11-9-18)25(3,4)5/h6-13,16,21H,14-15H2,1-5H3,(H,28,29)
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n/an/an/an/a 5.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human PPAR delta receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103941
PNG
(2-Isopropoxy-3-(4-{2-[5-(3-trifluoromethyl-phenyl)...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(c2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H23F3N2O5/c1-14(2)32-19(22(29)30)12-15-6-8-18(9-7-15)31-11-10-20-27-21(33-28-20)16-4-3-5-17(13-16)23(24,25)26/h3-9,13-14,19H,10-12H2,1-2H3,(H,29,30)
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n/an/an/an/a 6n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103957
PNG
(3-(4-(2-(5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C24H22F6N2O5/c1-13(2)36-19(22(33)34)9-14-3-5-18(6-4-14)35-8-7-20-31-21(37-32-20)15-10-16(23(25,26)27)12-17(11-15)24(28,29)30/h3-6,10-13,19H,7-9H2,1-2H3,(H,33,34)
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n/an/an/an/a 4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human peroxisome proliferator activated receptor gamma was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50103957
PNG
(3-(4-(2-(5-(3,5-bis(trifluoromethyl)phenyl)-1,2,4-...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C24H22F6N2O5/c1-13(2)36-19(22(33)34)9-14-3-5-18(6-4-14)35-8-7-20-31-21(37-32-20)15-10-16(23(25,26)27)12-17(11-15)24(28,29)30/h3-6,10-13,19H,7-9H2,1-2H3,(H,33,34)
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n/an/an/an/a 50n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity of the compound against human Peroxisome proliferator activated receptor alpha was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103960
PNG
(3-(4-(2-(5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(F)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H23FN2O5/c1-14(2)29-19(22(26)27)12-15-6-8-18(9-7-15)28-11-10-20-24-21(30-25-20)16-4-3-5-17(23)13-16/h3-9,13-14,19H,10-12H2,1-2H3,(H,26,27)
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n/an/an/an/a 2n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103956
PNG
(2-Isopropoxy-3-[4-(5-m-tolyl-[1,2,4]oxadiazol-3-yl...)
Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cccc(C)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O5/c1-14(2)28-19(22(25)26)12-16-7-9-18(10-8-16)27-13-20-23-21(29-24-20)17-6-4-5-15(3)11-17/h4-11,14,19H,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 50n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50103953
PNG
(3-(4-(2-(5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl)e...)
Show SMILES CC(C)OC(Cc1ccc(OCCc2noc(n2)-c2cccc(Cl)c2)cc1)C(O)=O
Show InChI InChI=1S/C22H23ClN2O5/c1-14(2)29-19(22(26)27)12-15-6-8-18(9-7-15)28-11-10-20-24-21(30-25-20)16-4-3-5-17(23)13-16/h3-9,13-14,19H,10-12H2,1-2H3,(H,26,27)
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n/an/an/an/a 4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined

Bioorg Med Chem Lett 11: 2385-8 (2001)


BindingDB Entry DOI: 10.7270/Q2CJ8CSF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%