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PubMed code 18698756

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244398
PNG
(1-[6-(4-bromo-phenoxy)-5-nitro-pyrimidin-4-yl]-pip...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(Br)cc2)c1[N+]([O-])=O
Show InChI InChI=1S/C18H19BrN4O5/c1-2-27-18(24)12-7-9-22(10-8-12)16-15(23(25)26)17(21-11-20-16)28-14-5-3-13(19)4-6-14/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 50n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244851
PNG
(CHEMBL461765 | ethyl 1-(6-(1-methyl-3-(trifluorome...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2cc(nn2C)C(F)(F)F)c1[N+]([O-])=O
Show InChI InChI=1S/C17H19F3N6O5/c1-3-30-16(27)10-4-6-25(7-5-10)14-13(26(28)29)15(22-9-21-14)31-12-8-11(17(18,19)20)23-24(12)2/h8-10H,3-7H2,1-2H3
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n/an/a 84n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244537
PNG
(CHEMBL508439 | ethyl 1-(6-(4-(2-methoxyethoxy)phen...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(OCCOC)cc2)c1[N+]([O-])=O
Show InChI InChI=1S/C21H26N4O7/c1-3-30-21(26)15-8-10-24(11-9-15)19-18(25(27)28)20(23-14-22-19)32-17-6-4-16(5-7-17)31-13-12-29-2/h4-7,14-15H,3,8-13H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inverse agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244539
PNG
(1-[5-Nitro-6-(4-sulfamoyl-phenoxy)-pyrimidin-4-yl]...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)S(N)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C18H21N5O7S/c1-2-29-18(24)12-7-9-22(10-8-12)16-15(23(25)26)17(21-11-20-16)30-13-3-5-14(6-4-13)31(19,27)28/h3-6,11-12H,2,7-10H2,1H3,(H2,19,27,28)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244793
PNG
(3-fluoro-N-isopropyl-4-(6-(4-(3-isopropyl-1,2,4-ox...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(=O)(=O)C(C)C)c1[N+]([O-])=O
Show InChI InChI=1S/C23H28FN7O5S/c1-13(2)20-28-23(36-29-20)15-7-9-30(10-8-15)22-19(31(32)33)21(25-12-26-22)27-18-6-5-16(11-17(18)24)37(34,35)14(3)4/h5-6,11-15H,7-10H2,1-4H3,(H,25,26,27)
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n/an/an/an/a 7.90n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244791
PNG
((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 0.680n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244734
PNG
(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Show SMILES CCS(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C(C)C)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H27N7O4S/c1-4-34(32)17-7-5-16(6-8-17)25-20-18(29(30)31)21(24-13-23-20)28-11-9-15(10-12-28)22-26-19(14(2)3)27-33-22/h5-8,13-15H,4,9-12H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 17.1n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244640
PNG
(6-[4-(3-Cyclopropylmethyl-[1,2,4]oxadiazol-5-yl)-p...)
Show SMILES CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc(CC4CC4)[n-][o+]3)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H25N7O5S/c1-35(32,33)17-6-4-16(5-7-17)25-20-19(29(30)31)21(24-13-23-20)28-10-8-15(9-11-28)22-26-18(27-34-22)12-14-2-3-14/h4-7,13-15H,2-3,8-12H2,1H3,(H,23,24,25)
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n/an/an/an/a 160n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244538
PNG
(1-[6-(4-Methanesulfonyl-phenoxy)-5-nitro-pyrimidin...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C19H22N4O7S/c1-3-29-19(24)13-8-10-22(11-9-13)17-16(23(25)26)18(21-12-20-17)30-14-4-6-15(7-5-14)31(2,27)28/h4-7,12-13H,3,8-11H2,1-2H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244790
PNG
((3-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(c(F)c2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-14-4-5-16(15(22)10-14)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 3.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244683
PNG
((4-Methanesulfonyl-phenyl)-(5-nitro-6-{4-[3-(3-tri...)
Show SMILES CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)-c3cccc(c3)C(F)(F)F)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C25H22F3N7O5S/c1-41(38,39)19-7-5-18(6-8-19)31-22-20(35(36)37)23(30-14-29-22)34-11-9-15(10-12-34)24-32-21(33-40-24)16-3-2-4-17(13-16)25(26,27)28/h2-8,13-15H,9-12H2,1H3,(H,29,30,31)
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n/an/an/an/a 24n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244638
PNG
((4-Methanesulfonyl-phenyl)-{5-nitro-6-[4-(3-propyl...)
Show SMILES CCCc1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H25N7O5S/c1-3-4-17-25-21(33-26-17)14-9-11-27(12-10-14)20-18(28(29)30)19(22-13-23-20)24-15-5-7-16(8-6-15)34(2,31)32/h5-8,13-14H,3-4,9-12H2,1-2H3,(H,22,23,24)
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n/an/an/an/a 430n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244588
PNG
(1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrim...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)-n2cncn2)c1[N+]([O-])=O
Show InChI InChI=1S/C20H21N7O5/c1-2-31-20(28)14-7-9-25(10-8-14)18-17(27(29)30)19(23-12-22-18)32-16-5-3-15(4-6-16)26-13-21-11-24-26/h3-6,11-14H,2,7-10H2,1H3
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n/an/an/an/a 2.50E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244639
PNG
(CHEMBL451798 | {6-[4-(3-Cyclopropyl-[1,2,4]oxadiaz...)
Show SMILES CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C3CC3)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C21H23N7O5S/c1-34(31,32)16-6-4-15(5-7-16)24-19-17(28(29)30)20(23-12-22-19)27-10-8-14(9-11-27)21-25-18(26-33-21)13-2-3-13/h4-7,12-14H,2-3,8-11H2,1H3,(H,22,23,24)
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244792
PNG
(CHEMBL461385 | N-ethyl-3-fluoro-4-(6-(4-(3-isoprop...)
Show SMILES CCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C(C)C)c2[N+]([O-])=O)c(F)c1
Show InChI InChI=1S/C22H26FN7O5S/c1-4-36(33,34)15-5-6-17(16(23)11-15)26-20-18(30(31)32)21(25-12-24-20)29-9-7-14(8-10-29)22-27-19(13(2)3)28-35-22/h5-6,11-14H,4,7-10H2,1-3H3,(H,24,25,26)
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n/an/an/an/a 7n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244680
PNG
(CHEMBL462196 | {6-[4-(3-Isopropyl-[1,2,4]oxadiazol...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H25N7O5S/c1-13(2)18-25-21(33-26-18)14-8-10-27(11-9-14)20-17(28(29)30)19(22-12-23-20)24-15-4-6-16(7-5-15)34(3,31)32/h4-7,12-14H,8-11H2,1-3H3,(H,22,23,24)
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n/an/an/an/a 5.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244733
PNG
(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(=O)(=O)C(C)C)c1[N+]([O-])=O
Show InChI InChI=1S/C23H29N7O5S/c1-14(2)20-27-23(35-28-20)16-9-11-29(12-10-16)22-19(30(31)32)21(24-13-25-22)26-17-5-7-18(8-6-17)36(33,34)15(3)4/h5-8,13-16H,9-12H2,1-4H3,(H,24,25,26)
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n/an/an/an/a 7.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244590
PNG
(1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenylamino)-p...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)-n2cncn2)c1[N+]([O-])=O
Show InChI InChI=1S/C20H22N8O4/c1-2-32-20(29)14-7-9-26(10-8-14)19-17(28(30)31)18(22-12-23-19)25-15-3-5-16(6-4-15)27-13-21-11-24-27/h3-6,11-14H,2,7-10H2,1H3,(H,22,23,25)
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n/an/an/an/a 400n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244589
PNG
(1-[6-(4-Methanesulfonyl-phenylamino)-5-nitro-pyrim...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C19H23N5O6S/c1-3-30-19(25)13-8-10-23(11-9-13)18-16(24(26)27)17(20-12-21-18)22-14-4-6-15(7-5-14)31(2,28)29/h4-7,12-13H,3,8-11H2,1-2H3,(H,20,21,22)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244591
PNG
((4-Methanesulfonyl-phenyl)-{6-[4-(3-methyl-[1,2,4]...)
Show SMILES Cc1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C19H21N7O5S/c1-12-22-19(31-24-12)13-7-9-25(10-8-13)18-16(26(27)28)17(20-11-21-18)23-14-3-5-15(6-4-14)32(2,29)30/h3-6,11,13H,7-10H2,1-2H3,(H,20,21,23)
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n/an/an/an/a 260n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244735
PNG
(CHEMBL461934 | N-(4-(ethylthio)phenyl)-6-(4-(3-iso...)
Show SMILES CCSc1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C(C)C)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H27N7O3S/c1-4-33-17-7-5-16(6-8-17)25-20-18(29(30)31)21(24-13-23-20)28-11-9-15(10-12-28)22-26-19(14(2)3)27-32-22/h5-8,13-15H,4,9-12H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 110n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244684
PNG
(CHEMBL459873 | N-(4-(ethylsulfonyl)phenyl)-6-(4-(3...)
Show SMILES CCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C(C)C)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H27N7O5S/c1-4-35(32,33)17-7-5-16(6-8-17)25-20-18(29(30)31)21(24-13-23-20)28-11-9-15(10-12-28)22-26-19(14(2)3)27-34-22/h5-8,13-15H,4,9-12H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 17n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244637
PNG
(CHEMBL451793 | {6-[4-(3-Ethyl-[1,2,4]oxadiazol-5-y...)
Show SMILES CCc1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C20H23N7O5S/c1-3-16-24-20(32-25-16)13-8-10-26(11-9-13)19-17(27(28)29)18(21-12-22-19)23-14-4-6-15(7-5-14)33(2,30)31/h4-7,12-13H,3,8-11H2,1-2H3,(H,21,22,23)
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n/an/an/an/a 10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244441
PNG
(1-{6-[4-(2-Methoxycarbonyl-acetyl)-phenoxy]-5-nitr...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(cc2)C(=O)CC(=O)OC)c1[N+]([O-])=O
Show InChI InChI=1S/C22H24N4O8/c1-3-33-22(29)15-8-10-25(11-9-15)20-19(26(30)31)21(24-13-23-20)34-16-6-4-14(5-7-16)17(27)12-18(28)32-2/h4-7,13,15H,3,8-12H2,1-2H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244681
PNG
(CHEMBL518819 | {6-[4-(3-tert-Butyl-[1,2,4]oxadiazo...)
Show SMILES CC(C)(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C22H27N7O5S/c1-22(2,3)21-26-20(34-27-21)14-9-11-28(12-10-14)19-17(29(30)31)18(23-13-24-19)25-15-5-7-16(8-6-15)35(4,32)33/h5-8,13-14H,9-12H2,1-4H3,(H,23,24,25)
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n/an/an/an/a 1.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244682
PNG
(CHEMBL462197 | N-(4-(methylsulfonyl)phenyl)-5-nitr...)
Show SMILES CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)-c3cccnc3)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C23H22N8O5S/c1-37(34,35)18-6-4-17(5-7-18)27-21-19(31(32)33)22(26-14-25-21)30-11-8-15(9-12-30)23-28-20(29-36-23)16-3-2-10-24-13-16/h2-7,10,13-15H,8-9,11-12H2,1H3,(H,25,26,27)
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n/an/an/an/a 660n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244536
PNG
(1-{5-Nitro-6-[4-(3-oxo-butyl)-phenoxy]-pyrimidin-4...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc(Oc2ccc(CCC(C)=O)cc2)c1[N+]([O-])=O
Show InChI InChI=1S/C22H26N4O6/c1-3-31-22(28)17-10-12-25(13-11-17)20-19(26(29)30)21(24-14-23-20)32-18-8-6-16(7-9-18)5-4-15(2)27/h6-9,14,17H,3-5,10-13H2,1-2H3
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n/an/an/an/a 1.70E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 (unknown origin) expressed in HEK293 cells assessed as cAMP level by flash plate assay

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244732
PNG
(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Show SMILES CCCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C(C)C)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C23H29N7O5S/c1-4-13-36(33,34)18-7-5-17(6-8-18)26-21-19(30(31)32)22(25-14-24-21)29-11-9-16(10-12-29)23-27-20(15(2)3)28-35-23/h5-8,14-16H,4,9-13H2,1-3H3,(H,24,25,26)
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n/an/an/an/a 4.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%