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PubMed code 19007200

Compile data set for download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Perforin-1


(Homo sapiens (Human))		BDBM50275059
PNG
((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12
Show InChI InChI=1S/C17H11NO2S2/c1-9-6-12-13(20-17(19)15(12)16(21)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,21)/b13-7-
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n/an/a 970n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275013
PNG
((Z)-1-((1H-Indol-2-yl)methylene)-6-methyl-4-thioxo...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O2S/c1-9-6-12-14(21-17(20)15(12)16(22)18-9)8-11-7-10-4-2-3-5-13(10)19-11/h2-8,19H,1H3,(H,18,22)/b14-8-
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274962
PNG
((Z)-1-((5-Methoxybenzofuran-2-yl)methylene)-6-meth...)
Show SMILES COc1ccc2oc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)cc2c1
Show InChI InChI=1S/C18H13NO4S/c1-9-5-13-15(23-18(20)16(13)17(24)19-9)8-12-7-10-6-11(21-2)3-4-14(10)22-12/h3-8H,1-2H3,(H,19,24)/b15-8-
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275239
PNG
((Z)-6-Methyl-1-((5-methylfuran-2-yl)methylene)-4-t...)
Show SMILES Cc1ccc(\C=C2/OC(=O)c3c2cc(C)[nH]c3=S)o1
Show InChI InChI=1S/C14H11NO3S/c1-7-5-10-11(6-9-4-3-8(2)17-9)18-14(16)12(10)13(19)15-7/h3-6H,1-2H3,(H,15,19)/b11-6-
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274964
PNG
((Z)-1-((7-Methoxybenzofuran-2-yl)methylene)-6-meth...)
Show SMILES COc1cccc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)oc12
Show InChI InChI=1S/C18H13NO4S/c1-9-6-12-14(23-18(20)15(12)17(24)19-9)8-11-7-10-4-3-5-13(21-2)16(10)22-11/h3-8H,1-2H3,(H,19,24)/b14-8-
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275015
PNG
((Z)-1-((6-Methoxy-1H-indol-2-yl)methylene)-6-methy...)
Show SMILES COc1ccc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)[nH]c2c1
Show InChI InChI=1S/C18H14N2O3S/c1-9-5-13-15(23-18(21)16(13)17(24)19-9)7-11-6-10-3-4-12(22-2)8-14(10)20-11/h3-8,20H,1-2H3,(H,19,24)/b15-7-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275274
PNG
((Z)-6-Methyl-1-((5-phenylthiophen-2-yl)methylene)-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(s1)-c1ccccc1
Show InChI InChI=1S/C19H13NO2S2/c1-11-9-14-15(22-19(21)17(14)18(23)20-11)10-13-7-8-16(24-13)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,23)/b15-10-
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275060
PNG
((Z)-1-[(4-Methoxy-1-benzothien-3-yl)methylene]-6-m...)
Show SMILES COc1cccc2scc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)c12
Show InChI InChI=1S/C18H13NO3S2/c1-9-6-11-13(22-18(20)16(11)17(23)19-9)7-10-8-24-14-5-3-4-12(21-2)15(10)14/h3-8H,1-2H3,(H,19,23)/b13-7-
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275241
PNG
((Z)-6-Methyl-1-((5-phenylfuran-2-yl)methylene)-4-t...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C19H13NO3S/c1-11-9-14-16(23-19(21)17(14)18(24)20-11)10-13-7-8-15(22-13)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,24)/b16-10-
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275134
PNG
((Z)-1-((1H-Indol-7-yl)methylene)-6-methyl-4-thioxo...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cccc2cc[nH]c12
Show InChI InChI=1S/C17H12N2O2S/c1-9-7-12-13(21-17(20)14(12)16(22)19-9)8-11-4-2-3-10-5-6-18-15(10)11/h2-8,18H,1H3,(H,19,22)/b13-8-
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275098
PNG
((Z)-6-Methyl-1-((1-methyl-1H-indol-3-yl)methylene)...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cn(C)c2ccccc12
Show InChI InChI=1S/C18H14N2O2S/c1-10-7-13-15(22-18(21)16(13)17(23)19-10)8-11-9-20(2)14-6-4-3-5-12(11)14/h3-9H,1-2H3,(H,19,23)/b15-8-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275240
PNG
((Z)-1-(Furan-2-ylmethylene)-6-methyl-4-thioxo-4,5-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccco1
Show InChI InChI=1S/C13H9NO3S/c1-7-5-9-10(6-8-3-2-4-16-8)17-13(15)11(9)12(18)14-7/h2-6H,1H3,(H,14,18)/b10-6-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275014
PNG
((Z)-1-((5-Methoxy-1H-indol-2-yl)methylene)-6-methy...)
Show SMILES COc1ccc2[nH]c(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)cc2c1
Show InChI InChI=1S/C18H14N2O3S/c1-9-5-13-15(23-18(21)16(13)17(24)19-9)8-11-6-10-7-12(22-2)3-4-14(10)20-11/h3-8,20H,1-2H3,(H,19,24)/b15-8-
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274991
PNG
((Z)-1-(Benzo[b]thiophen-2-ylmethylene)-6-methylfur...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=O)[nH]1)=C\c1cc2ccccc2s1
Show InChI InChI=1S/C17H11NO3S/c1-9-6-12-13(21-17(20)15(12)16(19)18-9)8-11-7-10-4-2-3-5-14(10)22-11/h2-8H,1H3,(H,18,19)/b13-8-
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275094
PNG
((Z)-1-((6-Methoxybenzo[b]thiophen-3-yl)methylene)-...)
Show SMILES COc1ccc2c(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)csc2c1
Show InChI InChI=1S/C18H13NO3S2/c1-9-5-13-14(22-18(20)16(13)17(23)19-9)6-10-8-24-15-7-11(21-2)3-4-12(10)15/h3-8H,1-2H3,(H,19,23)/b14-6-
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274829
PNG
((Z)-6-Methyl-1-((5-phenylthiophen-2-yl)methylene)f...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=O)[nH]1)=C\c1ccc(s1)-c1ccccc1
Show InChI InChI=1S/C19H13NO3S/c1-11-9-14-15(23-19(22)17(14)18(21)20-11)10-13-7-8-16(24-13)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,21)/b15-10-
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275093
PNG
((Z)-1-((5-Methoxybenzo[b]thiophen-3-yl)methylene)-...)
Show SMILES COc1ccc2scc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)c2c1
Show InChI InChI=1S/C18H13NO3S2/c1-9-5-13-14(22-18(20)16(13)17(23)19-9)6-10-8-24-15-4-3-11(21-2)7-12(10)15/h3-8H,1-2H3,(H,19,23)/b14-6-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274987
PNG
((Z)-1-((6-(Benzyloxy)-5-methoxybenzofuran-2-yl)met...)
Show SMILES COc1cc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)oc2cc1OCc1ccccc1
Show InChI InChI=1S/C25H19NO5S/c1-14-8-18-20(31-25(27)23(18)24(32)26-14)11-17-9-16-10-21(28-2)22(12-19(16)30-17)29-13-15-6-4-3-5-7-15/h3-12H,13H2,1-2H3,(H,26,32)/b20-11-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274990
PNG
((Z)-1-((6-Methoxybenzo[b]thiophen-2-yl)methylene)-...)
Show SMILES COc1ccc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)sc2c1
Show InChI InChI=1S/C18H13NO3S2/c1-9-5-13-14(22-18(20)16(13)17(23)19-9)8-12-6-10-3-4-11(21-2)7-15(10)24-12/h3-8H,1-2H3,(H,19,23)/b14-8-
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275017
PNG
((Z)-1-((5-Fluoro-6-methoxy-1H-indol-3-yl)methylene...)
Show SMILES COc1cc2[nH]c(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)cc2cc1F
Show InChI InChI=1S/C18H13FN2O3S/c1-8-3-11-14(24-18(22)16(11)17(25)20-8)6-10-4-9-5-12(19)15(23-2)7-13(9)21-10/h3-7,21H,1-2H3,(H,20,25)/b14-6-
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n/an/a 6.30E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274961
PNG
((Z)-1-((4-Methoxybenzofuran-2-yl)methylene)-6-meth...)
Show SMILES COc1cccc2oc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)cc12
Show InChI InChI=1S/C18H13NO4S/c1-9-6-12-15(23-18(20)16(12)17(24)19-9)8-10-7-11-13(21-2)4-3-5-14(11)22-10/h3-8H,1-2H3,(H,19,24)/b15-8-
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n/an/a 6.70E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275273
PNG
((Z)-6-Methyl-1-((5-methylthiophen-2-yl)methylene)-...)
Show SMILES Cc1ccc(\C=C2/OC(=O)c3c2cc(C)[nH]c3=S)s1
Show InChI InChI=1S/C14H11NO2S2/c1-7-5-10-11(6-9-4-3-8(2)19-9)17-14(16)12(10)13(18)15-7/h3-6H,1-2H3,(H,15,18)/b11-6-
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n/an/a 7.20E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274963
PNG
((Z)-1-((6-Methoxybenzofuran-2-yl)methylene)-6-meth...)
Show SMILES COc1ccc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)oc2c1
Show InChI InChI=1S/C18H13NO4S/c1-9-5-13-15(23-18(20)16(13)17(24)19-9)8-12-6-10-3-4-11(21-2)7-14(10)22-12/h3-8H,1-2H3,(H,19,24)/b15-8-
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n/an/a 7.20E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275095
PNG
((Z)-1-((5-Bromobenzo[b]thiophen-3-yl)methylene)-6-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccc(Br)cc12
Show InChI InChI=1S/C17H10BrNO2S2/c1-8-4-12-13(21-17(20)15(12)16(22)19-8)5-9-7-23-14-3-2-10(18)6-11(9)14/h2-7H,1H3,(H,19,22)/b13-5-
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n/an/a 7.50E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274960
PNG
((Z)-1-(Benzofuran-2-ylmethylene)-6-methyl-4-thioxo...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cc2ccccc2o1
Show InChI InChI=1S/C17H11NO3S/c1-9-6-12-14(21-17(19)15(12)16(22)18-9)8-11-7-10-4-2-3-5-13(10)20-11/h2-8H,1H3,(H,18,22)/b14-8-
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n/an/a 8.20E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275096
PNG
((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methylfur...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=O)[nH]1)=C\c1csc2ccccc12
Show InChI InChI=1S/C17H11NO3S/c1-9-6-12-13(21-17(20)15(12)16(19)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,19)/b13-7-
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n/an/a 8.50E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275242
PNG
((Z)-6-Methyl-1-(thiophen-2-ylmethylene)-4-thioxo-4...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cccs1
Show InChI InChI=1S/C13H9NO2S2/c1-7-5-9-10(6-8-3-2-4-18-8)16-13(15)11(9)12(17)14-7/h2-6H,1H3,(H,14,17)/b10-6-
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n/an/a 8.60E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274988
PNG
((Z)-1-(Benzo[b]thiophen-2-ylmethylene)-6-methyl-4-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cc2ccccc2s1
Show InChI InChI=1S/C17H11NO2S2/c1-9-6-12-13(20-17(19)15(12)16(21)18-9)8-11-7-10-4-2-3-5-14(10)22-11/h2-8H,1H3,(H,18,21)/b13-8-
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n/an/a 9.50E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274989
PNG
((Z)-1-((5-Methoxybenzo[b]thiophen-2-yl)methylene)-...)
Show SMILES COc1ccc2sc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)cc2c1
Show InChI InChI=1S/C18H13NO3S2/c1-9-5-13-14(22-18(20)16(13)17(23)19-9)8-12-7-10-6-11(21-2)3-4-15(10)24-12/h3-8H,1-2H3,(H,19,23)/b14-8-
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n/an/a 1.31E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274827
PNG
((Z)-1-(Biphenyl-4-ylmethylene)-6-methyl-4-thioxo-4...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H15NO2S/c1-13-11-17-18(24-21(23)19(17)20(25)22-13)12-14-7-9-16(10-8-14)15-5-3-2-4-6-15/h2-12H,1H3,(H,22,25)/b18-12-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275277
PNG
((Z)-6-Methyl-1-((1-methyl-1H-pyrrol-2-yl)methylene...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cccn1C
Show InChI InChI=1S/C14H12N2O2S/c1-8-6-10-11(7-9-4-3-5-16(9)2)18-14(17)12(10)13(19)15-8/h3-7H,1-2H3,(H,15,19)/b11-7-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275058
PNG
((Z)-1-(Benzofuran-3-ylmethylene)-6-methyl-4-thioxo...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1coc2ccccc12
Show InChI InChI=1S/C17H11NO3S/c1-9-6-12-14(21-17(19)15(12)16(22)18-9)7-10-8-20-13-5-3-2-4-11(10)13/h2-8H,1H3,(H,18,22)/b14-7-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274825
PNG
((Z)-1-(4-(Dimethylamino)benzylidene)-6-methyl-4-th...)
Show SMILES CN(C)c1ccc(\C=C2/OC(=O)c3c2cc(C)[nH]c3=S)cc1
Show InChI InChI=1S/C17H16N2O2S/c1-10-8-13-14(21-17(20)15(13)16(22)18-10)9-11-4-6-12(7-5-11)19(2)3/h4-9H,1-3H3,(H,18,22)/b14-9-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275316
PNG
((Z)-1-(4-Methoxybenzylidene)-6-methyl-4-thioxo-4,5...)
Show SMILES COC1=CCC(\C=C2/OC(=O)c3c2cc(C)[nH]c3=S)C=C1 |c:21,t:2|
Show InChI InChI=1S/C16H15NO3S/c1-9-7-12-13(20-16(18)14(12)15(21)17-9)8-10-3-5-11(19-2)6-4-10/h3,5-8,10H,4H2,1-2H3,(H,17,21)/b13-8-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275016
PNG
((Z)-1-((6-(Benzyloxy)-5-methoxy-1H-indol-2-yl)meth...)
Show SMILES COc1cc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)[nH]c2cc1OCc1ccccc1
Show InChI InChI=1S/C25H20N2O4S/c1-14-8-18-20(31-25(28)23(18)24(32)26-14)11-17-9-16-10-21(29-2)22(12-19(16)27-17)30-13-15-6-4-3-5-7-15/h3-12,27H,13H2,1-2H3,(H,26,32)/b20-11-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274826
PNG
((Z)-N-(4-((6-Methyl-3-oxo-4-thioxo-4,5-dihydrofuro...)
Show SMILES CC(=O)Nc1ccc(\C=C2/OC(=O)c3c2cc(C)[nH]c3=S)cc1
Show InChI InChI=1S/C17H14N2O3S/c1-9-7-13-14(22-17(21)15(13)16(23)18-9)8-11-3-5-12(6-4-11)19-10(2)20/h3-8H,1-2H3,(H,18,23)(H,19,20)/b14-8-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274935
PNG
((Z)-6-Methyl-1-((5-phenylthiophen-2-yl)methylene)-...)
Show SMILES Cc1cc2\C(NC(=O)c2c(=S)[nH]1)=C\c1ccc(s1)-c1ccccc1
Show InChI InChI=1S/C19H14N2OS2/c1-11-9-14-15(21-18(22)17(14)19(23)20-11)10-13-7-8-16(24-13)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,23)(H,21,22)/b15-10-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275318
PNG
((Z)-6-Methyl-1-(4-(methylthio)benzylidene)-4-thiox...)
Show SMILES CSc1ccc(\C=C2/OC(=O)c3c2cc(C)[nH]c3=S)cc1
Show InChI InChI=1S/C16H13NO2S2/c1-9-7-12-13(19-16(18)14(12)15(20)17-9)8-10-3-5-11(21-2)6-4-10/h3-8H,1-2H3,(H,17,20)/b13-8-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275315
PNG
((Z)-6-Methyl-4-thioxo-1-(4-(trifluoromethyl)benzyl...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H10F3NO2S/c1-8-6-11-12(22-15(21)13(11)14(23)20-8)7-9-2-4-10(5-3-9)16(17,18)19/h2-7H,1H3,(H,20,23)/b12-7-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275278
PNG
((Z)-1-Benzylidene-6-methyl-4-thioxo-4,5-dihydrofur...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccccc1
Show InChI InChI=1S/C15H11NO2S/c1-9-7-11-12(8-10-5-3-2-4-6-10)18-15(17)13(11)14(19)16-9/h2-8H,1H3,(H,16,19)/b12-8-
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n/an/a>2.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274937
PNG
((Z)-1-(Furan-3-ylmethylene)-6-methyl-4-thioxo-4,5-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccoc1
Show InChI InChI=1S/C13H9NO3S/c1-7-4-9-10(5-8-2-3-16-6-8)17-13(15)11(9)12(18)14-7/h2-6H,1H3,(H,14,18)/b10-5-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274936
PNG
((Z)-6-Methyl-1-((5-phenylthiophen-2-yl)methylene)-...)
Show SMILES Cc1cc2\C(NC(=O)c2c(=O)[nH]1)=C\c1ccc(s1)-c1ccccc1
Show InChI InChI=1S/C19H14N2O2S/c1-11-9-14-15(21-19(23)17(14)18(22)20-11)10-13-7-8-16(24-13)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,22)(H,21,23)/b15-10-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275133
PNG
((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...)
Show SMILES Cc1cc2\C(NC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12
Show InChI InChI=1S/C17H12N2OS2/c1-9-6-12-13(19-16(20)15(12)17(21)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,21)(H,19,20)/b13-7-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274830
PNG
((Z)-1-((1H-Pyrrol-2-yl)methylene)-6-methylfuro[3,4...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=O)[nH]1)=C\c1ccc[nH]1
Show InChI InChI=1S/C13H10N2O3/c1-7-5-9-10(6-8-3-2-4-14-8)18-13(17)11(9)12(16)15-7/h2-6,14H,1H3,(H,15,16)/b10-6-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275275
PNG
((Z)-1-((1H-Pyrrol-2-yl)methylene)-6-methyl-4-thiox...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc[nH]1
Show InChI InChI=1S/C13H10N2O2S/c1-7-5-9-10(6-8-3-2-4-14-8)17-13(16)11(9)12(18)15-7/h2-6,14H,1H3,(H,15,18)/b10-6-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275057
PNG
((Z)-6-Methyl-1-((1-methyl-1H-indol-2-yl)methylene)...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cc2ccccc2n1C
Show InChI InChI=1S/C18H14N2O2S/c1-10-7-13-15(22-18(21)16(13)17(23)19-10)9-12-8-11-5-3-4-6-14(11)20(12)2/h3-9H,1-2H3,(H,19,23)/b15-9-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275314
PNG
((Z)-6-Methyl-1-(4-methylbenzylidene)-4-thioxo-4,5-...)
Show SMILES Cc1ccc(\C=C2/OC(=O)c3c2cc(C)[nH]c3=S)cc1
Show InChI InChI=1S/C16H13NO2S/c1-9-3-5-11(6-4-9)8-13-12-7-10(2)17-15(20)14(12)16(18)19-13/h3-8H,1-2H3,(H,17,20)/b13-8-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275313
PNG
((Z)-1-(4-Chlorobenzylidene)-6-methyl-4-thioxo-4,5-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C15H10ClNO2S/c1-8-6-11-12(7-9-2-4-10(16)5-3-9)19-15(18)13(11)14(20)17-8/h2-7H,1H3,(H,17,20)/b12-7-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275056
PNG
((Z)-1-((5-(Benzyloxy)-1H-indol-2-yl)methylene)-6-m...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C24H18N2O3S/c1-14-9-19-21(29-24(27)22(19)23(30)25-14)12-17-10-16-11-18(7-8-20(16)26-17)28-13-15-5-3-2-4-6-15/h2-12,26H,13H2,1H3,(H,25,30)/b21-12-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274939
PNG
((Z)-6-Methyl-1-((5-phenylthiophen-3-yl)methylene)-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc(c1)-c1ccccc1
Show InChI InChI=1S/C19H13NO2S2/c1-11-7-14-15(22-19(21)17(14)18(23)20-11)8-12-9-16(24-10-12)13-5-3-2-4-6-13/h2-10H,1H3,(H,20,23)/b15-8-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275097
PNG
((Z)-1-((1H-Indol-3-yl)methylene)-6-methyl-4-thioxo...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H12N2O2S/c1-9-6-12-14(21-17(20)15(12)16(22)19-9)7-10-8-18-13-5-3-2-4-11(10)13/h2-8,18H,1H3,(H,19,22)/b14-7-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275276
PNG
((Z)-1-((1H-Imidazol-2-yl)methylene)-6-methyl-4-thi...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ncc[nH]1
Show InChI InChI=1S/C12H9N3O2S/c1-6-4-7-8(5-9-13-2-3-14-9)17-12(16)10(7)11(18)15-6/h2-5H,1H3,(H,13,14)(H,15,18)/b8-5-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275132
PNG
((Z)-6-Methyl-1-((1-methyl-1H-indol-3-yl)methylene)...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=O)[nH]1)=C\c1cn(C)c2ccccc12
Show InChI InChI=1S/C18H14N2O3/c1-10-7-13-15(23-18(22)16(13)17(21)19-10)8-11-9-20(2)14-6-4-3-5-12(11)14/h3-9H,1-2H3,(H,19,21)/b15-8-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274828
PNG
((Z)-6-Methyl-1-((5-methylfuran-2-yl)methylene)furo...)
Show SMILES Cc1ccc(\C=C2/OC(=O)c3c2cc(C)[nH]c3=O)o1
Show InChI InChI=1S/C14H11NO4/c1-7-5-10-11(6-9-4-3-8(2)18-9)19-14(17)12(10)13(16)15-7/h3-6H,1-2H3,(H,15,16)/b11-6-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275317
PNG
((Z)-6-Methyl-4-thioxo-1-(4-(trifluoromethoxy)benzy...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C16H10F3NO3S/c1-8-6-11-12(22-15(21)13(11)14(24)20-8)7-9-2-4-10(5-3-9)23-16(17,18)19/h2-7H,1H3,(H,20,24)/b12-7-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50275279
PNG
((Z)-1-(4-Fluorobenzylidene)-6-methyl-4-thioxo-4,5-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNO2S/c1-8-6-11-12(7-9-2-4-10(16)5-3-9)19-15(18)13(11)14(20)17-8/h2-7H,1H3,(H,17,20)/b12-7-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274938
PNG
((Z)-6-Methyl-1-(thiophen-3-ylmethylene)-4-thioxo-4...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccsc1
Show InChI InChI=1S/C13H9NO2S2/c1-7-4-9-10(5-8-2-3-18-6-8)16-13(15)11(9)12(17)14-7/h2-6H,1H3,(H,14,17)/b10-5-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
Perforin-1


(Homo sapiens (Human))		BDBM50274934
PNG
((Z)-6-Methyl-1-((5-methylfuran-2-yl)methylene)-1H-...)
Show SMILES Cc1ccc(\C=C2/NC(=O)c3c2cc(C)[nH]c3=O)o1
Show InChI InChI=1S/C14H12N2O3/c1-7-5-10-11(6-9-4-3-8(2)19-9)16-14(18)12(10)13(17)15-7/h3-6H,1-2H3,(H,15,17)(H,16,18)/b11-6-
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University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%