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PubMed code 22172704

Compile data set for download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
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n/an/an/an/a 4.17E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393286
PNG
(CHEMBL2130848)
Show SMILES C(Cc1ccccc1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-3-9-17(10-4-1)14-16-24-22-20(18-11-5-2-6-12-18)26-27-21(25-22)19-13-7-8-15-23-19/h1-13,15H,14,16H2,(H,24,25,27)
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n/an/an/an/a 3.63E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM49766
PNG
(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Show SMILES O=C(NCCCn1ccnc1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c21-16(18-7-4-9-20-10-8-17-12-20)14-11-15(22-19-14)13-5-2-1-3-6-13/h1-3,5-6,8,10-12H,4,7,9H2,(H,18,21)
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n/an/an/an/a 7.72E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48235
PNG
(MLS000541553 | N,N-dimethyl-6-phenyl-3-(2-pyridiny...)
Show SMILES CN(C)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C16H15N5/c1-21(2)16-14(12-8-4-3-5-9-12)19-20-15(18-16)13-10-6-7-11-17-13/h3-11H,1-2H3
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n/an/an/an/a 9.82E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393302
PNG
(CHEMBL2140280)
Show SMILES OCCCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H17N5O/c23-12-6-11-19-17-15(13-7-2-1-3-8-13)21-22-16(20-17)14-9-4-5-10-18-14/h1-5,7-10,23H,6,11-12H2,(H,19,20,22)
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n/an/an/an/a 1.05E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393304
PNG
(CHEMBL2152030)
Show SMILES C(CNc1nc(nnc1-c1ccccc1)-c1ccccn1)CN1CCOCC1
Show InChI InChI=1S/C21H24N6O/c1-2-7-17(8-3-1)19-21(23-11-6-12-27-13-15-28-16-14-27)24-20(26-25-19)18-9-4-5-10-22-18/h1-5,7-10H,6,11-16H2,(H,23,24,26)
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n/an/an/an/a 6.27E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393305
PNG
(CHEMBL2131608)
Show SMILES OCC1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H21N5O/c26-14-15-9-12-25(13-10-15)20-18(16-6-2-1-3-7-16)23-24-19(22-20)17-8-4-5-11-21-17/h1-8,11,15,26H,9-10,12-14H2
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n/an/an/an/a 1.16E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393306
PNG
(CHEMBL2152031)
Show SMILES CN1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C19H20N6/c1-24-11-13-25(14-12-24)19-17(15-7-3-2-4-8-15)22-23-18(21-19)16-9-5-6-10-20-16/h2-10H,11-14H2,1H3
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n/an/an/an/a 1.02E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393280
PNG
(CHEMBL2134094)
Show SMILES Cc1ccccc1CNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-16-9-5-6-12-18(16)15-24-22-20(17-10-3-2-4-11-17)26-27-21(25-22)19-13-7-8-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 9.54E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393282
PNG
(CHEMBL2139663)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 1.19E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
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n/an/an/an/a 2.06E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393286
PNG
(CHEMBL2130848)
Show SMILES C(Cc1ccccc1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-3-9-17(10-4-1)14-16-24-22-20(18-11-5-2-6-12-18)26-27-21(25-22)19-13-7-8-15-23-19/h1-13,15H,14,16H2,(H,24,25,27)
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n/an/an/an/a 9.82E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393287
PNG
(CHEMBL2134352)
Show SMILES C(Cc1ccccn1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C21H18N6/c1-2-8-16(9-3-1)19-21(24-15-12-17-10-4-6-13-22-17)25-20(27-26-19)18-11-5-7-14-23-18/h1-11,13-14H,12,15H2,(H,24,25,27)
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n/an/an/an/a 9.84E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393294
PNG
(CHEMBL2136245)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C20H16N6/c1-2-8-15(9-3-1)18-20(23-14-16-10-4-6-12-21-16)24-19(26-25-18)17-11-5-7-13-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 6.45E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.56E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48250
PNG
(6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...)
Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)
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n/an/an/an/a 7.13E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393303
PNG
(CHEMBL2152029)
Show SMILES C(CN1CCOCC1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H22N6O/c1-2-6-16(7-3-1)18-20(22-10-11-26-12-14-27-15-13-26)23-19(25-24-18)17-8-4-5-9-21-17/h1-9H,10-15H2,(H,22,23,25)
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n/an/an/an/a 2.08E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393277
PNG
(CHEMBL2152032)
Show SMILES Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1
Show InChI InChI=1S/C20H16N6/c1-14-8-7-12-17(22-14)23-20-18(15-9-3-2-4-10-15)25-26-19(24-20)16-11-5-6-13-21-16/h2-13H,1H3,(H,22,23,24,26)
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n/an/an/an/a 2.24E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393282
PNG
(CHEMBL2139663)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 4.58E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
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n/an/an/an/a 2.33E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393291
PNG
(CHEMBL2140244)
Show SMILES COc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5O/c1-28-18-11-7-8-16(14-18)15-24-22-20(17-9-3-2-4-10-17)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 4.15E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48250
PNG
(6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...)
Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)
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n/an/an/an/a 4.62E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393301
PNG
(CHEMBL2141722)
Show SMILES CC(C)(C)CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H23N5/c1-20(2,3)12-14-22-19-17(15-9-5-4-6-10-15)24-25-18(23-19)16-11-7-8-13-21-16/h4-11,13H,12,14H2,1-3H3,(H,22,23,25)
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n/an/an/an/a 3.82E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393278
PNG
(CHEMBL2141631)
Show SMILES N(c1cnc2ccccc2n1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H15N7/c1-2-8-15(9-3-1)20-22(27-21(29-28-20)18-12-6-7-13-23-18)26-19-14-24-16-10-4-5-11-17(16)25-19/h1-14H,(H,25,26,27,29)
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n/an/an/an/a 4.46E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393301
PNG
(CHEMBL2141722)
Show SMILES CC(C)(C)CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H23N5/c1-20(2,3)12-14-22-19-17(15-9-5-4-6-10-15)24-25-18(23-19)16-11-7-8-13-21-16/h4-11,13H,12,14H2,1-3H3,(H,22,23,25)
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n/an/an/an/a 2.48E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393304
PNG
(CHEMBL2152030)
Show SMILES C(CNc1nc(nnc1-c1ccccc1)-c1ccccn1)CN1CCOCC1
Show InChI InChI=1S/C21H24N6O/c1-2-7-17(8-3-1)19-21(23-11-6-12-27-13-15-28-16-14-27)24-20(26-25-19)18-9-4-5-10-22-18/h1-5,7-10H,6,11-16H2,(H,23,24,26)
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n/an/an/an/a 8.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393281
PNG
(CHEMBL2139973)
Show SMILES Cc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5/c1-16-8-7-9-17(14-16)15-24-22-20(18-10-3-2-4-11-18)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 2.91E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/an/an/a 1.88E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393285
PNG
(CHEMBL2140836)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCOCC1
Show InChI InChI=1S/C20H21N5O/c1-2-6-16(7-3-1)18-20(22-14-15-9-12-26-13-10-15)23-19(25-24-18)17-8-4-5-11-21-17/h1-8,11,15H,9-10,12-14H2,(H,22,23,25)
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n/an/an/an/a 8.38E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
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n/an/an/an/a 1.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393307
PNG
(CHEMBL1505546)
Show SMILES O=C(NCCCN1CCOCC1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C17H21N3O3/c21-17(18-7-4-8-20-9-11-22-12-10-20)15-13-16(23-19-15)14-5-2-1-3-6-14/h1-3,5-6,13H,4,7-12H2,(H,18,21)
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n/an/an/an/a 2.39E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393297
PNG
(CHEMBL2152027)
Show SMILES OCCCCNC(=O)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H16N2O3/c17-9-5-4-8-15-14(18)12-10-13(19-16-12)11-6-2-1-3-7-11/h1-3,6-7,10,17H,4-5,8-9H2,(H,15,18)
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n/an/an/an/a 2.20E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393299
PNG
(CHEMBL2141772)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CC1
Show InChI InChI=1S/C18H17N5/c1-2-6-14(7-3-1)16-18(20-12-13-9-10-13)21-17(23-22-16)15-8-4-5-11-19-15/h1-8,11,13H,9-10,12H2,(H,20,21,23)
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n/an/an/an/a 1.27E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393279
PNG
(CHEMBL600512 | GNF-Pf-100)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C21H17N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h1-14H,15H2,(H,23,24,26)
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n/an/an/an/a 7.74E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393281
PNG
(CHEMBL2139973)
Show SMILES Cc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5/c1-16-8-7-9-17(14-16)15-24-22-20(18-10-3-2-4-11-18)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 5.41E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/an/an/a 6.73E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393285
PNG
(CHEMBL2140836)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCOCC1
Show InChI InChI=1S/C20H21N5O/c1-2-6-16(7-3-1)18-20(22-14-15-9-12-26-13-10-15)23-19(25-24-18)17-8-4-5-11-21-17/h1-8,11,15H,9-10,12-14H2,(H,22,23,25)
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n/an/an/an/a 2.95E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393298
PNG
(CHEMBL2152028)
Show SMILES O=C(NCC1CC1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(15-9-10-6-7-10)12-8-13(18-16-12)11-4-2-1-3-5-11/h1-5,8,10H,6-7,9H2,(H,15,17)
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n/an/an/an/a 1.66E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393299
PNG
(CHEMBL2141772)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CC1
Show InChI InChI=1S/C18H17N5/c1-2-6-14(7-3-1)16-18(20-12-13-9-10-13)21-17(23-22-16)15-8-4-5-11-19-15/h1-8,11,13H,9-10,12H2,(H,20,21,23)
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n/an/an/an/a 4.27E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393293
PNG
(CHEMBL2152106)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccnc1
Show InChI InChI=1S/C20H16N6/c1-2-8-16(9-3-1)18-20(23-14-15-7-6-11-21-13-15)24-19(26-25-18)17-10-4-5-12-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 4.35E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
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n/an/an/an/a 1.71E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393297
PNG
(CHEMBL2152027)
Show SMILES OCCCCNC(=O)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H16N2O3/c17-9-5-4-8-15-14(18)12-10-13(19-16-12)11-6-2-1-3-7-11/h1-3,6-7,10,17H,4-5,8-9H2,(H,15,18)
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n/an/an/an/a 3.04E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393281
PNG
(CHEMBL2139973)
Show SMILES Cc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5/c1-16-8-7-9-17(14-16)15-24-22-20(18-10-3-2-4-11-18)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 2.39E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a 2.30E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393291
PNG
(CHEMBL2140244)
Show SMILES COc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5O/c1-28-18-11-7-8-16(14-18)15-24-22-20(17-9-3-2-4-10-17)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 6.27E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48235
PNG
(MLS000541553 | N,N-dimethyl-6-phenyl-3-(2-pyridiny...)
Show SMILES CN(C)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C16H15N5/c1-21(2)16-14(12-8-4-3-5-9-12)19-20-15(18-16)13-10-6-7-11-17-13/h3-11H,1-2H3
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n/an/an/an/a 9.06E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393299
PNG
(CHEMBL2141772)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CC1
Show InChI InChI=1S/C18H17N5/c1-2-6-14(7-3-1)16-18(20-12-13-9-10-13)21-17(23-22-16)15-8-4-5-11-19-15/h1-8,11,13H,9-10,12H2,(H,20,21,23)
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n/an/an/an/a 6.21E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393305
PNG
(CHEMBL2131608)
Show SMILES OCC1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H21N5O/c26-14-15-9-12-25(13-10-15)20-18(16-6-2-1-3-7-16)23-24-19(22-20)17-8-4-5-11-21-17/h1-8,11,15,26H,9-10,12-14H2
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n/an/an/an/a 1.21E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393278
PNG
(CHEMBL2141631)
Show SMILES N(c1cnc2ccccc2n1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H15N7/c1-2-8-15(9-3-1)20-22(27-21(29-28-20)18-12-6-7-13-23-18)26-19-14-24-16-10-4-5-11-17(16)25-19/h1-14H,(H,25,26,27,29)
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n/an/an/an/a 3.26E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393280
PNG
(CHEMBL2134094)
Show SMILES Cc1ccccc1CNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-16-9-5-6-12-18(16)15-24-22-20(17-10-3-2-4-11-17)26-27-21(25-22)19-13-7-8-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 3.08E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 2.57E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.63E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393307
PNG
(CHEMBL1505546)
Show SMILES O=C(NCCCN1CCOCC1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C17H21N3O3/c21-17(18-7-4-8-20-9-11-22-12-10-20)15-13-16(23-19-15)14-5-2-1-3-6-14/h1-3,5-6,13H,4,7-12H2,(H,18,21)
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n/an/an/an/a 2.80E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393309
PNG
(CHEMBL1342148)
Show SMILES CCCCNC(=O)c1cc(on1)-c1ccc(F)cc1
Show InChI InChI=1S/C14H15FN2O2/c1-2-3-8-16-14(18)12-9-13(19-17-12)10-4-6-11(15)7-5-10/h4-7,9H,2-3,8H2,1H3,(H,16,18)
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n/an/an/an/a 8.85E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393298
PNG
(CHEMBL2152028)
Show SMILES O=C(NCC1CC1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(15-9-10-6-7-10)12-8-13(18-16-12)11-4-2-1-3-5-11/h1-5,8,10H,6-7,9H2,(H,15,17)
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n/an/an/an/a 2.49E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393301
PNG
(CHEMBL2141722)
Show SMILES CC(C)(C)CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H23N5/c1-20(2,3)12-14-22-19-17(15-9-5-4-6-10-15)24-25-18(23-19)16-11-7-8-13-21-16/h4-11,13H,12,14H2,1-3H3,(H,22,23,25)
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n/an/an/an/a 2.97E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393306
PNG
(CHEMBL2152031)
Show SMILES CN1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C19H20N6/c1-24-11-13-25(14-12-24)19-17(15-7-3-2-4-8-15)22-23-18(21-19)16-9-5-6-10-20-16/h2-10H,11-14H2,1H3
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n/an/an/an/a 2.19E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393287
PNG
(CHEMBL2134352)
Show SMILES C(Cc1ccccn1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C21H18N6/c1-2-8-16(9-3-1)19-21(24-15-12-17-10-4-6-13-22-17)25-20(27-26-19)18-11-5-7-14-23-18/h1-11,13-14H,12,15H2,(H,24,25,27)
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n/an/an/an/a 1.75E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393290
PNG
(CHEMBL2131991)
Show SMILES COc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5O/c1-28-18-12-10-16(11-13-18)15-24-22-20(17-7-3-2-4-8-17)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 4.74E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 2.49E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393285
PNG
(CHEMBL2140836)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCOCC1
Show InChI InChI=1S/C20H21N5O/c1-2-6-16(7-3-1)18-20(22-14-15-9-12-26-13-10-15)23-19(25-24-18)17-8-4-5-11-21-17/h1-8,11,15H,9-10,12-14H2,(H,22,23,25)
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n/an/an/an/a 7.67E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393290
PNG
(CHEMBL2131991)
Show SMILES COc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5O/c1-28-18-12-10-16(11-13-18)15-24-22-20(17-7-3-2-4-8-17)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 3.73E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
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n/an/an/an/a 600n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393294
PNG
(CHEMBL2136245)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C20H16N6/c1-2-8-15(9-3-1)18-20(23-14-16-10-4-6-12-21-16)24-19(26-25-18)17-11-5-7-13-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 7.62E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 500n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393298
PNG
(CHEMBL2152028)
Show SMILES O=C(NCC1CC1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(15-9-10-6-7-10)12-8-13(18-16-12)11-4-2-1-3-5-11/h1-5,8,10H,6-7,9H2,(H,15,17)
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n/an/an/an/a 2.15E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393306
PNG
(CHEMBL2152031)
Show SMILES CN1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C19H20N6/c1-24-11-13-25(14-12-24)19-17(15-7-3-2-4-8-15)22-23-18(21-19)16-9-5-6-10-20-16/h2-10H,11-14H2,1H3
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n/an/an/an/a 8.69E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393277
PNG
(CHEMBL2152032)
Show SMILES Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1
Show InChI InChI=1S/C20H16N6/c1-14-8-7-12-17(22-14)23-20-18(15-9-3-2-4-10-15)25-26-19(24-20)16-11-5-6-13-21-16/h2-13H,1H3,(H,22,23,24,26)
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n/an/an/an/a 7.55E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393282
PNG
(CHEMBL2139663)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 2.60E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
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n/an/an/an/a 2.77E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393290
PNG
(CHEMBL2131991)
Show SMILES COc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5O/c1-28-18-12-10-16(11-13-18)15-24-22-20(17-7-3-2-4-8-17)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 3.67E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393291
PNG
(CHEMBL2140244)
Show SMILES COc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5O/c1-28-18-11-7-8-16(14-18)15-24-22-20(17-9-3-2-4-10-17)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 3.92E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM47715
PNG
(DEFEROXAMINE | DEFEROXAMINE MESYLATE | MLS00002871...)
Show SMILES CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
Show InChI InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)
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n/an/an/an/a 1.78E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393300
PNG
(CHEMBL2130568)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C21H23N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h2,5-8,11-14,16H,1,3-4,9-10,15H2,(H,23,24,26)
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n/an/an/an/a 4.74E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393278
PNG
(CHEMBL2141631)
Show SMILES N(c1cnc2ccccc2n1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H15N7/c1-2-8-15(9-3-1)20-22(27-21(29-28-20)18-12-6-7-13-23-18)26-19-14-24-16-10-4-5-11-17(16)25-19/h1-14H,(H,25,26,27,29)
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n/an/an/an/a 7.64E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393280
PNG
(CHEMBL2134094)
Show SMILES Cc1ccccc1CNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-16-9-5-6-12-18(16)15-24-22-20(17-10-3-2-4-11-17)26-27-21(25-22)19-13-7-8-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 6.67E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393293
PNG
(CHEMBL2152106)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccnc1
Show InChI InChI=1S/C20H16N6/c1-2-8-16(9-3-1)18-20(23-14-15-7-6-11-21-13-15)24-19(26-25-18)17-10-4-5-12-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 2.60E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.40E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393287
PNG
(CHEMBL2134352)
Show SMILES C(Cc1ccccn1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C21H18N6/c1-2-8-16(9-3-1)19-21(24-15-12-17-10-4-6-13-22-17)25-20(27-26-19)18-11-5-7-14-23-18/h1-11,13-14H,12,15H2,(H,24,25,27)
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n/an/an/an/a 9.60E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393307
PNG
(CHEMBL1505546)
Show SMILES O=C(NCCCN1CCOCC1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C17H21N3O3/c21-17(18-7-4-8-20-9-11-22-12-10-20)15-13-16(23-19-15)14-5-2-1-3-6-14/h1-3,5-6,13H,4,7-12H2,(H,18,21)
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n/an/an/an/a 2.00E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a 2.96E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393300
PNG
(CHEMBL2130568)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C21H23N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h2,5-8,11-14,16H,1,3-4,9-10,15H2,(H,23,24,26)
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n/an/an/an/a 2.46E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393277
PNG
(CHEMBL2152032)
Show SMILES Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1
Show InChI InChI=1S/C20H16N6/c1-14-8-7-12-17(22-14)23-20-18(15-9-3-2-4-10-15)25-26-19(24-20)16-11-5-6-13-21-16/h2-13H,1H3,(H,22,23,24,26)
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n/an/an/an/a 5.41E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393279
PNG
(CHEMBL600512 | GNF-Pf-100)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C21H17N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h1-14H,15H2,(H,23,24,26)
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n/an/an/an/a 4.80E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393293
PNG
(CHEMBL2152106)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccnc1
Show InChI InChI=1S/C20H16N6/c1-2-8-16(9-3-1)18-20(23-14-15-7-6-11-21-13-15)24-19(26-25-18)17-10-4-5-12-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 5.02E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM49766
PNG
(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Show SMILES O=C(NCCCn1ccnc1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c21-16(18-7-4-9-20-10-8-17-12-20)14-11-15(22-19-14)13-5-2-1-3-6-13/h1-3,5-6,8,10-12H,4,7,9H2,(H,18,21)
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n/an/an/an/a 1.58E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393297
PNG
(CHEMBL2152027)
Show SMILES OCCCCNC(=O)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H16N2O3/c17-9-5-4-8-15-14(18)12-10-13(19-16-12)11-6-2-1-3-7-11/h1-3,6-7,10,17H,4-5,8-9H2,(H,15,18)
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n/an/an/an/a 7.57E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393300
PNG
(CHEMBL2130568)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C21H23N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h2,5-8,11-14,16H,1,3-4,9-10,15H2,(H,23,24,26)
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n/an/an/an/a 3.45E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393302
PNG
(CHEMBL2140280)
Show SMILES OCCCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H17N5O/c23-12-6-11-19-17-15(13-7-2-1-3-8-13)21-22-16(20-17)14-9-4-5-10-18-14/h1-5,7-10,23H,6,11-12H2,(H,19,20,22)
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n/an/an/an/a 1.06E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393279
PNG
(CHEMBL600512 | GNF-Pf-100)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C21H17N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h1-14H,15H2,(H,23,24,26)
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n/an/an/an/a 4.48E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
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n/an/an/an/a 2.55E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393286
PNG
(CHEMBL2130848)
Show SMILES C(Cc1ccccc1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-3-9-17(10-4-1)14-16-24-22-20(18-11-5-2-6-12-18)26-27-21(25-22)19-13-7-8-15-23-19/h1-13,15H,14,16H2,(H,24,25,27)
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n/an/an/an/a 8.72E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a 1.85E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 5.01E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM49766
PNG
(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Show SMILES O=C(NCCCn1ccnc1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c21-16(18-7-4-9-20-10-8-17-12-20)14-11-15(22-19-14)13-5-2-1-3-6-13/h1-3,5-6,8,10-12H,4,7,9H2,(H,18,21)
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n/an/an/an/a 8.67E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393302
PNG
(CHEMBL2140280)
Show SMILES OCCCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H17N5O/c23-12-6-11-19-17-15(13-7-2-1-3-8-13)21-22-16(20-17)14-9-4-5-10-18-14/h1-5,7-10,23H,6,11-12H2,(H,19,20,22)
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n/an/an/an/a 2.50E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393304
PNG
(CHEMBL2152030)
Show SMILES C(CNc1nc(nnc1-c1ccccc1)-c1ccccn1)CN1CCOCC1
Show InChI InChI=1S/C21H24N6O/c1-2-7-17(8-3-1)19-21(23-11-6-12-27-13-15-28-16-14-27)24-20(26-25-19)18-9-4-5-10-22-18/h1-5,7-10H,6,11-16H2,(H,23,24,26)
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n/an/an/an/a 1.42E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393305
PNG
(CHEMBL2131608)
Show SMILES OCC1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H21N5O/c26-14-15-9-12-25(13-10-15)20-18(16-6-2-1-3-7-16)23-24-19(22-20)17-8-4-5-11-21-17/h1-8,11,15,26H,9-10,12-14H2
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n/an/an/an/a 2.29E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393294
PNG
(CHEMBL2136245)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C20H16N6/c1-2-8-15(9-3-1)18-20(23-14-16-10-4-6-12-21-16)24-19(26-25-18)17-11-5-7-13-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 2.78E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393303
PNG
(CHEMBL2152029)
Show SMILES C(CN1CCOCC1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H22N6O/c1-2-6-16(7-3-1)18-20(22-10-11-26-12-14-27-15-13-26)23-19(25-24-18)17-8-4-5-9-21-17/h1-9H,10-15H2,(H,22,23,25)
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n/an/an/an/a 9.08E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
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n/an/an/an/a 1.49E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48250
PNG
(6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...)
Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)
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n/an/an/an/a 6.15E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393303
PNG
(CHEMBL2152029)
Show SMILES C(CN1CCOCC1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H22N6O/c1-2-6-16(7-3-1)18-20(22-10-11-26-12-14-27-15-13-26)23-19(25-24-18)17-8-4-5-9-21-17/h1-9H,10-15H2,(H,22,23,25)
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n/an/an/an/a 1.00E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48235
PNG
(MLS000541553 | N,N-dimethyl-6-phenyl-3-(2-pyridiny...)
Show SMILES CN(C)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C16H15N5/c1-21(2)16-14(12-8-4-3-5-9-12)19-20-15(18-16)13-10-6-7-11-17-13/h3-11H,1-2H3
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n/an/an/an/a 7.46E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%