Found 30 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50344367
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydrox...)Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H12ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-9,25H,(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382237
(CHEMBL2024668)Show SMILES OC1CCc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2C1 Show InChI InChI=1S/C18H16ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-3,5,7-8,12,25H,4,6,9H2,(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382237
(CHEMBL2024668)Show SMILES OC1CCc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2C1 Show InChI InChI=1S/C18H16ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-3,5,7-8,12,25H,4,6,9H2,(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382245
(CHEMBL2024494)Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1F Show InChI InChI=1S/C18H11ClF4N2O2/c19-12-6-5-10(8-11(12)18(21,22)23)24-17(27)25-13-3-1-2-9-4-7-14(26)16(20)15(9)13/h1-8,26H,(H2,24,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382240
(CHEMBL2024667)Show SMILES Cc1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1CCO Show InChI InChI=1S/C17H16ClF3N2O2/c1-10-3-2-4-15(12(10)7-8-24)23-16(25)22-11-5-6-14(18)13(9-11)17(19,20)21/h2-6,9,24H,7-8H2,1H3,(H2,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382243
(CHEMBL2024492)Show SMILES Oc1ccc2c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cccc2c1 Show InChI InChI=1S/C18H12ClF3N2O2/c19-15-7-4-11(9-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-8-12(25)5-6-13(10)16/h1-9,25H,(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382248
(CHEMBL2024498)Show SMILES CNc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C19H15ClF3N3O/c1-24-12-6-5-11-3-2-4-17(14(11)9-12)26-18(27)25-13-7-8-16(20)15(10-13)19(21,22)23/h2-10,24H,1H3,(H2,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382232
(CHEMBL2024660)Show SMILES FC(F)(F)c1nc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2[nH]1 Show InChI InChI=1S/C16H9ClF6N4O/c17-9-5-4-7(6-8(9)15(18,19)20)24-14(28)26-11-3-1-2-10-12(11)27-13(25-10)16(21,22)23/h1-6H,(H,25,27)(H2,24,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382231
(CHEMBL2024659)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc3[nH]ccc23)ccc1Cl Show InChI InChI=1S/C16H11ClF3N3O/c17-12-5-4-9(8-11(12)16(18,19)20)22-15(24)23-14-3-1-2-13-10(14)6-7-21-13/h1-8,21H,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382247
(CHEMBL2024497)Show SMILES Nc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H13ClF3N3O/c19-15-7-6-12(9-14(15)18(20,21)22)24-17(26)25-16-3-1-2-10-4-5-11(23)8-13(10)16/h1-9H,23H2,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382244
(CHEMBL2024493)Show SMILES Oc1cccc2c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cccc12 Show InChI InChI=1S/C18H12ClF3N2O2/c19-14-8-7-10(9-13(14)18(20,21)22)23-17(26)24-15-5-1-4-12-11(15)3-2-6-16(12)25/h1-9,25H,(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382235
(CHEMBL2024663)Show InChI InChI=1S/C16H14ClF3N2O2/c17-13-6-5-11(9-12(13)16(18,19)20)21-15(24)22-14-4-2-1-3-10(14)7-8-23/h1-6,9,23H,7-8H2,(H2,21,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382233
(CHEMBL2024661)Show SMILES Cc1nc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2[nH]1 Show InChI InChI=1S/C16H12ClF3N4O/c1-8-21-12-3-2-4-13(14(12)22-8)24-15(25)23-9-5-6-11(17)10(7-9)16(18,19)20/h2-7H,1H3,(H,21,22)(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382229
(CHEMBL2024657)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc3cc[nH]c23)ccc1Cl Show InChI InChI=1S/C16H11ClF3N3O/c17-12-5-4-10(8-11(12)16(18,19)20)22-15(24)23-13-3-1-2-9-6-7-21-14(9)13/h1-8,21H,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382225
(CHEMBL2024495)Show SMILES OC(=O)c1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C19H12ClF3N2O3/c20-15-7-6-12(9-14(15)19(21,22)23)24-18(28)25-16-3-1-2-10-4-5-11(17(26)27)8-13(10)16/h1-9H,(H,26,27)(H2,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382241
(CHEMBL2024669)Show SMILES OCC1CCc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2C1 Show InChI InChI=1S/C19H18ClF3N2O2/c20-16-7-6-13(9-15(16)19(21,22)23)24-18(27)25-17-3-1-2-12-5-4-11(10-26)8-14(12)17/h1-3,6-7,9,11,26H,4-5,8,10H2,(H2,24,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382242
(CHEMBL2024670)Show SMILES CC1CCc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2C1 Show InChI InChI=1S/C19H18ClF3N2O/c1-11-5-6-12-3-2-4-17(14(12)9-11)25-18(26)24-13-7-8-16(20)15(10-13)19(21,22)23/h2-4,7-8,10-11H,5-6,9H2,1H3,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382246
(CHEMBL2024496)Show SMILES Oc1ccc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2c1 Show InChI InChI=1S/C18H12ClF3N2O2/c19-16-6-4-13(9-15(16)18(20,21)22)24-17(26)23-12-3-1-10-2-5-14(25)8-11(10)7-12/h1-9,25H,(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382249
(CHEMBL2024499)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc3ccc(NCc4ccccc4)cc23)ccc1Cl Show InChI InChI=1S/C25H19ClF3N3O/c26-22-12-11-19(14-21(22)25(27,28)29)31-24(33)32-23-8-4-7-17-9-10-18(13-20(17)23)30-15-16-5-2-1-3-6-16/h1-14,30H,15H2,(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382230
(CHEMBL2024658)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc3nn[nH]c23)ccc1Cl Show InChI InChI=1S/C14H9ClF3N5O/c15-9-5-4-7(6-8(9)14(16,17)18)19-13(24)20-10-2-1-3-11-12(10)22-23-21-11/h1-6H,(H2,19,20,24)(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382234
(CHEMBL2024662)Show InChI InChI=1S/C17H16ClF3N2O2/c18-14-8-7-12(10-13(14)17(19,20)21)22-16(25)23-15-6-2-1-4-11(15)5-3-9-24/h1-2,4,6-8,10,24H,3,5,9H2,(H2,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382239
(CHEMBL2024666)Show InChI InChI=1S/C16H14ClF3N2O2/c17-14-5-4-12(9-13(14)16(18,19)20)22-15(24)21-11-3-1-2-10(8-11)6-7-23/h1-5,8-9,23H,6-7H2,(H2,21,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382236
(CHEMBL2024664)Show InChI InChI=1S/C15H12ClF3N2O2/c16-12-6-5-10(7-11(12)15(17,18)19)20-14(23)21-13-4-2-1-3-9(13)8-22/h1-7,22H,8H2,(H2,20,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382227
(CHEMBL2024504)Show SMILES NS(=O)(=O)Cc1ccccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C15H13ClF3N3O3S/c16-12-6-5-10(7-11(12)15(17,18)19)21-14(23)22-13-4-2-1-3-9(13)8-26(20,24)25/h1-7H,8H2,(H2,20,24,25)(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382251
(CHEMBL2024501)Show SMILES CC(=O)Nc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C20H15ClF3N3O2/c1-11(28)25-13-6-5-12-3-2-4-18(15(12)9-13)27-19(29)26-14-7-8-17(21)16(10-14)20(22,23)24/h2-10H,1H3,(H,25,28)(H2,26,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382226
(CHEMBL2024503)Show SMILES NS(=O)(=O)c1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H13ClF3N3O3S/c19-15-7-5-11(8-14(15)18(20,21)22)24-17(26)25-16-3-1-2-10-4-6-12(9-13(10)16)29(23,27)28/h1-9H,(H2,23,27,28)(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382238
(CHEMBL2024665)Show InChI InChI=1S/C16H15ClF3N3O/c17-13-6-5-11(9-12(13)16(18,19)20)22-15(24)23-14-4-2-1-3-10(14)7-8-21/h1-6,9H,7-8,21H2,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382252
(CHEMBL2024502)Show SMILES CS(=O)(=O)Nc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C19H15ClF3N3O3S/c1-30(28,29)26-13-6-5-11-3-2-4-17(14(11)9-13)25-18(27)24-12-7-8-16(20)15(10-12)19(21,22)23/h2-10,26H,1H3,(H2,24,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382250
(CHEMBL2024500)Show SMILES Nc1cc2c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cccc2cc1Cl Show InChI InChI=1S/C18H12Cl2F3N3O/c19-13-5-4-10(7-12(13)18(21,22)23)25-17(27)26-16-3-1-2-9-6-14(20)15(24)8-11(9)16/h1-8H,24H2,(H2,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50382228
(CHEMBL2024505)Show SMILES NS(=O)(=O)c1ccccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C14H11ClF3N3O3S/c15-10-6-5-8(7-9(10)14(16,17)18)20-13(22)21-11-3-1-2-4-12(11)25(19,23)24/h1-7H,(H2,19,23,24)(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... |
Bioorg Med Chem Lett 22: 3408-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7 |
More data for this
Ligand-Target Pair | |
Search and Browse
