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PubMed code 26496175

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133328
PNG
(CHEMBL3632807)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(cc1C(=O)C2=O)[N+]([O-])=O |c:5|
Show InChI InChI=1S/C15H13NO5/c1-15(2)6-5-10-12(17)13(18)11-7-8(16(19)20)3-4-9(11)14(10)21-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133350
PNG
(8-methoxy-beta-lapachone | CHEMBL2036880)
Show SMILES COc1ccc2C3=C(CCC(C)(C)O3)C(=O)C(=O)c2c1 |t:6|
Show InChI InChI=1S/C16H16O4/c1-16(2)7-6-11-13(17)14(18)12-8-9(19-3)4-5-10(12)15(11)20-16/h4-5,8H,6-7H2,1-3H3
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n/an/a 600n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM81348
PNG
(β-Lapachone (A3) | Beta lapachone | R115 (Rea...)
Show SMILES CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O |c:5|
Show InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133340
PNG
(CHEMBL3635001)
Show SMILES O=C1C=C(NC2CCN(Cc3ccccc3)C2)c2ccccc2C1=O |t:2|
Show InChI InChI=1S/C21H20N2O2/c24-20-12-19(17-8-4-5-9-18(17)21(20)25)22-16-10-11-23(14-16)13-15-6-2-1-3-7-15/h1-9,12,16,22H,10-11,13-14H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133331
PNG
(CHEMBL3632804)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(F)cc1C(=O)C2=O |c:5|
Show InChI InChI=1S/C15H13FO3/c1-15(2)6-5-10-12(17)13(18)11-7-8(16)3-4-9(11)14(10)19-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133347
PNG
(CHEMBL3634995)
Show SMILES CN(C)CCNC1=CC(=O)C(=O)c2ccccc12 |t:6|
Show InChI InChI=1S/C14H16N2O2/c1-16(2)8-7-15-12-9-13(17)14(18)11-6-4-3-5-10(11)12/h3-6,9,15H,7-8H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133329
PNG
(CHEMBL3632806)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(cc1C(=O)C2=O)C#N |c:5|
Show InChI InChI=1S/C16H13NO3/c1-16(2)6-5-11-13(18)14(19)12-7-9(8-17)3-4-10(12)15(11)20-16/h3-4,7H,5-6H2,1-2H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM81348
PNG
(β-Lapachone (A3) | Beta lapachone | R115 (Rea...)
Show SMILES CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O |c:5|
Show InChI InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133351
PNG
(CHEMBL177685)
Show SMILES COc1cc2C(=O)C(=O)C3=C(OC(C)(C)CC3)c2cc1OC |t:9|
Show InChI InChI=1S/C17H18O5/c1-17(2)6-5-9-14(18)15(19)10-7-12(20-3)13(21-4)8-11(10)16(9)22-17/h7-8H,5-6H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133349
PNG
(CHEMBL3634993)
Show SMILES CN(C)C1=CC(=O)C(=O)c2ccccc12 |t:3|
Show InChI InChI=1S/C12H11NO2/c1-13(2)10-7-11(14)12(15)9-6-4-3-5-8(9)10/h3-7H,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133338
PNG
(CHEMBL3635003)
Show SMILES CNC(=O)CNC1=CC(=O)C(=O)c2ccccc12 |t:6|
Show InChI InChI=1S/C13H12N2O3/c1-14-12(17)7-15-10-6-11(16)13(18)9-5-3-2-4-8(9)10/h2-6,15H,7H2,1H3,(H,14,17)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133336
PNG
(CHEMBL3632800)
Show SMILES O=C(CNC1=CC(=O)C(=O)c2ccccc12)NCCc1ccccc1 |t:4|
Show InChI InChI=1S/C20H18N2O3/c23-18-12-17(15-8-4-5-9-16(15)20(18)25)22-13-19(24)21-11-10-14-6-2-1-3-7-14/h1-9,12,22H,10-11,13H2,(H,21,24)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133332
PNG
(CHEMBL3183233)
Show SMILES COCCOc1nc(-c2ccc(Cl)c(Cl)c2)n(n1)-c1ccc(NC(=O)CCl)cc1
Show InChI InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133337
PNG
(CHEMBL3632799)
Show SMILES O=C(CNC1=CC(=O)C(=O)c2ccccc12)N1CCCC1 |t:4|
Show InChI InChI=1S/C16H16N2O3/c19-14-9-13(11-5-1-2-6-12(11)16(14)21)17-10-15(20)18-7-3-4-8-18/h1-2,5-6,9,17H,3-4,7-8,10H2
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n/an/a 4.10E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133339
PNG
(CHEMBL3635002)
Show SMILES O=C1C=C(NC2CCN(Cc3ccccc3)CC2)c2ccccc2C1=O |t:2|
Show InChI InChI=1S/C22H22N2O2/c25-21-14-20(18-8-4-5-9-19(18)22(21)26)23-17-10-12-24(13-11-17)15-16-6-2-1-3-7-16/h1-9,14,17,23H,10-13,15H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133346
PNG
(CHEMBL3634996)
Show SMILES COCCNC1=CC(=O)C(=O)c2ccccc12 |t:5|
Show InChI InChI=1S/C13H13NO3/c1-17-7-6-14-11-8-12(15)13(16)10-5-3-2-4-9(10)11/h2-5,8,14H,6-7H2,1H3
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n/an/a 7.80E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133352
PNG
(CHEMBL3632808)
Show SMILES COc1ccc2C(=O)C(=O)C3=C(OC(C)(C)CC3)c2c1 |t:10|
Show InChI InChI=1S/C16H16O4/c1-16(2)7-6-11-14(18)13(17)10-5-4-9(19-3)8-12(10)15(11)20-16/h4-5,8H,6-7H2,1-3H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133330
PNG
(CHEMBL3632805)
Show SMILES CC1(C)CCC2=C(O1)c1ccc(Br)cc1C(=O)C2=O |c:5|
Show InChI InChI=1S/C15H13BrO3/c1-15(2)6-5-10-12(17)13(18)11-7-8(16)3-4-9(11)14(10)19-15/h3-4,7H,5-6H2,1-2H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133354
PNG
(CHEMBL3632809)
Show SMILES CC1(C)CCC2=C(O1)c1cc(O)ccc1C(=O)C2=O |c:5|
Show InChI InChI=1S/C15H14O4/c1-15(2)6-5-10-13(18)12(17)9-4-3-8(16)7-11(9)14(10)19-15/h3-4,7,16H,5-6H2,1-2H3
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n/an/a 9.30E+3n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrate

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133335
PNG
(CHEMBL3632801)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]-1=[#6](-[#8])-[#6](=O)-c2cc(F)ccc2-[#6]-1=O |c:5|
Show InChI InChI=1S/C15H13FO3/c1-8(2)3-5-11-13(17)10-6-4-9(16)7-12(10)15(19)14(11)18/h3-4,6-7,18H,5H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133334
PNG
(CHEMBL3632802)
Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]-1=[#6](-[#8])-[#6](=O)-c2cc(Br)ccc2-[#6]-1=O |c:5|
Show InChI InChI=1S/C15H13BrO3/c1-8(2)3-5-11-13(17)10-6-4-9(16)7-12(10)15(19)14(11)18/h3-4,6-7,18H,5H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133333
PNG
(CHEMBL3632803)
Show SMILES COc1cc2C(=O)C3=C(OC(C)(C)CC3)C(=O)c2cc1OC |t:7|
Show InChI InChI=1S/C17H18O5/c1-17(2)6-5-9-14(18)10-7-12(20-3)13(21-4)8-11(10)15(19)16(9)22-17/h7-8H,5-6H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133344
PNG
(CHEMBL3634998)
Show SMILES O=C1C=C(NCCCN2CCCC2)c2ccccc2C1=O |t:2|
Show InChI InChI=1S/C17H20N2O2/c20-16-12-15(13-6-1-2-7-14(13)17(16)21)18-8-5-11-19-9-3-4-10-19/h1-2,6-7,12,18H,3-5,8-11H2
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n/an/a 1.19E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133343
PNG
(CHEMBL3634999)
Show SMILES O=C1CCCN1CCCNC1=CC(=O)C(=O)c2ccccc12 |t:11|
Show InChI InChI=1S/C17H18N2O3/c20-15-11-14(12-5-1-2-6-13(12)17(15)22)18-8-4-10-19-9-3-7-16(19)21/h1-2,5-6,11,18H,3-4,7-10H2
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n/an/a 1.44E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133342
PNG
(CHEMBL3635000)
Show SMILES CC(C)(C)OC(=O)NCCNC1=CC(=O)C(=O)c2ccccc12 |t:11|
Show InChI InChI=1S/C17H20N2O4/c1-17(2,3)23-16(22)19-9-8-18-13-10-14(20)15(21)12-7-5-4-6-11(12)13/h4-7,10,18H,8-9H2,1-3H3,(H,19,22)
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n/an/a 1.49E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133348
PNG
(CHEMBL3634994)
Show SMILES CC(C)NC1=CC(=O)C(=O)c2ccccc12 |t:4|
Show InChI InChI=1S/C13H13NO2/c1-8(2)14-11-7-12(15)13(16)10-6-4-3-5-9(10)11/h3-8,14H,1-2H3
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n/an/a 2.04E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133345
PNG
(CHEMBL3634997)
Show SMILES O=C1C=C(NCCN2CCOCC2)c2ccccc2C1=O |t:2|
Show InChI InChI=1S/C16H18N2O3/c19-15-11-14(12-3-1-2-4-13(12)16(15)20)17-5-6-18-7-9-21-10-8-18/h1-4,11,17H,5-10H2
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n/an/a 2.19E+4n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM50133341
PNG
(CHEMBL1966084)
Show SMILES O=C1C=C(NCCc2ccccc2)c2ccccc2C1=O |t:2|
Show InChI InChI=1S/C18H15NO2/c20-17-12-16(14-8-4-5-9-15(14)18(17)21)19-11-10-13-6-2-1-3-7-13/h1-9,12,19H,10-11H2
PDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



Institute of Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of MALT1 in human Jurkat cell lysate preincubated for 2 hrs followed by addition of 25 uM Ac-LRSR-AMC substrate for 3 hrs by fluorescence ...

J Med Chem 58: 8491-502 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01415
BindingDB Entry DOI: 10.7270/Q2PZ5BN1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%